39 results about "Intestinal tumor" patented technology

The invention provides a control method of an intestinal tumor resection robot combining preoperative images and intraoperative navigation, and relates to the technical field of medical instrument control. The method comprises the following steps: acquiring preoperative multi-modal image data of the intestinal tract of a patient, and performing three-dimensional reconstruction on the image data to generate an initial three-dimensional model; dividing a navigation area in the enteric cavity according to the initial three-dimensional model; based on the core area, collecting a dynamic image of the intestinal tract inner cavity in real time through intraoperative navigation equipment, extracting anatomical mark points in the dynamic image, registering the dynamic image with the initial three-dimensional model, updating tissue deformation parameters in the three-dimensional model, and obtaining an updated three-dimensional model; on the basis of the updated three-dimensional model, obstacles in the intestinal tract are recognized, and the minimum space distance between the obstacles and the robot tail end instrument is calculated; and according to the spatial distribution and the minimum spatial distance of the obstacles, an initial motion path of the robot tail end instrument is planned. According to the invention, the efficiency and accuracy of the intestinal tumor resection operation can be improved.

The invention discloses a culture system, culture method and application of gastrointestinal tumor chemotherapy drug-resistant organoid, the culture system comprises: a basic culture medium, which is a DMEM / F12 culture medium, and is additionally added with a special growth promoting factor obtained from a natural extract; the multiple growth factors comprise an epidermal growth factor (EGF), a fibroblast growth factor (FGF), a bone morphogenetic protein (BMP) and a vascular endothelial growth factor receptor inhibitor (VEGFRi), and the concentration of each growth factor is accurately screened and optimized; the extracellular matrix is Matrigel modified by physical and chemical methods; the specific additive comprises an antioxidant N-acetylcysteine (NAC). According to the culture system, the culture method and the application of the gastrointestinal tumor chemotherapy drug-resistant organoid, the culture system which is closer to a real environment in vivo is constructed by optimizing basic culture medium components, setting various growth factors and specific additive concentrations and adopting modified Matrigel as an extracellular matrix.

The invention relates to the technical field of gastrointestinal tumor chemotherapy risk assessment, and particularly discloses a gastrointestinal tumor chemotherapy risk scoring model and a construction method thereof, and the method comprises the steps: obtaining the individualized feature data and basic physiological data of a historical patient, and constructing an individualized difference library with a unique ID, and a core influence library; the method comprises the following steps: standardizing and coding double-library data, synchronizing clinical data containing treatment effect codes, forming a data dictionary, acquiring and coding current gastrointestinal tumor patient data, and matching the data dictionary to judge individual difference abnormity; when the first data set is abnormal, constructing a first data set, screening core independent variables through Logistic regression, and constructing a scoring model by using an LSTM (Long Short Term Memory) model; when no abnormity exists, redundant codes are removed to obtain a second data set, and modeling is conducted through the same method. Through double-library linkage and scene-divided modeling, the three-level toxicity risk prediction precision is improved, data support is provided for clinical chemotherapy dose adjustment and toxicity prevention, and the risk of excessive treatment or insufficient treatment is reduced.

The invention discloses a robot guide path optimization method and system for gastrointestinal tumor assisted surgery, particularly relates to the technical field of robot assisted navigation, and is used for solving the problem of unstable and inaccurate path planning. According to the method, fusion of multi-modal information under the unified time and space is achieved through space-time alignment of a preoperative model and intraoperative perception data, registration uncertainty and visibility indexes are dynamically calculated, and the fusion of the multi-modal information under the unified time and space is achieved through construction of an anatomical risk layer, a forbidden zone, geometric stenosis, perfusion evidence, a collision distance margin and a puncture point remote rotation center constraint satisfaction degree. A multi-channel path cost graph is generated, the safety of the path is evaluated, a constraint propagation and regulation causal graph mechanism is combined, a conflict solution contribution degree and a path optimization priority sequence can be rapidly output, it is ensured that the robot executes the optimal path in a complex anatomical environment, a conservative mode is switched when a key risk index triggers a threshold value, and the optimal path is obtained. Real-time regulation and control and safety guarantee are achieved, and the stability of the operation process is improved.

