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51results about How to "Control degradation time" patented technology
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Preparation method of three-layer lead tissue regenerating velum with gradient
InactiveCN101584885AGood for repair and regenerationIncreased dust compatibilityProsthesisSelf-assemblyElectrospinning
The invention relates to a preparation method of three-layer lead tissue regenerating velum with gradient, belonging to macromolecule biomedical material field. The velum is a three-layer composite velum made from natural biological material, degradable polymer and nanometer hydroxyapatite as raw materials. The method comprises steps of dissolving mixture of the natural biological material, degradable polymer and nanometer hydroxyapatite with different proportions in a special solvent; preparing the natural biological material / degradable polymer / nanometer hydroxyapatite three-layer gradient composite velum through static spinning layer by layer; and using pure natural biological material to modify surface of the velum by means of static self-assembly layer by layer. The velum has excellentbiological compatibility and mechanical property; one side of the velum is crude and loose, so the side can face to a defect area and is helpful for bones to absorb and grow and for blood coagulationblocks to stabilize; the other side is smooth and compact, so the side can face to surrounding tissue to prevent connective tissues from entering the defect area.
Owner:TONGJI UNIV
Polymerizable biodegradable polymers including carbonate or dioxanone linkages
InactiveUSRE39713E1More elasticityHigh viscosityPowder deliveryBiocideControl mannerUltraviolet lights
Water-soluble macromers including at least one hydrolysable linkage formed from carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one polymerizable group, and methods of preparation and use thereof are described. The macromers are preferably polymerized using free radical initiators under the influence of long wavelength ultraviolet light or visible light excitation. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. The macromers can be used to encapsulate cells, deliver prophylactic, therapeutic or diagnostic agents in a controlled manner, plug leaks in tissue, prevent adhesion formation after surgical procedures, temporarily protect or separate tissue surfaces, and adhere or seal tissues together.
Owner:GENZYME CORP
Degradation time controllable and breaking elongation adjustable medical degradable polyurethane
InactiveCN107778446AControl degradation timeControl elongation at breakSurgeryCoatingsRegenerative medicineHydrophily
The invention provides degradation time controllable and breaking elongation adjustable medical degradable polyurethane, a preparation method thereof and an application of the polyurethane. By adjusting the proportion of components in the synthesis process of the polyurethane and selecting different chain extenders, the performances such as the degradation time, the breaking elongation, the strength, the lubricating property, hydrophily and hydrophobicity of the PU (polyurethane) can be controlled within a wide range, and the medical degradable polyurethane with different performances can be selected according to the requirements of regenerative medicine and medical instruments implanted into bodies.
Owner:YUANRONG BIOLOGICAL PHARMA WUXI CO LTD
Gelatin embolism microsphere and preparation method and application thereof
ActiveCN102585258AUniform crosslinkingControl degradation timePowder deliverySurgeryMicrosphereDistilled water
The invention provides a gelatin embolism microsphere and a preparation method and an application thereof. The preparation method of the gelatin embolism microsphere comprises the following steps of: (1) preparing a gelatin aqueous solution of which the concentration is 10-50 percent g / ml; (2) adding the gelatin aqueous solution prepared in the step (1) into an emulsifier-containing oil phase of which the temperature is 50-60 DEG C, stirring for 10 minutes, lowering the temperature to 2-5 DEG C, stirring for 30 minutes at the stirring speed of 100-900 revolutions per minute, and standing to precipitate the microsphere; (3) pouring the oil phase out, repeatedly washing the oil phase left on the surface of the microsphere with acetone, and filtering the microsphere out; and (4) adding the microsphere obtained in the step (3) into a crosslinking agent aqueous solution of which the pH is 8-9 and the concentration is 1-15 percent g / ml, reacting at the temperature of 4 DEG C for 0.5-25 hours, and washing the microsphere with distilled water. The gelatin embolism microsphere provided by the invention is crosslinked uniformly, is regularly spherical, and is convenient for screening grading and accurate marking of the particle diameter; and the degradation time and elasticity of the gelatin embolism microsphere are more suitable for clinical application.
