7 results about "Colon tumors" patented technology

The invention discloses an application of isolithocholic acid in preparation of a medicine for preventing or treating colorectal cancer induced by high fat diet. The invention proves that the isolithocholic acid can be accurately replenished by intragastric administration of 100g / kg of isoLCA at one time, and meanwhile, the isolithocholic acid can obviously inhibit the occurrence of obesity-related colon tumors, reduce the proliferation index of tumor cells and repair the intestinal barrier structure. Isolithocholic acid is endogenous secondary bile acid, can be chemically synthesized or semi-synthesized, is high in safety and good in patient compliance through oral administration, is expected to reduce the occurrence rate of colorectal cancer of obese people, and has important significance in treatment of colorectal cancer.

The application belongs to the technical field of pharmacy, and relates to a thiazole compound, a preparation method and application thereof, and a pharmaceutical composition.The thiazole compound is shown in formula (I), is a PRMT5-MTA inhibitor, and can be used for preventing and / or treating PRMT5-mediated diseases, such as ovarian cancer, lung cancer, lymphoma, glioblastoma, colon tumor, melanoma, gastric cancer, pancreatic cancer or bladder cancer.

The invention belongs to the technical field of intelligent drug delivery control, and particularly discloses a colon tumor drug delivery method and system based on AI control, and the method comprises the steps: collecting and preprocessing whole genome sequencing, radiomics, clinical pathology and historical drug treatment response data of a patient, extracting tumor image features, and carrying out drug delivery. The method comprises the following steps: screening oxaliplatin response related gene mutation markers by combining Lasso regression with a Cox model, forming feature vectors by t-SNE dimensionality reduction clinical pathological data, training a model through a gradient boosting tree and deep neural network fusion algorithm, taking oxaliplatin response probability as output, and recommending an FOLFOX scheme or an FULV scheme according to a model result. According to the method, precision and individuation of chemotherapy are achieved, unnecessary toxic and side effects are reduced, the life quality and lifetime of a patient are improved, and the problems that in the prior art, dependence on experience, single data dimension, no dynamic adjustment mechanism and poor stability are solved. Therefore, the problems of low response rate of oxaliplatin and obvious side effect are solved.

This invention relates to a composition for preventing colitis-associated colorectal cancer and controlling weight, comprising seahorse, laver, kelp, spirulina, Ulva procumbens, and Gracilaria in a specific ratio. This formula is based on traditional Chinese medicine theories such as "five colors entering the five internal organs," "five flavors entering the meridians," and "salt can soften hardness," while also considering the combined use of warming and cooling properties, and the integration of clearing and tonifying. Through the combination of various marine algae and seahorse, it achieves synergistic effects on multiple targets, including immune regulation, anti-inflammation, intestinal barrier repair, and weight control. The preparation method is simple and low-cost, suitable for large-scale production in food and dietary supplements. Animal experiments show that this composition can significantly slow weight gain in normal mice. In an AOM / DSS-induced colitis-associated colorectal cancer model, it can reduce the disease activity index, decrease the number of colon tumors, alleviate abnormal organ enlargement and intestinal pathological damage, downregulate inflammatory factors such as iNOS and Cox-2, and upregulate intestinal barrier-related factors such as Cdh1, demonstrating a good preventive intervention effect.

Drug-eluting devices and methods for the treatment of tumors of the pancreas, biliary system, gallbladder, liver, small bowel, or colon, are provided. Methods include deploying a drug-eluting device having a film which includes a mixture of a degradable polymer and a chemotherapeutic drug, wherein the film has a thickness from about 2 μm to about 1000 μm, into a tissue site and releasing a therapeutically effective amount of the chemotherapeutic drug from the film to treat the tumor, wherein the release of the therapeutically effective amount of the drug from the film is controlled by in vivo degradation of the polymer at the tissue site.

The invention relates to the technical field of biological medicines, in particular to application of garlic polysaccharide in preparation of a medicine for preventing and / or inflammatory colonoma. The invention provides an application of garlic polysaccharide in preparation of a medicine for preventing and / or inflammatory colon tumor, the garlic polysaccharide is mainly formed by connecting fructose and glucose through a beta-configuration glucosidic bond, and the garlic polysaccharide can resist gastrointestinal tract enzyme in digestion simulation to be utilized by intestinal flora glycolysis, so that the total sugar content is continuously reduced. The anti-tumor activity of the garlic polysaccharide is proved by constructing an azomethane (AOM) / dextran sodium sulfate (DSS) induced inflammatory coloma mouse model; meanwhile, a basis is provided for research and development of garlic polysaccharide medicines for preventing and / or treating inflammatory colonoma.

The invention belongs to the technical field of biological medicines, and particularly relates to an oligopeptide-sound-sensitive agent conjugate capable of destroying bacterial cell membranes as well as a preparation method and application of the oligopeptide-sound-sensitive agent conjugate. The oligopeptide-sound sensitive agent conjugate provided by the invention is formed by coupling a sound sensitive agent and oligopeptide through an amido bond. The conjugate has double antibacterial mechanisms: on one hand, the structure of the conjugate can destroy bacterial cell membranes to cause bacterial structure damage and content leakage; on the other hand, active oxygen can be efficiently generated under ultrasonic excitation, and the killing effect on bacteria is further enhanced. Experiments show that the conjugate has remarkable antibacterial activity on gram-negative bacteria. In addition, the conjugate also shows a good inhibition effect on colon tumor cells. The oligopeptide-sonosensitizer conjugate provided by the invention has potential industrial value in preparation of antibacterial and anti-tumor materials.