The invention relates to the technical field of tumor risk assessment, in particular to an intestinal tumor risk assessment method based on image analysis, and the method comprises the steps: carrying out the continuous image division and parameter collection; identifying abnormal density image blocks; identifying concerned risk image blocks; judging a response risk image block; adjusting a preset synchronization degree risk threshold value; early warning judgment is carried out, and a serious early warning report is generated. According to the method, a self-adaptive and dynamically-adjusted three-level judgment system is established through real-time collaborative analysis of multi-dimensional parameters of an enteroscope image block, firstly, a suspected focus is locked based on the texture change duration, then, the focus characteristics are verified through vascular abnormality and contrast fluctuation depth, and finally, the accuracy of the focus is improved. And finally, the risk threshold is corrected in combination with intestinal wall peristalsis and the lens shielding degree, so that the problem of low early flat tumor recognition accuracy caused by insufficient flat tumor image feature capture due to excessive dependence on intestinal environment microorganism and metabolite biochemical detection is effectively solved.

This invention discloses a robot-guided path optimization system for assistive surgery in gastrointestinal tumors, specifically relating to the field of robot-assisted navigation technology, to address the problem of unstable and inaccurate path planning. This invention achieves spatiotemporal alignment of preoperative models and intraoperative sensory data, fusing multimodal information in a unified time and space. It dynamically calculates registration uncertainty and visibility indices, constructs anatomical risk layers, no-entry zones, geometric stenosis, perfusion evidence, collision distance margin, and remote rotation center constraint satisfaction at the puncture point, and generates a multi-channel path cost graph to assess path safety. Combined with constraint propagation and causal graph control mechanisms, it can quickly output conflict resolution contribution and path optimization priority sequences, ensuring the robot executes the optimal path in complex anatomical environments. When key risk indicators trigger thresholds, it switches to a conservative mode, achieving real-time control and safety assurance, and improving the stability of the surgical procedure.

The mouse intestinal tumor cell injector comprises a handle, an injection device installed in the handle, and a radially telescopic support ring structure connected with the handle, tumor cells can be discharged from a first injection needle by operating a first push rod, and antibiotics can be discharged from a second injection needle by operating a second push rod; when the support ring structure is in a contracted state, the first injection needle and the second injection needle are located in the support ring structure; when the support ring structure is in an expanded support state, the needle heads of the first injection needle and the second injection needle can both extend to the outside of the outer edge of the support ring structure and are inserted into the mouse intestinal wall. The present application supports the mouse intestine by the support ring structure, supports the insertion of the first injection needle and the second injection needle into the mouse intestinal wall, ensures that only the mouse intestinal endothelium is punctured and the mouse intestinal canal is not punctured, ensures that tumor cells are injected into the mouse intestinal wall, and when the tumor cells are injected, antibiotics are also injected for anti-inflammatory treatment, which is beneficial to the recovery of the mouse intestinal puncture point.

The present application relates to gastrointestinal tumor minimally invasive diagnosis and treatment data intelligent evaluation technical field, specifically to gastrointestinal tumor minimally invasive diagnosis and treatment data intelligent evaluation system based on deep learning, system includes lesion perception module tracking abnormal edge and describing moving path, evolution sketch module extracts direction change to express evolution order, stage interpretation module contrasts guide feature and makes clear stage attribution, diagnosis and treatment mapping module combines operation time sequence to make clear stage and operation order, evaluation convergence module is associated with whole process data, generates gastrointestinal tumor minimally invasive diagnosis and treatment data intelligent evaluation result.The present application, through the relationship between the displacement of the lesion boundary and the direction evolution, makes the lesion change present a continuous evolution process, uses the sequential expression feature to make clear the stage direction, corresponds the image evolution and the diagnosis and treatment semantics to establish the judgment basis, associates the lesion evolution and the operation behavior on the unified time axis to form consistent mapping, thereby improves the coherent expression and the explanation of diagnosis and treatment, enhances the support value of evaluation result.

