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High-molecular based transmitting tissue regeneration membrane as well as preparation method and application thereof

A polymer-based technology for guiding tissue regeneration, applied in the field of polymer-based guided tissue regeneration film and its preparation, can solve the problems of poor material performance, poor adhesion, poor compatibility, etc., achieve moderate thickness and reduce costs , The effect of degradation performance promotion

Inactive Publication Date: 2017-05-10
BEIJING ALLGENS MEDICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the degradation time will be accelerated after blending racemic polylactic acid (PDLLA), the compatibility between PDLLA and PCL is poor, the adhesion between the two phases is poor, and macroscopic phase separation is easy to occur, resulting in poor performance of the material.

Method used

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  • High-molecular based transmitting tissue regeneration membrane as well as preparation method and application thereof
  • High-molecular based transmitting tissue regeneration membrane as well as preparation method and application thereof
  • High-molecular based transmitting tissue regeneration membrane as well as preparation method and application thereof

Examples

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preparation example Construction

[0044] see figure 1 , is a flowchart of a method for preparing a polymer-based guided tissue regeneration membrane according to a preferred embodiment of the present invention. Such as figure 1 Shown, this preparation method comprises the following steps:

[0045] Step S1, preparation of mineralized collagen, specifically includes:

[0046] Step S1-1, dissolving type I collagen in any one of hydrochloric acid, nitric acid or acetic acid to prepare an acid solution of collagen, wherein the concentration of collagen is 0.01-0.2 g / ml (such as 0.01, 0.05, 0.1 or 0.2 g / ml ml). Wherein the concentration of hydrochloric acid, nitric acid or acetic acid is preferably 0.1-1 mol / L, more preferably 0.5 mol / L.

[0047] Step S1-2, adding calcium salt solution dropwise to the collagen acid solution, wherein the amount of calcium ions added is 0.1-2 mol (eg 0.1, 0.5, 1, 1.5 or 2 mol) of calcium ions per gram of collagen. More preferably, 1-2 mol of calcium ions are added per gram of col...

Embodiment 1

[0078] (1) Dissolving type I collagen in acetic acid with a concentration of 0.1M to form an acid solution of collagen, wherein the concentration of collagen is 0.01g / ml;

[0079] (2) adding a calcium salt solution dropwise to the acid solution of the collagen, wherein the amount of calcium ions added is 1 mol of calcium ions corresponding to each gram of collagen;

[0080] (3) Add phosphoric acid solution dropwise in the solution obtained in step 2, wherein the molar ratio of the amount of phosphate ions added to the amount of calcium ions added in step S1-2 is Ca / P=1.5 / 1;

[0081] (4) NaOH solution is added dropwise in the solution obtained in step 3 to form a mixed solution, and the pH value is adjusted to be 8;

[0082] (5) After the mixed solution obtained in step 4 was left to stand for 4 hours, the precipitate was centrifuged at a speed of 3000 r / min, and then air-dried at 60° C. for 36 hours to obtain powdered mineralized collagen.

[0083] (6) Take by weighing PCL, P...

Embodiment 2 to 22

[0088] Except for the contents of Table 1 below, it was carried out in substantially the same manner as in Example 1. Table 2 shows the contact angle, tensile strength and suture tensile strength of the polymer-based guided tissue regeneration membranes of Examples 1-4 and 19-20.

[0089]

[0090]

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Abstract

The invention relates to a high-molecular based transmitting tissue regeneration membrane as well as a preparation method and application thereof, wherein the high-molecular based transmitting tissue regeneration membrane is formed by compounding a high-molecular polymer and mineralized collagen; the high-molecular polymer comprises polycaprolactone and poly-dl-lactide in a mass ratio of (2 to 1) to (9 to 1); and the mineralized collagen is formed by compounding I type collagen and nano-hydroxyapatite in a mass ratio being (1 to 9) to (1 to 3). According to the high-molecular based transmitting tissue regeneration membrane, a high-molecular material which is relatively good in biocompatibility and is controllable in degrading speed is compounded with mineralized hydroxyapatite to form a membrane, wherein one surface of the membrane is smooth and the other surface of the membrane is crude; dental bone powder can be replaced to certain extent to treat periodontal defects; and the regeneration membrane is high in stretching strength, is high in suture-resistant tensile strength and can meet clinical needs.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a polymer-based guided tissue regeneration membrane, a preparation method and application thereof. Background technique [0002] Guided Tissue Regeneration (GTR) is a new technology developed in the late 1980s and early 1990s. It is a method often used in oral clinical practice to treat bone defects and obtain periodontal tissue regeneration. Its principle It uses the physical barrier function of the membrane to isolate the lesion area from the surrounding tissue, creating a relatively closed tissue environment, so that the regenerative function of the specific tissue can be maximized. [0003] GTR film can be divided into absorbable film and non-absorbable film according to whether the film material is absorbed and degraded in the body. The nonabsorbable membrane continues to function as a mechanical barrier in vivo, allowing sufficient time for the regeneration of target ti...

Claims

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Application Information

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IPC IPC(8): A61L31/14A61L31/06A61L31/02A61L31/16A61L31/04
CPCA61L31/028A61L31/044A61L31/06A61L31/14A61L31/148A61L31/16A61L2300/252A61L2300/412C08L89/00C08L67/04
Inventor 胡艳丽宋天喜仇志烨张华崔菡崔福斋
Owner BEIJING ALLGENS MEDICAL SCI & TECH
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