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A kind of biodegradable medical operation anti-adhesion film and preparation method thereof

An anti-adhesion film and surgery technology, applied in the field of medical supplies, can solve the problems of unfavorable application, limited flexibility, poor degradation controllability, etc., and achieve better application effect, good degradation time, and control of degradation time

Active Publication Date: 2015-10-07
CHANGCHUN SINOBIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Compared with blending modification and molding processing modification, the above-mentioned materials have obvious advantages of improving the toughness and softness of polylactic acid by adding polyglycolic acid for copolymerization modification, but the flexibility of the above-mentioned materials is still limited and can be degraded. The controllability is also poor, which is not conducive to the application

Method used

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  • A kind of biodegradable medical operation anti-adhesion film and preparation method thereof
  • A kind of biodegradable medical operation anti-adhesion film and preparation method thereof
  • A kind of biodegradable medical operation anti-adhesion film and preparation method thereof

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preparation example Construction

[0055] The present invention also provides a preparation method of a biodegradable anti-adhesion film for medical operations, comprising the following steps:

[0056] The polyethylene glycol polymer is copolymerized with at least one of lactide and ε-caprolactone and glycolide to obtain a polyethylene glycol polymer with a number average molecular weight of 50,000 to 150,000- Polyester block copolymers;

[0057] Forming the polyethylene glycol polymer-polyester block copolymer into a film to obtain a biodegradable anti-adhesion film for medical operations;

[0058] The polyethylene glycol polymer is shown in formula (I):

[0059]

[0060] Wherein, R is selected from any one of hydroxyl, methyl, ethyl, propyl, isopropyl, amino, propenyl, propynyl, mercapto, carboxyl and azido; n is the degree of polymerization.

[0061] In the present invention, the polyethylene glycol polymer represented by formula (I) is mixed with at least one of lactide and ε-caprolactone and glycolide...

Embodiment 1

[0083] Add 25g of polyethylene glycol monomethyl ether (MPEG) with a molecular weight of 5000 to a 1000mL round bottom flask, place it in an oil bath and heat it to 120°C for vacuum drying. After 5 hours, cool the system down to room temperature, and then Add 416g of lactide (LA) and 59g of glycolide (GA) under low temperature conditions, and continue vacuum drying at a temperature of 110°C. After 6 hours, add a catalyst amount of stannous octoate to carry out copolymerization at 130°C, and polymerize for 24 After 1 hour, the crude product was obtained;

[0084] Dissolve the obtained crude product in chloroform, then slowly pour it into ethanol for sedimentation, filter off the clear liquid, and after vacuum drying, obtain a white solid polymerization product, namely polyethylene glycol-polylactide glycolide block Copolymer, its number average molecular weight is 100,000, LA / GA=85 / 15;

[0085] Dissolve the obtained polymer product in chloroform, after fully dissolving, carefu...

Embodiment 2

[0087] Add 25g of polyethylene glycol monomethyl ether (MPEG) with a molecular weight of 5000 to a 1000mL round bottom flask, place it in an oil bath and heat it to 120°C for vacuum drying. After 5 hours, cool the system down to room temperature, and then 374g of lactide (LA) and 101g of glycolide (GA) were added under low temperature conditions, and the vacuum drying was continued at a temperature of 110°C. After 6 hours, a catalytic amount of stannous octoate was added to carry out a copolymerization reaction at 130°C, and the polymerization was carried out for 24 After 1 hour, the crude product was obtained;

[0088] Dissolve the obtained crude product in chloroform, then slowly pour it into ethanol for sedimentation, filter off the clear liquid, and after vacuum drying, obtain a white solid polymerization product, namely polyethylene glycol-polylactide glycolide block Copolymer, its number average molecular weight is 100,000, LA / GA=75 / 25;

[0089] Dissolve the obtained po...

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Abstract

The invention provides a biodegradable medical surgery anti-adhesion membrane and a preparation method thereof. According to the method, polyethylene glycol compound, at least one of lactide and epsilon-caprolactone and glycolide are subjected to copolymerization so as to obtain a polyethylene glycol compound-polyester segmented copolymer of which the number-average molecular weight is 50000 to 150000; and a polymer material containing the polyethylene glycol compound-polyester segmented copolymer is made into a membrane so as to obtain the biodegradable medical surgery anti-adhesion membrane, wherein the polyethylene glycol compound is shown in formula (I) shown in the specification, R is any one selected from hydroxyl, methyl, ethyl, propyl, isopropyl, amino, allyl, propinyl, sulfydryl, carboxyl and azide; and n is the polymerization degree. Through double modulation of the polyethylene glycol compound and glycolid, the anti-adhesion membrane is better in controllability and good in flexibility, has certain tension resistance strength and is beneficial for application.

Description

technical field [0001] The invention relates to the technical field of medical supplies, in particular to a biodegradable anti-adhesion film for medical operations and a preparation method thereof. Background technique [0002] Adhesions are abnormal structures in which connective tissue fibers join together with adjacent tissues or organs, and can range in size from a fibrous film to a dense vascular scar. Adhesion formation is universal. According to reports, 50% to 100% of abdominal and pelvic surgeries will lead to different degrees of adhesions. Adhesions often lead to serious clinical complications, including intestinal obstruction, infertility, chronic pelvic pain, and postoperative epilepsy, increasing the difficulty of reoperation and the potential for complications. In surgical operations, how to prevent postoperative adhesions is still one of the important topics at home and abroad. [0003] In recent years, it has become a common practice in the world to preven...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/06A61L31/14C08G63/664
Inventor 陈学思孙海高战团许午黄经伟刘明崔毅庄秀丽
Owner CHANGCHUN SINOBIOMATERIALS
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