22 results about "Intestinal tumor" patented technology

The invention relates to the technical field of gastrointestinal tumor chemotherapy risk assessment, and particularly discloses a gastrointestinal tumor chemotherapy risk scoring model and a construction method thereof, and the method comprises the steps: obtaining the individualized feature data and basic physiological data of a historical patient, and constructing an individualized difference library with a unique ID, and a core influence library; the method comprises the following steps: standardizing and coding double-library data, synchronizing clinical data containing treatment effect codes, forming a data dictionary, acquiring and coding current gastrointestinal tumor patient data, and matching the data dictionary to judge individual difference abnormity; when the first data set is abnormal, constructing a first data set, screening core independent variables through Logistic regression, and constructing a scoring model by using an LSTM (Long Short Term Memory) model; when no abnormity exists, redundant codes are removed to obtain a second data set, and modeling is conducted through the same method. Through double-library linkage and scene-divided modeling, the three-level toxicity risk prediction precision is improved, data support is provided for clinical chemotherapy dose adjustment and toxicity prevention, and the risk of excessive treatment or insufficient treatment is reduced.

This invention discloses a robot-guided path optimization system for assistive surgery in gastrointestinal tumors, specifically relating to the field of robot-assisted navigation technology, to address the problem of unstable and inaccurate path planning. This invention achieves spatiotemporal alignment of preoperative models and intraoperative sensory data, fusing multimodal information in a unified time and space. It dynamically calculates registration uncertainty and visibility indices, constructs anatomical risk layers, no-entry zones, geometric stenosis, perfusion evidence, collision distance margin, and remote rotation center constraint satisfaction at the puncture point, and generates a multi-channel path cost graph to assess path safety. Combined with constraint propagation and causal graph control mechanisms, it can quickly output conflict resolution contribution and path optimization priority sequences, ensuring the robot executes the optimal path in complex anatomical environments. When key risk indicators trigger thresholds, it switches to a conservative mode, achieving real-time control and safety assurance, and improving the stability of the surgical procedure.

The present application relates to gastrointestinal tumor minimally invasive diagnosis and treatment data intelligent evaluation technical field, specifically to gastrointestinal tumor minimally invasive diagnosis and treatment data intelligent evaluation system based on deep learning, system includes lesion perception module tracking abnormal edge and describing moving path, evolution sketch module extracts direction change to express evolution order, stage interpretation module contrasts guide feature and makes clear stage attribution, diagnosis and treatment mapping module combines operation time sequence to make clear stage and operation order, evaluation convergence module is associated with whole process data, generates gastrointestinal tumor minimally invasive diagnosis and treatment data intelligent evaluation result.The present application, through the relationship between the displacement of the lesion boundary and the direction evolution, makes the lesion change present a continuous evolution process, uses the sequential expression feature to make clear the stage direction, corresponds the image evolution and the diagnosis and treatment semantics to establish the judgment basis, associates the lesion evolution and the operation behavior on the unified time axis to form consistent mapping, thereby improves the coherent expression and the explanation of diagnosis and treatment, enhances the support value of evaluation result.

The invention discloses a recombinant clostridium praeparatum fpPRPS protein, the amino acid sequence of the recombinant protein is shown as SED ID No.3, and the nucleotide sequence of a gene for coding the recombinant protein is shown as SED ID No.2. The invention further discloses a preparation method of the recombinant clostridium praeparatum fpPRPS protein. Experiments prove that the recombinant clostridium praeparatum fpPRPS protein prepared by the invention has effective anti-inflammatory and anti-tumor components, and is simple to prepare, good in activity, high in purity, low in toxicity and easy to popularize and apply clinically and commercially; the invention has important significance for effectively treating and relieving intestinal inflammation and occurrence of various tumors including intestinal tumors and treating various Th17-related inflammations or tumors.

