A kind of hemostatic material and preparation method thereof

Abstract

The invention belongs to the field of medical hemostatic materials, in particular to a hemostatic material and a preparation method thereof. The hemostatic material includes the following raw materials in parts by weight: carboxymethyl chitosan 0.1-1.5, polyvinyl alcohol (PVA) 0.5-2, compound toughening material (hereinafter also referred to as: plasticizing system) 0.2-5 , 0.5-1.5 parts of ionic cross-linking agent, and the hemostatic material may also include 0.5-3 parts by weight of a broad-spectrum hemostatic antibacterial agent. The product of the invention has good mechanical elasticity, rapid hemostasis, complete degradation, non-toxicity, and strong antibacterial property; it is suitable for wound hemostasis, preferably for body cavity hemostasis, especially for nasal cavity hemostasis.

Description

technical field [0001] The invention belongs to the field of medical hemostatic materials, in particular to a hemostatic material and a preparation method thereof. Background technique [0002] Chitosan is a polymer polysaccharide formed after chitin is hydrolyzed to remove part or all of its acetic acid groups under alkaline conditions. Its chemical name is poly(1,4)-2-amino-2-deoxy- β-D-glucose, the structural formula is as follows: [0003] [0004] The structure of the chitosan molecule itself is very complex, with many ionic primary amino groups, which can easily undergo chemical reactions and react with acids to form salts. Therefore, a series of amino reactions can be carried out; at the same time, chitosan and other polysaccharides Similarly, there are reactive hydroxyl groups available in its structure, so it can also be derivatized. Various derivatives of chitosan have different physical and chemical properties and functions due to the difference in molecular ...

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Problems solved by technology

[0011] But it also has defects: ①The main component is polyurethane, and its final degradation product is humic acid, commonly known as "corpse poison"

As a result, the product can only be retained in a small amount and needs to be excreted from the body in a short time, so it can only act on the human pipeline system in a short time, such as the body cavity, reproductive tract and other parts

②The polyurethane component does not have hemostatic properties, and can only rely on mechanical elastic compression, so the hemostatic effect is general; ③The material itself has no antibacterial properties

[0013] But it also has defects: 1. the pressure caused by volume expansion after the product absorbs body fluid is limited, and there is a possibility of failure of packing to stop bleeding, and its packing success rate is not as good as that of traditional packing materials such as vaseline packing strips; 2. its raw material polyvinyl alcohol (PVA ) itself has no hemostatic and anti-inflammatory effects, so the performance of the material in terms of anti-inflammatory and sterilization needs to be improved; ③In clinical operations, if multiple parts of this material are filled into the body cavity, it is not easy to take out part of the filled multiple parts of the material, The other part remains in the body cavity, and the filling pressure cannot be selected according to the actual situation of the patient

[0015] However, it also has disadvantages: ① There are certain requirements for the wound surface, and it is suitable for narrow and deep wounds. If the wound surface is too large, an effective hemostatic interface cannot be formed; ② The packing pressure is very limited, and effective packing must be combined with Vaseline gauze or expansion sponge use

[0016] At present, the hemostatic materials with excellent performance, especially the body cavity filling materials are mainly expensive foreign products, and the performance of domestic related products is generally poor

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