36 results about "Intestinal tumor" patented technology

The invention relates to a culturing, passage, cryopreserving and resuscitating method for the biopsy intestinal tumor organic and an application method thereof. Culturing and passage are conducted ona small amount of biopsy tumor tissue, an organoid with the genetic background highly consistent with that of source cancer tissue and the genetic mutation matched with the mutation level of a corresponding tissue sample can be cultured, the cultured organoid can be cryopreserved and resuscitated, the culturing and medicine effect testing time is shorter, compared with a PDTX model, the culturingcost is low, high throughput medicine screening can be achieved by building a tumor organoid sample library, the cultured organoid can test the ray sensibility of a sample and the like, and the application is wide.

Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.

The invention provides a narciclasine derivative represented by the following structural formula I, wherein R1 is alkyl, cycloalkyl, benzyl or substituted benzyl, R2 is alkyl, cycloalkyl, benzyl or substituted benzyl, and n is an integer from 1 to 10. The narciclasine derivative is subjected to a tumor cell toxicity killing effect test, and results prove that the narciclasine derivative has strong toxicity killing effects on lung gland tumor cells, intestinal tumor cells, breast tumor cells, liver tumor cells, prostate tumor cells, melanoma tumor cells, endometrial tumor cells and neuroglia tumor cells, so the narciclasine derivative can be used for preparation of antitumor drugs. The invention provides a preparation method of the narciclasine derivative. The narciclasine derivative has a novel side-chain structure, shows excellent inhibitory activity on a variety of tumor cell strains, has drug efficacy better than that of narciclasine, allows toxic and side effects of the compound to be improved, provides new drugs for treatment of malignant tumors, and is of great clinical application value.

The invention belongs to the technical field of biological medicine and specifically relates to a rectal tumor marker which is Beclin1 protein, and application of a reagent for detecting expression level and / or phosphorylation level of the Beclin1 protein in the preparation of a kit used for detection and / or diagnosis of rectal tumor or used for treatment and / or prognostic evaluation of rectal tumor patients. The kit for detection and / or diagnosis of rectal tumor or treatment and / or prognostic evaluation of rectal tumor patients comprises the reagent for detecting expression level and / or phosphorylation level of the Beclin1 protein. Through joint evaluation of total level and phosphorylation level of the marker, the marker can be used as the reference for early detection and / or diagnosis of rectal tumor as well as the reference for medication monitoring and drug resistance prediction for rectal tumor patients.

The invention belongs to the technical field of biological medicines and in particular relates to an application method of lactococcus lactis in treating intestinal diseases, and is mainly used for treating the intestinal diseases including enteritis and intestinal tumors. The lactococcus lactis does not belong to normal microbiota of humans and animals and can not be colonized in an oral cavity or a gastrointestinal tract, so that immune tolerance caused by long-term simulation is avoided to a certain extent; in addition, the lactococcus lactis is probiotics in the gastrointestinal tract and can not attack intestinal mucosa without causing strong immune response, thus being very suitable for treating the intestinal diseases including the enteritis and the intestinal tumors.

The invention relates to a three-dimensional porous graphene assembled drug temperature controlled chemotherapy and thermotherapy gastrointestinal tumor device, which comprises a three-dimensional porous graphene assembled drug multi-temperature-controlled chemotherapy and thermotherapy tumor instrument, wherein the tumor instrument comprises a three-dimensional porous graphene assembled drug multi-temperature-controlled therapeutic apparatus, a telescopic multi-beam optical fiber rod and a dimming chamber; the three-dimensional porous graphene assembled drug multi-temperature-controlled therapeutic apparatus, the dimming chamber and the telescopic multi-beam optical fiber rod form an integrated controllable telescopic structure together which can generate actions such as linkage extensionand retraction in the whole device; the three-dimensional porous graphene assembled drug multi-temperature-controlled therapeutic apparatus comprises a three-dimensional porous graphene assembled multi-temperature-controlled drug releasing chamber; the three-dimensional porous graphene assembled multi-temperature-controlled drug releasing chamber comprises three-dimensional porous graphene and assembled drugs; and different types of drugs can be released for multiple times under different temperature control conditions. The device in the embodiment of the invention can also be applicable to chemotherapy and thermotherapy for tumors at the throat and tumors in the skin of the human body.