The application provides a rectal tumor image segmentation method and device, which can be applied to the technical field of medical image processing. The method comprises the following steps: performing image segmentation on a magnetic resonance image by using a segmentation block in a target segmentation model to obtain an initial segmentation image, wherein the magnetic resonance image is obtained by scanning a rectal region of a target object by an imaging device in a first medical institution, the labeling accuracy of the rectal tumor region in the initial segmentation image does not meet a segmentation accuracy condition, and the training sample of the target segmentation model is obtained by scanning by an imaging device in a second medical institution; performing image segmentation on the magnetic resonance image by using a general segmentation model by fusing the magnetic resonance image and the initial segmentation image to output a corrected segmentation image; performing feature extraction on the corrected segmentation image by using a feature extraction block of the target segmentation model to obtain corrected image features; and performing image segmentation on the magnetic resonance image according to the corrected image features by using the segmentation block to obtain a target segmentation image that meets the segmentation accuracy condition.

This invention relates to a composition for preventing colitis-associated colorectal cancer and controlling weight, comprising seahorse, laver, kelp, spirulina, Ulva procumbens, and Gracilaria in a specific ratio. This formula is based on traditional Chinese medicine theories such as "five colors entering the five internal organs," "five flavors entering the meridians," and "salt can soften hardness," while also considering the combined use of warming and cooling properties, and the integration of clearing and tonifying. Through the combination of various marine algae and seahorse, it achieves synergistic effects on multiple targets, including immune regulation, anti-inflammation, intestinal barrier repair, and weight control. The preparation method is simple and low-cost, suitable for large-scale production in food and dietary supplements. Animal experiments show that this composition can significantly slow weight gain in normal mice. In an AOM / DSS-induced colitis-associated colorectal cancer model, it can reduce the disease activity index, decrease the number of colon tumors, alleviate abnormal organ enlargement and intestinal pathological damage, downregulate inflammatory factors such as iNOS and Cox-2, and upregulate intestinal barrier-related factors such as Cdh1, demonstrating a good preventive intervention effect.

The invention belongs to the field of image region segmentation, and particularly relates to an AI-based colorectal tumor image region segmentation method and system, and the method comprises the following steps: S1, obtaining original 3D colorectal tumor image data; according to the method, the high-quality 3D colorectal tumor image data is processed through the surface parameterization technology, the obtained 2D feature map is more suitable for processing the hybrid FMU-attention network model, and the processing efficiency and the processing speed of the hybrid FMU-attention network model are greatly improved; in addition, an AI framework is formed by jointly fusing a hybrid FMU-attention network model, a Vision Transformers module and a DeepLabV3 + model, the AI framework enables the boundary to be more accurate and the multi-scale performance to be more excellent, and it is ensured that the tumor can be effectively recognized and segmented regardless of the size.

The utility model relates to the technical field of medical instruments, in particular to a gastrointestinal tumor surgery diversion device. The gastrointestinal tumor surgery diversion device comprises a diversion bottle, a thickening layer is arranged at the bottom of the diversion bottle, and a plurality of clamping grooves distributed in the circumferential direction are formed in the thickening layer; a rotating shaft is fixed on the thickening layer, and a limiting rotating disc is rotationally connected to the rotating shaft; a thickening layer is additionally arranged at the bottom of an original flow guide bottle, and a supporting mechanism, a supporting ring, a sleeving piece, anti-skid lines, a hand screwing bolt, a connecting strip, a limiting rotating disc, a rotating shaft, a limiting groove, an embedding opening, an elastic clamping head, a positioning groove and a clamping groove are arranged, so that the sleeving piece can be fixed to an infusion support, and therefore the flow guide bottle is placed in a suspended mode; and moreover, the flow guide bottle is fixed on the infusion support, so that medical staff can conveniently observe the internal liquid amount, diagnosis and treatment of the patient are facilitated, and the infusion support is high in practicability.

