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Human monoclonal antibody binding to human cytomegalovirus and its antigen binding portion
The present invention aims to provide a human monoclonal antibody and an antigen binding portion of a human monoclonal antibody with higher affinity and neutralizing capacity to the human cytomegalovirus (HCMV), a virus which causes various diseases in situations where immunodeficiencies are present. The current invention provides an anti-human cytomegalovirus (HCMV) monoclonal antibody which is a human monoclonal antibody capable of binding to HCMV and neutralizing bioactivity of the HCMV, and which may be further characterized as possessing a light chain (L chain) comprising an amino acid sequence of SEQ ID. NO. 1, and has a heavy chain (H chain) comprising an amino acid sequence of SEQ ID NO. 2.
Owner:EVEC +1
Absorbable endocranium healing patch and preparation method thereof
The invention discloses an absorbable endocranium healing patch and a preparation method thereof. The preparation method comprises: firstly processing a degradable high molecular material into a film impervious layer; at the same time weaving the degradable high molecular material into a netted sheet layer; then performing heat sealing processing on the film impervious layer and the netted sheet layer to prepare a double-layer composite material containing the impervious layer and the netted layer; and finally coating a bioactive component on the surface of the netted layer of the double-layer composite material to prepare the absorbable endocranium healing patch. The absorbable endocranium healing patch has excellent biodegradability, biocompatibility, biological absorbability, excellent flexibility, no repulsion reaction, and no toxicity, no carcinogenic and teratogenic effects, and can be completely absorbed after cambium is generated, and thus the absorbable endocranium healing patch can be more safely and more effectively applied to endocranium healing correlated medical operations.
Owner:TIANJIN KANGER MEDICAL DEVICE
Method for preparing multi-layer composite functional surgical dressing
InactiveCN103239755AGuaranteed softnessChieve protectiveAdhesive dressingsAbsorbent padsPolyesterBiocompatibility Testing
The invention relates to a method for preparing a multi-layer composite functional surgical dressing. The method comprises the following steps: respectively and independently carding the fiber layers comprising a functional layer which is formed by mixing chitosan fiber or chitosan fiber and viscose and is directly contacted with the skin, a water-absorbing layer which is made of viscose and has high liquid absorption performance and a protective layer which is formed by mixing the viscose and polyester fiber and has the supporting and protecting functions so as to form a net, manufacturing a three-layer laminate with an upper functional layer, a middle water-absorbing layer and a lower protective layer by employing a water jet strengthening technology, coating a waterproof agent on the protective layer of the three-layer laminate to form a waterproof layer, and finally rolling to obtain the surgical dressing. The product has high biocompatibility and promotes healing, the antibacterial rate is up to 96.7 percent, the liquid absorption rate is 1259 percent, the waterproofing grade is up to level 5, and the surgical dressing can be used for clinical repair for operative incision, burn, scald, ulcer and other skin injury and is simple in production process, low in cost and environmentally-friendly.
Owner:DONGHUA UNIV +1
Moisturizing eye mask prepared from bacterial cellulose
InactiveCN102784071AReliable hardnessGood flexibilityCosmetic preparationsToilet preparationsBiotechnologyMembrane surface
The invention discloses a moisturizing eye mask prepared from bacterial cellulose. The method for preparing a moisturizing eye mask from bacterial cellulose comprises: inoculating 1-2 rings of activated inclined seed Gluconacetobacter xylinum into a medium, and conducting oscillating culture to obtain a seed solution; then inoculating the seed solution into the medium, fully oscillating the bacterial solution obtained by mixing the seed solution and the medium to make them mixed uniformly, then conducting stationary culture, thus generating a bacterial cellulose membrane floating on the solution surface, flushing the generated bacterial cellulose membrane with water to remove the medium and impurities on the membrane surface, then immersing the membrane in an alkali solution to remove thalli and residual medium from the membrane, and finally flushing the membrane with distilled water till the pH value of the membrane is measured up to 7-7.2, thus obtaining a bacterial cellulose wet membrane, which is then cut into an eye mask. The eye mask has the advantages of good moisturizing property and biological tissue compatibility, no toxicity, harmlessness, and simple material processing technology.