The invention discloses a recombinant clostridium praeparatum fpPRPS protein, the amino acid sequence of the recombinant protein is shown as SED ID No.3, and the nucleotide sequence of a gene for coding the recombinant protein is shown as SED ID No.2. The invention further discloses a preparation method of the recombinant clostridium praeparatum fpPRPS protein. Experiments prove that the recombinant clostridium praeparatum fpPRPS protein prepared by the invention has effective anti-inflammatory and anti-tumor components, and is simple to prepare, good in activity, high in purity, low in toxicity and easy to popularize and apply clinically and commercially; the invention has important significance for effectively treating and relieving intestinal inflammation and occurrence of various tumors including intestinal tumors and treating various Th17-related inflammations or tumors.

The present invention belongs to the field of microorganisms, and specifically relates to the use of Lactobacillus rhamnosus AFY01 and a product thereof in inflammatory colon cancer. Provided is a strain of Lactobacillus rhamnosus AFY01 with the deposit number of CGMCC No. 27362. The AFY01 can effectively alleviate weight loss in mice with colon cancer and colon shortening caused by intestinal inflammation and edema, reduce the colon coefficient of mice, reduce the visceral index and reduce the occurrence of intestinal tumors in mice, alleviate intestinal inflammation, and promote intestinal tumor cell apoptosis to slow down the development of colon cancer. By means of the present invention, the strain resources are expanded, thus providing technical support for the prevention and treatment of intestinal cancers.

This invention discloses a polysaccharide from *Ganoderma lucidum* (also known as *Ganoderma lucidum* or *Ganoderma sinense*) with efficacy in alleviating colorectal cancer, its preparation method, and its applications, belonging to the field of biomedical technology. The polysaccharide is composed of mannose, glucose, galactose, and fucose, with a molar ratio of 3.221:1.414:80.539:14.826 and a molecular weight of 7.056 kDa. It has been confirmed that the polysaccharide can significantly reduce the number and size of colon tumors; alleviate pathological symptoms such as colonic weight index, bleeding, crypt budding, dysplasia, and hyperplasia; and significantly inhibit the levels of IFN-γ, TGF-β, and IL-17A in the colon while increasing the level of IL-4. Therefore, the polysaccharide provided by this invention has a significant effect in alleviating colorectal cancer, and this invention provides theoretical support for the development of effective and biosafe colorectal cancer drugs.

The application provides a rectal tumor image segmentation method and device, which can be applied to the technical field of medical image processing. The method comprises the following steps: performing image segmentation on a magnetic resonance image by using a segmentation block in a target segmentation model to obtain an initial segmentation image, wherein the magnetic resonance image is obtained by scanning a rectal region of a target object by an imaging device in a first medical institution, the labeling accuracy of the rectal tumor region in the initial segmentation image does not meet a segmentation accuracy condition, and the training sample of the target segmentation model is obtained by scanning by an imaging device in a second medical institution; performing image segmentation on the magnetic resonance image by using a general segmentation model by fusing the magnetic resonance image and the initial segmentation image to output a corrected segmentation image; performing feature extraction on the corrected segmentation image by using a feature extraction block of the target segmentation model to obtain corrected image features; and performing image segmentation on the magnetic resonance image according to the corrected image features by using the segmentation block to obtain a target segmentation image that meets the segmentation accuracy condition.