Owner:HYGEA MEDICAL TECH CO LTD
Medical biology degradable magnesium alloy composite material
InactiveCN102652840AControl degradation timeEnhance memoryCoatingsProsthesisSurface layerUltimate tensile strength
The invention relates to a novel degradable medical magnesium alloy composite material. The medical magnesium alloy composite material provided by the invention has the characteristics of high strength, good temperature memory and controllable degradation velocity and can be used in the field of orthopedic implantation. The composite material is characterized in that the composite material contains Mg-Al-Zn magnesium alloys, wherein the content of Al is 0.5-3.5wt% and the content of Zn is 0.5-1.8wt%; besides, the magnesium alloy material can contain a few impurities including Fe, Mn, Cu and Ni, wherein the total of the impurities is not greater than 0.3wt%; and a medical biology degradable material exists on the surface layer of the composite material and can be a pure carbon dioxide copolymer, pure polyhydroxyalkanoate or a blend of the carbon dioxide copolymer and polyhydroxyalkanoate, which has to be medically purified before use.
Owner:吉林金源北方科技发展有限公司
Biodegradable composite film material of controllable degradation rate and preparation method thereof
The invention aims to provide a biodegradable composite film material of controllable degradation rate with good mechanical property, faster and more through degradation and no environmental harm, and a preparation method thereof. The material comprises the following components in parts by weight: 100 parts of matrix resin, 0-40 parts of other biodegradable polymers, 0.5-1.5 parts of heat stabilizer, 0.3-5 parts of nucleating agent, 1-5 parts of compatilizer, 2-15 parts of plasticizer and 0.3-5 parts of opener. The matrix resin is obtained by mixing poly lactic acid (PLA) and 3-hydroxybutyrate-3-hydroxy acid copolyester (PHBH) with each 20-80 parts by weight. The other biodegradable polymers are poly butylenes succinate (PBS), poly propylene carbonate (PPC), 3-hydroxybutyrate-3-hydroxyvalerate copolyester (PHBV) and terephthalic acid-butanediol-adipic acid copolyester (PBAT).
Owner:BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY
High strength starch-based degrading and environment-protecting material and preparation method
The invention provides a high-intensity starch-based degradation environmental protection material and a manufacturing method thereof, which relates to a rapid degradation raw material used for manufacturing disposable tableware and disposable wrappage and the manufacturing method thereof. The present disposable foaming plastic tableware has the disadvantages of hard heat insulation, complicated process line, high production cost, undesirable production quality and white pollution. The components of the product include macromolecular natural starch, polyvinyl alcohol, plant sugar, polyvinyl alcohol, a degradation control agent, a multipolymer of polycaprolactone and poly-beta-hydroxybutyrate and hexa-butyl ester hexa-butyl glycan; wherein, the starch is 51-80 weight portions, the polyvinyl alcohol is 12-20 weight portions, the plant sugar is 2-10.5 weight portions, plasticizer is 2.5-8 weight portions, the degradation control agent is 0.2-1 weight portions, the multipolymer of polycaprolactone and poly-beta-hydroxybutyrate is 5-9 weight portions and the hexa-butyl ester hexa-butyl glycan is 0.2-0.5 weight portions. The high-intensity starch-based degradation environmental protection material of the invention is used for manufacturing the disposable tableware and the disposable warppage.
Owner:季国良
Degradable mulching film containing plant fiber degradable filler
The invention belongs to the technical field of manufacturing ground mulching films and particularly relates to a degradable mulching film containing plant fiber degradable filler. The degradable mulching film includes: resin as a mulching film substrate, a degradable master batch that promotes degradation of the mulching film, degradable filler that contains natural plant fiber powders, an antifogging agent, and an additive. The resin is polyvinyl chloride (PVC) or is mixed resin composed of polyethylene (LDPE), linear low density polyethylene (LLDPE) and metallocene polyethylene (mPE). In manufacturing of the degradable mulching film, by means of the plant celluloses such as straw powder, rice hull powder, cottonseed powder and the like, conditions for reproduction of microorganisms in soil are created, thus achieving the objects of turning waste into resources by straw returning. These natural plant fibers have the effect of promoting degradation of the mulching film.
