34results about How to "Enhanced Ultrasound Imaging" patented technology

An ultrasonically visible solid device for inserting into a non-gas target medium comprises an echogenic surface having structures entrapping gas when the device is in the target medium, the entrapped gas causing the device to be ultrasonically visible, wherein the gas-entrapping structures are covered with a flexible overcoat that does not significantly reduce the compressibility of the gas trapped in the structures.

A surgical biopsy apparatus for cutting tissue comprising a housing having a longitudinal axis, first and second members movable from a retracted position to an extended position with respect to the housing, a third member slidably positioned and extendable with respect to the first member, a fourth member slidably positioned and extendable with respect to the second member, and an electrocautery cutting wire slidable with respect to the third and fourth members to surround a region of tissue positioned between the third and fourth members to cut the tissue.

The invention relates to a novel multifunctional ultrasound contrast agent and a preparation method thereof. The multifunctional ultrasound contrast agent of the invention is a nanoparticle lipid emulsion containing a core-shell structure, wherein materials of a shell membrane comprise lecithin, cholesterin and magnetic nanometer materials; the center is coated by lqiuid fluorocarbon; and magnetic nanoparticles are inlaid on the shell membrane. The ultrasound contrast agent of the invention is a specificity contrast agent of a reticuloendothelial system, thereby being capable of not only strengthening ultrasonoscopy, but also enhancing CT and MRI development, having good development effects, and having wide application prospects.

The present disclosure is directed to an ultrasonic catheter assembly. More specifically, the catheter assembly includes a catheter and one or more piezoelectric or echogenic components. The catheter has a side wall that extends from a proximal end and a distal end that defines a lumen extending from the proximal end to the distal end. Thus, the lumen is configured to deliver a treatment fluid from the proximal end to the distal end. In addition, the piezoelectric component(s) are configured with the side wall of the catheter and/or embedded at least partially within the side wall of the catheter. As such, the piezoelectric component(s) are configured to enhance ultrasonic imaging of the catheter, e.g. when activated by a stimulator assembly.

A needle assembly has a needle having an echogenic feature proximate to its distal sharp tip mounted to an echogenic cannula, with the echogenic tip of the needle extending beyond the distal end of the cannula. The echogenic tip provides guidance for the movement of the needle assembly under ultrasound observation so that the needle assembly may be more readily maneuvered inside a body. Once correctly positioned, the needle is removed and further confirmation may be made under ultrasound observation that the cannula has been correctly positioned inside the body. The echogenic feature of the needle may be at least one spiral groove that is tilted at an angle relative to the tip of the needle to effect a substantially 180° reflection of the ultrasound. An alternative echogenic feature to improve reflected echogeneity has crisscrossing grooves each having a predetermined pitch density formed at a neutral position on the needle.

The invention relates to the field of pharmacy, and particularly relates to a multi-mode ultrasonic contrast agent and a preparing method thereof. Micro bubbles of the contrast agent are small and can enter tissue gaps, and developing time is stable. According to a technical scheme, mesoporous silicon covering gold nanorods adsorbs a paramagnet and liquid fluorocarbon, and the surface of the obtained product is modified with biocompatible hyaluronic acid to obtain the contrast agent having a targeting property. The contrast agent has stable physical and chemical properties and good biocompatibility, can be effectively used as a contrast agent for tumor diagnosis, and can enhance ultrasonic development, opto-acoustic development and magnetic resonance development. The application range of the contrast agent is wide.

The invention relates to a gold particle-loaded mesoporous silica nanocapsule multi-mode contrast agent, which can be used for strengthening drug release, and used as an ultrasonic contrast agent and a high intensity focused ultrasound (HIFU) synergist and an HIFU synergist and a preparation method of the contrast agent. The multi-mode contrast agent and the HIFU synergist comprise mesoporous silica nanoparticle capsules which modified by polyethylene glycol on surfaces and beneficiated by gold nanoparticles, and guest molecules loaded to the mesoporous silica nanoparticle capsules for HIFU synergism.