Lacticaseibacillus rhamnosus AFY01 and an application of a product prepared from Lacticaseibacillus rhamnosus AFY01 in inflammatory colon cancer are provided, which relates the field of microbes. A preservation number of the Lacticaseibacillus rhamnosus AFY01 is CGMCC No. 27362. The Lacticaseibacillus rhamnosus AFY01 can effectively alleviate weight loss, intestinal inflammation and edema induced colon shortening in mice with colon cancer, reduce colon coefficient, visceral index and incidence of intestinal tumors in mice, improve intestinal inflammation, promote apoptosis of intestinal tumor cells to slow down the development of colon cancer. The Lacticaseibacillus rhamnosus AFY01 expands bacterial resources to provide technical support for the prevention and treatment of colorectal cancer.

The invention discloses a cell culture device for stem cell detection of gastrointestinal tumor, and particularly relates to the technical field of cell culture.The cell culture device mainly comprises a rectangular frame column and a linkage screw, the linkage screw is located in the rectangular frame column and rotationally connected with the rectangular frame column, and the top end of the rectangular frame column is fixedly connected with a gear motor used for driving the linkage screw to rotate; a layered linkage mechanism is arranged on the outer wall of the linkage screw rod; the layered linkage mechanism comprises a plurality of sleeving sliding blocks arranged on the outer wall of the linkage screw. A layered linkage mechanism is adopted to start a gear motor to drive a linkage screw to rotate reversely, a concave block enables a connecting shaft to drive an inclined sleeve rod to move upwards, a sealing rotary disc is far away from an arc-shaped limiting plate along the top end of a culture disc, and the top ends of multiple culture dish groove bodies are synchronously opened; the plurality of gastrointestinal tumor stem cell culture dishes in the culture box can be quickly uncovered and checked, and the culture of the gastrointestinal tumor stem cells is more time-saving and labor-saving.

The present invention discloses colorectal cancer biomarkers and their applications in diagnosis, prevention, treatment, and prognosis. The present invention also discloses distinct single-cell characteristics of blood and intestinal ILCs subsets under healthy conditions and in the setting of colorectal cancer. The healthy intestine is composed of ILC1s, ILC3s, and ILC3s / NK cells, but lacks ILC2s. Additional tumor-specific ILC1s and ILC2s subsets were identified in CRC patients. The present invention also discloses that SLAMF1 is selectively expressed on tumor-specific ILCs, and higher levels of SLAMF1+ ILCs are observed in the blood of CRC patients. The survival rate of rectal cancer patients with high SLAMF1 expression was significantly higher than that of those with low SLAMF1 expression, indicating that SLAMF1 is an anti-tumor biomarker in CRC. The present invention also discloses the use of unsupervised hierarchical clustering methods to investigate the heterogeneity of auxiliary ILCs in blood, normal mucosa, and intestinal tumors during steady state and CRC. These biomarkers can effectively diagnose, prevent, treat, assess prognosis, and predict survival for CRC.

An intestinal tumor suppressor that contains a Dectin-1 inhibitor or a β-glucan having a Dectin-1 inhibitory activity and that suppresses an intestinal tumor through Dectin-1 inhibition; a PGE2 production inhibitor that contains a β-glucan having a Dectin-1 inhibitory activity; and an IL-22BP production promoter containing a β-glucan having a Dectin-1 inhibitory activity, are provided.

The present application relates to the field of biological medicine, and particularly relates to the use of WAY-262611 or a pharmaceutically acceptable salt thereof in the treatment of inflammatory bowel disease. The present application has the beneficial effect that the use of WAY-262611 or a pharmaceutically acceptable salt thereof in improving the symptoms of inflammatory bowel disease in mice and reducing intestinal damage is discovered and verified for the first time, can significantly promote the proliferation and repair of intestinal epithelial cells in mice, and has outstanding effects in reducing the incidence of intestinal tumors caused by inflammatory bowel disease.

