51results about How to "Control degradation time" patented technology

The invention relates to a novel degradable medical magnesium alloy composite material. The medical magnesium alloy composite material provided by the invention has the characteristics of high strength, good temperature memory and controllable degradation velocity and can be used in the field of orthopedic implantation. The composite material is characterized in that the composite material contains Mg-Al-Zn magnesium alloys, wherein the content of Al is 0.5-3.5wt% and the content of Zn is 0.5-1.8wt%; besides, the magnesium alloy material can contain a few impurities including Fe, Mn, Cu and Ni, wherein the total of the impurities is not greater than 0.3wt%; and a medical biology degradable material exists on the surface layer of the composite material and can be a pure carbon dioxide copolymer, pure polyhydroxyalkanoate or a blend of the carbon dioxide copolymer and polyhydroxyalkanoate, which has to be medically purified before use.

The invention provides a high-intensity starch-based degradation environmental protection material and a manufacturing method thereof, which relates to a rapid degradation raw material used for manufacturing disposable tableware and disposable wrappage and the manufacturing method thereof. The present disposable foaming plastic tableware has the disadvantages of hard heat insulation, complicated process line, high production cost, undesirable production quality and white pollution. The components of the product include macromolecular natural starch, polyvinyl alcohol, plant sugar, polyvinyl alcohol, a degradation control agent, a multipolymer of polycaprolactone and poly-beta-hydroxybutyrate and hexa-butyl ester hexa-butyl glycan; wherein, the starch is 51-80 weight portions, the polyvinyl alcohol is 12-20 weight portions, the plant sugar is 2-10.5 weight portions, plasticizer is 2.5-8 weight portions, the degradation control agent is 0.2-1 weight portions, the multipolymer of polycaprolactone and poly-beta-hydroxybutyrate is 5-9 weight portions and the hexa-butyl ester hexa-butyl glycan is 0.2-0.5 weight portions. The high-intensity starch-based degradation environmental protection material of the invention is used for manufacturing the disposable tableware and the disposable warppage.

The invention belongs to the technical field of manufacturing ground mulching films and particularly relates to a degradable mulching film containing plant fiber degradable filler. The degradable mulching film includes: resin as a mulching film substrate, a degradable master batch that promotes degradation of the mulching film, degradable filler that contains natural plant fiber powders, an antifogging agent, and an additive. The resin is polyvinyl chloride (PVC) or is mixed resin composed of polyethylene (LDPE), linear low density polyethylene (LLDPE) and metallocene polyethylene (mPE). In manufacturing of the degradable mulching film, by means of the plant celluloses such as straw powder, rice hull powder, cottonseed powder and the like, conditions for reproduction of microorganisms in soil are created, thus achieving the objects of turning waste into resources by straw returning. These natural plant fibers have the effect of promoting degradation of the mulching film.

The invention relates to the technical field of PBAT/PLA (poly(butyleneadipate-co-terephthalate)/polylactic acid) blend compatibilization, particularly a controllable-degradation PBAT/PLA composite film. The controllable-degradation PBAT/PLA composite film comprises the following components in parts by weight: 50-60 parts of PBAT, 10-30 parts of PLA, 10-20 parts of calcium carbonate, 0.5-2 parts of antibacterial compatibilizer and 0.5-2 parts of tetrabutyl titanate. The mass ratio of the PLA to the calcium carbonate is (1-3):1. The PLA/calcium carbonate proportion is strictly controlled and restricted within the range of (1-3):1; and the PLA/calcium carbonate proportion can be regulated to control the degradation start time of the PBAT/PLA composite film at 60-90 days and control the complete degradation time at 120-150 days.

The invention discloses a full-biodegradable mulching film with a controllable degradation period and a preparation method thereof. Raw materials for preparing the mulching film comprise the followingcomponents in parts by weight: 40-60 parts of polyadipic acid/butylene terephthalate, 5-20 parts of high-crystallinity polylactic acid, 5-15 parts of polybutylene succinate, 2-10 parts of modified polyamidoamine, 2-6 parts of aliphatic polyol, 5-20 parts of inorganic filler, 1-5 parts of compatilizer, 1-2.5 parts of dispersing agent, 0.1-2 part of antioxidant, 0.1-5 part of ultraviolet light absorber, 0.1-3 part of a light stabilizer, and 0-0.5 part of an auxiliary agent. By selecting high-crystallinity polylactic acid with good air tightness, the air tightness of the mulching film can be effectively improved, degradation of the mulching film can be accelerated by adding modified polyamidoamine into a polymer, and degradation of the mulching film can be accelerated by adjusting the typesand the use amounts of the antioxidant, the ultraviolet light absorber and the light stabilizer as well as the dispersing agent and the auxiliary agent. The degradation time of the full-biodegradablemulching film can be regulated and controlled, and the growth requirements of different altitudes, different regions and different crops can be met.

The invention discloses preparation and application of a linear biodegradable polyester elastomer with a controllable elasticity and shape memory effect. The linear biodegradable polyester elastomer with the controllable elasticity and shape memory effect is formed by conducting copolymerization on a caprolactone monomer containing a lateral cyclic ether structural unit and caprolactone, wherein the molar ratio of the caprolactone monomer containing the lateral cyclic ether structural unit to the caprolactone is 5:95-25:75, and the structural formula can be found in description. The viscoelasticity of the linear biodegradable polyester elastomer with the controllable elasticity and shape memory effect is remarkably improved, the elongation at break can reach 1600% and above, the elastomer can be dissolved in a conventional organic solvent, a three-dimensional porous support can be constructed conveniently through a construction technology of the porous support such as, electrostatic spinning, three-dimensional printing and phase separation, tissue engineering blood vessel scaffold materials, myocardial patches, nervous tissue engineering scaffold materials and the like are prepared, and the preparation and application of the linear biodegradable polyester elastomer can be widely applied to the fields of soft tissue engineering scaffolds, tissue repair and regenerative medicine.

