51results about How to "Control degradation time" patented technology

The invention provides degradation time controllable and breaking elongation adjustable medical degradable polyurethane, a preparation method thereof and an application of the polyurethane. By adjusting the proportion of components in the synthesis process of the polyurethane and selecting different chain extenders, the performances such as the degradation time, the breaking elongation, the strength, the lubricating property, hydrophily and hydrophobicity of the PU (polyurethane) can be controlled within a wide range, and the medical degradable polyurethane with different performances can be selected according to the requirements of regenerative medicine and medical instruments implanted into bodies.

The invention provides a gelatin embolism microsphere and a preparation method and an application thereof. The preparation method of the gelatin embolism microsphere comprises the following steps of: (1) preparing a gelatin aqueous solution of which the concentration is 10-50 percent g / ml; (2) adding the gelatin aqueous solution prepared in the step (1) into an emulsifier-containing oil phase of which the temperature is 50-60 DEG C, stirring for 10 minutes, lowering the temperature to 2-5 DEG C, stirring for 30 minutes at the stirring speed of 100-900 revolutions per minute, and standing to precipitate the microsphere; (3) pouring the oil phase out, repeatedly washing the oil phase left on the surface of the microsphere with acetone, and filtering the microsphere out; and (4) adding the microsphere obtained in the step (3) into a crosslinking agent aqueous solution of which the pH is 8-9 and the concentration is 1-15 percent g / ml, reacting at the temperature of 4 DEG C for 0.5-25 hours, and washing the microsphere with distilled water. The gelatin embolism microsphere provided by the invention is crosslinked uniformly, is regularly spherical, and is convenient for screening grading and accurate marking of the particle diameter; and the degradation time and elasticity of the gelatin embolism microsphere are more suitable for clinical application.

The invention provides a biodegradable medical surgery anti-adhesion membrane and a preparation method thereof. According to the method, polyethylene glycol compound, at least one of lactide and epsilon-caprolactone and glycolide are subjected to copolymerization so as to obtain a polyethylene glycol compound-polyester segmented copolymer of which the number-average molecular weight is 50000 to 150000; and a polymer material containing the polyethylene glycol compound-polyester segmented copolymer is made into a membrane so as to obtain the biodegradable medical surgery anti-adhesion membrane, wherein the polyethylene glycol compound is shown in formula (I) shown in the specification, R is any one selected from hydroxyl, methyl, ethyl, propyl, isopropyl, amino, allyl, propinyl, sulfydryl, carboxyl and azide; and n is the polymerization degree. Through double modulation of the polyethylene glycol compound and glycolid, the anti-adhesion membrane is better in controllability and good in flexibility, has certain tension resistance strength and is beneficial for application.

The invention provides a phase-transition targeted nanovesicle and a preparation method and application thereof. The nanovesicle is composed of 1.0-15.0wt% of core filler, 0.1-5.0wt% of a coating material and the balance ultrapure water and is in a sandwiched spherical structure. The core filler is liquid perfluorinated pentane; the coating material is amino terminated polylactic acid. The prepared nanovesicle is milk white and in particle size of 318.4+ / -5.1nm, small in-vitro 3-month particle size change and high stability are realized, ultrasonic imaging effects can be enhanced by the nanovesicle under the action of ultrasonic waves, the nanovesicle can be broken by the ultrasonic waves, and ultrasonic tumor imaging effects can be remarkably improved in a living mouse subcutaneous tumormodel.

The invention provides a gelatin embolism microsphere and a preparation method and an application thereof. The preparation method of the gelatin embolism microsphere comprises the following steps of: (1) preparing a gelatin aqueous solution of which the concentration is 10-50 percent g / ml; (2) adding the gelatin aqueous solution prepared in the step (1) into an emulsifier-containing oil phase of which the temperature is 50-60 DEG C, stirring for 10 minutes, lowering the temperature to 2-5 DEG C, stirring for 30 minutes at the stirring speed of 100-900 revolutions per minute, and standing to precipitate the microsphere; (3) pouring the oil phase out, repeatedly washing the oil phase left on the surface of the microsphere with acetone, and filtering the microsphere out; and (4) adding the microsphere obtained in the step (3) into a crosslinking agent aqueous solution of which the pH is 8-9 and the concentration is 1-15 percent g / ml, reacting at the temperature of 4 DEG C for 0.5-25 hours, and washing the microsphere with distilled water. The gelatin embolism microsphere provided by the invention is crosslinked uniformly, is regularly spherical, and is convenient for screening grading and accurate marking of the particle diameter; and the degradation time and elasticity of the gelatin embolism microsphere are more suitable for clinical application.