The invention discloses a multifunctional nano-carrier for tumor photo-thermal synergistic treatment and ultrasonic imaging and a preparation method thereof. The multifunctional nano-carrier is characterized in that the nano-carrier is of a core-shell structure and takes soluble polypyrrole as a shell structure, and a core is filled with a phase-change material and a small-molecule inhibitor drug.The nano-carrier has the functions of ultrasound contrast diagnosis and photo-thermal synergistic treatment at the same time, the contrast ratio and the definition of an ultrasound image are enhancedby bubbles generated by phase change of the carried phase-change material under the external stimulation, the released drug reduces the level of thermostable protein in cancer cells through a seriesof cascade functions, so that the sensitivity of the cancer cells to heat is remarkably improved, and the effect of photo-thermal treatment is enhanced.

The invention relates to a multifunctional nano diagnosis system integrated with common support of hydrophilic and hydrophobic molecules, temperature response release, enhanced ultrasound imaging and high-intensity focused ultrasound (HIFU) treatment, and a preparation method thereof. The nano diagnosis system mainly comprises hollow mesoporous silica and menthol, and the hollow mesoporous silica and menthol are good in biosecurity, and have broad application prospects in inhibition of the tolerance in a multi-drug support manner, controllable local temperature response release, enhancement of the ultrasound imaging contrast as an ultrasonic contrast agent and an HIFU synergist and improvement of the HIFU treatment efficiency. The preparation method comprises the following steps: preparing hollow mesoporous silica balls of which the particle sizes are 600+/-50nm and the shell layer thickness is 75+/-5nm by a modified structure difference selection etching method; then carrying out menthol support or common support of a menthol and dye molecule mixture by taking the hollow mesoporous silica as a vector, so as to obtain the multifunctional nano diagnosis system. The preparation method disclosed by the invention is simple and feasible, free of pollution, high in yield, and good in flexibility.

The invention discloses an ultrasonic contrast agent for stem cell ultrasonic tracing and a preparation method thereof. The ultrasonic contrast agent is constructed from stem cells modified by lipid PLGA nano-micro-bubbles,wherein the complex comprises CD90-targeted lipid PLGA nano-micro-bubbles and stem cells which are interacted with each other. According to the ultrasonic contrast agent,the lipid PLGA nano-micro-bubble and stem cell complex is successfully constructed by using modified nano-micro-bubble groups and an abundantly expressed CD90 antigen molecular reaction,endocytosis of the stem cells on the lipid PLGA nano-micro-bubbles can be enhanced,the activity and dryness of the stem cells are kept,ultrasonic real-time imaging guide stem cell transplantation therapy is realized,thenenhancement of the stem cell transplantation treatment effect is further assisted,and the ultrasonic contrast agent has certain significance in the field of stem cell tracing.

The invention discloses a silicon plastid-entrapped perfluocarbon preparation as well as a preparation method and application thereof. The prepared preparation can be used as an oxygen and drug delivery system to synchronously deliver oxygen and drugs to tumors in a targeted manner, and under the stimulation of high-intensity focused ultrasound, oxygen and drugs can be quickly released at tumor parts, the hypoxic microenvironment of tumors is improved, and the drug effect of the drugs is improved. A silicate network structure on the surface of the silicon plastid enables the preparation to have good structural stability and drug loading stability, early leakage of drugs in a blood circulation system can be reduced, and toxic and side effects of the drugs are reduced. The preparation can also enhance the effect of ultrasonic imaging and realize drug delivery and drug release under image monitoring.

Embodiments of catheters, imaging systems and methods for intravascular ultrasound imaging are presented. At least one miniaturized transducer element adapted to be inserted into a vascular structure and configured to produce signals for use in generating one or more ultrasound images of a desired region within the vascular structure is used. Further, one or more apodizing structures operably coupled to the transducer element and configured to decrease the responsiveness of the transducer element at one or more boundaries of the transducer element with respect to the center of the transducer element are used. Particularly, the apodizing structures reduce sidelobe amplitude of an ultrasound beam profile in the region of interest, thereby generating improved ultrasound images.

The invention discloses a phase-change nanobubble, and a preparation method and application thereof. The nanobubble is prepared by taking an amphiphilic material chitosan-polylactic acid grafted copolymer as a coating material and taking perfluoropentane capable of generating liquid-gas phase transformation under the action of temperature as a bubble core filling substance by adopting an emulsifying solvent volatilization method. The prepared nanobubble is creamy yellow, and the particle size is 101.1+/-2.7 nm. The particle size change is small in two months in vitro, and stability is good. The nanobubble can enhance the ultrasonic imaging effect under action of ultrasonic waves and can be broken by the ultrasonic waves. The chitosan-polylactic acid grafted copolymer nanobubble prepared bythe emulsifying solvent evaporation method is good in in-vitro stability, and ultrasonic imaging can be enhanced. The nanobubble can load an MRI contrast agent, so that the MRI imaging effect of tumor lesions is improved. The nanobubble can also load anti-tumor drugs for targeted therapy of tumors, is a novel multifunctional iconography nano contrast agent integrating diagnosis and treatment, andthus has a great application value.