Owner:BEIJING SUNSHINE SPECTACLE ECOLOGICAL SCI&TECH
Controllable-degradation PBAT/PLA (poly(butyleneadipate-co-terephthalate)/polylactic acid) composite film and preparation method thereof
The invention relates to the technical field of PBAT / PLA (poly(butyleneadipate-co-terephthalate) / polylactic acid) blend compatibilization, particularly a controllable-degradation PBAT / PLA composite film. The controllable-degradation PBAT / PLA composite film comprises the following components in parts by weight: 50-60 parts of PBAT, 10-30 parts of PLA, 10-20 parts of calcium carbonate, 0.5-2 parts of antibacterial compatibilizer and 0.5-2 parts of tetrabutyl titanate. The mass ratio of the PLA to the calcium carbonate is (1-3):1. The PLA / calcium carbonate proportion is strictly controlled and restricted within the range of (1-3):1; and the PLA / calcium carbonate proportion can be regulated to control the degradation start time of the PBAT / PLA composite film at 60-90 days and control the complete degradation time at 120-150 days.
Owner:常州绿之源高分子材料有限公司
Degradable high-performance plant fiber comprehensive agricultural plastic mulching film and preparation method thereof
InactiveCN106718414AReduce the cost of farmingLow costClimate change adaptationPlant protective coveringsFiberAgricultural engineering
The invention discloses a degradable high-performance plant fiber comprehensive agricultural plastic mulching film and a preparation method thereof. The agricultural plastic mulching film is prepared from the following raw materials: plant fibers, starch, cellulose, an enhancer, a waterproof agent and a filter aid. The texture of the agricultural plastic mulching film is between paper and cloth, so that the agricultural plastic mulching film is a novel degradable agricultural plastic mulching film; furthermore, after being degraded, the agricultural plastic mulching film can become fertilizer for nourishing soil; in addition, the degradation time of the agricultural plastic mulching film can be controlled by controlling the consumption of the starch and the waterproof agent in the raw materials. The degradable high-performance plant fiber comprehensive agricultural plastic mulching film does not need to be recovered after autumn, so that the manpower is saved, and the environment is protected.
Owner:魏坤年
High-molecular based transmitting tissue regeneration membrane as well as preparation method and application thereof
The invention relates to a high-molecular based transmitting tissue regeneration membrane as well as a preparation method and application thereof, wherein the high-molecular based transmitting tissue regeneration membrane is formed by compounding a high-molecular polymer and mineralized collagen; the high-molecular polymer comprises polycaprolactone and poly-dl-lactide in a mass ratio of (2 to 1) to (9 to 1); and the mineralized collagen is formed by compounding I type collagen and nano-hydroxyapatite in a mass ratio being (1 to 9) to (1 to 3). According to the high-molecular based transmitting tissue regeneration membrane, a high-molecular material which is relatively good in biocompatibility and is controllable in degrading speed is compounded with mineralized hydroxyapatite to form a membrane, wherein one surface of the membrane is smooth and the other surface of the membrane is crude; dental bone powder can be replaced to certain extent to treat periodontal defects; and the regeneration membrane is high in stretching strength, is high in suture-resistant tensile strength and can meet clinical needs.
