31results about How to "Meet different clinical needs" patented technology

The invention provides a gelatin embolism microsphere and a preparation method and an application thereof. The preparation method of the gelatin embolism microsphere comprises the following steps of: (1) preparing a gelatin aqueous solution of which the concentration is 10-50 percent g / ml; (2) adding the gelatin aqueous solution prepared in the step (1) into an emulsifier-containing oil phase of which the temperature is 50-60 DEG C, stirring for 10 minutes, lowering the temperature to 2-5 DEG C, stirring for 30 minutes at the stirring speed of 100-900 revolutions per minute, and standing to precipitate the microsphere; (3) pouring the oil phase out, repeatedly washing the oil phase left on the surface of the microsphere with acetone, and filtering the microsphere out; and (4) adding the microsphere obtained in the step (3) into a crosslinking agent aqueous solution of which the pH is 8-9 and the concentration is 1-15 percent g / ml, reacting at the temperature of 4 DEG C for 0.5-25 hours, and washing the microsphere with distilled water. The gelatin embolism microsphere provided by the invention is crosslinked uniformly, is regularly spherical, and is convenient for screening grading and accurate marking of the particle diameter; and the degradation time and elasticity of the gelatin embolism microsphere are more suitable for clinical application.

The invention provides a fibroin bone nail and a preparation method thereof. The preparation method of the fibroin bone nail comprises the following steps: firstly, preparing a fibroin solution; then concentrating the fibroin solution, drying in a mold, demolding, and implementing a cutting process so as to obtain a fibroin rod; finally, cutting the fibroin rod into a bone nail. By adjusting the molecular weight, curing parameters and molding means, the mechanical properties and the degradation speed of fibroin can be regulated and controlled, so that different clinical requirements are met. The fibroin bone nail provided by the invention is free of toxic and / or side effects, can be absorbed by human bodies and is excellent in mechanical property and free of chemical reagent with toxic and / or side effects in the preparation process, and conventional metal and polymer material bone nails can be replaced.

The present invention relates to biomedicine metal implant material, and is especially biomedicine implant material with controllable degrading rate and its application. The biomedicine implant material with controllable degrading rate has a magnesium or magnesium alloy matrix and a coated degradable polymer layer with thickness controlled within 0.01-5 mm. The biodegradation is completed step by step so as to ensure the mechanical performance of the material during degradation and match the degradation rate with the service period of the implanted device. The biomedicine metal implant material of magnesium or magnesium alloy may be used in preparing temporary or short term implanted device, such as degradable blood rack and peripheral rack, bone fracture plate and bone nail for inner fixing, tissue engineering rack, etc.

The invention relates to injectable composite bone cement with photothermal effect as well as a preparation method and application of the injectable composite bone cement. The injectable composite bone cement is prepared from the following components in percentage by weight: 30 to 65 percent of bioglass powder, 5 to 30 percent of titanium nitride nano powder and 30 to 40 percent of a sodium alginate mixed solution. Compared with the prior art, the bone cement disclosed by the invention not only has the characteristics of being moldable and easy to operate, but also has a remarkable photothermal effect, and the photothermal effect of the bone cement can be regulated and controlled by changing the adding amount of the titanium nitride nanoparticles; process equipment for preparing the bone cement is simple, easy to operate and low in cost, good injectability can be obtained without adding a cross-linking agent, and minimally invasive treatment can be realized; the injectable composite bone cement can be used for preparing bone fillers after bone tumor surgical resection, and is applied to the fields of bone repair, regeneration and the like in bone tissue engineering.

The invention provides a gelatin embolism microsphere and a preparation method and an application thereof. The preparation method of the gelatin embolism microsphere comprises the following steps of: (1) preparing a gelatin aqueous solution of which the concentration is 10-50 percent g / ml; (2) adding the gelatin aqueous solution prepared in the step (1) into an emulsifier-containing oil phase of which the temperature is 50-60 DEG C, stirring for 10 minutes, lowering the temperature to 2-5 DEG C, stirring for 30 minutes at the stirring speed of 100-900 revolutions per minute, and standing to precipitate the microsphere; (3) pouring the oil phase out, repeatedly washing the oil phase left on the surface of the microsphere with acetone, and filtering the microsphere out; and (4) adding the microsphere obtained in the step (3) into a crosslinking agent aqueous solution of which the pH is 8-9 and the concentration is 1-15 percent g / ml, reacting at the temperature of 4 DEG C for 0.5-25 hours, and washing the microsphere with distilled water. The gelatin embolism microsphere provided by the invention is crosslinked uniformly, is regularly spherical, and is convenient for screening grading and accurate marking of the particle diameter; and the degradation time and elasticity of the gelatin embolism microsphere are more suitable for clinical application.

