Degradation time controllable and breaking elongation adjustable medical degradable polyurethane

A technology of elongation at break and degradation time, applied in the field of medical degradable polyurethane with controllable degradation time and adjustable elongation at break, can solve problems such as slow degradation of polyurethane

Inactive Publication Date: 2018-03-09
YUANRONG BIOLOGICAL PHARMA WUXI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In all the degradable polyurethane preparation methods in the open literature, the hard segment of polyurethane has the problem of slow degradation rate, which takes a long time to cause the complete disappearance of polyurethane in the body, which greatly limits its use in regenerative medicine. To solve this technical problem and prepare polyurethane with a controllable degradation time, our team has designed an amino acid diamine chain extender with a degradation site after years of research, and successfully synthesized various degradable polyurethanes required by different tissues and organs. Achieved mass production, making it possible to develop biodegradable polyurethanes for medical-related products

Method used

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  • Degradation time controllable and breaking elongation adjustable medical degradable polyurethane
  • Degradation time controllable and breaking elongation adjustable medical degradable polyurethane
  • Degradation time controllable and breaking elongation adjustable medical degradable polyurethane

Examples

Experimental program
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Effect test

Embodiment 1

[0080] Weigh 9.0g ε-caprolactone, 3.0g PEG-600, and stannous octoate (0.03wt% of the total) as catalysts, add them to a vacuum reaction bottle, add a magnetic stirrer, and vacuumize / fill with nitrogen Circulate 3 times, and seal the vacuum reaction bottle mouth under vacuum conditions, put it in an oil bath at 140°C for 24 h to obtain a linear polymer. Then weigh 2 g of L-lysine diisocyanate and 0.6 g of glycine diamine, vacuumize and seal the bottle mouth, put them into an oil bath at 50° C. for 4 h to obtain the final product.

Embodiment 2

[0082] Weigh 9.0g ε-caprolactone, 0.5g PEG-600, and stannous octoate (0.03wt% of the total) as catalysts, add them to a vacuum reaction bottle, add a magnetic stirrer, and vacuumize / fill with nitrogen Circulate 3 times, and seal the vacuum reaction bottle mouth under vacuum conditions, put it into an oil bath at 140° C. for 18 hours to obtain a linear polymer. Then weigh 2.6g of L-lysine diisocyanate and 0.68g of phenylalanine diamine, vacuumize and seal the bottle mouth, and put them in an oil bath at 70°C for 8 hours to obtain the final product.

Embodiment 3

[0084] Weigh 9.0g ε-lactide, 1.0g PEG-200, and bismuth neodecanoate (1.0wt% of the total) as catalysts, add them into a vacuum reaction bottle, and then add a magnetic stirrer, vacuumize / fill Nitrogen was circulated 3 times, and the vacuum reaction bottle was sealed under vacuum conditions, and placed in an oil bath at 130°C for 24 h to obtain a linear polymer. Then weigh 2 g of L-lysine diisocyanate and 0.7 g of cysteine ​​diamine, vacuumize and seal the bottle mouth, put them in an oil bath at 70° C. for 4 h to obtain the final product.

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Abstract

The invention provides degradation time controllable and breaking elongation adjustable medical degradable polyurethane, a preparation method thereof and an application of the polyurethane. By adjusting the proportion of components in the synthesis process of the polyurethane and selecting different chain extenders, the performances such as the degradation time, the breaking elongation, the strength, the lubricating property, hydrophily and hydrophobicity of the PU (polyurethane) can be controlled within a wide range, and the medical degradable polyurethane with different performances can be selected according to the requirements of regenerative medicine and medical instruments implanted into bodies.

Description

technical field [0001] The invention belongs to the field of degradable biomaterials, in particular to a medical degradable polyurethane with controllable degradation time and adjustable elongation at break, a preparation method and its application. The chain extender can control the elasticity and degradation time of PU in a wide range, and can be applied to various medical products that require different degrees of hardness and biocompatibility for interventional implantation into the human body. Background technique [0002] The full name of polyurethane (PU) is polyurethane, which is a general term for macromolecular compounds containing carbamate (-NHC00-) groups in the main chain. It is composed of organic diisocyanate or polyisocyanate and dihydroxy or polyhydroxy compound formed by addition polymerization. As shown in the typical PU chemical structure, the polymer main chain is composed of a flexible segment (soft segment) whose glass transition temperature is lower...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/73C08G18/75C08G18/66C08G18/42C08G18/44C08G18/32C08G63/664A61L31/10A61L31/02A61L31/14A61L31/18A61L27/34A61L27/04A61L27/58A61L27/50
CPCA61L27/047A61L27/34A61L27/50A61L27/58A61L31/022A61L31/10A61L31/148A61L31/18A61L2420/02A61L2420/06C08G18/3206C08G18/3228C08G18/4277C08G18/44C08G18/664C08G18/6651C08G18/73C08G18/755C08G63/664C08G2230/00C08L75/04C08L67/04
Inventor 不公告发明人
Owner YUANRONG BIOLOGICAL PHARMA WUXI CO LTD
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