The invention discloses a multifunctional aseptic protective sleeve for a disposable esophageal ultrasonic probe, includes a packaging bag, a sealing mechanism, a protective sleeve body and a fixing mechanism, wherein the protective sleeve body comprises a pulling belt, a coupling agent adding pipe, a sleeve body, a sleeve head and an ultrasonic probe; one end of the sleeve body is provided with asleeve opening; one side of the sleeve opening is provided with a pulling belt; The outer part of the protective sleeve body is sleeved with a packaging bag, and a sealing mechanism is arranged at the opening of the packaging bag; One side of the packaging bag is provided with a fixing mechanism, As that sterile protective cov of the ultrasonic probe reduces the transmission of disease and iatrogenic cross infection, the most important thing is that part of the air in the stomach can be sucked away through a suction tube when the stomach is full of air, and the coupling agent can be adde through a coupling agent addition tube when the coupling agent is needed, thereby ensuring the clarity of the image to a great extent.

Belonging to the technical field of biomedicine, the invention specifically relates to an in-vivo phase transition tumor targeted nanobubble, its preparation method and application. The nanobubble takes a polyphosphate-polyester copolymer of a coupling tumor targeting factor as a coating material, adopts perfluoropentane able to undergo liquid-gas phase transition in vivo as a bubble core filling material, and is prepared by a pre-multiple emulsion-hollow membrane tube emulsification method. When the nanobubble enters the body, the liquid perfluoropentane undergoes liquid-gas phase transition at body temperature to form a gas-containing nanobubble. By means of the specific combination of a targeting factor and a tumor cell, the nanobubble can concentrate a tumor focus part, thus improving the tumor focus ultrasonic imaging effect. The nanobubble can be loaded with an MRI contrast agent to improve the tumor focus MRI imaging effect. The nanobubble can also be loaded with an antitumor drug and used for targeted treatment of tumors, thus being a novel diagnosis-treatment integrated multifunctional imageological nano-contrast agent.

A system and method for providing enhanced ultrasound images for accessing a vasculature of a patient is disclosed. The system includes an ultrasound imaging device including a probe with a light detector disposed at a distal end thereof. A medical device includes an infrared emitter disposed a distal tip thereof. The emitter provides infrared light that illuminates surrounding tissue. Reflected light is detected and interpreted based on the profile of absorbance spectra which can be used to identify different tissue structures. This light-based information is superimposed on an ultrasound image of the vessel to facilitate first-stick access of patient vasculature.

Provided are an ultrasound system and a method for operating the ultrasound system, which may calculate a direction of an ultrasonic beam in real time and may adjust the ultrasonic beam based on the calculation result. The ultrasound system may include a probe to emit an ultrasonic beam to an object, a processor to measure a first reflection angle of the ultrasonic beam at a predetermined point in the object, a mapping table to map the measured first reflection angle to the predetermined point and to record mapping data, and a controller to determine an emission angle of the ultrasonic beam to the predetermined point based on the first reflection angle recorded in the mapping table, and to control the probe to emit the ultrasonic beam at the determined emission angle.

The invention discloses a nano-ultrasonic microbubble, as well as a preparation method and application thereof. The nano-ultrasonic microbubble has a shell-kernel structure, wherein the inner kernel is liquid fluorocarbon nano-particles and curcumin, and the shell is a lipid film; and the surface of the lipid film is coupled with CD44 antibody. The nano-ultrasonic microbubble has good imaging, canbe used as an ultrasonic developing contrast agent, a CT contrast agent and an MRI contrast medium, is a multifunctional contrast medium and shows specific superiority in the aspect of targeting development. The nano-ultrasonic microbubble can achieve transformation from nano-grade to micron-grade after accepting ultrasonic excitation, and can release coated drugs to improve the curative effect of sonodynamic treatment. Due to the common effects of nano-grade particle size, sound-sensitive agent curcumin and CD44 antibody, the nano-ultrasonic microbubble achieves excellent target property andtreatment effect in tumor treatment and can be used for treating ovarian cancer, cervical cancer, lung cancer, colorectal cancer, breast cancer and esophagus cancer.