The invention provides a microecological special diet ate by large intestine tumor patients. The special diet adopts foodborne oligopeptides as main raw materials. According to physical characteristics of the large intestine tumor patients and by adoption of a traditional Chinese medicine quintessence theory, the special diet specifically comprises extracts of edible and medicinal Chinese herb such as dendrobe, coix seed, Chinese yam, dandelion, hawthorn, fig, honeysuckle flower, chicken's gizzard-membrane, hericium erinaceus, sea-buckthorn and fingered citron, and a plurality of anti-inflammatory probiotics, vitamins, and mineral compounds. The food prepared by the formula is easily soluble, can be rapidly absorbed and utilized, and improves the nutrition status of the large intestine tumor patients. By co-function of biological active components in the edible and medicinal Chinese herb extracts, the plurality of the anti-inflammatory probiotics, and the like, the special diet assists boosting of body immunity, inhibits cancer, is anticancer, and is suitable to be ate by the large intestine tumor patients especially cancer patients receiving radiotherapy or chemotherapy, and therefore the special diet is advantaged by integrating a dietary therapy function, a prevention function and a nursing function.

The invention provides an Ackerman bacteria Amuc2172 protein, which contains an amino acid sequence as shown in SEQ ID NO. 1 or SEQ ID NO. 5. The Ackerman bacteria Amuc2172 protein has the advantages that the Akerman bacteria Amuc2172 protein can be used for preparing a recombinant strain; the invention also provides a preparation method of the Akkerman's bacteria Amuc2172 protein, and the Akkerman's bacteria Amuc2172 protein can be used for preparing the The invention further provides a pharmaceutical composition, and the pharmaceutical composition contains a therapeutically effective amount of the ackermania Amuc2172 protein. The invention also provides an application of the Ackerman's bacteria Amuc2172 protein in preparation of a medicine for inhibiting Th17 cell differentiation or intestinal inflammation or intestinal cancer, and also provides an application of the Ackerman's bacteria Amuc2172 protein in preparation of a medicine for inhibiting Th17 cell differentiation or intestinal inflammation or intestinal cancer. The invention finds that an active ingredient Amuc2172 protein of Ackerman's bacteria can inhibit Th17 cells, treat and relieve intestinal inflammation and generation and development of intestinal tumors, and can be used for treating various autoimmune diseases related to Th17, including but not limited to Crohn's disease, ulcerative colitis, multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus.

The invention discloses a traditional Chinese medicine for treating susceptible intestinal obstruction after colon tumor operation. The traditional Chinese medicine is a medicament prepared from the following components in parts by weight: 5-15 parts of Chinese angelica, 10-20 parts of red paeony root, 5-15 parts of szechuan lovage rhizome, 10-20 parts of rehmannia glutinosa, 5-15 parts of peach seed, 3-10 parts of safflower, 5-15 parts of curcuma zedoary, 10-20 parts of immature bitter orange, 3-10 parts of costustoot, 3-10 parts of combined spicebush root, 3-10 parts of areca nut, 10-30 parts of astragalus membranaceus, 5-15 parts of largehead atractylodesrhizome and 10-30 parts of sargentgloryvine stem. A traditional Chinese medicine composition disclosed by the invention takes the effects of promoting blood circulation and removing stasis, promoting the circulation of qi and removing stagnation, removing swelling and relieving pain, and dredging the intestines as treatment principles, adopts qi tonifying medicaments such as Chinese angelica, astragalus membranaceus, red paeony root and the like in an auxiliary way, has a reasonable formula, is convenient to take, can be used for effectively treating intestinal obstruction, and especially can be used for treating intestinal obstruction caused by the colon tumor operation.

