A multi-mode ultrasonic contrast agent and a preparing method thereof

An ultrasonic contrast agent and a technology of contrast agent, which are applied in the field of pharmacy, can solve the problems of poor imaging effect and single function of the contrast agent, and achieve the effects of improving dispersibility, enhancing effect and improving acoustic impedance characteristics.

Inactive Publication Date: 2017-06-20
贵州灿石正科信息咨询服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention provides a multimodal ultrasound contrast agent for the problems of single function and poor imaging effect of the current contrast agent

Method used

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  • A multi-mode ultrasonic contrast agent and a preparing method thereof
  • A multi-mode ultrasonic contrast agent and a preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A multimodal ultrasound contrast agent and its preparation method:

[0033] (1) Mix 7.5 mL of 0.1 mol / L cetyltrimethylammonium bromide with 250 μL of 10 mmol / L HAuCl4, add water to a total volume of 9.4 mL. Then add 0.6 mL of ice-bathed NaBH4 aqueous solution (0.01 mol / L) to the above mixed solution to form gold nano-seeds (used within 2-5 h). Use 100mL0.1mol / L cetyltrimethylammonium bromide, 5mL0.01mol / LHAuCl4, 0.8mL10mmol / LAgNO3, 2mL0.5mol / LH2SO4 and 800μL0.1mol / L ascorbic acid to prepare the growth solution of gold nanorods. After adding 240 μL of the above nano-gold seeds, the reaction was started. The experimental process was kept at a constant temperature of 30 ° C. After the synthesized gold nanorods were centrifuged (40 mL per tube, rotating speed 9500 r / min, 25 min), the precipitate was extremely gold nanorods.

[0034] (2) Add water to dilute the gold nanorods prepared in (1) to 20 mL. Add 200 μL of 0.1mol / L NaOH solution under stirring conditions, and then ...

Embodiment 2

[0040] A multimodal ultrasound contrast agent and its preparation method:

[0041] (1) Mix 7.3 mL of 0.05 mol / L cetyltrimethylammonium bromide with 260 μL of 8 mmol / L HAuCl 4 Mix and add water to a total volume of 9.8 mL. Then add 0.7mL of ice-bathed NaBH4 aqueous solution (0.01mol / L) to the above mixed solution to form gold nanoparticles (used within 2-5h), and bromide with 98mL of 0.1mol / L hexadecyl trimethyl Ammonium, 6mL0.01mol / LHAuCl 4 , 0.8mL10mmol / LAgNO 3 , 2mL0.5mol / LH 2 SO 4 and 800 μL 0.1mol / L ascorbic acid to make the growth solution of gold nanorods, add 240 μL of the above-mentioned nano-gold seeds, and start the reaction. The experimental process is kept at a constant temperature of 30 ° C. The synthesized gold nanorods are centrifuged and cleaned (40 mL per tube, rotating speed 9500r / min, 25min), the precipitate is extremely gold nanorods;

[0042] (2) Add water to dilute the gold nanorods prepared in (1) to 18 mL, add 195 μL 0.15 mol / L NaOH solution under...

Embodiment 3

[0048] A multimodal ultrasound contrast agent and its preparation method:

[0049] (1) Mix 8 mL of 0.05 mol / L cetyltrimethylammonium bromide with 260 μL of 8 mmol / L HAuCl 4 Mix and add water to a total volume of 9.8 mL. Then add 0.7mL of ice-bathed NaBH4 aqueous solution (0.01mol / L) to the above mixed solution to form gold nanoparticles (used within 2-5h), and bromide with 98mL of 0.1mol / L hexadecyl trimethyl Ammonium, 6mL0.01mol / LHAuCl 4 , 0.8mL10mmol / LAgNO 3 , 2mL0.5mol / LH 2 SO 4 and 800 μL 0.1mol / L ascorbic acid to make the growth solution of gold nanorods, add 240 μL of the above-mentioned nano-gold seeds, and start the reaction. The experimental process is kept at a constant temperature of 30 ° C. The synthesized gold nanorods are centrifuged and cleaned (40 mL per tube, rotating speed 9500r / min, 25min), the precipitate is extremely gold nanorods;

[0050] (2) Add water to dilute the gold nanorods prepared in (1) to 18 mL, add 195 μL 0.15 mol / L NaOH solution under s...

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Abstract

The invention relates to the field of pharmacy, and particularly relates to a multi-mode ultrasonic contrast agent and a preparing method thereof. Micro bubbles of the contrast agent are small and can enter tissue gaps, and developing time is stable. According to a technical scheme, mesoporous silicon covering gold nanorods adsorbs a paramagnet and liquid fluorocarbon, and the surface of the obtained product is modified with biocompatible hyaluronic acid to obtain the contrast agent having a targeting property. The contrast agent has stable physical and chemical properties and good biocompatibility, can be effectively used as a contrast agent for tumor diagnosis, and can enhance ultrasonic development, opto-acoustic development and magnetic resonance development. The application range of the contrast agent is wide.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a multimodal ultrasonic contrast agent and a preparation method thereof. Background technique [0002] Since Gramiak and Shah reported for the first time in 1968 that injection of saline produced small air bubbles to enhance right ventricle imaging, various ultrasound contrast agents have appeared successively. Ultrasound contrast agents currently used are all microbubbles containing different gas components, and most of their shell materials are surfactants, human blood proteins, lipids, etc. With the development of polymer chemistry, scholars at home and abroad have prepared microbubble ultrasound contrast agents by using polymer materials and air or other insoluble gases. Attenuation and other aspects have some progress. For example, the patent number is CN201010505467.3, a novel multi-functional ultrasound contrast agent and its preparation method. It is a lipid emulsion containing...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K49/18A61K49/12A61K49/08A61K49/04
CPCA61K49/225A61K49/0002A61K49/0433A61K49/048A61K49/08A61K49/183A61K49/1863A61K49/221
Inventor 黄智王碧曾正可
Owner 贵州灿石正科信息咨询服务有限公司
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