Owner:BEIJING ALLGENS MEDICAL SCI & TECH
Biodegradable medical surgery anti-adhesion membrane and preparation method thereof
The invention provides a biodegradable medical surgery anti-adhesion membrane and a preparation method thereof. According to the method, polyethylene glycol compound, at least one of lactide and epsilon-caprolactone and glycolide are subjected to copolymerization so as to obtain a polyethylene glycol compound-polyester segmented copolymer of which the number-average molecular weight is 50000 to 150000; and a polymer material containing the polyethylene glycol compound-polyester segmented copolymer is made into a membrane so as to obtain the biodegradable medical surgery anti-adhesion membrane, wherein the polyethylene glycol compound is shown in formula (I) shown in the specification, R is any one selected from hydroxyl, methyl, ethyl, propyl, isopropyl, amino, allyl, propinyl, sulfydryl, carboxyl and azide; and n is the polymerization degree. Through double modulation of the polyethylene glycol compound and glycolid, the anti-adhesion membrane is better in controllability and good in flexibility, has certain tension resistance strength and is beneficial for application.
Owner:CHANGCHUN SINOBIOMATERIALS
Full-biodegradable mulching film with controllable degradation period and preparation method thereof
InactiveCN112280258AImprove air tightnessImprove moisture conservation effectClimate change adaptationPlant protective coveringsPolymer scienceButanedioic acid
The invention discloses a full-biodegradable mulching film with a controllable degradation period and a preparation method thereof. Raw materials for preparing the mulching film comprise the followingcomponents in parts by weight: 40-60 parts of polyadipic acid / butylene terephthalate, 5-20 parts of high-crystallinity polylactic acid, 5-15 parts of polybutylene succinate, 2-10 parts of modified polyamidoamine, 2-6 parts of aliphatic polyol, 5-20 parts of inorganic filler, 1-5 parts of compatilizer, 1-2.5 parts of dispersing agent, 0.1-2 part of antioxidant, 0.1-5 part of ultraviolet light absorber, 0.1-3 part of a light stabilizer, and 0-0.5 part of an auxiliary agent. By selecting high-crystallinity polylactic acid with good air tightness, the air tightness of the mulching film can be effectively improved, degradation of the mulching film can be accelerated by adding modified polyamidoamine into a polymer, and degradation of the mulching film can be accelerated by adjusting the typesand the use amounts of the antioxidant, the ultraviolet light absorber and the light stabilizer as well as the dispersing agent and the auxiliary agent. The degradation time of the full-biodegradablemulching film can be regulated and controlled, and the growth requirements of different altitudes, different regions and different crops can be met.
Owner:LANZHOU XINYINHUAN RUBBER & PLASTIC PROD CO LTD
Preparation and application of linear biodegradable polyester elastomer with controllable elasticity and shape memory effect
InactiveCN105504248AMeet biomechanical needsHigh viscoelasticitySuture equipmentsPharmaceutical delivery mechanismElastomerTissue repair
The invention discloses preparation and application of a linear biodegradable polyester elastomer with a controllable elasticity and shape memory effect. The linear biodegradable polyester elastomer with the controllable elasticity and shape memory effect is formed by conducting copolymerization on a caprolactone monomer containing a lateral cyclic ether structural unit and caprolactone, wherein the molar ratio of the caprolactone monomer containing the lateral cyclic ether structural unit to the caprolactone is 5:95-25:75, and the structural formula can be found in description. The viscoelasticity of the linear biodegradable polyester elastomer with the controllable elasticity and shape memory effect is remarkably improved, the elongation at break can reach 1600% and above, the elastomer can be dissolved in a conventional organic solvent, a three-dimensional porous support can be constructed conveniently through a construction technology of the porous support such as, electrostatic spinning, three-dimensional printing and phase separation, tissue engineering blood vessel scaffold materials, myocardial patches, nervous tissue engineering scaffold materials and the like are prepared, and the preparation and application of the linear biodegradable polyester elastomer can be widely applied to the fields of soft tissue engineering scaffolds, tissue repair and regenerative medicine.
