Polymerizable biodegradable polymers including carbonate or dioxanone linkages

a biodegradable, carbonate or dioxanone technology, applied in the direction of biocide, prosthesis, bandages, etc., can solve the problems of inherently difficult sealing or plugging holes in lung tissue, polymerizable groups are revealed on the polymer, etc., to achieve the effect of increasing the viscosity of the macromer, reducing the degradation time of the polymer, and increasing the elasticity of the polymer
USRE39713E1Inactive Publication Date: 2007-07-03GENZYME CORP
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Patents(United States)
Current Assignee / Owner
GENZYME CORP
Publication Date
2007-07-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

Water-soluble macromers including at least one hydrolysable linkage formed from carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one polymerizable group, and methods of preparation and use thereof are described. The macromers are preferably polymerized using free radical initiators under the influence of long wavelength ultraviolet light or visible light excitation. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. The macromers can be used to encapsulate cells, deliver prophylactic, therapeutic or diagnostic agents in a controlled manner, plug leaks in tissue, prevent adhesion formation after surgical procedures, temporarily protect or separate tissue surfaces, and adhere or seal tissues together.
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Description

[0001] This application is a divisional of application Ser. No. 08 / 944,739, filed Oct. 6, 1997, now U.S. Pat. No. 6,083,524 which is a continuation-in-part of application Ser. No. 08 / 710,689 filed Sep. 23, 1996, now U.S. Pat. No. 5,900,245.FIELD OF THE INVENTION

[0002] The present invention relates to improved photopolymerizable biodegradable hydrogels for use as tissue adhesives, coatings, sealants and in controlled drug delivery devices. The improved materials incorporate carbonate and / or dioxanone linkages. These biodegradable linkages allow improved control of various properties of the macromers, particular increasing viscosity while preserving biodegradability.BACKGROUND OF THE INVENTION

[0003] U.S. Pat. No. 5,410,016 to Hubbell et al. discloses biocompatible, biodegradable macromers which can be polymerized to form hydrogels. The macromers are block copolymers that include a biodegradable block, a water-soluble block with sufficient hydrophilic character to make the macromer water-...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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