PLA microbubbles compounded with Fe3O4-GO-ASA and preparation method thereof

A technology of microbubbles and composites, applied in the field of biomedicine, can solve the problems of staying in the preliminary stage, and achieve the effect of large safety range, excellent magnetic properties, and increased clarity

Active Publication Date: 2021-02-26
JIAMUSI UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the last ten years, the scientific research on graphene oxide has made some progress. However, the research on the application of graphene oxide in the field of biomedicine is still in the preliminary stage. Experimental work needs to be done

Method used

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  • PLA microbubbles compounded with Fe3O4-GO-ASA and preparation method thereof
  • PLA microbubbles compounded with Fe3O4-GO-ASA and preparation method thereof
  • PLA microbubbles compounded with Fe3O4-GO-ASA and preparation method thereof

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Embodiment 1

[0048] Embodiment 1: composite Fe in the present embodiment 3 o 4 -The preparation method of the PLA microbubble of GO-ASA is to realize by following steps:

[0049] Step one, Fe 3 o 4 Preparation of -GO complex:

[0050] Will Fe 2 (SO 4 ) 3 and FeSO 4 ·7H 2 O according to Fe 2+ :Fe 3+ The molar concentration ratio is 1:1.5, and the total concentration of iron salt is 0.3mol L in 20mL double distilled water. -1 solution, ultrasonically disperse 0.174g of GO in 30mL double-distilled water, add it to the above iron salt solution under stirring conditions, and when the temperature of the system reaches 60°C, add 0.25mol·L dropwise - 1 NaOH solution until excess, stirred for 1 h, after the reaction was completed, the precipitate was repeatedly washed with water and filtered, then vacuum freeze-dried to obtain Fe 3 o 4 -GO complex.

[0051] Step two, Fe 3 o 4 - Preparation of GO-ASA complex

[0052] 0.5gFe 3 o 4 -GO complex was placed in 50mL absolute ethanol to...

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Abstract

The invention discloses PLA microbubbles compounded with Fe3O4-GO-ASA and a preparation method thereof, and belongs to the field of biomedicine. A multi-functional contrast agent integrated targeted radiography and auxiliary thrombus-inhibiting functions and a preparation method thereof are provided. The microbubbles are composed of PLA microbubbles and shells formed by adhering PVA on the surfaces of the PLA microbubbles; the PLA microbubbles are microbubble walls formed by PLA films; Fe3O4-GO-ASA compounds are embedded in the PLA films and on the inner walls of the PLA films; the PLA microbubbles are filled with inactive gas; and the Fe3O4-GO-ASA compounds are obtained by depositing Fe3O4 on the surface of GO and using pi-pi to adsorb and load ASA. The prepared PLA microbubbles can effectively prolong clotting time and prevent thrombus from forming, so that assistant treatment effects of anticoagulation can be achieved.

Description

technical field [0001] The invention belongs to the field of biomedical; be specifically related to composite Fe 3 o 4 -PLA microbubbles of GO-ASA and preparation method thereof. Background technique [0002] With the aging of the population, the number of patients with thrombotic diseases is increasing. There are many thrombotic diseases, usually divided into arterial thrombotic disease, venous thrombotic disease, and capillary thrombotic disease. Among them, common coronary heart disease, cerebral infarction, stroke, etc. are the "number one killer" of human life safety and health. According to statistics, more than 10 million people worldwide die of thrombosis every year. In the process of diagnosing thrombotic diseases, time is very precious. Therefore, a fast, safe and accurate diagnostic method is needed. Ultrasound imaging (CEUS) is the first-line method for the evaluation of thrombosis symptoms. Its wide application is based on many advantages. In addition to the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K9/50A61K47/32A61K9/127A61K47/34A61K47/52A61K31/616A61P7/02
CPCA61K49/223A61K49/221A61K9/5089A61K9/5026A61K9/1273A61K47/34A61K47/52A61K31/616A61P7/02
Inventor 张杰刘忠涛常存一胡明李进京吴义班宋立梅
Owner JIAMUSI UNIVERSITY
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