Owner:JINAN UNIVERSITY
Polylactic acid microsphere and preparation method and application thereof
ActiveCN109265942AAccurate screening and gradingAccurately mark the particle sizeSurgical adhesivesPharmaceutical non-active ingredientsMicrosphereOil phase
The invention discloses a polylactic acid microsphere and a preparation method and application thereof. The grain size of the microsphere is between 100 mu m and 1000 mu m, preferably between 100 mu mand 300 mu m, between 300 mu m and 500 mu m, between 500 mu m and 700 mu m or between 700 mu m and 1000 mu m, the microsphere is a regular sphere, and the surface and interior of the microsphere areprovided with holes. Because the polylactic acid microsphere is a regular sphere, by adjusting the variety and molecular weight of polylactic acid, the degradation time of the microsphere can be controlled, which is favorable for the determination of the degradation time of the microsphere in the body and the recanalization time of blood vessels in clinical application. The preparation method disclosed by the invention can cut out drops with small grain size under low flow velocity, moreover, the stability of oil-phase fluid is good, the drops do not have tails after coagulant is added, the sphericity of the solidified microsphere is good, and the effect is best. Moreover, by forming the holes in the surface and interior of the microsphere, solvent can be conveniently volatilized, so thatthe amount of remaining solvent is small, meeting the standard of the pharmacopoeia.
Owner:张海军
Uterine cavity implant as well as preparation method and application thereof
The invention relates to a uterine cavity implant as well as a preparation method and application thereof. The uterine cavity implant is characterized by having a bagged structure. The uterine cavity implant comprises a substrate material of animal small intestine submucosa subjected to decellularization treatment. An implantable medical device for preventing and treating intrauterine adhesion comprises a biological tissue substrate material. The present decellularization technology for a biological repairing material is improved; compared with the present product, the biological tissue substrate material provided by the invention has the advantages of lower DNA residual quantity, lower immunogenicity, higher anti-infection capacity and higher repairing capacity; and the uterine cavity implant is beneficial to the recovering of tissues, such as, uterine cavity base layer, submucosa and mucous layer. Besides, the invention prepares the biological repairing material into the uterine cavity built-in structure which is used for isolating wound surfaces, repairing uterine cavity tissues and reducing scar forming, so that the intrauterine adhesion problem is solved, and the accordingly generated sterility problem also can be solved.
Owner:BEIJING BIOSIS HEALING BIOLOGICAL TECH
Functional adjusting master batch for biodegradation and preparation method thereof
InactiveCN111875937ANo pollution in the processAchieve bidirectional degradationProcess engineeringAnoxomer
The invention belongs to the technical field of bio-based degradation, and relates to a functional adjusting master batch for biodegradation and a preparation method thereof. The functional adjustingmaster batch comprises the following components in parts by weight: 60-90 parts of carrier resin, 0.1-50 parts of degradation accelerant, 0.1-10 parts of heat stabilizer, 0.1-5 parts of light stabilizer, 0.1-5 parts of antioxidant, 0.1-20 parts of chain extender and 0.1-20 parts of other functional aids. The function adjusting master batch can effectively adjust degradation time and degradation speed, and has good anti-aging performance.
Owner:宁夏中原塑业科技有限公司
Phase-transition targeted nanovesicle and preparation method and application thereof
InactiveCN109966514AGood biocompatibilityImprove toughnessGeneral/multifunctional contrast agentsEchographic/ultrasound-imaging preparationsUltrasound imagingSize change
The invention provides a phase-transition targeted nanovesicle and a preparation method and application thereof. The nanovesicle is composed of 1.0-15.0wt% of core filler, 0.1-5.0wt% of a coating material and the balance ultrapure water and is in a sandwiched spherical structure. The core filler is liquid perfluorinated pentane; the coating material is amino terminated polylactic acid. The prepared nanovesicle is milk white and in particle size of 318.4+ / -5.1nm, small in-vitro 3-month particle size change and high stability are realized, ultrasonic imaging effects can be enhanced by the nanovesicle under the action of ultrasonic waves, the nanovesicle can be broken by the ultrasonic waves, and ultrasonic tumor imaging effects can be remarkably improved in a living mouse subcutaneous tumormodel.