The invention discloses an intestinal tumor microscopic hyperspectral image processing method based on a convolutional neural network, and particularly relates to the technical field of gastrointestinal tumor detection, and the hyperspectral image processing method comprises the following steps: 1, obtaining a hyperspectral initial image, and irradiating the gastrointestinal tumor position of a patient by using related equipment. According to the invention, the hyperspectral initial image is segmented; a second sub-image is obtained by using the first sub-image, the feature points in each section of the second sub-image is extracted in a convolutional neural network manner; a third sub-image is constructed, and the feature points are integrated in each group of third sub-images; therefore, the hyperspectral target image formed by combining the feature points is obtained, the hyperspectral initial image can be effectively processed, the hyperspectral initial image is more visual and concise, the processing efficiency of a large amount of data in the hyperspectral initial image is improved, and meanwhile the disease diagnosis accuracy of people is improved.

The invention provides preparation and application of hydroxyethyl cellulose-sodium alginate hydrogel. The provided hydroxyethyl cellulose-sodium alginate hydrogel is used as a medicine carrying carrier and has the characteristics of simple synthesis method and high encapsulation efficiency. The carrier hydrogel has a group having high affinity for a living body, has low biological toxicity, and is an oral hydrogel carrier. Drugs in the carrier hydrogel is prevented from being released under a acidic condition in the stomach, so that the drugs can target intestinal tumors, the treatment effectof the drugs can be slowly released, the repair function of intestinal mucosa and the like can be promoted, the side effects such as hematochezia caused by the intestinal tumors can be effectively reduced, and the hydrogel serving as a new drug carrier hydrogel has wide substantive application.

The present invention discloses a garlic activin, which comprises 100-200 g of salt, 20-50 g of fried atractylodes lancea, 10-40 g of sophora flavescens ait, 50-100 g of rhizoma phragmitis, 5-30 g of white ginseng fibrous root, 20-50 g of taxus chinensis, 5-30 g of schisandra chinensis, 30-80 g of agrimonia pilosa ledeb, 10-50 g of actinidia valvata dunn, and 20-60 g of loquat leaf. The garlic activin of the present invention has the following beneficial effects that: after the garlic activin and garlic are combined, the sulfur-containing compounds in the garlic can be completely provided, the intestine can be promoted to produce an enzyme or substance known as the diallyl disulfide, and the risk that the substance in the intestine causes the intestinal tumor can be eliminated through body immunity enhancing, lipid peroxide formation blocking, anti-mutation, and other approaches.

The invention provides an intestinal tumor detection system, which comprises a detection device, a sampling device, a processing device, a navigation device, a sensing device, a steering device and aprocessor, and is characterized in that the detection device is configured to collect the environment in the intestinal tract, the sampling device is configured to collect the parameters of the tumorin the intestinal tract, the processing device is configured to sample the tumor, the navigation device is configured to navigate the processing device, the sensing device is configured to adjust theposture of the sampling device, and the steering device is configured to adjust the detection position of the detection device. According to the invention, the navigation device is used for navigatingthe position of the processing device, so that the situation that the inner wall of the intestinal tract is touched in the detection or sampling or data collection process is reduced, and it is guaranteed that a patient has high comfort in the detection process.

The invention provides an anti-cancer compound capable of targeting intestinal tumors. The anti-cancer compound is formed by fixing a nano material on the surface of probiotics by connecting molecules,the nano material is selected from any one of a transition metal-containing composite nano material, a transition metal-containing nano metal oxide, a transition metal-containing nano metal peroxide, a transition metal-containing nano metal sulfide or a transition metal-containing nano metal material; one end of the connecting molecule is combined with the bacteria surface molecule, and the other end of the connecting molecule is combined with the nano material. According to the invention, the probiotics and the nanometer material capable of generating active oxygen are compounded, so that the enrichment of the nanometer material in the intestinal tract, especially the focus of the intestinal tumor, is remarkably improved, the capability of generating the active oxygen in the intestinal tract of the nanometer material is enhanced, and the treatment capability on the intestinal tumor is improved; the obtained compound can be used for preparing oral medicines for treating intestinal cancer, the preparation method is simple, convenient and controllable, the production efficiency is high, and the treatment effect is remarkable.