The utility model discloses a special intelligent infusion system for gastrointestinal tumor nursing, and particularly relates to the xx field, the system comprises a reinforcing shell, the reinforcing shell is provided with a flow guide connecting assembly, the flow guide connecting assembly comprises a connecting cover arranged on one side of the reinforcing shell, the connecting cover is provided with a host, and the host is connected with the reinforcing shell. The bottom of the reinforcing shell and the bottom of the connecting cover are each provided with an electric butterfly valve, and the top of each electric butterfly valve is provided with two flow guide connectors. By arranging the flow guide connecting assembly, interference between the bottle and the reinforcing shell and interference between the bottle and the connecting cover are staggered through the limiting buckles, the supporting lining can limit the bottle, the stability of the bottle in the placing process is ensured, the bottle is arranged between the reinforcing shell and the connecting cover, and media in the bottle are conveyed through the flow guide connector; medium is conveyed into the electric butterfly valve through the flow guide connector and connected to the connecting plug through the infusion tube, then the medium in the bottle can be discharged through the connecting plug, and a worker does not need to replace a medicine bottle.

This invention relates to a composition for preventing colitis-associated colorectal cancer and controlling weight, comprising seahorse, laver, kelp, spirulina, Ulva procumbens, and Gracilaria in a specific ratio. This formula is based on traditional Chinese medicine theories such as "five colors entering the five internal organs," "five flavors entering the meridians," and "salt can soften hardness," while also considering the combined use of warming and cooling properties, and the integration of clearing and tonifying. Through the combination of various marine algae and seahorse, it achieves synergistic effects on multiple targets, including immune regulation, anti-inflammation, intestinal barrier repair, and weight control. The preparation method is simple and low-cost, suitable for large-scale production in food and dietary supplements. Animal experiments show that this composition can significantly slow weight gain in normal mice. In an AOM / DSS-induced colitis-associated colorectal cancer model, it can reduce the disease activity index, decrease the number of colon tumors, alleviate abnormal organ enlargement and intestinal pathological damage, downregulate inflammatory factors such as iNOS and Cox-2, and upregulate intestinal barrier-related factors such as Cdh1, demonstrating a good preventive intervention effect.

The invention belongs to the field of image region segmentation, and particularly relates to an AI-based colorectal tumor image region segmentation method and system, and the method comprises the following steps: S1, obtaining original 3D colorectal tumor image data; according to the method, the high-quality 3D colorectal tumor image data is processed through the surface parameterization technology, the obtained 2D feature map is more suitable for processing the hybrid FMU-attention network model, and the processing efficiency and the processing speed of the hybrid FMU-attention network model are greatly improved; in addition, an AI framework is formed by jointly fusing a hybrid FMU-attention network model, a Vision Transformers module and a DeepLabV3 + model, the AI framework enables the boundary to be more accurate and the multi-scale performance to be more excellent, and it is ensured that the tumor can be effectively recognized and segmented regardless of the size.

The utility model relates to the technical field of medical instruments, in particular to a gastrointestinal tumor surgery diversion device. The gastrointestinal tumor surgery diversion device comprises a diversion bottle, a thickening layer is arranged at the bottom of the diversion bottle, and a plurality of clamping grooves distributed in the circumferential direction are formed in the thickening layer; a rotating shaft is fixed on the thickening layer, and a limiting rotating disc is rotationally connected to the rotating shaft; a thickening layer is additionally arranged at the bottom of an original flow guide bottle, and a supporting mechanism, a supporting ring, a sleeving piece, anti-skid lines, a hand screwing bolt, a connecting strip, a limiting rotating disc, a rotating shaft, a limiting groove, an embedding opening, an elastic clamping head, a positioning groove and a clamping groove are arranged, so that the sleeving piece can be fixed to an infusion support, and therefore the flow guide bottle is placed in a suspended mode; and moreover, the flow guide bottle is fixed on the infusion support, so that medical staff can conveniently observe the internal liquid amount, diagnosis and treatment of the patient are facilitated, and the infusion support is high in practicability.