Owner:HUBEI UNIV OF SCI & TECH
Degradation-controllable drug-loaded hemostatic sponge and preparation method thereof
InactiveCN111035796AControl degradation timeControl releaseSurgical adhesivesPharmaceutical delivery mechanismFormularyPtru catalyst
The invention discloses a degradation-controllable drug-loaded hemostatic sponge. A formula for the degradation-controllable drug-loaded hemostatic sponge comprises the following components in parts by mass: 10-20 parts of DL-lactide, 16-71 parts of epsilon-caprolactone, 8-23 parts of dihydric alcohol, 48-138 parts of diisocyanate, 0.5-1.5 parts of glucocorticoid drugs, 19.6-56.7 parts of an initiator, 0.112-0.324 part of a catalyst and 50-100 parts of an organic solvent, wherein a feeding molar ratio of the DL-lactide to the epsilon-caprolactone is (10-50): (50-90). According to the invention, the degradation time of a polyurethane sponge is controlled by adjusting the proportion of each component in an amorphous chain segment, so the release of the glucocorticoid drugs is controlled, thenose can be temporarily pressed to realize hemostasis and support; and degradation time and drug release are accurately controlled, so the clinical use of the hemostatic sponge is simpler and more accurate.
Owner:HANGZHOU VITEX MEDICAL DEVICE CO LTD
Multi-layer degradation film
InactiveCN110126402AInhibit oxidative decompositionKeep drySynthetic resin layered productsSurface layerOxygen
The invention discloses a degradation film, particularly to a multi-layer degradation film, and belongs to the technical field of degradation, wherein the multi-layer degradation film sequentially comprises plural layers of degradation films from top to bottom, and separation films are respectively arranged between any two layers of the degradation films, and are used for isolating each degradation film, such that various layers of the degradation films can be separately degraded. According to the present invention, by arranging the separation layer to isolate oxygen and moisture, oxygen and moisture cannot enter the interior of the degradation film, such that the degradation film can be degraded layer by layer, and canot be degraded simultaneously; after the degradation film on the surface layer is degraded, the separation layer is dissolved under the action of water, and the degradation film on the next layer is degraded; and by controlling the number of the layers of the degradationfilms, the degradation time of the whole degradation film can be controlled at 6 months to 8 years.
Owner:SICHUAN SANHE SLOPE TECH CO LTD
Gelatin embolism microsphere and preparation method and application thereof
ActiveCN102585258BUniform crosslinkingControl degradation timePowder deliverySurgeryMicrosphereDistilled water
Owner:HYGEA MEDICAL TECH CO LTD
Phase-change nanobubble, and preparation method and application thereof
PendingCN111632154AEnhanced Ultrasound ImagingImprove sensitivity and accuracyDispersion deliveryGeneral/multifunctional contrast agentsSolventImaging study
The invention discloses a phase-change nanobubble, and a preparation method and application thereof. The nanobubble is prepared by taking an amphiphilic material chitosan-polylactic acid grafted copolymer as a coating material and taking perfluoropentane capable of generating liquid-gas phase transformation under the action of temperature as a bubble core filling substance by adopting an emulsifying solvent volatilization method. The prepared nanobubble is creamy yellow, and the particle size is 101.1+ / -2.7 nm. The particle size change is small in two months in vitro, and stability is good. The nanobubble can enhance the ultrasonic imaging effect under action of ultrasonic waves and can be broken by the ultrasonic waves. The chitosan-polylactic acid grafted copolymer nanobubble prepared bythe emulsifying solvent evaporation method is good in in-vitro stability, and ultrasonic imaging can be enhanced. The nanobubble can load an MRI contrast agent, so that the MRI imaging effect of tumor lesions is improved. The nanobubble can also load anti-tumor drugs for targeted therapy of tumors, is a novel multifunctional iconography nano contrast agent integrating diagnosis and treatment, andthus has a great application value.