The invention provides a pharmaceutical composition for treating colon cancer and application thereof. The pharmaceutical composition for treating colon cancer consists of 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazoline-4-yl)amino]-1H-pyrazole-5-yl}-N-(3-fluorophenyl) acetamide and 1,8-dihydroxy-3-carboxyanthraquinone. A compound group and a single drug group provided by the inventionboth have inhibitory effects on a colon cancer cell strain SW1116 in vivo, wherein the tumor inhibitory rate of the compound group is significantly different from that of the single drug group of 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazoline-4-yl)amino]-1H-pyrazole-5-yl}-N-(3-fluorophenyl) acetamide or the single drug group of 1,8-dihydroxy-3-carboxyanthraquinone; and both groups play a significant synergistic role in inhibiting the proliferation of the colon cancer cell strain SW1116, in which the compound group can inhibit the growth of colon tumor, and the tumor inhibitory rate can reach up to 90.3%.

A beverage product for nourishing lung and kidney, moistening intestines and facilitating feces excretion and a preparation method thereof are provided; the beverage product is prepared from the following raw materials in parts by weight: 20-60 parts of mulberry, 15-50 parts of lily, 15-50 parts of momordica grosvenori, 15-30 parts of semen cassiae torae, 10-25 parts of semen raphani, 5-15 parts of hawthorn, 3-10 parts of platycodon grandiflorum and 3-10 parts of flos sophorae. The beverage product has significant efficacies of nourishing lung and kidney, moistening intestines and facilitating feces excretion, and is confirmed to also have effectiveness of regulating blood fat, stabilizing blood pressure, improving sleep, preventing and curing chronic pharyngitis, haze damage, acne and colored patches, aphtha and halitosis, and hemorrhoids and hemafecia, and preventing arteriosclerosis, cardiovascular and cerebrovascular accidents and intestinal tumors through clinical practice. The beverage product is capable of nourishing lung and kidney, searching for the primary cause of disease in treatment, and moistening intestines and facilitating feces excretion, does not contain laxatives, has the advantages of homology of medicine and food, convenient oral administration, no any toxic or side effect and no dependence, is suitable for the sub-healthy group suffered from constipation, high blood fat and high blood pressure and easily getting angry, also is suitable for children and the elderly, and can be drunk for long term.

The invention provides a marker combination for predicting the treatment effect of a gastrointestinal tumor immune checkpoint inhibitor and application of the marker combination. The marker combination comprises at least one of HLA-B62 supertypes. According to the marker combination provided by the embodiment of the invention, the treatment effect of the gastrointestinal tumor immune checkpoint inhibitor of an object can be accurately predicted, for example, a PD-1 / PD-L1 inhibitor is singly used or combined with a CTLA-4 inhibitor, so that the response rate of treatment of the gastrointestinal tumor immune checkpoint inhibitor is improved.

The invention provides a preparation method and an application of a polypropylene oxide-sodium alginate hydrogel. The polypropylene oxide-sodium alginate hydrogel provided by the invention is used asa drug carrier, and has the characteristics of simple synthesis method, high encapsulation efficiency and the like; and the carrier hydrogel has a group having high affinity for a living body, is lowin biotoxicity, is an oral hydrogel carrier, can protect medicines in the hydrogel carrier from being released under the acidic condition of the stomach, enables the medicines to target intestinal tumors rich in glutathione, can slowly release and transfer the medicines to improve the treatment effect, and is expected to have wide substantive application as a new medicine carrying carrier hydrogel.

Provided are a method of predicting the onset and causative factors of colon tumors such as a colon polyp, colon cancer, and the like through metagenomic analysis of bacteria-derived extracellular vesicles present in a human body-derived substance, and a method of diagnosing causative factors and risk of colon tumors by sequencing of a metagenome present in bacteria-derived extracellular vesicles in stool or urine.