Owner:SHANGHAI INST OF TECH
Continuous carbon fiber reinforced composite material for bone repair
The continuous carbon fiber reinforced composite material for bone repair is prepared with continuous carbon fiber, continuous carbon fiber felt or continuous carbon fiber, cloth through soaking in methyl methacrylate monomer or pre-polymer and subsequent extruding or bulk molding. The composite material of the present invention includes methyl methacrylate and carbon fiber, and the carbon fiber content is 20-80 wt%. The composite material may be used as the external fracture fixing material, internal fracture fixing material and bone repairing material. The composite material has the features of light weight, no interference on NMR examination and excellent biocompatibility. It may be implanted inside life body without negative effect on tissue, blood, etc.
Owner:SHANGHAI GENIUS ADVANCED MATERIAL (GRP) CO LTD
Mume flower grafting rapid reproduction method by using big apricot tree as rootstock
InactiveCN1918974AShorten the cultivation cycleStrong affinityCultivating equipmentsHorticulture methodsReproductionRootstock
The invention discloses a mume flower grafting rapid-breeding method through big apricot tree as stock, which comprises the following steps: disposing big apricot tree, selecting to scion at 4.5-5.5cm, cutting at 3cm position into 'horse ear shape' oblique plane, grafting at 16-28 deg.c in each April, picking core of mume flower.
Owner:朱志奇
Method for preparing tensionless net cloth for repairing hernia
InactiveCN101890186AGood biocompatibilityHave the ability to resist infectionSurgeryWarp knittingEngineeringEthylene oxide sterilizer
The invention provides a method for preparing a tensionless net cloth for repairing hernia. The method comprises the following steps of: selecting medicinal polypropylene granules, assembling the polypropylene granules into a finished product by cutting and cleaning after three times of cooling, drafting, drawing and weaving processes, and sterilizing the finished product by using an ethylene oxide sterilizer for later use. The imported good-quality medicinal polypropylene granules are adopted in the method; monofilaments are woven into a mesh patch; and the patch has good biological tissue compatibility, can be quickly stuck and fixed with tissues, has no rejection reaction, has certain capability against infection, is an ideal hernia repair material, and has the same properties and functions as the imported product. The method creates a condition for clinical popularization and use, and has broad market prospect.
Owner:高炳源
Method for preparing biological scaffold by 3D printing
InactiveCN105903078AGood biocompatibilityNo toxicityAdditive manufacturing apparatusProsthesisBiologic scaffoldNormal bone
The invention provides a method for preparing a biological scaffold by 3D printing. The method comprises the steps of grinding allogeneic bones or heterogeneous bones at a low temperature in a freezing grinder to obtain a printing material, modeling 3D printing with the aid of a computer, and then performing post treatment in a genipin solution. The prepared biological scaffold has good biological compatibility, and the bone graft material does not have toxicity, rejection, mutagenicity or antigenicity in vivo, and does not disturb bone and tissue regeneration; the prepared biological scaffold can be gradually degraded and absorbed and replaced by autologous bone tissues, can bear the pressure close to 20MPa with normal bone cortex, and has good initial mechanical properties; and the elastic modulus is gradually reduced, stress shielding is avoided, fracture, collapse and loosening of implants in the long-term healing process are avoided, bone fusion can be accelerated, and the implants can be finally completely converted into autologous bone tissues.
Owner:THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
Preparation method of completely humanized antibody of infectious disease pathogen
InactiveCN103045607AFully humanizedNo rejectionImmunoglobulins against bacteriaImmunoglobulins against virusesHumanized antibodyInfectious illness
The invention relates to a preparation method of the completely humanized antibody of a infectious disease pathogen, which mainly comprises the following steps of: preparing an infectious disease pathogen antigen; fluorescently labeling an infectious disease pathogen antibody; concentrating and purifying the peripheral B cells of an infectious disease patient; combining the labeled pathogen antigen and the antigenic-specificity B cells; screening antigenic-specificity single B cells through a flow cytometer; carrying out single cell RT-PCR (Reverse Transcription-Polymerase Chain Reaction) amplification on genes positioned in the heavy chain and light chain variable region of the infectious disease pathogen antibody; connecting with a heavy chain and light chain constant region to construct the eukaryotic expression vector of the humanized antibody; and carrying out the high-efficiency expression and purification of a recombined antibody in an eukaryotic cell. The humanized monoclonal antibody prepared through the method disclosed by the invention can be used for the infectious disease diagnosis and the infectious disease treatment.