The invention provides an expert dynamic scheduling method, system and device for intestinal tumor MDT and a storage medium, and the method comprises the steps: collecting the diagnosis and treatment data of an intestinal tumor patient from a hospital multi-source heterogeneous system, and constructing a case portrait meeting the requirements of the intestinal tumor MDT through the specific semantic analysis and structural processing of the intestinal tumor; intestinal tumor MDT expert multi-source information is integrated, and an intestinal tumor field expert knowledge graph containing expert entities, intestinal tumor diagnosis and treatment cooperation relations and graph node weights is constructed; matching and scheduling of intestinal tumor MDT candidate experts are completed based on case portraits and expert knowledge maps through cooperative work of multiple types of agents; and combining reinforcement learning and a multi-objective optimization algorithm to establish an optimal MDT expert combination meeting the intestinal tumor diagnosis and treatment constraint and individualized requirements. In the intestinal tumor MDT expert scheduling process, expert matching can be more accurate, the treatment scheme meets the actual requirements of patients, and the overall diagnosis and treatment efficiency is remarkably improved.

A pharmaceutical composition for treating or preventing at least one disease selected from the group consisting of inflammatory bowel disease and intestinal tumor, the pharmaceutical composition comprising a dendritic cell immunoreceptor inhibitor or a binding inhibitor between a dendritic cell immunoreceptor and an asialo-biantennary N-glycan, and a pharmaceutically acceptable carrier.

This invention relates to the field of medical device technology. This application discloses a surgical margin positioning device for rectal tumor surgery, including a travel hole and a travel groove. The travel hole and travel groove are distributed in a ring array. A travel rod is movably installed inside the travel hole. A mating hole is opened at the top of the travel rod. Sliding grooves are opened on both sides of the outer surface of the mating hole. A push rod is movably installed inside the sliding groove. A spring is provided at the top of the outer surface of the push rod, and the top of the spring is connected to the top of the inner wall of the travel rod. During the upward movement of the travel rod, it drives the travel rod, the ratchet rack, and the first side plate to move upward simultaneously, thereby driving the outer ring frame to move away from the main body, thus realizing the distance between the first positioner and the second positioner. This allows the operator to adjust the distance between the first positioner and the second positioner according to the size of the tumor inside the rectum. The tumor can be located with a single marking, improving the ease of operation of the device.

As described herein ingestion of high amounts of sugar, especially fructose, can increase the growth of intestinal tumors. Such cancer growth can be inhibited or prevented by limiting the amounts of sugar and amino acids ingested, by inhibiting ketohexokinase (KHK), fructose transport (via GLUT5), fatty acid synthesis (via FASN), phosphoinositide 3-kinases (PI3K), or by limiting amounts of sugar and amino acids ingested while also receiving KHK inhibitors, GLUT5 inhibitors, FASN inhibitors, PI3K inhibitors, or a combination of such inhibitors.

This invention discloses a diagnostic and screening system for early screening of gastrointestinal tumors, comprising a detector body, a detector gate, a placement block, a drive component, an extraction component, a liquid dosing component, a pushing component, an adjusting component, and a limiting component. This invention addresses the standard testing process for early screening of gastrointestinal tumors by achieving fully automated operation through an integrated structural design, including constant temperature incubation, automatic quantitative dosing of washing and reaction solutions, sequential switching, and waste liquid extraction. The entire process requires no manual intervention, significantly simplifying the testing operation, effectively avoiding errors and instability caused by human intervention, and significantly improving the standardization and reliability of the testing process, making early screening for gastrointestinal tumors more efficient, convenient, and stable.

The invention belongs to the technical field of biological medicines, and relates to an intelligently designed oral targeting ferroptosis biological preparation. The preparation comprises a core function unit, a carrier unit and a targeted delivery unit. The core function unit is a ferroptosis targeted intelligent peptide which is reasonably designed through an AlphaFold2 and Anand generation model AI and is introduced with non-natural amino acid; the vector unit is a recombinant lentiviral vector which is optimized by AI and carries a ferroptosis regulation gene; and the targeted delivery unit is a probiotic source exosome which is subjected to engineering modification by virtue of an AS1411 aptamer, Fe3O4 (at) PDA nanoparticles and an anti-EGFR monoclonal antibody fragment. The intelligent peptide and the recombinant lentiviral vector form a functional compound through click chemistry, and the functional compound is efficiently loaded in the modified exosome to prepare the oral capsule. According to the preparation, the bioavailability and the targeting property of the medicine are improved, and the preparation can be used for treating ferroptosis pathway disorder related diseases such as intestinal tumors and inflammatory bowel diseases.

