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A silk fibroin bone nail and a preparing method thereof

A technology of silk protein and bone nails, applied in the field of silk protein bone nails and its preparation, can solve the problems of low breaking strength and easy fatigue of bone nails, and achieve good compatibility and human affinity

Inactive Publication Date: 2017-08-15
杨潮潮
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above, the object of the present invention is to provide a silk protein bone nail and its preparation method, which is used to solve the problems of low fracture strength, brittleness, and fatigue resistance of bone nails in the prior art.

Method used

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  • A silk fibroin bone nail and a preparing method thereof
  • A silk fibroin bone nail and a preparing method thereof
  • A silk fibroin bone nail and a preparing method thereof

Examples

Experimental program
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Embodiment 1

[0039] Such as figure 1 As shown, the present invention provides a kind of preparation method of silk protein-based capsule, and concrete preparation steps are:

[0040] First, step S1 is performed to prepare a silk protein solution.

[0041] The specific method for preparing the silk protein microneedle is:

[0042] 1) Heat the cocoons in sodium carbonate solution to degumming and form silk.

[0043] As an example, the concentration of the sodium carbonate solution is 0-100 g / L, and the mass ratio of the added cocoons to the sodium carbonate solution is 10:(1-100) g / L. The heating method is electric furnace heating or pressure cooker heating, the heating temperature is 50-120°C, the heating pressure is 0.1-1MPa, and the heating time is 1s-1000h. By adjusting the process parameters of the degumming process, the molecular weight of silk protein can be controlled.

[0044] 2) Washing the silk in ultrapure water, repeating several times, and drying.

[0045]As an example, th...

Embodiment 2

[0063] What this embodiment prepares is silk protein bone nail.

[0064] Such as Figure 2 ~ Figure 6 As shown, 1 is a silk protein solution, 2 is anhydrous silk protein, 3 is a hexafluoroisopropanol solution of silk protein, 4 is a silk protein rod, and 5 is a silk protein bone nail body. The specific implementation steps include:

[0065] First execute step S1: figure 2 As indicated, silk protein solution 1 was prepared.

[0066] Specifically, in this embodiment, first, each portion of 10g silkworm cocoon is cut into pieces and placed in 4L of sodium carbonate solution with a concentration of 2g / L, heated to boil in an electric furnace and magnetically stirred at a speed of 200r / min, and the heating time is 0.5h .

[0067] Then, each portion of boiled silk is placed in 2L of ultrapure water, stirred, washed and kneaded dry, repeated 6 times, and then dried, the stirring speed is 200r / min, and the stirring time is 20min. The volume of ultrapure water changed each time is...

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Abstract

A silk fibroin bone nail and a preparing method thereof are provided. The method includes steps of firstly preparing a silk fibroin solution, converting the silk fibroin solution into anhydrous silk fibroin through a freeze-drying process, then dissolving the anhydrous silk fibroin into hexafluoroisopropanol to obtain a hexafluoroisopropanol solution of the silk fibroin, then injecting the hexafluoroisopropanol solution of the silk fibroin into a mold, preparing a silk fibroin rod through methanol treatment and an air drying process, and then cutting the silk fibroin rod into the bone nail. Through adjusting the molecular weight and curing parameters, mechanical performance and the degradation speed of the silk fibroin can be adjusted and controlled to meet different clinical needs. The silk fibroin bone nail having high strength, good brittleness and good human body tissue compatibility can be prepared by the method.

Description

technical field [0001] The invention belongs to the technical field of degradable bone nails and their preparation, and relates to a silk protein bone nail and a preparation method thereof. Background technique [0002] In medicine, bone nails are commonly used bone fixation devices in the bone repair process. Traditional bone nails are made of stainless steel, titanium and their alloy materials. These materials have the advantages of high strength and good toughness. The disadvantage is that after the patient recovers, a second operation is required to take out the metal bone nails, which brings pain to the patient. It is painful for the second time, and the cavity left after the second operation will also leave the patient with a potential risk of fracture. Traditional metal materials for fixing broken bones usually do not degrade, and compared with bones, metal screws have higher mechanical strength, which will cause differences in the force of the bones after a long tim...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/02A61L31/14
CPCA61L31/047A61L31/028A61L31/148
Inventor 王琰顾林娣杨潮潮
Owner 杨潮潮
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