The invention discloses PLA microbubbles compounded with Fe3O4-GO-ASA and a preparation method thereof, and belongs to the field of biomedicine. A multi-functional contrast agent integrated targeted radiography and auxiliary thrombus-inhibiting functions and a preparation method thereof are provided. The microbubbles are composed of PLA microbubbles and shells formed by adhering PVA on the surfaces of the PLA microbubbles; the PLA microbubbles are microbubble walls formed by PLA films; Fe3O4-GO-ASA compounds are embedded in the PLA films and on the inner walls of the PLA films; the PLA microbubbles are filled with inactive gas; and the Fe3O4-GO-ASA compounds are obtained by depositing Fe3O4 on the surface of GO and using pi-pi to adsorb and load ASA. The prepared PLA microbubbles can effectively prolong clotting time and prevent thrombus from forming, so that assistant treatment effects of anticoagulation can be achieved.

The invention relates to the technical field of a coupling product for a supersonic wave diagnostic device, particularly to a hydrogel coupling pad special for a medical supersonic wave diagnostic device. The coupling pad is mainly made from carbomer 940 GE, glycerin, triethanolamine, sodium dodecyl sulfate, ethyl acrylate and water. The preparation method of the hydrogel coupling pad comprises the following steps: (1) adjusting a special hydrogel original liquid, (2) solidifying the hydrogel original liquid, (3) radiating a freezed hydrogel pad blank, (4) cleaning and purifying the radiated hydrogel pad, and (5) checking and packaging the obtained pad to obtain a final product. The technical scheme provided in the invention has the beneficial effect that the definition of medical ultrasound imaging is greatly improved, and the hydrogel coupling pad is in a hydrogel solid state, has no viscosity, and leaves no residue on the surface of people's skin, so that the pad doesn't require wiping with a tissue and is eco-friendly and clean.

An ultrasound probe includes a transducer layer, a first matching layer, a lens layer, and a backing layer. The first matching layer is disposed at a first side of the transducer layer and a material of the first matching layer is PMMA or PO. The lens layer is disposed at the first side of the transducer layer and the first matching layer is located between the transducer layer and the lens layer. The backing layer is disposed at a second side of the transducer layer, wherein the first side is opposite to the second side.

The invention relates to the technical field of medical supplies, in particular to a two-layer intracavitary probe cannula capable of being filled with water. The intracavitary probe cannula comprisesa cannula body and a water injection tube, wherein a front port of the cannula body is closed, a rear port of the cannula body is an insertion port, and the cannula body comprises an arched top faceand a horizontal bottom face; the top face comprises two layers of stacked thin films, the edges of the two layers of thin films are sealed, and thus a water storage cavity is formed between the two layers of thin films, and connected with the water injection tube. The intracavitary probe cannula is disposable, and cross infection of viruses can be avoided; meanwhile, ultrasonic imaging can be enhanced, the quality of ultrasonic images is improved, when the intracavitary probe cannula is applied to a paracentesis, more precise positioning can be provided, and the accuracy of the paracentesis position is ensured.

The invention discloses a composite drug-loading nanoscale ultrasonic multifunctional microbubble based on three lesions and a preparation method thereof, and belongs to the field of biomedical treatment. The microbubble comprises a microbubble membrane wall, Fe3O4-CNTs-ASA, Fe3O 4-CNTs-GM or Fe3O4-CNTs-DOX magnetic targeting drug-loading compound and inert gas wrapped in the microbubble membranewall. The prepared PLA microbubble of the composite Fe3O4-GO-ASA can effectively prolong the coagulation time, prevent the formation of thrombus and achieve the auxiliary treatment effect of anticoagulation. The prepared Span-PEG microbubble of the composite Fe3O4-CNTs-GM has a good inhibitory effect on escherichia coli and staphylococcus aureus, and the inhibitory effect on the escherichia coli is higher than that of the staphylococcus aureus. The prepared Span-PEG microbubble of the composite Fe3O4-CNTs-DOX has a proliferation inhibition effect on liver cancer SMMC-7721 cells and mouse normal fibroblast 3T3 cells, and compared with free DOX, the Span-PEG microbubble of the composite Fe3O4-CNTs-DOX can reduce the direct toxic effect of adriamycin on normal cells.