A kind of magnetic nanoparticle wrapped by erythrocyte membrane and its preparation method and application
A technology of magnetic nanoparticles and red blood cell membranes, which is applied in the field of nano-biomedical materials, can solve the problems of unfavorable metabolism, hidden dangers of toxicity, and easy accumulation of particles, and achieve good biocompatibility, long-term blood circulation, increased deformability, and preparation simple effect
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[0070] (1) PEG-Fe 3 o 4 preparation:
[0071] 2.00g (0.01mol) FeCl 2 4H 2 O, 4.725g (0.02mol) FeCl 3 ·6H 2 O Add 20 mL of distilled water, then add 6 g of PEG6000, and sonicate for 10 min (the power of the ultrasonic cell disruptor is 800 W, the frequency is 20 kHz) until dissolved. Stir at 1400r / min under a nitrogen atmosphere, heat up to 60°C, and react for 30min. Then add dropwise a solution containing 6g of PEG6000, the volume of which is about 1 / 5 of the reaction solution, transfer the reaction solution to a polytetrafluoroethylene reactor, set the temperature at 160°C, raise the temperature for 1 hour, and react for 5 hours. get Fe 3 o 4 For nanoparticle precipitation, first wash the precipitate with pure water and ethanol, repeat several times, and dry in a vacuum oven at 60°C for 10 hours to finally obtain PEG-Fe 3 o 4 nanoparticles.
[0072] (2) Extraction and targeted modification of erythrocyte membrane fragments:
[0073] Put the sheep blood into a cent...
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