2 results about "Colon tumors" patented technology

The application belongs to the technical field of pharmacy, and relates to a thiazole compound, a preparation method and application thereof, and a pharmaceutical composition.The thiazole compound is shown in formula (I), is a PRMT5-MTA inhibitor, and can be used for preventing and / or treating PRMT5-mediated diseases, such as ovarian cancer, lung cancer, lymphoma, glioblastoma, colon tumor, melanoma, gastric cancer, pancreatic cancer or bladder cancer.

This invention relates to a composition for preventing colitis-associated colorectal cancer and controlling weight, comprising seahorse, laver, kelp, spirulina, Ulva procumbens, and Gracilaria in a specific ratio. This formula is based on traditional Chinese medicine theories such as "five colors entering the five internal organs," "five flavors entering the meridians," and "salt can soften hardness," while also considering the combined use of warming and cooling properties, and the integration of clearing and tonifying. Through the combination of various marine algae and seahorse, it achieves synergistic effects on multiple targets, including immune regulation, anti-inflammation, intestinal barrier repair, and weight control. The preparation method is simple and low-cost, suitable for large-scale production in food and dietary supplements. Animal experiments show that this composition can significantly slow weight gain in normal mice. In an AOM / DSS-induced colitis-associated colorectal cancer model, it can reduce the disease activity index, decrease the number of colon tumors, alleviate abnormal organ enlargement and intestinal pathological damage, downregulate inflammatory factors such as iNOS and Cox-2, and upregulate intestinal barrier-related factors such as Cdh1, demonstrating a good preventive intervention effect.