The invention discloses a polylactic acid microsphere and a preparation method and application thereof. The grain size of the microsphere is between 100 mu m and 1000 mu m, preferably between 100 mu mand 300 mu m, between 300 mu m and 500 mu m, between 500 mu m and 700 mu m or between 700 mu m and 1000 mu m, the microsphere is a regular sphere, and the surface and interior of the microsphere areprovided with holes. Because the polylactic acid microsphere is a regular sphere, by adjusting the variety and molecular weight of polylactic acid, the degradation time of the microsphere can be controlled, which is favorable for the determination of the degradation time of the microsphere in the body and the recanalization time of blood vessels in clinical application. The preparation method disclosed by the invention can cut out drops with small grain size under low flow velocity, moreover, the stability of oil-phase fluid is good, the drops do not have tails after coagulant is added, the sphericity of the solidified microsphere is good, and the effect is best. Moreover, by forming the holes in the surface and interior of the microsphere, solvent can be conveniently volatilized, so thatthe amount of remaining solvent is small, meeting the standard of the pharmacopoeia.

The invention relates to a uterine cavity implant as well as a preparation method and application thereof. The uterine cavity implant is characterized by having a bagged structure. The uterine cavity implant comprises a substrate material of animal small intestine submucosa subjected to decellularization treatment. An implantable medical device for preventing and treating intrauterine adhesion comprises a biological tissue substrate material. The present decellularization technology for a biological repairing material is improved; compared with the present product, the biological tissue substrate material provided by the invention has the advantages of lower DNA residual quantity, lower immunogenicity, higher anti-infection capacity and higher repairing capacity; and the uterine cavity implant is beneficial to the recovering of tissues, such as, uterine cavity base layer, submucosa and mucous layer. Besides, the invention prepares the biological repairing material into the uterine cavity built-in structure which is used for isolating wound surfaces, repairing uterine cavity tissues and reducing scar forming, so that the intrauterine adhesion problem is solved, and the accordingly generated sterility problem also can be solved.

The invention belongs to the technical field of bio-based degradation, and relates to a functional adjusting master batch for biodegradation and a preparation method thereof. The functional adjustingmaster batch comprises the following components in parts by weight: 60-90 parts of carrier resin, 0.1-50 parts of degradation accelerant, 0.1-10 parts of heat stabilizer, 0.1-5 parts of light stabilizer, 0.1-5 parts of antioxidant, 0.1-20 parts of chain extender and 0.1-20 parts of other functional aids. The function adjusting master batch can effectively adjust degradation time and degradation speed, and has good anti-aging performance.

The invention discloses a degradation-controllable drug-loaded hemostatic sponge. A formula for the degradation-controllable drug-loaded hemostatic sponge comprises the following components in parts by mass: 10-20 parts of DL-lactide, 16-71 parts of epsilon-caprolactone, 8-23 parts of dihydric alcohol, 48-138 parts of diisocyanate, 0.5-1.5 parts of glucocorticoid drugs, 19.6-56.7 parts of an initiator, 0.112-0.324 part of a catalyst and 50-100 parts of an organic solvent, wherein a feeding molar ratio of the DL-lactide to the epsilon-caprolactone is (10-50): (50-90). According to the invention, the degradation time of a polyurethane sponge is controlled by adjusting the proportion of each component in an amorphous chain segment, so the release of the glucocorticoid drugs is controlled, thenose can be temporarily pressed to realize hemostasis and support; and degradation time and drug release are accurately controlled, so the clinical use of the hemostatic sponge is simpler and more accurate.

The invention discloses a degradation film, particularly to a multi-layer degradation film, and belongs to the technical field of degradation, wherein the multi-layer degradation film sequentially comprises plural layers of degradation films from top to bottom, and separation films are respectively arranged between any two layers of the degradation films, and are used for isolating each degradation film, such that various layers of the degradation films can be separately degraded. According to the present invention, by arranging the separation layer to isolate oxygen and moisture, oxygen and moisture cannot enter the interior of the degradation film, such that the degradation film can be degraded layer by layer, and canot be degraded simultaneously; after the degradation film on the surface layer is degraded, the separation layer is dissolved under the action of water, and the degradation film on the next layer is degraded; and by controlling the number of the layers of the degradationfilms, the degradation time of the whole degradation film can be controlled at 6 months to 8 years.

The invention relates to an antibacterial polyurethane foam material and a preparation method and application thereof, solves the technical problems of high cost and non-ideal effect of the existing nasal cavity hemostatic material, and provides the antibacterial polyurethane foam material. The antibacterial effective component in the antibacterial polyurethane foam material is long side chain quaternized chitosan with 12 carbons on the side chain. The invention also provides a preparation method and application thereof. The material can be used in the field of antibacterial materials.

The invention discloses a material which comprises at least two structural layers, and the crystallinity of the adjacent structural layers is different. The structural layers are formed by degradableresin.