51results about How to "Control degradation time" patented technology

The invention provides a gelatin embolism microsphere and a preparation method and an application thereof. The preparation method of the gelatin embolism microsphere comprises the following steps of: (1) preparing a gelatin aqueous solution of which the concentration is 10-50 percent g / ml; (2) adding the gelatin aqueous solution prepared in the step (1) into an emulsifier-containing oil phase of which the temperature is 50-60 DEG C, stirring for 10 minutes, lowering the temperature to 2-5 DEG C, stirring for 30 minutes at the stirring speed of 100-900 revolutions per minute, and standing to precipitate the microsphere; (3) pouring the oil phase out, repeatedly washing the oil phase left on the surface of the microsphere with acetone, and filtering the microsphere out; and (4) adding the microsphere obtained in the step (3) into a crosslinking agent aqueous solution of which the pH is 8-9 and the concentration is 1-15 percent g / ml, reacting at the temperature of 4 DEG C for 0.5-25 hours, and washing the microsphere with distilled water. The gelatin embolism microsphere provided by the invention is crosslinked uniformly, is regularly spherical, and is convenient for screening grading and accurate marking of the particle diameter; and the degradation time and elasticity of the gelatin embolism microsphere are more suitable for clinical application.

The invention discloses a postoperative anti-adhesion membrane material and a method for preparing the same, which belong to the technical field of biomedical materials. The membrane material takes degradable biological materials of konjac glucomannan and sodium carboxymethyl cellulose which have good biocompatibility as basic materials, the two are mixed together to prepare mixed sol, the modified sol is prepared through an acid solution modifying and microwave technology, and then, a tape casting method is utilized to prepare a konjac glucomannan / sodium carboxymethyl cellulose composite postoperative anti-adhesion degradable membrane material. The degradation rate of the membrane material can be controlled through the double-crosslinking degree of the konjac glucomannan and the sodium carboxymethyl cellulose, the preparation technology is simple, the cost is low, and moreover, the prepared degradable membrane material has good biomechanical property. Cell experiments and animal experiments show that the membrane material can be commonly used in human bodies and is an ideal degradable postoperative anti-adhesion material.

Disclosed are a uterine cavity implant, a preparation method and the use thereof. The uterine cavity implant has a bag-shaped structure, and comprises a substrate material of an animal small intestine submucosa having been subjected to a decellularization treatment. The uterine cavity implant is prepared by subjecting the substrate material to tissue pre-processing, virus inactivation, washing, decellularization in a multi-frequency ultrasonic device, washing, vacuum freeze-drying, and a molding step. The uterine cavity implant is used in uterine cavity-implanted medical instruments, and can treat and prevent intrauterine adhesion, and improve the decellularization process for a biological repair material, so that the uterine cavity implant has a lower quantity of residual DNA, lower immunogenicity, stronger anti-infection capacity and stronger repair capacity; and same is beneficial for the recovery of tissues, such as the uterine cavity basal layer, submucosa and mucous layer. The uterine cavity implant, as a built-in uterine cavity structure, is used for isolating wound surfaces, repairing uterine cavity tissues and reducing scar formation, so that the problem of intrauterine adhesion is solved, and the problem of sterility caused by same can also be solved.