36 results about "Intestinal tumor" patented technology

The invention provides a narciclasine derivative represented by the following structural formula I, wherein R1 is alkyl, cycloalkyl, benzyl or substituted benzyl, R2 is alkyl, cycloalkyl, benzyl or substituted benzyl, and n is an integer from 1 to 10. The narciclasine derivative is subjected to a tumor cell toxicity killing effect test, and results prove that the narciclasine derivative has strong toxicity killing effects on lung gland tumor cells, intestinal tumor cells, breast tumor cells, liver tumor cells, prostate tumor cells, melanoma tumor cells, endometrial tumor cells and neuroglia tumor cells, so the narciclasine derivative can be used for preparation of antitumor drugs. The invention provides a preparation method of the narciclasine derivative. The narciclasine derivative has a novel side-chain structure, shows excellent inhibitory activity on a variety of tumor cell strains, has drug efficacy better than that of narciclasine, allows toxic and side effects of the compound to be improved, provides new drugs for treatment of malignant tumors, and is of great clinical application value.

The invention provides a microecological special diet ate by large intestine tumor patients. The special diet adopts foodborne oligopeptides as main raw materials. According to physical characteristics of the large intestine tumor patients and by adoption of a traditional Chinese medicine quintessence theory, the special diet specifically comprises extracts of edible and medicinal Chinese herb such as dendrobe, coix seed, Chinese yam, dandelion, hawthorn, fig, honeysuckle flower, chicken's gizzard-membrane, hericium erinaceus, sea-buckthorn and fingered citron, and a plurality of anti-inflammatory probiotics, vitamins, and mineral compounds. The food prepared by the formula is easily soluble, can be rapidly absorbed and utilized, and improves the nutrition status of the large intestine tumor patients. By co-function of biological active components in the edible and medicinal Chinese herb extracts, the plurality of the anti-inflammatory probiotics, and the like, the special diet assists boosting of body immunity, inhibits cancer, is anticancer, and is suitable to be ate by the large intestine tumor patients especially cancer patients receiving radiotherapy or chemotherapy, and therefore the special diet is advantaged by integrating a dietary therapy function, a prevention function and a nursing function.

The present invention discloses a garlic activin, which comprises 100-200 g of salt, 20-50 g of fried atractylodes lancea, 10-40 g of sophora flavescens ait, 50-100 g of rhizoma phragmitis, 5-30 g of white ginseng fibrous root, 20-50 g of taxus chinensis, 5-30 g of schisandra chinensis, 30-80 g of agrimonia pilosa ledeb, 10-50 g of actinidia valvata dunn, and 20-60 g of loquat leaf. The garlic activin of the present invention has the following beneficial effects that: after the garlic activin and garlic are combined, the sulfur-containing compounds in the garlic can be completely provided, the intestine can be promoted to produce an enzyme or substance known as the diallyl disulfide, and the risk that the substance in the intestine causes the intestinal tumor can be eliminated through body immunity enhancing, lipid peroxide formation blocking, anti-mutation, and other approaches.

The invention provides a pharmaceutical composition for treating colon cancer and application thereof. The pharmaceutical composition for treating colon cancer consists of 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazoline-4-yl)amino]-1H-pyrazole-5-yl}-N-(3-fluorophenyl) acetamide and 1,8-dihydroxy-3-carboxyanthraquinone. A compound group and a single drug group provided by the inventionboth have inhibitory effects on a colon cancer cell strain SW1116 in vivo, wherein the tumor inhibitory rate of the compound group is significantly different from that of the single drug group of 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazoline-4-yl)amino]-1H-pyrazole-5-yl}-N-(3-fluorophenyl) acetamide or the single drug group of 1,8-dihydroxy-3-carboxyanthraquinone; and both groups play a significant synergistic role in inhibiting the proliferation of the colon cancer cell strain SW1116, in which the compound group can inhibit the growth of colon tumor, and the tumor inhibitory rate can reach up to 90.3%.

The invention provides a preparation method and an application of a polypropylene oxide-sodium alginate hydrogel. The polypropylene oxide-sodium alginate hydrogel provided by the invention is used asa drug carrier, and has the characteristics of simple synthesis method, high encapsulation efficiency and the like; and the carrier hydrogel has a group having high affinity for a living body, is lowin biotoxicity, is an oral hydrogel carrier, can protect medicines in the hydrogel carrier from being released under the acidic condition of the stomach, enables the medicines to target intestinal tumors rich in glutathione, can slowly release and transfer the medicines to improve the treatment effect, and is expected to have wide substantive application as a new medicine carrying carrier hydrogel.

The invention discloses a preparation method of ornithogalum thyrsoide polysaccharide, and application of the ornithogalum thyrsoide polysaccharide to preparation of medicines for treating intestinaltumors or to promotion of growth of probiotics. Polysaccharide in corms of ornithogalum thyrsoide which has been cultured for three years is extracted through a Soxhlet extraction method, and dry powder is obtained through a two-step lyophilization method. Through pre-freezing, it can be guaranteed that a polysaccharide structure in an extract is fixed, and modification of polysaccharide caused bya heating-drying mode is prevented. It is found that the ornithogalum thyrsoide polysaccharide can effectively restrain human colon carcinoma cells and rectal cancer cells and can promote growth of intestinal probiotics, when the ornithogalum thyrsoide polysaccharide is used as a medicine for resisting intestinal tumors, the ornithogalum thyrsoide polysaccharide not only can restrain cancer cellsbut also can promote growth of probiotics, and intestinal tumors can be better treated through the synergistic effect.

