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3D printing artificial biodegradable cerebral dura mater and preparation method thereof

A 3D printing, dura mater technology, applied in tissue regeneration, coating, medical science and other directions, can solve the problems of 3D printing blank, achieve the effect of small tissue reaction, adjustable degradation rate, and promote wound healing

Inactive Publication Date: 2019-07-02
SHANDONG JIANZHU UNIV
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of 3D printing in artificial dura mater is still relatively blank.

Method used

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Experimental program
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Effect test

Embodiment 1

[0028] Step 1: Prepare the base

[0029] Weigh polyhydroxybutyrate, polycaprolactone nanofibers, dibenzoyl peroxide, and acetone into the reaction kettle, fill it with nitrogen for protection, raise the temperature to 40°C, and pressure 0.4Mpa, react for 2.5 hours, and the reaction is complete. The product is separated by centrifugation to obtain the base copolymer. The dura mater matrix is ​​printed based on the patient's CT data.

[0030] The second step: preparation of bacterial cellulose / polylactic acid composite membrane

[0031] 1) Dissolve polylactic acid (PLA) in a composite solvent [V (chloroform): V (ethanol) = 17:5] to obtain a PLA solution with a mass fraction of 15%. Using an electrospinning apparatus to spin the membrane at 20kV and 45°C, the amount of PLA solution was 5.0mL, and the spinning speed was 0.15mm / s to prepare a PLA membrane with a diameter of 0.5mm;

[0032] 2) Acetobacter xylinum stored at 4°C was inoculated on the plate medium, and cultured at c...

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Abstract

The invention belongs to the technical field of bio-based materials, and especially relates to a 3D printing artificial biodegradable cerebral dura mater and a preparation method thereof. The invention provides a three-layer composite structure cerebral dura mater repair material, an artificially synthesized degradable material is utilized as a base material, a bacterial cellulose / . polylactic acid composite membrane is used as a reinforcing layer, a collagen sponge membrane layer is used as a biological membrane, an internal structure of the artificial cerebral dura mater prepared by a 3D printing technique is highly similar to human meninges, and the artificial cerebral dura mater can be directly attached to damaged meninges of a patient to achieve the effect of stitching a wound. Compared with a traditional method, the 3D printing artificial biodegradable cerebral dura mater and the preparation method thereof are more beneficial to growth of dura mater cells, enable the probabilityof adhesion to calvarium skull, and provide a powerful guarantee for repair of the cerebral dura mater and prevention of occurrence of epilepsy.

Description

technical field [0001] The invention belongs to the technical field of bio-based materials, in particular to a 3D printed artificial biodegradable dura mater and a preparation method thereof. Background technique [0002] The dura mater is a thick and tough double-membrane tissue between the skull and brain tissue. It plays an important role in protecting brain tissue, preventing cerebrospinal fluid leakage, intracranial infection, encephalocele, epilepsy and other complications , is an important barrier to protect brain tissue. The dura mater is very likely to be damaged during trauma, tumor erosion, or intracranial surgery. At this time, it is necessary to apply repair materials for dural defects to ensure the integrity of the anatomical structure of the dura mater. According to research data, 10% to 30% of brain surgeries require dural repair. [0003] Collagen is the fibrin component of animal connective tissue and intercellular matrix. It is prepared from bovine Achi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/34A61L27/58A61L27/50
CPCA61L27/34A61L27/50A61L27/58A61L2430/00C08L89/00C08L1/00C08L67/04
Inventor 徐淑波刘建营王瀚林孙星任国成景财年
Owner SHANDONG JIANZHU UNIV
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