Owner:HUBEI UNIV OF SCI & TECH
Postoperative anti-adhesion membrane material and method for preparing same
InactiveCN103044700BOvercome the disadvantages of poor mechanical propertiesGood hemostasisSurgeryBiomechanicsBiocompatibility
The invention discloses a post-operative anti-adhesion film material and a preparation method thereof. It belongs to the technical field of biomedical materials. The invention uses degradable biological materials such as konjac glucomannan and carboxymethyl cellulose with good biocompatibility. Sodium is the basic raw material, and the two are mixed to prepare a mixed sol. The modified sol is obtained through acid solution modification and microwave technology, and then the konjac glucomannan / carboxymethyl cellulose sodium composite is prepared by tape casting. Degradable membrane material to prevent adhesion after surgery. The degradation rate of the membrane material can be controlled by the double cross-linking degree of konjac glucomannan and carboxymethyl cellulose sodium. Not only the preparation process is simple and the cost is low, but also the Degradable membrane materials have good biomechanical properties. Cell experiments and animal experiments show that this membrane material can be widely used in the body and is an ideal degradable postoperative anti-adhesion material.
Owner:KUNMING UNIV OF SCI & TECH
Biodegradable composite film material with controllable degradation rate and preparation method thereof
The invention aims to provide a biodegradable composite film material of controllable degradation rate with good mechanical property, faster and more through degradation and no environmental harm, and a preparation method thereof. The material comprises the following components in parts by weight: 100 parts of matrix resin, 0-40 parts of other biodegradable polymers, 0.5-1.5 parts of heat stabilizer, 0.3-5 parts of nucleating agent, 1-5 parts of compatilizer, 2-15 parts of plasticizer and 0.3-5 parts of opener. The matrix resin is obtained by mixing poly lactic acid (PLA) and 3-hydroxybutyrate-3-hydroxy acid copolyester (PHBH) with each 20-80 parts by weight. The other biodegradable polymers are poly butylenes succinate (PBS), poly propylene carbonate (PPC), 3-hydroxybutyrate-3-hydroxyvalerate copolyester (PHBV) and terephthalic acid-butanediol-adipic acid copolyester (PBAT).
Owner:BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY
A kind of biodegradable medical operation anti-adhesion film and preparation method thereof
The invention provides a biodegradable medical surgery anti-adhesion membrane and a preparation method thereof. According to the method, polyethylene glycol compound, at least one of lactide and epsilon-caprolactone and glycolide are subjected to copolymerization so as to obtain a polyethylene glycol compound-polyester segmented copolymer of which the number-average molecular weight is 50000 to 150000; and a polymer material containing the polyethylene glycol compound-polyester segmented copolymer is made into a membrane so as to obtain the biodegradable medical surgery anti-adhesion membrane, wherein the polyethylene glycol compound is shown in formula (I) shown in the specification, R is any one selected from hydroxyl, methyl, ethyl, propyl, isopropyl, amino, allyl, propinyl, sulfydryl, carboxyl and azide; and n is the polymerization degree. Through double modulation of the polyethylene glycol compound and glycolid, the anti-adhesion membrane is better in controllability and good in flexibility, has certain tension resistance strength and is beneficial for application.
Owner:CHANGCHUN SINOBIOMATERIALS
Lycorine nanoparticle as well as preparation method and application thereof
PendingCN111671917AGood stabilityImprove curative effectOrganic active ingredientsPowder deliveryPolylactic acidHigh polymer
The invention provides a lycorine nanoparticle as well as a preparation method and application thereof. The nanoparticle is prepared by dissolving a drug in or packaging the drug with a high polymer carrier material containing an emulsifying agent, wherein the drug is lycorine; and the carrier material is racemic polylactic acid. Proportions are as follows: the volume ratio of an oil phase to an inner water phase is (2 to 1)-(5 to 1); and the mass ratio of the carrier to the drug is (2.5 to 1)-(5 to 1). The prepared nanoparticle has a clear blue appearance, a nanoparticle solution has the specific characteristic that the appearance presents blue opalescence, the prepared nanoparticle is nano-scale, the average particle size is 96.3+ / -5.1nm, a PDI (polydispersion index) is 0.141+ / -0.020 (the particle sizes of the particles are more uniformly and stably dispersed when the PDI value is lower), and a centrifugal accelerated experiment result shows that conditions of precipitation and demulsification do not exist; after the nanoparticles are released for 24h, the accumulated release rate of the nanoparticles reach up to 98.99%, and a fitting Ritger-Pappas model (R=0.9327) is best matched with a releasing mechanism. An optimized prescription and process of the nanoparticle meet the demands, and an in-vitro slow-release effect of the particle is obvious.