The invention discloses an anus lifting exercise device for rectal tumor nursing, and relates to the technical field of anorectal nursing instruments. The device comprises an inflator and a connecting pipe, a linear telescopic piece is fixedly connected to the upper side of the inflator, an air outlet pipe is fixedly connected to the output end of the upper portion of the linear telescopic piece, a fixing block is fixedly connected to one side of the inflator, a groove is formed in the fixing block, and a pedal is rotationally matched with the interior of the groove; a treading inflation assembly is arranged between the groove and the pedal, the treading inflation assembly is communicated with the inflator, and a soft air pipe is fixedly connected between the air outlet pipe and the inflator. The height and position of the air outlet pipe can be adjusted through the linear telescopic piece of the device according to the body position and requirement of a patient, the use comfort and flexibility are improved, the connecting pipe and the air outlet pipe are in threaded connection, dismounting and mounting are convenient, the device is convenient to clean and disinfect, and the infection risk of the patient is reduced.

The use of Campylobacter jejuni and its toxin in the preparation of drugs for preventing, diagnosing, predicting, treating colorectal cancer and extra-intestinal tumor metastasis. Campylobacter, especially Campylobacter jejuni and toxin CDT, can be used as a marker to distinguish whether a colorectal cancer patient has metastasis. Experiments have proved that Campylobacter jejuni has the ability to promote metastasis and invasion. Campylobacter jejuni promotes the invasion and metastasis of colon cancer cells by CDT protein and the up-regulated JAK2 / STAT3 / MMP9 signaling pathway activated by CDT protein. When the process is blocked, the tumor metastasis-promoting ability of Campylobacter jejuni is weakened or lost. Campylobacter jejuni also promotes the metastasis of extra-intestinal tumors. Based on drugs or agents that can block this process, the metastasis of colorectal cancer cells and extra-intestinal tumors can be prevented and inhibited. Based on Campylobacter jejuni and its toxin, corresponding reagents or methods are developed for diagnosing or predicting the metastasis of colorectal cancer and extra-intestinal tumors. Through the marker provided in the present application, it is expected to inhibit tumor metastasis and prolong the survival of patients.

The invention relates to the technical field of biology, in particular to application of lactobacillus johnsonii in colorectal tumor. According to the application, low-abundance lactobacillus johnsonii is used as a biomarker of colorectal tumors, and the abundance ratio of the low-abundance lactobacillus johnsonii to normal-abundance lactobacillus johnsonii is smaller than or equal to 0.9. Based on a large number of experiments in the early stage, the abundance of lactobacillus johnsonii in the intestinal tract of a patient with colorectal tumor shows a significant reduction trend; in addition, the abundance of the lactobacillus johnsonii in the intestinal tract of the patient with colorectal tumor is highly positively correlated with the beneficial bacterium bacteroides simplex in the intestinal tract and is negatively correlated with harmful bacteria in the intestinal tract; in addition, lactobacillus johnsonii is used for intragastric administration, and the number and the volume of tumors of a mouse with colorectal tumors are obviously reduced, so that the lactobacillus johnsonii can be used as a biomarker of the colorectal tumors, and the blank of application of the lactobacillus johnsonii in the aspect of the colorectal tumors in the prior art is filled.

The application discloses a kind of recombinant prasillum fpPRPS protein, the amino acid sequence of the recombinant protein is as shown in SED ID No.3, the nucleotide sequence of the gene of the recombinant protein is as shown in SED ID No.2.It is proved by experiment that the recombinant prasillum fpPRPS protein prepared by the application has effective anti-inflammatory and antitumor components, and is simple to prepare, good in activity, high in purity, small in toxicity, easy to promote and apply clinically and commercially, and has important significance for effectively treating and relieving intestinal inflammation and the occurrence of various tumors including intestinal tumors and the treatment of various inflammations or tumors related to Th17.

