Preparation method of three-layer lead tissue regenerating velum with gradient
A technique of guiding tissue regeneration and gradient, applied in the field of preparation of three-layer guided tissue regeneration membrane, can solve the problems of poor mechanical strength, affecting tissue regeneration, membrane collapse, etc., and achieve the advantages of repairing regeneration and increasing dust compatibility Effect
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[0027] Example 1:
[0028] 1. Dissolve different amounts of gelatin in trifluoroethanol to obtain solutions A, B, and C with gelatin concentrations of 3%, 5%, and 10% respectively, and magnetically stir for 12 hours.
[0029] 2. Add different amounts of polylactic acid and nano-hydroxyapatite into solutions A, B and C to obtain solutions D, E and F. The contents of polylactic acid in D, E and F are 10%, 5% and 3, respectively. %, the concentration of nano-hydroxyapatite is 0.005%, and the D, E and F solutions are magnetically stirred for 12h.
[0030] 3. Take solution E (3mL) for electrospinning, use aluminum foil as a receiver, electrospinning voltage of 10kv, receiving distance of 12cm, and flow rate of 0.2mL / h to obtain the first film;
[0031] 4. Take solution D (10mL) and continue electrospinning on the first layer of membrane material, using aluminum foil as a receiver, electrospinning voltage of 10kv, receiving distance of 12cm, and flow rate of 0.2mL / h to obtain a double-l...
Example Embodiment
[0035] Example 2:
[0036] 1. Dissolve different amounts of collagen in hexafluoroisopropanol to obtain solutions A, B, and C with gelatin concentrations of 1%, 3%, and 8% respectively, and magnetically stir for 8 hours.
[0037] 2. Add different amounts of polycaprolactone and nano-hydroxyapatite into solutions A, B and C to obtain solutions D, E and F. The content of polycaprolactone in D, E and F is 10%, 6% and 2%, the concentration of nano-hydroxyapatite was 0.1% respectively, and the D, E and F solutions were magnetically stirred for 20 hours.
[0038] 3. Take solution E (3mL) for electrospinning, use aluminum foil as a receiver, electrospinning voltage of 8kv, receiving distance of 18cm, and flow rate of 1mL / h to obtain the first film;
[0039] 4. Take solution D (5mL) and continue electrospinning on the first layer of membrane material, using aluminum foil as a receiver, electrospinning voltage of 13kv, receiving distance of 10cm, and flow rate of 3mL / h to obtain a double-l...
Example Embodiment
[0043] Example 3:
[0044] 1. Dissolve different amounts of collagen in hexafluoroisopropanol to obtain solutions A, B, and C with gelatin concentrations of 3%, 8%, and 12% respectively, and magnetically stir for 24 hours.
[0045]2. Add different amounts of polylactic acid and nano-hydroxyapatite into solutions A, B and C to obtain solutions D, E and F. The contents of polylactic acid in D, E and F are 7%, 6% and 2 respectively. %, the concentration of nano-hydroxyapatite is 1% respectively, and the D, E, and F solutions are magnetically stirred for 10 hours.
[0046] 3. Take solution E (3mL) for electrospinning, use aluminum foil as a receiver, electrospinning voltage of 20kv, receiving distance of 11cm, and flow rate of 1mL / h to obtain the first layer of membrane material;
[0047] 4. Take solution D (12mL) and continue electrospinning on the first layer of membrane material, using aluminum foil as a receiver, electrospinning voltage of 10kv, receiving distance of 12cm, and flo...
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