Owner:HUBEI UNIV OF SCI & TECH
A kind of intrauterine intrauterine object, preparation method and application thereof
Disclosed are a uterine cavity implant, a preparation method and the use thereof. The uterine cavity implant has a bag-shaped structure, and comprises a substrate material of an animal small intestine submucosa having been subjected to a decellularization treatment. The uterine cavity implant is prepared by subjecting the substrate material to tissue pre-processing, virus inactivation, washing, decellularization in a multi-frequency ultrasonic device, washing, vacuum freeze-drying, and a molding step. The uterine cavity implant is used in uterine cavity-implanted medical instruments, and can treat and prevent intrauterine adhesion, and improve the decellularization process for a biological repair material, so that the uterine cavity implant has a lower quantity of residual DNA, lower immunogenicity, stronger anti-infection capacity and stronger repair capacity; and same is beneficial for the recovery of tissues, such as the uterine cavity basal layer, submucosa and mucous layer. The uterine cavity implant, as a built-in uterine cavity structure, is used for isolating wound surfaces, repairing uterine cavity tissues and reducing scar formation, so that the problem of intrauterine adhesion is solved, and the problem of sterility caused by same can also be solved.
Owner:BEIJING BIOSIS HEALING BIOLOGICAL TECH
A kind of tpu film with controllable degradation time and preparation method thereof
ActiveCN105104036BHas antibacterial activityControl degradation timeFlat articlesPlant protectionPhosphonium saltLiquid state
The invention relates to a TPU thin film with controllable degradation time and a preparation method thereof. The TPU thin film comprises a TPU thin film layer and an antibacterial agent layer covering the outer part of the TPU thin film, wherein the raw material of the TPU thin film layer comprises TPU grafted with PLA; the isocyanate index of the TPU thin film layer is smaller than 1; raw materials of the antibacterial agent layer comprise quaternary phosphonium salt and / or quaternary ammonium salt. The preparation method comprises the following steps: adding the TPU grafted with the PLA into liquid-state quaternary phosphonium salt and / or quaternary ammonium salt to be immersed; and extruding the TPU by an extruding machine to obtain the TPU thin film. According to the TPU thin film provided by the invention, the degradation time is controllable and the TPU thin film can be completely degraded into H2O and CO2 which have no pollution to the environment, so that the TPU thin film is suitable for being popularized and applied in a large scale.
Owner:雄林(越南)责任有限公司
Antibacterial polyurethane foam material and preparation method and application thereof
InactiveCN113603855AImprove antibacterial propertiesLong-term stable antibacterial effectSurgical adhesivesPharmaceutical delivery mechanismPolymer scienceSide chain
The invention relates to an antibacterial polyurethane foam material and a preparation method and application thereof, solves the technical problems of high cost and non-ideal effect of the existing nasal cavity hemostatic material, and provides the antibacterial polyurethane foam material. The antibacterial effective component in the antibacterial polyurethane foam material is long side chain quaternized chitosan with 12 carbons on the side chain. The invention also provides a preparation method and application thereof. The material can be used in the field of antibacterial materials.
Owner:BEIJING UNIV OF CHEM TECH +1
Material and preparation method and application thereof
ActiveCN111941967AHigh elongation at breakHigh impact strengthSynthetic resin layered productsEngineeringStructural engineering
The invention discloses a material which comprises at least two structural layers, and the crystallinity of the adjacent structural layers is different. The structural layers are formed by degradableresin.
Owner:PUJING CHEM IND SHA
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