The invention relates to lamivudine solid dispersion and a preparation method and a use of the lamivudine solid dispersion. The lamivudine solid dispersion provided by the invention is prepared by using a methoxy-terminated polyethylene glycol-polylactic acid block copolymer and derivatives of the block copolymer, polylactic acid, polylactic acid-glycolic acid copolymer or polycaprolactone as carrier materials by a hot melting method. The preparation method of the lamivudine solid dispersion provided by the invention avoids use of an organic solvent. The lamivudine solid dispersion provided by the invention can be applied in subcutaneous injection or intramuscular injection for treating chronic hepatitis B.

The invention provides a fibroin bone nail and a preparation method thereof. The preparation method of the fibroin bone nail comprises the following steps: firstly, preparing a fibroin solution; then concentrating the fibroin solution, drying in a mold, demolding, and implementing a cutting process so as to obtain a fibroin rod; finally, cutting the fibroin rod into a bone nail. By adjusting the molecular weight, curing parameters and molding means, the mechanical properties and the degradation speed of fibroin can be regulated and controlled, so that different clinical requirements are met. The fibroin bone nail provided by the invention is free of toxic and / or side effects, can be absorbed by human bodies and is excellent in mechanical property and free of chemical reagent with toxic and / or side effects in the preparation process, and conventional metal and polymer material bone nails can be replaced.

The invention relates to the field of medical supplies, and discloses a pediatric special chair convenient for seeing a doctor. A fixed shaft is fixed on a chair body; a shaft sleeve sleeves the fixedshaft; a sleeve pipe is fixed on the shaft sleeve; a mandrel is defined in the sleeve pipe; the mandrel extends to the exterior of the sleeve pipe and is fixedly connected with a strip-plate-shaped supporting plate; when the supporting plate is positioned at a handheld station, the supporting plate is positioned on one side of the upper portion of a seat plate and is used as a handrail; when thesupporting plate is located at a bearing station, the supporting plate is located above the seat plate and can be adjusted in position around the mandrel, and a pediatric patient can sit on the supporting plate; and when the supporting plate is positioned at a pedal station, the supporting plate is positioned below the front side of the seat plate and can be used as a pedal. The pediatric specialchair is simple, ingenious and reasonable in structure; the supporting plate has multiple stations; different stations of the supporting plate can be switched through simple and convenient operation so as to meet different clinical actual requirements; and particularly, the burden of parents of pediatric patients can be reduced, the parents can communicate with doctors in illness condition wholeheartedly, and the diagnosis efficiency and effect are improved.

The invention discloses a bedside active exercise device for neurosurgery, comprising a base, the base is provided with a first protective tube, a second protective tube and a connecting shaft, and the first protective tube is provided with a first fixing hole , the second casing is provided with a second fixing hole, the second casing is provided with an extension block and a third fixing hole, the extension block is vertically fixed with a connecting rod and a connection hole, and the extension block An arc-shaped slide rail and an arc-shaped slide block are provided below the slide rail, an angle ruler is provided on the slide rail, fixing cards are provided in the chute on both sides of the slide block, and all The base is provided with an upper connecting block and a lower connecting block, the other end of the lower connecting block is connected with a supporting plate and a collar, and an elastic damping device is arranged between the collar and the connecting hole on the connecting rod. The device solves the problems of improving the safety of the upper limbs of the patient's voluntary activities, the workload of the nurses or family members assisting the contraction and stretching of the upper limbs of the patients, and the general effect of passive exercises.

The invention provides a traditional Chinese medicine pellet and a preparation method thereof, and particularly relates to a traditional Chinese medicine pellet preparation and a preparation method of the traditional Chinese medicine pellet preparation. The traditional Chinese medicine pellet preparation is prepared by six traditional Chinese medicines including radix astragali, fructus ligustri lucidi, hirudo, radix et rhizoma rhei, radix pseudostellariae and fructus lycii and other medical auxiliary materials. The traditional Chinese medicine pellet preparation contains a traditional Chinese medicine composition, a diluent and a disintegrant according to a specific ratio. The prepared pellet is obvious in moistureproof effect, high in pellet roundness and bioavailability, uniform in particle size distribution, relatively high in yield and excellent in drug release performance, and provides better selection for clinical medication.

The invention relates to an injectable composite bone cement with photothermal effect and its preparation method and application. The bone cement contains the following components in weight percent: 30-65% of biological glass powder, 5-30% of titanium nitride nano powder , sodium alginate mixed solution 30‑40%. Compared with the prior art, the bone cement of the present invention not only has the characteristics of being plastic and easy to operate, but also has a significant photothermal effect, which can be regulated by changing the amount of titanium nitride nanoparticles added; the bone cement prepared The process equipment of cement is simple, easy to operate, low in cost, good injectability can be obtained without adding cross-linking agent, and minimally invasive treatment can be realized; it can be used to prepare bone filler after surgical resection of bone tumor and applied to bone tissue Engineering bone repair, regeneration and other fields.

