Multifunctional nano diagnosis system and preparation method thereof

A diagnosis and treatment system and a multifunctional technology, applied in the field of multifunctional nanosystems and their preparation, can solve problems such as non-patent, and achieve the effects of simple preparation method, easy mass production, and pollution-free mass production.

Inactive Publication Date: 2014-06-11
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In summary, the combination of hollow mesoporous silica as a carrier combined with some volatile organic molecules with organic solid-liquid phase transition simultaneously realizes dual loading of hydrophilic and hydrophobic drugs, temperature-responsive release, and enhanced ultrasound contrast and HIFU treatment effects. It has not been reported yet, and there is no relevant patent to be found, which needs further research

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  • Multifunctional nano diagnosis system and preparation method thereof
  • Multifunctional nano diagnosis system and preparation method thereof
  • Multifunctional nano diagnosis system and preparation method thereof

Examples

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preparation example Construction

[0055] At the same time, the present invention provides a preparation method for preparing the multifunctional nano-diagnosis and treatment system, the method comprising:

[0056] Monodisperse hollow media with a particle size of 600±50nm were prepared by a modified structural difference selective etching method (see "American Chemical Society Journal NANO" ("ACSNano") 2010, 4(1), 529-539 for details). Porous silica sphere (HMSN) carrier step (1);

[0057] Combining the synthesized hollow mesoporous silica with a phase change medium (i.e. racemic menthol (LM)), according to the need or not, prepare the step of separately loading hydrophilic and hydrophobic molecules or two or more kinds of co-loading (2).

[0058] In step 1, the method for preparing HMSNs with a size of 600±50 nm refers to the modified structural difference selective etching method. First use the traditional Synthesis of monodisperse solid SiO 2 Nanoparticles were cocondensed with tetraethyl orthosilicate...

Embodiment 1

[0076] Step 1: Preparation of 600±50nm HMSN

[0077] Mix 35.7mL of absolute ethanol, 5mL of deionized water and 3.20mL of ammonia water, and stir at 30°C for 30 minutes; quickly add 6mL of tetraethyl orthosilicate, and magnetically stir for 60 minutes; After mixing evenly with 1.43mL octadecyltrimethoxysilane (C18TMS), quickly add the above solution, and magnetically stir for 60 minutes, and the product is centrifuged to obtain highly dispersed solid core / mesoporous shell SiO 2 Nanospheres, divided into 6 parts. Each part is dispersed in 0.6mol / L Na 2 CO 3 solution, and then stirred at 80°C for 5 hours. After centrifugation, the product was washed three times with deionized water, freeze-dried, and then calcined at 550° C. for 6 hours.

[0078] Step 2:

[0079] Disperse 100 mg of HMSN prepared in step 1 into 4 mL of methanol solution. Take 4g of LM solid and heat it to 80°C, then pour the above 4mL HMSN methanol solution into the liquid LM, stir for 30 minutes and seal i...

Embodiment 2

[0081] Referring to the process of Example 1, hollow mesoporous silica (HMSN-LM-MB) wrapped with hydrophilic MB was prepared. 100 mg of HMSN prepared in Example 1 was dispersed into 4 mL of methanol solution. Weighed 4g of LM and heated it to 80°C until it became liquid, then added 250mg of MB to it, stirred evenly, and the subsequent treatment was as in Example 1.

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Abstract

The invention relates to a multifunctional nano diagnosis system integrated with common support of hydrophilic and hydrophobic molecules, temperature response release, enhanced ultrasound imaging and high-intensity focused ultrasound (HIFU) treatment, and a preparation method thereof. The nano diagnosis system mainly comprises hollow mesoporous silica and menthol, and the hollow mesoporous silica and menthol are good in biosecurity, and have broad application prospects in inhibition of the tolerance in a multi-drug support manner, controllable local temperature response release, enhancement of the ultrasound imaging contrast as an ultrasonic contrast agent and an HIFU synergist and improvement of the HIFU treatment efficiency. The preparation method comprises the following steps: preparing hollow mesoporous silica balls of which the particle sizes are 600+/-50nm and the shell layer thickness is 75+/-5nm by a modified structure difference selection etching method; then carrying out menthol support or common support of a menthol and dye molecule mixture by taking the hollow mesoporous silica as a vector, so as to obtain the multifunctional nano diagnosis system. The preparation method disclosed by the invention is simple and feasible, free of pollution, high in yield, and good in flexibility.

Description

technical field [0001] The invention belongs to the technical field of nano-biological materials, and in particular relates to a multifunctional nano-system which is also used as co-loading of hydrophilic and hydrophobic drugs or molecules, temperature-responsive release, ultrasound contrast agent and HIFU synergist and a preparation method thereof. Background technique [0002] Stimulus-responsive drug release systems have attracted widespread interest in nanobiomedicine because of their functions in drug storage and on-demand controlled release, especially mesoporous silica-based nanoparticles due to their high specific surface area. , good biological safety, adjustable size, and easy modification have shown incomparable advantages in being used as a carrier for the preparation of drug controlled release systems. At present, although traditional mesoporous silica supports, such as MCM-41, SBA-15, MSN, etc. Journal of the American Chemical Society ("J.Am.Chem.Soc."), 2011,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22
Inventor 张坤陈航榕施剑林黄贤良金智渊
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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