The invention discloses a new traditional Chinese medicine compound for treating intestinal tumor and a preparation method thereof, wherein the traditional Chinese medicine compound of the invention mainly comprises the following raw material medicines: fried pangolin, fried frankincense, fried myrrh, rhizoma sparganii, rhizoma zedoariae, trichosanthes root, dried orange peel, elecampane, peach kernel, safflower, stir-fried maticated leaven, amomum villosum, yam, woodlouse, angelica, fried turtle shell, fried tortoise plastron, rhizoma ligustici wallichii, aspongopus, rhizoma atractylodis, magnolia officinalis and the like. The traditional Chinese medicine compound of the invention can be prepared into any common oral preparation according to a conventional traditional Chinese medicine preparation method. The invention can markedly improve the symptoms of carreau, abdominal pain, diarrhea, inappetence, intestinal bleeding, hematochezia or pyoid stool and the like, and has exact clinical curative effect, remarkable curative effect and rapid effect taking. Because the traditional Chinese medicine compound of the invention is combined by basically adopting medicine-food homologous medicaments specified in National Formulary, the traditional Chinese medicine compound has the advantages of low cost, basically no toxic or side effect and the like.

The invention discloses a rectal tumor surgical magnetic ring anastomat. A first magnetic ring and a second magnetic ring are provided for implementing a magnetic ring anastomosis operation for a patient of the proctology department; an outer rigid member and an inner rigid member are also provided, a first inflation member, a second inflation member and a third inflation member constitute a mechanism for placing the first magnetic ring and the second magnetic ring, and the characteristics that the inflation members occupy space when inflated and do not occupy space when deflated are utilized,wherein the first inflation member is provided with a first annular protrusion for positioning the first magnetic ring, the second inflation member is provided with a hemispherical airbag for entering the anorectum smoothly, and the third inflation member is provided with a second annular projection for separating the first magnetic ring and the second magnetic ring smoothly. According to the scheme above, the rectal tumor surgical magnetic ring anastomat has the advantages of being simple in structure, reasonable in design and capable of being conveniently used in upper mucosal resection operations of patients suffered from hemorrhoids, low-level colectomy and anastomotic operations and low-level rectal resection and anastomotic operations; the mode of clamping the inflation members is adopted, so that not only can less damage and pain during placement be ensured, and also the anastomat is very convenient to take out.

A group of molecular biomarkers having the genes SLC35D3, POSTN, KLK6 and MUC2 can be used in objective and quantitative methods for the classification, prediction of prognosis and for guiding treatment decisions of a subject with colorectal cancer. More specifically, a method for determining the metastatic potential and / or tumor aggressiveness of a colorectal cancer in a subject can include determining the gene expression levels of genes SLC35D3, POSTN, KLK6 and / or MUC2 in a regional lymph node, a primary intestinal tumor, blood, or feces sample obtained from the subject.

The invention discloses a postoperative rehabilitation training device for intestinal tumor patients, which comprises a training bed board, a perineum stimulation module and a protection module, the perineum stimulation module comprises a stimulation wearing assembly and a mode switching base, and the protection module comprises a hip falling protection base and a protection base plate. The inner side of the mode switching base is provided with a pipeline lifting assembly and a pelvic cavity drainage tube lifting assembly which are relatively fixed, the inner side of the pelvic cavity drainage tube lifting assembly is provided with a pelvic cavity drainage tube contraction assembly, the inner side of the stimulation wearing assembly is provided with a stimulation head assembly, and the bottom end of the stimulation head assembly is connected with a double-row stimulation pipeline. According to the device, the contraction stimulation of the outside to the anal sphincter of a patient is enhanced, the situation that the patient directly urinates due to the poor defecation control ability of the patient, and consequently the perineum muscle is relaxed is avoided, and the rehabilitation training effect of the patient is guaranteed.