The present invention relate to the field of catheter technology, in particular to a visual gastric tube implantation system, comprising a connector and a liquid guide pipe arranged on one side of theconnector. An imager is arranged at one end of the liquid guide tube, cameras are arranged on that inn walls of the upper and lower sides of the liquid guide pipe close to the other end, a liquid guide tube is embed with a guide wire, the guide wire is provided with a plurality of distal end side holes at positions close to the end portions, a distal end side hole is embedded with a drainage device. The advantages of that invention are simple structure, easy to use. By setting up the imager, the catheter can be directly inserted into the esophagus, thereby improving operational effectiveness,and reducing patient injury and ensure that the final site of the gastric tube must be the esophagus. The gastric tube insertion depth can be adjusted according to the image information to meet different clinical use requirements. The gastric tube is supported by the guide wire to ensure that the gastric tube has sufficient strength to reach the stomach. Secondly, the guide wire blockage can be effectively prevented by a drainage device, which is beneficial to repeated use after disinfection, reduces cost, and improves market competitiveness.

The invention discloses a bedside active exercise device for the neurosurgery department. The device includes a base, wherein a first pile casing, a second pile casing and a connecting shaft are arranged on the base; a first fixing hole is formed in the first pile casing; a second fixing hole is formed in the second pile casing; the second pile casing is provided with a lengthening block and a third fixing hole; a connecting rod and a connecting hole are vertically fixed on the lengthening block; an arc-shaped sliding rail and an arc-shaped sliding block are arranged below the lengthening block; an angle ruler is arranged on the sliding rail, fixing clamps are arranged in chutes in the two sides of the sliding block, an upper connecting block and a lower connecting block are arranged on the base below the lengthening block, the other end of the lower connecting block is connected with a supporting plate and a lantern ring, and an elastic damping device is arranged between the lantern ring and a connecting hole in the connecting rod. The device solves the problems that the safety of the patient moving the upper limbs autonomously is improved, nursing personnel or family members assist the upper limbs of the patient in contracting and stretching exercises, the workload is large, and the passive exercising effect is common.

The present invention provides an implantable nerve stimulation device with multiple frequency modes, including a control circuit for determining the frequency modes, the frequency modes include independent frequency modes and the same frequency mode, and multiple frequency modes are provided in the independent frequency mode Different pulse frequencies, providing a unique pulse frequency in the same frequency mode; a signal output circuit, used to output multiple groups of pulse signals according to the multiple different pulse frequencies in the independent frequency mode, wherein different groups of The pulse frequencies of the pulse signals are different. In the same frequency mode, multiple groups of pulse signals are output according to the unique pulse frequency, wherein the pulse frequencies of each group of pulse signals are the same.

The invention relates to the field of medical supplies, and discloses a supporting assembly used for pediatrics. The supporting assembly comprises a fastening seat used for being combined with a chair; a fixing shaft with a locking hole is fixed onto the fastening seat; the fixing shaft is sleeved with a shaft sleeve; a casing pipe is fixed onto the shaft sleeve; a positioning pin is defined at one side of the casing pipe through a pin seat; a core shaft is defined in the casing pipe; a positioning hole and a positioning groove are formed in the core shaft; the core shaft is connected with a supporting plate; and the fastening seat or fixing shaft is provided with a lower limiting part. The supporting assembly used for pediatrics has a simple, skillful and reasonable structure; the supporting plate has three stations for adjustment; when the supporting plate is located at a supporting station, a pediatric patient can be supported, and thus, the burden on parents of the pediatric patient during visiting is greatly reduced, and the parents can wholeheartedly communicate with a doctor about the disease condition, and the efficiency and effectiveness of diagnosis are improved; when thesupporting plate is located at a pedal station, the pediatric patient can step on the supporting plate, so that the comfort of the patient is improved; and when the supporting plate is located at a hand-holding station, the supporting plate can act as a handrail, so that the comfort of the parents of the patient are improved to a certain extent.

The invention relates to the technical field of biomedicine. The invention provides a method for preparing a spider silk protein bone nail. The preparation method of the spider silk protein bone nail comprises the following steps: (1) preparing a spider silk protein solution; (2) injecting the spider silk protein solution into a mold, methanol Or ethanol treatment and drying to obtain spidroin protein bone nails. The preparation method of the spider silk protein bone nail provided by the present invention is simple to operate and can be produced industrially. The spider silk protein bone nail prepared by it has the advantages of high strength, high toughness, lightness, ultraviolet resistance, and biodegradability. It is an amino acid and a polypeptide, which is non-toxic to the human body.