Injectable composite bone cement with photothermal effect as well as preparation method and application thereof

A photothermal effect, bone cement technology, applied in pharmaceutical formulations, medical science, prostheses, etc., can solve the problem of single function of bone cement, and achieve the effect of promoting wound healing, good injectability, and satisfying operation requirements.

Active Publication Date: 2020-04-17
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the commonly used bone cements in clinical practice include polymethyl methacrylate (PMMA), calcium phosphate and calcium sulfate bone cements, etc. These bone cements have single functions and only play the role of support, fixation and filling.

Method used

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  • Injectable composite bone cement with photothermal effect as well as preparation method and application thereof
  • Injectable composite bone cement with photothermal effect as well as preparation method and application thereof
  • Injectable composite bone cement with photothermal effect as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Preparation of mixed powder (bone cement solid phase) of biological glass powder and titanium nitride nanopowder

[0036] Prepare the bone cement solid phase with the following mass percentages of each component: the particle size is 30-40 microns, and the silicate bioactive glass 45S5 (45SiO 2 -24.5Na 2 O-24.5CaO-6P 2 o 5 , wt%) powder 60%, titanium nitride nanometer powder 10%. Put 6g of biological glass powder and 1g of titanium nitride nanometer powder (average particle size is 20nm) in a mortar, grind and mix at room temperature for 3min, and obtain the solid phase of bone cement.

[0037] (2) Preparation of sodium alginate mixed solution (bone cement liquid phase)

[0038]Prepare the bone cement liquid phase with the following mass percentages of the components: 3% sodium alginate, 2% gluconolactone, 3% disodium hydrogen phosphate, and 92% deionized water. Add 3g of sodium alginate, 2g of gluconolactone, and 3g of disodium hydrogen phosphate into 92g of d...

Embodiment 2

[0047] (1) Preparation of mixed powder of biological glass powder and titanium nitride nanopowder

[0048] Prepare the bone cement solid phase with the following mass percentages of each component: the particle size is 20-40 microns, borate bioactive glass (6Na 2 O-8K 2 O-22CaO-8MgO-54B 2 o 3 -2P 2 o 5 , wt%) powder 50%, titanium nitride nano powder 20%. 5 g of borate bioglass powder and 2 g of titanium nitride nano powder (average particle size 20 nm) were placed in a mortar, ground and mixed at room temperature for 5 min to obtain a solid phase of bone cement.

[0049] (2) Preparation of sodium alginate mixed solution

[0050] The mass percentage of each component was prepared as follows bone cement liquid phase: sodium alginate 3%, gluconolactone 4%, disodium hydrogen phosphate 4%, deionized water 89%. Add 3g of sodium alginate, 4g of gluconolactone, and 4g of disodium hydrogen phosphate into 89g of deionized water in sequence, and stir magnetically at room temperatu...

Embodiment 3

[0056] (1) Preparation of mixed powder of biological glass powder and titanium nitride nanopowder

[0057] Prepare the bone cement solid phase with the following mass percentages of each component: the particle size is 50-100 nanometers, and the silicate bioactive glass (30CaO-70SiO 2 , wt%) powder 30%, titanium nitride nano powder 30%. Put 3g of silicate bioglass powder and 3g of titanium nitride nanometer powder (average particle size is 20nm) in a mortar, grind and mix at room temperature for 3min, and obtain the solid phase of composite bone cement.

[0058] (2) Preparation of sodium alginate mixed solution

[0059] Prepare the bone cement liquid phase in mass percent as follows: sodium alginate 4%, gluconolactone 4%, disodium hydrogen phosphate 4%, deionized water 88%. Add 4g of sodium alginate, 4g of gluconolactone, and 4g of disodium hydrogen phosphate into 88g of deionized water in sequence, and stir magnetically at room temperature for 1 hour to make the solution cl...

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Abstract

The invention relates to injectable composite bone cement with photothermal effect as well as a preparation method and application of the injectable composite bone cement. The injectable composite bone cement is prepared from the following components in percentage by weight: 30 to 65 percent of bioglass powder, 5 to 30 percent of titanium nitride nano powder and 30 to 40 percent of a sodium alginate mixed solution. Compared with the prior art, the bone cement disclosed by the invention not only has the characteristics of being moldable and easy to operate, but also has a remarkable photothermal effect, and the photothermal effect of the bone cement can be regulated and controlled by changing the adding amount of the titanium nitride nanoparticles; process equipment for preparing the bone cement is simple, easy to operate and low in cost, good injectability can be obtained without adding a cross-linking agent, and minimally invasive treatment can be realized; the injectable composite bone cement can be used for preparing bone fillers after bone tumor surgical resection, and is applied to the fields of bone repair, regeneration and the like in bone tissue engineering.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to an injectable composite bone cement with photothermal effect and its preparation method and application. Background technique [0002] Bone is a common metastatic site of malignant tumors. In secondary bone tumors, tumor cells release cytokines to activate osteoclasts and lead to osteolysis, resulting in pathological fractures, hypercalcemia, pain, and spinal cord compression complications, which greatly reduce the quality of life of patients. And increased the mortality of bone tumors. At present, the commonly used clinical method is surgical resection of the lesion, supplemented by radiotherapy and chemotherapy. Surgical treatment is prone to recurrence, while chemotherapy and radiotherapy can kill normal cells. Photothermal therapy developed in recent years provides a new therapeutic approach for the treatment of tumors. Photothermal therapy technology is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/46A61L27/58A61L27/50A61L27/54
CPCA61L27/446A61L27/46A61L27/50A61L27/54A61L27/58A61L2300/102A61L2300/412A61L2300/416A61L2400/06C08L5/04
Inventor 姚爱华林健张敏慧
Owner TONGJI UNIV
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