The invention discloses a postoperative anti-adhesion membrane material and a method for preparing the same, which belong to the technical field of biomedical materials. The membrane material takes degradable biological materials of konjac glucomannan and sodium carboxymethyl cellulose which have good biocompatibility as basic materials, the two are mixed together to prepare mixed sol, the modified sol is prepared through an acid solution modifying and microwave technology, and then, a tape casting method is utilized to prepare a konjac glucomannan / sodium carboxymethyl cellulose composite postoperative anti-adhesion degradable membrane material. The degradation rate of the membrane material can be controlled through the double-crosslinking degree of the konjac glucomannan and the sodium carboxymethyl cellulose, the preparation technology is simple, the cost is low, and moreover, the prepared degradable membrane material has good biomechanical property. Cell experiments and animal experiments show that the membrane material can be commonly used in human bodies and is an ideal degradable postoperative anti-adhesion material.

The invention aims to provide a biodegradable composite film material of controllable degradation rate with good mechanical property, faster and more through degradation and no environmental harm, and a preparation method thereof. The material comprises the following components in parts by weight: 100 parts of matrix resin, 0-40 parts of other biodegradable polymers, 0.5-1.5 parts of heat stabilizer, 0.3-5 parts of nucleating agent, 1-5 parts of compatilizer, 2-15 parts of plasticizer and 0.3-5 parts of opener. The matrix resin is obtained by mixing poly lactic acid (PLA) and 3-hydroxybutyrate-3-hydroxy acid copolyester (PHBH) with each 20-80 parts by weight. The other biodegradable polymers are poly butylenes succinate (PBS), poly propylene carbonate (PPC), 3-hydroxybutyrate-3-hydroxyvalerate copolyester (PHBV) and terephthalic acid-butanediol-adipic acid copolyester (PBAT).

The invention provides a biodegradable medical surgery anti-adhesion membrane and a preparation method thereof. According to the method, polyethylene glycol compound, at least one of lactide and epsilon-caprolactone and glycolide are subjected to copolymerization so as to obtain a polyethylene glycol compound-polyester segmented copolymer of which the number-average molecular weight is 50000 to 150000; and a polymer material containing the polyethylene glycol compound-polyester segmented copolymer is made into a membrane so as to obtain the biodegradable medical surgery anti-adhesion membrane, wherein the polyethylene glycol compound is shown in formula (I) shown in the specification, R is any one selected from hydroxyl, methyl, ethyl, propyl, isopropyl, amino, allyl, propinyl, sulfydryl, carboxyl and azide; and n is the polymerization degree. Through double modulation of the polyethylene glycol compound and glycolid, the anti-adhesion membrane is better in controllability and good in flexibility, has certain tension resistance strength and is beneficial for application.

Disclosed are a uterine cavity implant, a preparation method and the use thereof. The uterine cavity implant has a bag-shaped structure, and comprises a substrate material of an animal small intestine submucosa having been subjected to a decellularization treatment. The uterine cavity implant is prepared by subjecting the substrate material to tissue pre-processing, virus inactivation, washing, decellularization in a multi-frequency ultrasonic device, washing, vacuum freeze-drying, and a molding step. The uterine cavity implant is used in uterine cavity-implanted medical instruments, and can treat and prevent intrauterine adhesion, and improve the decellularization process for a biological repair material, so that the uterine cavity implant has a lower quantity of residual DNA, lower immunogenicity, stronger anti-infection capacity and stronger repair capacity; and same is beneficial for the recovery of tissues, such as the uterine cavity basal layer, submucosa and mucous layer. The uterine cavity implant, as a built-in uterine cavity structure, is used for isolating wound surfaces, repairing uterine cavity tissues and reducing scar formation, so that the problem of intrauterine adhesion is solved, and the problem of sterility caused by same can also be solved.

The invention relates to a TPU thin film with controllable degradation time and a preparation method thereof. The TPU thin film comprises a TPU thin film layer and an antibacterial agent layer covering the outer part of the TPU thin film, wherein the raw material of the TPU thin film layer comprises TPU grafted with PLA; the isocyanate index of the TPU thin film layer is smaller than 1; raw materials of the antibacterial agent layer comprise quaternary phosphonium salt and / or quaternary ammonium salt. The preparation method comprises the following steps: adding the TPU grafted with the PLA into liquid-state quaternary phosphonium salt and / or quaternary ammonium salt to be immersed; and extruding the TPU by an extruding machine to obtain the TPU thin film. According to the TPU thin film provided by the invention, the degradation time is controllable and the TPU thin film can be completely degraded into H2O and CO2 which have no pollution to the environment, so that the TPU thin film is suitable for being popularized and applied in a large scale.