The invention relates to the technical field of traditional Chinese medicines, and discloses Daijianzhong decoction granules as well as a preparation method and application thereof. The granules are prepared from the following raw materials in parts by weight: 50-150 parts of fried Chinese prickly ash, 500-600 parts of dried ginger, 200-300 parts of
ginseng and 1000-3000 parts of
maltose. The preparation method comprises the following steps: mixing the fried pepper, the dried ginger and the
ginseng, soaking and decocting; performing
centrifugation and membrane separation
filtration on the liquid
medicine to obtain
clear liquid; adding
maltose, mixing, separating and purifying the
mixed solution, and respectively collecting a water leacheate and an
alcohol leacheate;
drying the water leacheate to obtain dry paste
powder, concentrating the
alcohol leacheate, and freeze-
drying to obtain freeze-dried
powder; and combining the dry paste
powder and the freeze-dried powder, and granulating to obtain the Dajianzhong decoction granules after
process improvement. A separation and purification technology is innovatively applied, active ingredients are effectively enriched, impurities are reduced, the wall sticking problem is solved by adopting a step-by-step
drying method, and the dosage of auxiliary materials is reduced. The obtained granules can be used for treating intestinal obstruction and protecting intestinal barriers, and have the advantages of being fast in
dissolution, good in taste, small in dosage, beneficial for patients to take
medicine and the like.