The invention provides an application of a substance for knocking down BACE2 gene expression in tumor resistance and a BACE2 inhibitor. The tumor is a colon tumor. According to the invention, the expression of the BACE2 gene is obviously reduced by selecting specific siRNA, and the migration, proliferation and invasion capabilities of tumor cells are effectively inhibited. Therefore, the proliferation of the colon tumor can be effectively inhibited by knocking down the expression of the BACE2 gene, and a new thought is provided for the treatment of the colon tumor.

The invention discloses an application of a traditional Chinese medicine composition in the preparation of a medicine for preventing and treating gastrointestinal tumors. The active ingredients of the traditional Chinese medicine composition include the following components, and the formula includes the following components: Coptis chinensis, Paojiang, Indigo Naturalis , Sophora flavescens, Panax notoginseng, simmering woody incense, Burnet charcoal, Zhigancao. The invention utilizes Qingchang Wenzhong Tablet to develop a new class of traditional Chinese medicines with good curative effect and high safety for preventing small intestinal tumors and colorectal cancer, which can prevent the occurrence of small intestinal tumors and colorectal tumors. This not only provides a new indication for the application of Qingchang Wenzhong Tablet, but also provides a new therapeutic drug and therapeutic approach for the prevention of small intestinal tumors and the prevention and treatment of colorectal cancer.

The invention discloses a catheter fixing device for gastrointestinal tumor surgery, and relates to the technical field of gastrointestinal tumor treatment. The catheter fixing device for the gastrointestinal tumor surgery comprises a fixing mechanism, the fixing mechanism comprises two fixing clamps, the two fixing clamps are arranged in a bilateral symmetry mode, the middle portions of the two fixing clamps are concave inwards and are close to each other, a first main shaft is arranged at the concave positions of the middle portions of the two fixing clamps, and the vertical section of the first main shaft is in an I shape; the first main shaft is fixedly connected with the concave position of the middle of the fixing clamp located on the left side, the middle of the first main shaft is movably sleeved with a second main shaft, the upper end face and the lower end face of the second main shaft are fixedly connected with first springs, and the ends, away from the second main shaft, of the first springs are correspondingly and fixedly connected with the first main shaft, and the second main shaft is fixedly connected with the concave position of the middle of the fixing clamp located on the right side. According to the catheter fixing device for the gastrointestinal tumor surgery, the device can be fixed and mounted more conveniently, and mounting and dismounting are quite easy.

The invention discloses a Lactococcus lactis subsp. lactis capable of significantly inhibiting the occurrence of colorectal cancer and an application thereof, belonging to the technical field of microorganisms. Lactococcus lactis subsp. lactic acid VM5 provided by the present invention has a preservation number of GDMCC No.60256, can tolerate gastric acid and bile salts, and can significantly reduce the inflammatory response in the colorectal region of colorectal cancer model mice. The expression of Notch1 signaling pathway and VEGFR2 molecules in tissues can reduce the number of tumors in the colon and rectum of model mice. In addition, Lactococcus lactis subsp. lactic acid VM5 can also improve the structure of intestinal flora and the level of short-chain fatty acids in the intestine. The Lactococcus lactis lactic acid subspecies VM5 is used to prepare fermented food for inhibiting the occurrence of colorectal cancer, and has very broad application prospects.

The invention is suitable for the technical field of medical instruments, and provides a catheter fixing device for a gastrointestinal tumor surgery. The device comprises a support and further comprises a clamping mechanism and a positioning mechanism, a first control piece drives a transmission piece to rotate, the transmission piece drives a first rack to move through a first connecting piece, the first rack drives a rotating piece to rotate through meshing teeth, when the rotating piece drives a movable piece to rotate, the rotating piece drives the movable piece to move towards the inner side in the mode that a second moving groove is in sliding connection with a fixed head and a first moving groove is in sliding connection with a fixed piece. The movable piece drives a reset piece to move towards the inner side through a connecting assembly, a second elastic piece drives the movable piece to move, and the movable piece positions the clamping mechanism in the mode that the movable piece is connected with a clamping groove in a clamped mode. The catheter fixing device can fix catheters with different diameters and is good in fixing effect, easy to operate and high in practicability.