Owner:李福胜
Bone graft capable of being directly implanted into intervertenral space and production tool thereof
InactiveCN102335050ANot easy to breakImprove securitySpinal implantsBone fusionBiomedical engineering
The invention provides a bone graft capable of being directly implanted into an intervertenral space. The bone graft is produced by compacting broken bone pieces obtained by pressure reduction in operations into a body of a required shape by a corresponding production tool, and can be directly implanted into an intervertenral space. The bone graft has certain compression resistance, can effectively support and maintain the intervertenral height, is not liable to break and has high safety. The bone graft does not need a fusing machine as a carrier, thus enlarging the contact area between the upper and lower end plate interfaces between the bone graft and a vertebral body, and being favorable for bone fusion. Moreover, the bone graft greatly reduces the operation cost, relieves patients of expensive treatment, and can be extensively applied to intervertenral bone graft fusion operations in hospitals. The invention also provides a production tool for producing the bone graft, the cavity depth of the production tool is set in proportion according to the thickness of the bone graft, spacing structures are arranged for limiting the depth of pressing a die block into a die cavity, and during compaction, the thickness of the bone graft can be obtained by filling broken bone pieces in the die cavity and compacting until the two spacing structures are in contact, so that the production tool is simple and convenient in operation and strong in practicability.
Owner:李健
Cell type used for producing induced pluripotent stem (iPS) cells and preparation method and application thereof
InactiveCN101984050AGreat therapeutic application prospectsGood pluripotencyFermentationVector-based foreign material introductionControl orientedDisease
The invention discloses four cell types which have wide heteroplastic transplantation application prospect and can be effectively induced into induced pluripotent stem (iPS) cells. The origins of three cell types are placental tissue, namely amnion mesenchymal cell, chorion mesenchymal cell and umbilical cord mesenchymal cell; and the origin of the other one is amniotic fluid cell. Besides, the invention also discloses an induction reprogramming method for producing cells capable of producing induced pluripotent stem (iPS) cells by efficient induction, including the following steps: cDNA containing pluripotent stem cell factor is respectively introduced into the four primary culture cells; the four primary cells in which cDNA is introduced are respectively cultured on appropriate culture mediums, primary iPS is obtained and then quality of iPS is optimized on appropriate culture mediums, and cloning of pluripotent stem cell can be primarily evaluated. In the invention, three mesenchymal cells of placenta origin and amniotic fluid cell all can be induced into iPS, wherein the chorion mesenchymal cell is compared with fibroblast, efficiency of induction reprogramming is improved by over 100 times, efficiency is about 2.3%, and the efficiency is slightly higher than that of horny cell; and a means which is more effective and more pertinent is provided for building disease model, screening drug and controlling oriented differentiation.
Owner:GUANGZHOU INST OF BIOMEDICINE & HEALTH CHINESE ACAD OF SCI
Non-scar plaster for treating trauma and its preparing process and usage
InactiveCN1382480APromote repairPromote healingPowder deliveryAerosol deliveryWound healingBletilla striata
A non-scar plaster for treating trauma is prepared from water-soluble chitosan (50-80 wt.%) and the extracts of 4 Chinese-medicinal amterials including bletilla tuber, rhubarb, etc. Its extracting process is also disclosed. Its advantages are high curative effect and no residual scar.
Owner:李高霖 +1
High-efficiency and antibacterial polymeric micelle with high pH sensibility and biocompatibility and preparation method thereof
InactiveCN102702451AGood antibacterial and bactericidal effectImprove antibacterial and bactericidal effectsAntibacterial agentsOrganic active ingredientsSelf-assemblyBiocompatibility Testing
The invention belongs to the field of macromolecular nano biological medicine materials, and in particular relates to a high-efficiency and antibacterial polymeric micelle with high pH sensibility and biocompatibility and a preparation method thereof. An amphipathic block polymer is subjected to self-assembly by a direct dissolution method to form the micelle; and the surface of the micelle has a large number of positive charges, so that the micelle has the effects of sterilizing and inhibiting bacteria in high efficiency under the condition that other antibiotics are not added. Simultaneously, the micelle has high biocompatibility and biodegradability. The polymeric micelle has high pH sensibility, and a structure of the polymeric micelle is changed with the change of the outside pH value, and multiple medicines can be wrapped by a core-shell structure of the micelle, so the polymeric micelle has a bright application prospect.