The invention discloses a rectal tumor surgical magnetic ring anastomat. A first magnetic ring and a second magnetic ring are provided for implementing a magnetic ring anastomosis operation for a patient of the proctology department; an outer rigid member and an inner rigid member are also provided, a first inflation member, a second inflation member and a third inflation member constitute a mechanism for placing the first magnetic ring and the second magnetic ring, and the characteristics that the inflation members occupy space when inflated and do not occupy space when deflated are utilized,wherein the first inflation member is provided with a first annular protrusion for positioning the first magnetic ring, the second inflation member is provided with a hemispherical airbag for entering the anorectum smoothly, and the third inflation member is provided with a second annular projection for separating the first magnetic ring and the second magnetic ring smoothly. According to the scheme above, the rectal tumor surgical magnetic ring anastomat has the advantages of being simple in structure, reasonable in design and capable of being conveniently used in upper mucosal resection operations of patients suffered from hemorrhoids, low-level colectomy and anastomotic operations and low-level rectal resection and anastomotic operations; the mode of clamping the inflation members is adopted, so that not only can less damage and pain during placement be ensured, and also the anastomat is very convenient to take out.

The invention discloses a postoperative rehabilitation training device for intestinal tumor patients, which comprises a training bed board, a perineum stimulation module and a protection module, the perineum stimulation module comprises a stimulation wearing assembly and a mode switching base, and the protection module comprises a hip falling protection base and a protection base plate. The inner side of the mode switching base is provided with a pipeline lifting assembly and a pelvic cavity drainage tube lifting assembly which are relatively fixed, the inner side of the pelvic cavity drainage tube lifting assembly is provided with a pelvic cavity drainage tube contraction assembly, the inner side of the stimulation wearing assembly is provided with a stimulation head assembly, and the bottom end of the stimulation head assembly is connected with a double-row stimulation pipeline. According to the device, the contraction stimulation of the outside to the anal sphincter of a patient is enhanced, the situation that the patient directly urinates due to the poor defecation control ability of the patient, and consequently the perineum muscle is relaxed is avoided, and the rehabilitation training effect of the patient is guaranteed.

The invention discloses an application of a traditional Chinese medicine composition in the preparation of a medicine for preventing and treating gastrointestinal tumors. The active ingredients of the traditional Chinese medicine composition include the following components, and the formula includes the following components: Coptis chinensis, Paojiang, Indigo Naturalis , Sophora flavescens, Panax notoginseng, simmering woody incense, Burnet charcoal, Zhigancao. The invention utilizes Qingchang Wenzhong Tablet to develop a new class of traditional Chinese medicines with good curative effect and high safety for preventing small intestinal tumors and colorectal cancer, which can prevent the occurrence of small intestinal tumors and colorectal tumors. This not only provides a new indication for the application of Qingchang Wenzhong Tablet, but also provides a new therapeutic drug and therapeutic approach for the prevention of small intestinal tumors and the prevention and treatment of colorectal cancer.

The invention discloses a catheter fixing device for gastrointestinal tumor surgery, and relates to the technical field of gastrointestinal tumor treatment. The catheter fixing device for the gastrointestinal tumor surgery comprises a fixing mechanism, the fixing mechanism comprises two fixing clamps, the two fixing clamps are arranged in a bilateral symmetry mode, the middle portions of the two fixing clamps are concave inwards and are close to each other, a first main shaft is arranged at the concave positions of the middle portions of the two fixing clamps, and the vertical section of the first main shaft is in an I shape; the first main shaft is fixedly connected with the concave position of the middle of the fixing clamp located on the left side, the middle of the first main shaft is movably sleeved with a second main shaft, the upper end face and the lower end face of the second main shaft are fixedly connected with first springs, and the ends, away from the second main shaft, of the first springs are correspondingly and fixedly connected with the first main shaft, and the second main shaft is fixedly connected with the concave position of the middle of the fixing clamp located on the right side. According to the catheter fixing device for the gastrointestinal tumor surgery, the device can be fixed and mounted more conveniently, and mounting and dismounting are quite easy.

The invention discloses a Lactococcus lactis subsp. lactis capable of significantly inhibiting the occurrence of colorectal cancer and an application thereof, belonging to the technical field of microorganisms. Lactococcus lactis subsp. lactic acid VM5 provided by the present invention has a preservation number of GDMCC No.60256, can tolerate gastric acid and bile salts, and can significantly reduce the inflammatory response in the colorectal region of colorectal cancer model mice. The expression of Notch1 signaling pathway and VEGFR2 molecules in tissues can reduce the number of tumors in the colon and rectum of model mice. In addition, Lactococcus lactis subsp. lactic acid VM5 can also improve the structure of intestinal flora and the level of short-chain fatty acids in the intestine. The Lactococcus lactis lactic acid subspecies VM5 is used to prepare fermented food for inhibiting the occurrence of colorectal cancer, and has very broad application prospects.

The invention discloses a recombinant fusion protein, which relates to the technical field of genetic engineering, and comprises an ice nucleoprotein N-terminal domain and a T antigen-binding short peptide. Among them, the N-terminal domain of the ice nucleoprotein provides the surface anchoring function of the bacteria, enabling the fusion protein to be anchored and displayed on the cell surface; the T-antigen-binding short peptide is an oligopeptide that can specifically bind to the T-antigen on the surface of intestinal tumor cells . In the present invention, the T antigen-binding short peptide is displayed on the surface of bacteria in the form of fusion protein. This strategy can realize the specific recognition of bacteria on intestinal tumors, solve the limitation of the existing intestinal exploration and detection technology that must invade the body, and lay the foundation for the further development of targeted drugs for early diagnosis and treatment of intestinal tumors .