Degradation-controllable drug-loaded hemostatic sponge and preparation method thereof

A drug-loading and formulation technology, applied in the field of medical materials, can solve the problems of slow degradation and long disappearance time of polyurethane, and achieve simple and accurate clinical use

Inactive Publication Date: 2020-04-21
HANGZHOU VITEX MEDICAL DEVICE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the polyurethanes obtained by all degradable polyurethane preparation technologies currently have the problem of slow degradation and long disappearance time after being applied to the human body.

Method used

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  • Degradation-controllable drug-loaded hemostatic sponge and preparation method thereof
  • Degradation-controllable drug-loaded hemostatic sponge and preparation method thereof
  • Degradation-controllable drug-loaded hemostatic sponge and preparation method thereof

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preparation example Construction

[0029] A method for preparing a drug-loaded hemostatic sponge with controllable degradation, comprising the steps of:

[0030] Step 1, synthesizing DL-lactide and ε-caprolactone prepolymer;

[0031] Under a nitrogen atmosphere, prepare 10-20 parts of DL-lactide and 16-71 parts of ε-caprolactone, and feed DL-lactide and ε-caprolactone with a molar ratio of 10-50:50-90 Mix, add initiator and catalyst respectively, put into an oil bath at 70-140°C and stir for 4-24 hours to obtain DL-lactide and ε-caprolactone prepolymer;

[0032] Step 2, synthetic chain extender;

[0033] Prepare 8-23 parts of diol, 48-138 parts of diisocyanate as raw materials, reaction temperature 60-120 ° C, reaction time 2-6 hours, synthesize chain extender, and purify the product;

[0034] Step 3, preparing a drug-loaded polyurethane sponge precursor solution with controllable degradation;

[0035] Dissolve the prepared DL-lactide and ε-caprolactone prepolymer, the purified chain extender and 0.5-1.5 par...

Embodiment 1

[0040] (1) Synthesis of DL-lactide and ε-caprolactone prepolymer

[0041] Under a nitrogen atmosphere, mix 10gDL-lactide and 71gε-caprolactone (the molar ratio of DL-lactide and ε-caprolactone is 10:90) in a three-necked reaction flask, and then add 56.7g Polyethylene glycol 600 and 324ul stannous octoate were placed in an oil bath at 120°C and stirred for 18 hours to obtain DL-lactide and ε-caprolactone prepolymers;

[0042] (2) Synthetic chain extender

[0043] Weigh 138g of hexamethylene diisocyanate into a three-necked reaction flask, put the reaction flask into an oil bath and heat up to 80°C, then slowly add 23g of 1,4-butanediol dropwise into the reaction system, and continue stirring React for 4 hours. After the reaction, the system was cooled to room temperature, and purified by adding refrigerated n-heptane, and the purified product was characterized by NMR.

[0044](3) Preparation of drug-loaded polyurethane sponge precursor solution

[0045] Weigh 25 g of the d...

Embodiment 2

[0049] (1) Synthesis of DL-lactide and ε-caprolactone prepolymer

[0050] Under a nitrogen atmosphere, mix 10g of DL-lactide and 32g of ε-caprolactone (the molar ratio of DL-lactide and ε-caprolactone is 20:80) in a three-necked reaction flask, and then add 29.4g Polyethylene glycol 600 and 168ul stannous octoate were placed in an oil bath at 130°C and stirred for 14 hours to obtain DL-lactide and ε-caprolactone prepolymers;

[0051] (2) Synthetic chain extender

[0052] Weigh 72g of hexamethylene diisocyanate and add it into a three-necked reaction bottle, put the reaction bottle into an oil bath and raise the temperature to 120°C, then slowly add 12g of 1,4-butanediol dropwise into the reaction system, and continue stirring React for 2 hours. After the reaction, the system was cooled to room temperature, and n-hexane was added for purification, and the purified product was characterized by NMR.

[0053] (3) Preparation of drug-loaded polyurethane sponge precursor solution...

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Abstract

The invention discloses a degradation-controllable drug-loaded hemostatic sponge. A formula for the degradation-controllable drug-loaded hemostatic sponge comprises the following components in parts by mass: 10-20 parts of DL-lactide, 16-71 parts of epsilon-caprolactone, 8-23 parts of dihydric alcohol, 48-138 parts of diisocyanate, 0.5-1.5 parts of glucocorticoid drugs, 19.6-56.7 parts of an initiator, 0.112-0.324 part of a catalyst and 50-100 parts of an organic solvent, wherein a feeding molar ratio of the DL-lactide to the epsilon-caprolactone is (10-50): (50-90). According to the invention, the degradation time of a polyurethane sponge is controlled by adjusting the proportion of each component in an amorphous chain segment, so the release of the glucocorticoid drugs is controlled, thenose can be temporarily pressed to realize hemostasis and support; and degradation time and drug release are accurately controlled, so the clinical use of the hemostatic sponge is simpler and more accurate.

Description

technical field [0001] The invention relates to medical materials, in particular to a drug-loaded hemostatic sponge with controllable degradation and a preparation method thereof. Background technique [0002] With the development of science and technology, people pay more and more attention to environmental protection and medical materials, and absorbable materials with good biodegradability and biocompatibility are developing rapidly. Among them, polyurethane material is known as the "fifth largest plastic" because of its good mechanical properties, biocompatibility, blood compatibility and easy processing. Polyurethane (referred to as PU) is a high molecular polymer made of polyisocyanate, polyether polyol or polyester polyol and / or small molecule polyol, polyamine or water and other chain extenders or crosslinking agents. By changing the type, composition and ratio of raw materials, the shape and performance of the product can be greatly changed, and the final product c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/04A61L24/00C08G18/73C08G18/42C08G18/32C08G63/664
CPCA61L24/0015A61L24/0036A61L24/0042A61L24/046A61L2300/222A61L2300/43A61L2400/04C08G18/3206C08G18/4277C08G18/428C08G18/73C08G63/664C08L67/04C08L75/04
Inventor 曹佩培赵中黄乃进
Owner HANGZHOU VITEX MEDICAL DEVICE CO LTD
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