Owner:TONGJI UNIV
HLA-A2 restrictive epitope polypeptide of LMP2A protein source and purpose thereof
InactiveCN101643497AChemically stableEasy to manufacturePeptide/protein ingredientsPeptidesLMP2A-Specific Cytotoxic T-LymphocytesT lymphocyte
The invention discloses HLA-A2 restrictive epitope polypeptide of an LMP2A protein source, which is polypeptide LMP2A264 and comprises 9 amino acids in the positions of 264 to 272; the sequence is QLSPLLGAV. Mycobacteria heat shock protein 70 (HSP70) is expressed, identified and purified; a transgene animal model for evaluating EBV relevant polypeptide vaccine in vivo tests is established; the immune research on inducing EBV specific CTL inside and outside healthy volunteers and transgene rats for the new EBV epitope polypeptide LMP2A264 is systemically researched and the tumor prevention andthe tumor treating test of the polypeptide LMP2A264 on LMP2A positive solid tumors are evaluated, thereby proving that the polypeptide LMP2A264 can induce LMP2A specific cell toxic T lymphocyte reaction. Therefore, the polypeptide LMP2A264 can be applied to prepare medicaments for treating or preventing LMP2A positive solid tumors.
Owner:NANJING MEDICAL UNIV
Medicament microcapsule composite calcium deficiency calcium phosphate bone cement and use, preparation method and application thereof
InactiveCN101905033ASimple and efficient operationGood effectAntibacterial agentsSkeletal disorderCalcium EDTAMicrostructure
The invention discloses medicament microcapsule composite calcium deficiency calcium phosphate bone cement and the use, the preparation method and the application thereof. The bone cement contains a medicament microcapsule in effective treatment dosage and calcium deficiency calcium phosphate bone cement, wherein the calcium deficiency calcium phosphate bone cement comprises calcium hydrophosphate and tetracalcium phosphate, and a molar ratio of calcium to phosphorus is 1.5. The bone cement is prepared by uniformly mixing the medicament microcapsule and the calcium deficiency calcium phosphate bone cement. When in use, the medicament microcapsule composite calcium deficiency calcium phosphate bone cement is uniformly mixed with curing liquid physiological saline or other saline solutions to be implanted into a body, wherein the liquid-to-solid ratio of the medicament microcapsule composite calcium deficiency calcium phosphate bone cement to the curing liquid is 0.25-2.6g / mL. After the bone cement is implanted into the human body for curing, a medicament is slowly released by a microstructure of curing body and has effects of inflammation elimination and sterilization during bone repair; and a micropore formed after the medicament is slowly released is beneficial to growing new bone tissue, accelerating the degradation of materials and effectively promoting the rapid healing of bones.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Anal fistula patch or plug, as well as preparation method and application thereof
The invention provides an anal fistula patch or plug, as well as a preparation method and application thereof. The anal fistula patch or the anal fistula plug is prepared from an acellular dermal matrix. The acellular dermal matrix is obtained by performing protein enzyme solution digestive treatment, surfactant-containing hypertonic saline acellular treatment, crosslinking treatment, DNA degradation treatment and amino acid nutritional treatment on allogenic skin. The invention further provides application of the anal fistula patch or the anal fistula plug to preparation of a biological material for treating anal fistula. The acellular dermal matrix derives from human skin tissue, special physicochemical and biochemical treatment is conducted, all the components which may cause immunologic rejection are removed, the fiber three-dimensional stent structure of the original tissue is retained integrally, new vessels and fibroblasts grow quickly after implanting, and a good clinical effect is achieved.
