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Magnetic black phosphorus microbubble and application thereof in preparation of ultrasonic diagnostic reagent and medicine for treating breast cancer

A technology of black phosphorus and microbubbles, applied in the field of magnetic black phosphorus microbubbles and its application in the preparation of ultrasonic diagnostic reagents and drugs for the treatment of breast cancer, can solve the problem of limiting bioavailability and treatment efficiency, and the inability to achieve tumor targeting treatment, inability to effectively load targeting ligands, etc., to improve the efficiency of photothermal therapy, shorten the administration time, and reduce the toxicity

Active Publication Date: 2021-10-01
SHENZHEN PEOPLES HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is still a key problem in the photothermal therapy of black phosphorus applied to tumors: it is difficult to chemically modify the surface of black phosphorus, and it cannot effectively load targeting ligands, so it is impossible to achieve targeted treatment of tumors, which limits its biological properties. Utilization and Treatment Efficiency

Method used

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  • Magnetic black phosphorus microbubble and application thereof in preparation of ultrasonic diagnostic reagent and medicine for treating breast cancer
  • Magnetic black phosphorus microbubble and application thereof in preparation of ultrasonic diagnostic reagent and medicine for treating breast cancer
  • Magnetic black phosphorus microbubble and application thereof in preparation of ultrasonic diagnostic reagent and medicine for treating breast cancer

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Embodiment 1

[0041] This embodiment provides a kind of magnetic black phosphorus microbubble, the preparation process is as follows figure 1 As shown, the specific preparation steps are as follows:

[0042] (1) Preparation of black phosphorus nanosheets: In this example, the liquid phase exfoliation method is used to prepare black phosphorus nanosheets with nanoscale size in N-methylpyrrolidone (NMP) solution through sonication and ultrasonic vibration, and centrifuged at 7000rpm 20 minutes, and the collected supernatant was further centrifuged at 15000 rpm for 5 minutes. The obtained precipitate was dispersed in (NMP) solution and stored under vacuum until use.

[0043] (2) Preparation of biotinylated cationic microbubbles: Distearoylphosphatidylcholine (DSPC), distearoylphosphatidylethanolamine-polyethylene glycol 2000 (DSPE-PEG2000), distearoylphosphatidyl Ethanolamine-polyethylene glycol-biotin (DSPE-PEGx-Biotin, x=0, 400, 1000, 2000 and 3400) and stearic acid-modified low-molecular-...

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Abstract

The invention discloses a magnetic black phosphorus microbubble and the application of the magnetic black phosphorus microbubble in preparation of an ultrasonic diagnostic reagent and a medicine for treating breast cancer. A preparation method of the magnetic black phosphorus microbubble comprises the following steps: adding reaction raw materials into a solvent for dissolving; wherein the reaction raw materials comprise distearoyl phosphatidylcholine, distearoyl phosphatidylethanolamine-polyethylene glycol, distearoyl phosphatidylethanolamine-polyethylene glycol-biotin and stearic acid modified polyethyleneimine, the stearic acid modified polyethyleneimine is obtained by grafting stearic acid on low-molecular-weight polyethyleneimine, volatilizing the solvent to form a film from the reaction raw material, adding a biological buffer reagent, heating at 50-70 DEG C to form phospholipid, oscillating in a perfluoropropane atmosphere to prepare biotinylated cationic microbubbles, adding black phosphorus nanosheets for incubation, and then adding streptavidin magnetic beads. The prepared magnetic black phosphorus microbubble can carry black phosphorus in an active targeting manner, and has the effects of ultrasonic diagnosis and tumor treatment.

Description

technical field [0001] The invention relates to the technical field of targeted drugs, in particular to a magnetic black phosphorus microbubble and its application in the preparation of ultrasonic diagnostic reagents and drugs for treating breast cancer. Background technique [0002] With the rapid development of biomedicine, chemistry, materials and other disciplines and the cross-integration of multiple disciplines, emerging tumor treatment models, tumor drugs and drug delivery systems have developed rapidly, bringing new hope to tumor treatment. Among them, tumor ablation triggered by external non-invasive laser excitation is regarded as a promising treatment mode. Laser has high tumor specificity, high controllability, good therapeutic effect and negligible side effects on normal tissues when it is used as an external motivating factor for tumor treatment. Therefore, photothermal therapy and photodynamic therapy in response to laser excitation are particularly attractiv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K41/00A61K47/34A61P35/00
CPCA61K49/223A61K41/0052A61K47/34A61P35/00
Inventor 朱瑶徐金锋刘莹莹谢中建张晗
Owner SHENZHEN PEOPLES HOSPITAL
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