This invention discloses a traditional Chinese medicine composition for dissolving nodules and tumors, its preparation method, and its application. The composition comprises the following components in parts by weight: 4-8g of *Taxus wallichiana*, 20-40g of *Actinidia chinensis* root, 5-25g of *Lobelia chinensis*, 20-40g of *Scutellaria barbata*, 20-40g of *Hedyotis diffusa*, 1-5g of *Scolopendra subspinipes*, 5-15g of *Curcuma zedoaria* (processed with vinegar), 5-25g of *Solanum lyratum*, 20-40g of *Astragalus membranaceus*, 5-15g of *Angelica sinensis*, 5-25g of *Pseudostellaria heterophylla*, 5-25g of *Poria cocos*, 5-25g of *Atractylodes macrocephala* (stir-fried with wheat bran), 20-40g of *Coix lacryma-jobi*, 5-15g of *Pinellia ternata* (processed with ginger), 5-15g of *Citrus reticulata* peel, and 5-15g of *Glycyrrhiza uralensis*. This formula combines tonification and purgation, nourishing qi and blood, regulating the spleen and stomach, and dissolving nodules and tumors. This invention, through the addition and subtraction of prescription drugs, can dissolve nodules and eliminate tumors in the early stage of gastric and intestinal tumor treatment, while protecting the spleen and stomach's qi and blood; in the middle stage of gastric and intestinal tumor treatment, it can strengthen the spleen, resolve dampness, detoxify and disperse nodules, combining attack and tonification; in the terminal stage of gastric and intestinal tumor treatment, it can invigorate qi and support the body's resistance, while also having anti-cancer effects.

The invention discloses a fluorescent developing injection-pushing device for gastrointestinal tumor surgery, and particularly relates to the technical field of developing injection-pushing devices.The fluorescent developing injection-pushing device comprises a transverse support, an injector is arranged at the top end of the transverse support, scales for displaying dosage are arranged on the surface of the injector, and a detachable connecting hose is arranged at the front end of the injector; an end pipe is fixedly arranged at the front end of the connecting hose, a detachable needle head is arranged at the front end of the end pipe, a mounting groove is formed in the front end of the transverse support, and a fixing assembly is arranged in the mounting groove. The extension plate is clamped and fixed between the pressing rod and the base plate through the elastic force of the pressing spring, after the needle pierces a tumor part, the needle is unfixed by pulling the shifting rod, the needle and an injector are connected through the connecting hose, interference to the needle due to hand shaking of a doctor can be avoided while a fluorescent developing agent is injected, and the working efficiency is improved. And the safety of the injection and pushing device is further improved.

The invention provides a rectal tumor image segmentation method and device, which can be applied to the technical field of medical image processing. The method comprises the following steps: performing image segmentation on a magnetic resonance image by using segmentation blocks in a target segmentation model to obtain an initial segmentation image, the magnetic resonance image being obtained by scanning a rectum area of a target object by an imaging device in a first medical institution, the marking precision for the rectal tumor region in the initial segmentation image does not meet the segmentation precision condition, and a training sample of the target segmentation model is obtained by scanning of imaging equipment in a second medical institution; outputting a corrected segmented image by fusing the magnetic resonance image and the initial segmented image by using a general segmentation model; performing feature extraction on the corrected segmented image by using a feature extraction block of the target segmentation model to obtain corrected image features; and carrying out image segmentation on the magnetic resonance image by utilizing the segmentation blocks according to the corrected image features to obtain a target segmentation image meeting a segmentation precision condition.

The invention discloses a culture medium and a culture method for small intestine tumor organoids, and relates to the field of organoid culture, the culture medium comprises a basic culture medium advanced DMEM / F12 and specific addition factors, and the specific addition factors comprise the following components: penicillin / streptomycin, HEPES, GlutaMAX, primocin, hR-spondin 1, Noggin combined medium, B27 Supplement without vitamine A, Nicotinamide, hEGF, Gastrin I, A83-01 and SB202190. The organoid culture medium disclosed by the invention can be used for successfully culturing the small intestine tumor organoids according to the growth characteristics of small intestine tumor tissue cells.