Owner:BEIJING JAYYALIFE BIOTECH CO LTD
Small and medium diameter artificial blood vessel with adjustable pressure and flow
The invention discloses a small and medium diameter artificial blood vessel with adjustable pressure and flow. The artificial blood vessel comprises a blood vessel wall, a blood vessel cavity is in the blood vessel wall, and a pressure and flow controller capable of adjusting the diameter of the artificial blood vessel is arranged outside the artificial blood vessel. Concave and convex grains are arranged on the blood vessel wall. The pressure and flow controller comprises a fixed shell and a control spring, wherein the fixed shell takes the shape of a cylindrical structure, and the control spring is configured to be a cylindrical structure, the control spring is arranged in the fixed shell and sleeved outside of the blood vessel wall of the artificial blood vessel, the control spring is provided with a limit spring handle for adjusting the diameter of the blood vessel, and the spring handle passes through a control frame. The fixed shell is provided with position fixing holes, and the control spring is provided with position fixing holes. The fixed shell is provided with a fastener. The pressure and flow controller comprises a mechanical pressure and flow controller, an in-vitro remote control pressure and flow controller and an in-vivo induction pressure and flow controller. The blood vessel is applicable to controlling the size of fractional flow according to an induced pressure of a hepatic portal vein after a portosystemic blood vessel is anastomosed and shunted so as to ensure the hepatic portal vein perfusion pressure required by individuals.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Preparation method of allogeneic biological patch
ActiveCN107890586AGuaranteed accuracyOrderly updateSurgeryTissue regenerationPhosphateBiocompatibility Testing
The invention relates to a preparation method of an allogeneic biological patch, and belongs to the technical field of biological material preparation. The preparation method comprises the steps of 1,obtaining people's skin tissues and a corium layer; 2, placing the corium layer in a fixing solution to perform fixing treatment; 3, placing the fixed corium layer in a decellularization solution toperform decellularization treatment to obtain decellularization corium tissues. The fixing solution is a phosphate buffer solution containing 1%-2% formaldehyde and 1.5%-3.0% o-phthalaldehyde; the decellularization solution is a 1.5-2.0 mol / L NaO or KOH alkaline solution containing 10-500 U / L trypsin, 1-25 mmol / L calcium chloride and 1-25 mmol / L magnesium chloride. The allogeneic biological patchhas effective fixing and supporting effects on breast implants, and different sizes are designed to satisfy the requirement of different patients and operating methods; in addition, because extremelylow immunogenicity and extremely excellent biocompatibility of the allogeneic biological patch, it is expected that occurrence rate of diolame contracture after the breast implants are implanted can be significantly reduced.
Owner:BEIJING QINGYUAN WEIYE BIO TISSUE ENG
Medical surgical suture and preparation method thereof
The invention discloses a medical surgical suture. The surgical suture is mainly prepared from, by weight, 48-62 parts of chitosan, 30-40 parts of silk protein, 4-7 parts of tangerine leaves, 3-6 parts of woundwort, 5-8 parts of short hairy antenoron, 7-11 parts of Chineses trichosanthes roots, 5-9 parts of lindera angustifolia cheng, 3-7 parts of hairyvein agrimony, 6-10 parts of ficus tikoua, 8-12 parts of japan clover herbs, 4-8 parts of rhizoma bletillae and 5-9 parts of Chinese umbrellaleaf rhizomes and roots. The medical surgical suture further has the advantages that healing of a wound can be promoted, ulcer resistance is achieved, the defect that chitosan medical fibers are quick in tensile rigidity loss in the in-vivo environment and other defects can be remedied, a tissue reaction is avoided, safety and effectiveness are achieved, and no toxic or side effect exists.
Owner:耿文真
Tissue engineered breast transplant and constructing method thereof
InactiveCN101850132ANo immune rejectionLess prone to complications such as capsular contractureMammary implantsMedicineArtificial organ
The invention belongs to the technical field of construction of artificial organs by a tissue engineering method in biomedical engineering and relates to a tissue engineered breast transplant and a constructing method thereof. The tissue engineered breast transplant of the invention takes injectable material I type collagen gel as a carrier bracket and takes adipose-derived stem cells as seed cells; the seed cells are attached to the carrier bracket to form an adipose-derived stem cell / I type collagen gel compound; the final concentration of collagen is 2 mg / ml; and the cell density is 2*10<7> / ml. The tissue engineered breast transplant of the invention consists of injectable material-loaded autologous adipose-derived stem cells and is simple and convenient to prepare. Experiments prove that a new adipose tissue can be produced and the tissue engineered breast transplant is finally converted into autologous fat without an immunological rejection problem, so a new solution is provided for the filling and reconstruction of a breast.
Owner:THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
Human liquid state derma preparation for injection and its preparation method
The invention relates to a human body liquid state corium layer preparation for injection and a preparation method thereof, and belongs to the field of medical bio engineering. The preparation method of the human body liquid state corium layer preparation for injection comprises the following steps: digesting and separating the skin from a curer himself; obtaining corium fibroblast stem cell, a fibroblast fore body cell and a fibroblast cell; performing the extraneous omnirange blood serum-free cultivation and expansion of the cells; preparing effective component and normal saline injection or other injection collected as well as other suitable components selected arbitrarily. The effective component is composed of at least one of the corium f fibroblast stem cell, the fibroblast fore body cell and the fibroblast cell collected after being cultivated and collagen. In each-liter filling agent for injection, the total quantity of the effective cell component is 10,000,000 to 80,000,000, and the collagen contains 10-100 mg / ml filling agent for injection. The human body liquid state corium layer preparation has the advantages that the used material is derived from the curer himself, no rejection reaction and side effect occur, the effect is quick after remedy, the effect is obvious, the expression is natural, the effect action is durable and can be kept for a plurality of years.