The invention provides an expert dynamic scheduling method, system and device for intestinal tumor MDT and a storage medium, and the method comprises the steps: collecting the diagnosis and treatment data of an intestinal tumor patient from a hospital multi-source heterogeneous system, and constructing a case portrait meeting the requirements of the intestinal tumor MDT through the specific semantic analysis and structural processing of the intestinal tumor; intestinal tumor MDT expert multi-source information is integrated, and an intestinal tumor field expert knowledge graph containing expert entities, intestinal tumor diagnosis and treatment cooperation relations and graph node weights is constructed; matching and scheduling of intestinal tumor MDT candidate experts are completed based on case portraits and expert knowledge maps through cooperative work of multiple types of agents; and combining reinforcement learning and a multi-objective optimization algorithm to establish an optimal MDT expert combination meeting the intestinal tumor diagnosis and treatment constraint and individualized requirements. In the intestinal tumor MDT expert scheduling process, expert matching can be more accurate, the treatment scheme meets the actual requirements of patients, and the overall diagnosis and treatment efficiency is remarkably improved.

A pharmaceutical composition for treating or preventing at least one disease selected from the group consisting of inflammatory bowel disease and intestinal tumor, the pharmaceutical composition comprising a dendritic cell immunoreceptor inhibitor or a binding inhibitor between a dendritic cell immunoreceptor and an asialo-biantennary N-glycan, and a pharmaceutically acceptable carrier.

This invention relates to the field of medical device technology. This application discloses a surgical margin positioning device for rectal tumor surgery, including a travel hole and a travel groove. The travel hole and travel groove are distributed in a ring array. A travel rod is movably installed inside the travel hole. A mating hole is opened at the top of the travel rod. Sliding grooves are opened on both sides of the outer surface of the mating hole. A push rod is movably installed inside the sliding groove. A spring is provided at the top of the outer surface of the push rod, and the top of the spring is connected to the top of the inner wall of the travel rod. During the upward movement of the travel rod, it drives the travel rod, the ratchet rack, and the first side plate to move upward simultaneously, thereby driving the outer ring frame to move away from the main body, thus realizing the distance between the first positioner and the second positioner. This allows the operator to adjust the distance between the first positioner and the second positioner according to the size of the tumor inside the rectum. The tumor can be located with a single marking, improving the ease of operation of the device.

As described herein ingestion of high amounts of sugar, especially fructose, can increase the growth of intestinal tumors. Such cancer growth can be inhibited or prevented by limiting the amounts of sugar and amino acids ingested, by inhibiting ketohexokinase (KHK), fructose transport (via GLUT5), fatty acid synthesis (via FASN), phosphoinositide 3-kinases (PI3K), or by limiting amounts of sugar and amino acids ingested while also receiving KHK inhibitors, GLUT5 inhibitors, FASN inhibitors, PI3K inhibitors, or a combination of such inhibitors.

This invention discloses a diagnostic and screening system for early screening of gastrointestinal tumors, comprising a detector body, a detector gate, a placement block, a drive component, an extraction component, a liquid dosing component, a pushing component, an adjusting component, and a limiting component. This invention addresses the standard testing process for early screening of gastrointestinal tumors by achieving fully automated operation through an integrated structural design, including constant temperature incubation, automatic quantitative dosing of washing and reaction solutions, sequential switching, and waste liquid extraction. The entire process requires no manual intervention, significantly simplifying the testing operation, effectively avoiding errors and instability caused by human intervention, and significantly improving the standardization and reliability of the testing process, making early screening for gastrointestinal tumors more efficient, convenient, and stable.

