Double-layer anti-adhesion polypropylene patch, and preparation method and application thereof

A polypropylene and anti-adhesion technology, which is applied in the field of medical materials, can solve the problems of small modification space, no anti-adhesion function, and poor anti-adhesion effect, and achieve stable properties, good hydrophilicity and biocompatibility Sexuality, texture smooth effect

Pending Publication Date: 2019-01-25
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Patent CN203226924U discloses a medical double-layer anti-adhesion hernia repair patch, which uses polyvinylidene fluoride yarn and polypropylene yarn to form an anti-adhesion patch through interweaving and compounding. Craft weaving, the texture is smoother to achieve the purpose of anti-adhesion, but polyvinylidene fluoride itself, as a synthetic polymer material, does not have anti-adhesion function, resulting in poor overall anti-adhesion effect, polyvinylidene fluoride and polypropylene materials The space for modification is small, and further performance improvement is needed

Method used

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  • Double-layer anti-adhesion polypropylene patch, and preparation method and application thereof

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Embodiment 1

[0029] A double-layer anti-adhesion polypropylene patch, comprising a polypropylene monofilament layer and a polypropylene / polydopamine composite monofilament layer, the polypropylene monofilament layer is woven through a double-comb warp knitting process, and the polypropylene / poly The dopamine composite monofilament layer is woven through a three-comb warp knitting process, and the specific preparation process is as follows:

[0030] Step S1: Put polypropylene filaments with a diameter of 0.1-0.2mm into tris buffer solution with a concentration of 10mmol / L, add dopamine hydrochloride solution with a concentration of 2.4g / L, and adjust the pH of the solution to 8.0, Stir at a constant speed of 200 rpm / min at room temperature, take it out after 72 hours of reaction, rinse with deionized water and dry to obtain a polypropylene / polydopamine composite monofilament material;

[0031] Step S2: Knit the polypropylene filament with a diameter of 0.1-0.2mm and the polypropylene / polydo...

Embodiment 2

[0033] A double-layer anti-adhesion polypropylene patch, comprising a polypropylene monofilament layer and a polypropylene / polydopamine composite monofilament layer, the polypropylene monofilament layer is woven through a double-comb warp knitting process, and the polypropylene / poly The dopamine composite monofilament layer is woven through a three-comb warp knitting process, and the specific preparation process is as follows:

[0034] Step S1: put the polypropylene wire with a diameter of 0.1-0.2 mm into a tris buffer solution with a concentration of 20 mmol / L, add a dopamine hydrochloride solution with a concentration of 2.8 g / L, and adjust the pH of the solution to 8.0, Stir at a constant speed of 600 rpm / min at room temperature, take it out after 48 hours of reaction, rinse with deionized water and dry to obtain a polypropylene / polydopamine composite monofilament material;

[0035]Step S2: Knit the polypropylene filament with a diameter of 0.1-0.2mm and the polypropylene / p...

Embodiment 3

[0037] A double-layer anti-adhesion polypropylene patch, comprising a polypropylene monofilament layer and a polypropylene / polydopamine composite monofilament layer, the polypropylene monofilament layer is woven through a double-comb warp knitting process, and the polypropylene / poly The dopamine composite monofilament layer is woven through a three-comb warp knitting process, and the specific preparation process is as follows:

[0038] Step S1: Put the polypropylene wire with a diameter of 0.1-0.2 mm into a tris buffer solution with a concentration of 5 mmol / L, add a dopamine hydrochloride solution with a concentration of 1.2 g / L, and adjust the pH of the solution to 8.0, Stir at a constant speed of 300rpm / min at room temperature, take it out after 24 hours of reaction, rinse with deionized water and dry to obtain a polypropylene / polydopamine composite monofilament material; the polypropylene / polydopamine composite monofilament material is added to a deacetylation degree of 89%...

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Abstract

The invention discloses a double-layer anti-adhesion polypropylene patch and a preparation method and application thereof, the double-layer anti-adhesion polypropylene patch comprises a polypropylenemonofilament layer and a polypropylene/polydopamine composite monofilament layer, wherein the polypropylene monofilament layer is knitted by a double-comb warp knitting process, and the polypropylene/polydopamine composite monofilament layer is knitted by a three-comb warp knitting process. The double-layer anti-adhesion polypropylene patch provided by the invention has the advantages of unilateral anti-adhesion, good biocompatibility and infection resistance, can be placed in the peritoneal cavity, can be used as a medical material for repairing abdominal external hernia, and remarkably reduces the incidence of complications such as intestinal adhesion, intestinal obstruction, intestinal fistula and infection.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a double-layer anti-adhesion polypropylene patch and its preparation method and application. Background technique [0002] External abdominal hernia is a disease of abdominal wall defect. For more than 100 years, surgeons have been trying various methods to repair the defect. Traditional hernia repairs destroy normal anatomical structures and have a high recurrence rate after surgery. Since 1986, Professor Lichtenstein of the United States proposed the concept of "tension-free hernia repair", which used a mesh to fill the posterior wall of the inguinal canal, eliminating the influence of traditional surgery on the normal tissue anatomy. There is no tension in the tissue in the operation area, the pain is light, and the recurrence rate is significantly reduced, which greatly promotes the development of hernia surgery and the application innovation of hernia repair materials. [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/06A61L31/14A61F2/00
CPCA61L31/048A61L31/06A61L31/14A61L31/146A61F2/0063C08L23/12C08L79/02
Inventor 王辉吴丁财过文泰杨清云黄榕康胡民辉林燕欢王怀明杨梓锋路婧焦燕罗坚初丽丽王磊吴小剑兰平汪建平
Owner SUN YAT SEN UNIV
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