Owner:赵紫电
Polylactic-acid-modified magnesium alloy medical composite material and preparation method thereof
ActiveCN107185032AGood biocompatibilityPromote degradationAnodisationPharmaceutical delivery mechanismMicro arc oxidationPlasma electrolytic oxidation
The invention relates to a polylactic-acid-modified magnesium alloy medical composite material and a preparation method thereof. The method comprises: 1) performing micro arc oxidation treatment on a surface of a magnesium alloy substrate, and performing coupling treatment to obtain a silicane coupling substrate; 2) adding a surfactant to a chitosan solution, and performing uniform mixing to obtain a chitosan mixed liquid, and dissolving polylactic acid in trichloromethane to prepare a polylactic acid solution, and adding the polylactic acid solution in the chitosan mixed liquid while performing stirring, and performing high speed emulsification to obtain a film-casting liquid; and 3) coating the surface of the silicane coupling substrate with the film-casting liquid, removing the solvent and the surfactant to obtain a dry film layer, and performing thermal insulation at 80-90 DEG C to obtain the composite material. The composite material is excellent in biological compatibility, surface activity and mechanical properties. The degradation rate of the material can be controlled by adjusting the thickness of a polylactic acid and chitosan film layer. After the material is implanted to a human body, the degradation product can be absorbed by the human body or excreted outside the body with metabolism, so that secondary operation is not required.
Owner:广州雄俊智能科技有限公司
Autologous epidermal melanin transplantation cell water survival method for treating vitiligo
InactiveCN107663512AAchieve rejectionNo rejectionCell dissociation methodsEpidermal cells/skin cellsCuticleTransplantation
The invention discloses a method for using vitiligo autologous epidermal melanin transplantation cells to divide and activate water, comprising the following steps: using a skin puncher to take a small amount of scalp containing hair follicles from the patient's head, separating and culturing the melanocytes in the hair follicles in vitro; The cultivation, cryopreservation and recovery of melanocytes; the cultivation and expansion of melanocytes; the biological identification of the morphology and function of melanocytes and the stability of genetic traits. In the present invention, a large number of autologous melanocytes are obtained by obtaining melanocytes in autologous scalp hair follicles, cultured and expanded in vitro, and these melanocytes have normal skin melanocyte functions and can normally produce skin melanin. The lack of melanocytes in the skin lesions, so as to achieve the purpose of treating vitiligo. This treatment method is different from the traditional treatment method, autologous cells will not appear rejection, and it does not need to be treated with drugs, and there is no potential risk.
Owner:长沙华研皮肤病医院有限公司
Lithographic Printing Original Plate, Method For Producing Lithographic Printing Plate Using Same, And Method For Producing Printed Matter
InactiveCN107430342AGood reproducibilityNo rejectionPlaten pressesPlate printingEngineeringPlanographic printing
Owner:TORAY IND INC
Uterine cavity implant as well as preparation method and application thereof
The invention relates to a uterine cavity implant as well as a preparation method and application thereof. The uterine cavity implant is characterized by having a bagged structure. The uterine cavity implant comprises a substrate material of animal small intestine submucosa subjected to decellularization treatment. An implantable medical device for preventing and treating intrauterine adhesion comprises a biological tissue substrate material. The present decellularization technology for a biological repairing material is improved; compared with the present product, the biological tissue substrate material provided by the invention has the advantages of lower DNA residual quantity, lower immunogenicity, higher anti-infection capacity and higher repairing capacity; and the uterine cavity implant is beneficial to the recovering of tissues, such as, uterine cavity base layer, submucosa and mucous layer. Besides, the invention prepares the biological repairing material into the uterine cavity built-in structure which is used for isolating wound surfaces, repairing uterine cavity tissues and reducing scar forming, so that the intrauterine adhesion problem is solved, and the accordingly generated sterility problem also can be solved.