The invention belongs to the technical field of biological medicines, and relates to an intelligently designed oral targeting ferroptosis biological preparation. The preparation comprises a core function unit, a carrier unit and a targeted delivery unit. The core function unit is a ferroptosis targeted intelligent peptide which is reasonably designed through an AlphaFold2 and Anand generation model AI and is introduced with non-natural amino acid; the vector unit is a recombinant lentiviral vector which is optimized by AI and carries a ferroptosis regulation gene; and the targeted delivery unit is a probiotic source exosome which is subjected to engineering modification by virtue of an AS1411 aptamer, Fe3O4 (at) PDA nanoparticles and an anti-EGFR monoclonal antibody fragment. The intelligent peptide and the recombinant lentiviral vector form a functional compound through click chemistry, and the functional compound is efficiently loaded in the modified exosome to prepare the oral capsule. According to the preparation, the bioavailability and the targeting property of the medicine are improved, and the preparation can be used for treating ferroptosis pathway disorder related diseases such as intestinal tumors and inflammatory bowel diseases.

The invention discloses an anus lifting exercise device for rectal tumor nursing, and relates to the technical field of anorectal nursing instruments. The device comprises an inflator and a connecting pipe, a linear telescopic piece is fixedly connected to the upper side of the inflator, an air outlet pipe is fixedly connected to the output end of the upper portion of the linear telescopic piece, a fixing block is fixedly connected to one side of the inflator, a groove is formed in the fixing block, and a pedal is rotationally matched with the interior of the groove; a treading inflation assembly is arranged between the groove and the pedal, the treading inflation assembly is communicated with the inflator, and a soft air pipe is fixedly connected between the air outlet pipe and the inflator. The height and position of the air outlet pipe can be adjusted through the linear telescopic piece of the device according to the body position and requirement of a patient, the use comfort and flexibility are improved, the connecting pipe and the air outlet pipe are in threaded connection, dismounting and mounting are convenient, the device is convenient to clean and disinfect, and the infection risk of the patient is reduced.

The use of Campylobacter jejuni and its toxin in the preparation of drugs for preventing, diagnosing, predicting, treating colorectal cancer and extra-intestinal tumor metastasis. Campylobacter, especially Campylobacter jejuni and toxin CDT, can be used as a marker to distinguish whether a colorectal cancer patient has metastasis. Experiments have proved that Campylobacter jejuni has the ability to promote metastasis and invasion. Campylobacter jejuni promotes the invasion and metastasis of colon cancer cells by CDT protein and the up-regulated JAK2 / STAT3 / MMP9 signaling pathway activated by CDT protein. When the process is blocked, the tumor metastasis-promoting ability of Campylobacter jejuni is weakened or lost. Campylobacter jejuni also promotes the metastasis of extra-intestinal tumors. Based on drugs or agents that can block this process, the metastasis of colorectal cancer cells and extra-intestinal tumors can be prevented and inhibited. Based on Campylobacter jejuni and its toxin, corresponding reagents or methods are developed for diagnosing or predicting the metastasis of colorectal cancer and extra-intestinal tumors. Through the marker provided in the present application, it is expected to inhibit tumor metastasis and prolong the survival of patients.

The invention relates to the technical field of biology, in particular to application of lactobacillus johnsonii in colorectal tumor. According to the application, low-abundance lactobacillus johnsonii is used as a biomarker of colorectal tumors, and the abundance ratio of the low-abundance lactobacillus johnsonii to normal-abundance lactobacillus johnsonii is smaller than or equal to 0.9. Based on a large number of experiments in the early stage, the abundance of lactobacillus johnsonii in the intestinal tract of a patient with colorectal tumor shows a significant reduction trend; in addition, the abundance of the lactobacillus johnsonii in the intestinal tract of the patient with colorectal tumor is highly positively correlated with the beneficial bacterium bacteroides simplex in the intestinal tract and is negatively correlated with harmful bacteria in the intestinal tract; in addition, lactobacillus johnsonii is used for intragastric administration, and the number and the volume of tumors of a mouse with colorectal tumors are obviously reduced, so that the lactobacillus johnsonii can be used as a biomarker of the colorectal tumors, and the blank of application of the lactobacillus johnsonii in the aspect of the colorectal tumors in the prior art is filled.