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Degradable biphase ceramics bone frame with high-strength and phosphate cement containing strontium and the preparing method

A technology of strontium calcium phosphate and bone scaffolds, which is applied in the preparation of high-strength degradable strontium-containing calcium phosphate dual-phase ceramic bone scaffolds, and the field of preparation of strontium-containing calcium phosphate dual-phase ceramic bone scaffolds, can solve the problems of no more than 5MPa, and achieve Effects of controllable pore structure, variable phase composition, and adjustable degradation rate

Inactive Publication Date: 2007-09-26
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

Based on this idea, we have used calcium-deficient strontium-doped strontium apatite bone cement as raw material, applied the foam template impregnation principle, and obtained a degradable foam-like strontium-doped calcium phosphate dual-phase ceramic bone scaffold by sintering method. The improved process of "secondary sintering" has obviously improved the strength of the bone scaffold (Guo Dagang et al., Preparation process of degradable foam-like strontium-doped calcium phosphate ceramic bone scaffold material, Chinese invention patent, CN1762897A), but the disadvantage is that the strength still does not exceed 5MPa

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Ca 4 (PO 4 ) 2 O. SrHPO 4 , CaHPO 4 The powders are mixed according to the molar ratio of 2:1.5:0.5 to prepare the strontium-containing calcium phosphate bone cement solid phase powder. Weigh 1.379g of the powder with a 50ml small beaker, then mix it with 0.7ml of dilute phosphoric acid solidification solution with a concentration of 0.75mol / L, and mix with a medicine spoon for 30s to form a uniform strontium-containing calcium phosphate bone cement slurry. Using rapid printing and forming RP technology, using photosensitive resin as the negative mold material, and according to the printing principle, an inner hollow cylinder negative mold with a height of 17mm, an outer diameter of Φ11mm, and a wall thickness of 0.5mm was prepared. The strontium-containing calcium phosphate bone cement slurry is injected into the negative mold, and the negative mold is continuously vibrated to eliminate the air bubbles mixed in the bone cement slurry during pouring, so that the bon...

Embodiment 2

[0023] Ca 4 (PO 4 ) 2 O. SrHPO 4 , CaHPO 4 The powders are mixed according to the molar ratio of 2:1.5:0.5 to prepare the strontium-containing calcium phosphate bone cement solid phase powder. Weigh 1.379g of the powder with a 50ml small beaker, then mix it with 0.7ml of dilute phosphoric acid solidification solution with a concentration of 0.75mol / L, and mix with a medicine spoon for 30s to form a uniform strontium-containing calcium phosphate bone cement slurry. Using rapid printing and forming RP technology, using photosensitive resin as the negative mold material, according to the printing principle, the height is 17mm, the outer diameter is Φ11mm, the wall thickness is 0.5mm, the internal skeleton diameter is 600μm, the pore diameter is 800μm, and the porosity is 30%. porous negative mold. The strontium-containing calcium phosphate bone cement slurry is injected into the negative mold, and the negative mold is continuously vibrated to eliminate the air bubbles mixed ...

Embodiment 3

[0026] Ca 4 (PO 4 ) 2 O. SrHPO 4 , CaHPO 4 The powders are mixed according to the molar ratio of 2:1.5:0.5 to prepare the strontium-containing calcium phosphate bone cement solid phase powder. Weigh 1.5486g of the powder with a 50ml small beaker, then mix it with 0.6ml of dilute phosphoric acid solidification solution with a concentration of 0.40mol / L, and mix with a medicine spoon for 30s to form a uniform strontium-containing calcium phosphate bone cement slurry. Using rapid printing and forming RP technology, using photosensitive resin as the negative mold material, and according to the printing principle, an inner hollow cylinder negative mold with a height of 17mm, an outer diameter of Φ11mm, and a wall thickness of 0.5mm was prepared. The strontium-containing calcium phosphate bone cement slurry is injected into the negative mold, and the negative mold is continuously vibrated to eliminate the air bubbles mixed in the bone cement slurry during pouring, so that the bo...

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Abstract

The invention discloses a high-strength degradable strontium phosphate dual-phase ceramic bone skeleton and relative preparation, wherein the initial material is calciprivia fermorite bone cement, whose solid phase powder is the mixture of Ca4(PO4)2O, SrHPO4, CaHPO4, and the liquid phase is 0.1mol / L-1mol / L H3PO4 water solution. The invention uses skeleton structure to controllably quickly print and shape RP optical sensitive resin as concave mold, to irrigate slurry, solidify, and thermally remove mold and following sinter to obtain the strontium phosphate dual-phase ceramic bone support with adjustable phases. The total porous rate of skeleton is 42.5-75%, the size of macro hole is 300mum-600mum, the volume of macro hole is 0-50%, the size of micro hole is 2-10mum, and the compression strength is 3.15MPa-21.53MPa, with wide application.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a preparation method of a high-strength degradable strontium-containing calcium phosphate biphasic ceramic bone scaffold, in particular to a controllable degradation rate and adjustable pore structure suitable for bone tissue engineering of the load-bearing parts of the human body The preparation method of the applied strontium-containing calcium phosphate biphasic ceramic bone scaffold. Background technique [0002] Bone tissue engineering provides a new idea for the permanent repair of human bone defects. However, the development of a bone tissue engineering scaffold material with good comprehensive properties is one of the key factors to determine the success of its final clinical repair operation. Studies have shown that bone tissue engineering scaffold materials must meet the following conditions: (1) good biocompatibility; (2) moderate biodegradability, the degradation ra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/42A61F2/28
Inventor 郭大刚徐可为憨勇
Owner XI AN JIAOTONG UNIV
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