Owner:BEIJING BIOSIS HEALING BIOLOGICAL TECH
Polylactic acid fiber reinforced polylactic acid/hydroxyapatite composite material and preparation method thereof
InactiveCN104001210AImprove mechanical propertiesImprove performanceSynthetic resin layered productsLaminationApatiteDrug biological activity
The invention discloses a polylactic acid fiber reinforced polylactic acid / hydroxyapatite composite material which is characterized by comprising a plurality of polylactic acid-hydroxyapatite film layers arranged from top to bottom, wherein a polylactic acid fiber layer is arranged between every adjacent two polylactic acid-hydroxyapatite film layers; each polylactic acid-hydroxyapatite film layer and each polylactic acid fiber layer are hotly pressed together; the polylactic acid-hydroxyapatite film layers are made from materials composed of 70-95 percent (weight) of polylactic acid and 5-30 percent (weight) of hydroxyapatite; the polylactic acid fiber layers are formed by paving polylactic acid fiber. The invention further provides a preparation method of the composite material. The preparation process of the composite material is simple, the cost is low, the obtained composite material is good in mechanical property, has good resistance to tensile stress and toughness, has biological activity and degradability, does not contain organic solvents having side effects for human bodies, and can act as a high-strength material.
Owner:ECOTA ENVIRONMENTAL TECH +1
Process for adding drug sterilizing in water washing procedure at mfg. printed circuit board
InactiveCN1559929AApparent proportionEfficient killingWater/sewage treatment using germicide/oligodynamic-processProduction lineDisinfectant
The invention relates to a sterilizing method in water washing course in making printed circuit board (PCB), a method of adding drug for sterilizing in water washing course in making PCB, and its characteristic: selecting a production line, in water washing course, adding disinfectant in each water washing tank, and the method of adding the disinfectant: adding the disinfectant in each water washing tank every 4 hours, and according to the flow of each water washing tank, the addition of the disinfectant (ml / 4h)= flow X (50-300) / 1000000; recording the addition and adding time for 1 week to collect bad proportions; simultaneously, randomly taking a PCB out of the PCBs produced on this production line to make confidence test, so as to detect if the product quality is abnormal; comparing the bad proportions in condition of not adding the disinfectant with those in condition of adding the disinfectant to confirm the effect; if the effect is confirmed good and the quality is not abnormal, starting normal adding. It adopts on-line mode of adding drug for sterilizing, no-repelling reaction, simple and obvious-effect. The on-line sterilizing method can effectively killing bacteria in the water washing tanks, and the proportion of copper residues is reduced obviously, thus increasing yield of production.
Owner:广州粤捷电子科技有限公司
Method for synthesizing organic fluorine modified polysiloxane linen finishing agent
The invention relates to a method for synthesizing organic fluorine modified polysiloxane linen finishing agent, belonging to the technical field of linen finishing agent. Polymethyl hydrogen polysiloxane, methyl methacrylate and fluorinated olefin are used as raw materials which have wide sources and moderate price and ensure sufficient addition reaction, easy reaction product separation and purification and high yield of organic fluorine modified polysiloxane linen finishing agent. Being the organic fluorine modified product with a stable structure, the finishing agent has good biological aging resistance, dose not repel the animal body, has no harmful effect on the environment, is green and environmental friendly and ensures that the linen fabric has durable finishing effect, resists water, oil and foul. The method adopts the hydrosilylation reaction and the simple reaction route and ensures high conversion rate.
Owner:QIQIHAR UNIVERSITY
Heat-resistant graphite paste paint
ActiveCN101941050AReduce typesEasy to prepareFoundry mouldsFoundry coresEpoxyCarboxymethyl cellulose
The invention relates to a graphite paste paint which comprises the following components in portions by weight: 90-110 portions of graphite powder, 2-6 portions of activated bentonite, 0.1-0.5 portion of sodium carboxymethyl cellulose mixture and the balance of water. The graphite paste paint also comprises a liquid epoxy resin, and the liquid epoxy resin accounts for 2-5 wt% of graphite paste paint. The sodium carboxymethyl cellulose mixture comprises the following components in portions by weight: 3-5 portions of sodium carboxymethyl cellulose and 100 portions of water. The graphite paste paint is in the form of soft paste, and the viscosity of the paste is 14-16. The invention has the advantages of simple components, easy preparation operation, easy uniform mixing and high adhesiveness.
Owner:WUJIANG HYDRAULIC COMPONENTS FOUNDRY
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