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Calcium polyphosphate/calcium sulfate complex phase biologic ceramic material and preparation method thereof

A bioceramic material, calcium polyphosphate technology, applied in medical science, prosthesis, etc., can solve the problems of differences in degradation rates, great influence on the degradation rate of calcium polyphosphate, and inability to match the growth rate of new bone

Inactive Publication Date: 2012-06-27
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, their degradation rates in the body are significantly different: calcium sulfate degrades faster in the human body, and often cannot match the growth rate of new bone at the repair site; while the degradation rate of calcium polyphosphate is greatly affected by the crystal form

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1: Calcium sulfate and amorphous calcium polyphosphate powder were weighed according to the volume content of calcium sulfate as 5%, the Ca / P ratio was 0.54, and absolute ethanol was used as the medium, and the mixture was ball-milled for 2 hours. The mixed slurry was dried at 60°C, granulated with polyvinyl alcohol solution, and passed through a 40-mesh sieve. The granulated material was dry-pressed under a pressure of 100 MPa, calcined at 550° C. for 8 hours, and cooled with the furnace. The obtained multiphase ceramic is composed of calcium sulfate and amorphous calcium polyphosphate, and the bulk density is 1.86 g / cm 3 , the apparent porosity is 31%. The weight loss was 0.5% in 5 days of degradation in simulated body fluids.

Embodiment 2

[0013] Example 2: Calcium sulfate and amorphous calcium polyphosphate powder were weighed according to the volume content of calcium sulfate as 25%, the Ca / P ratio was 0.72, and absolute ethanol was used as the medium, and the mixture was ball-milled for 2 hours. The mixed slurry was dried at 70°C, granulated with polyvinyl alcohol solution, and passed through a 60-mesh sieve. The granulated material is dry-pressed under a pressure of 150MPa, calcined at 600°C for 2 hours, and cooled with the furnace. The obtained multiphase ceramic is composed of calcium sulfate and β-type calcium polyphosphate, and the bulk density is 1.87 g / cm 3 , the apparent porosity is 35%. Degraded in simulated body fluids for 5 days with a weight loss of 4%

Embodiment 3

[0014] Example 3: Calcium sulfate and amorphous calcium polyphosphate powder were weighed according to the volume content of calcium sulfate as 35%, the Ca / P ratio was 0.86, and absolute ethanol was used as the medium, and the mixture was ball-milled for 2 hours. The mixed slurry was dried at 80°C, granulated with polyvinyl alcohol solution, and passed through a 50-mesh sieve. The granulated material was dry-pressed at 200MPa, calcined at 650°C for 4 hours, and cooled with the furnace. The obtained multiphase ceramic is composed of calcium sulfate and β-type calcium polyphosphate, and the bulk density is 1.79 g / cm 3 , the apparent porosity is 34%. 9% weight loss in 5 days of degradation in simulated body fluids

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Abstract

The invention relates to a calcium polyphosphate / calcium sulfate complex phase biologic ceramic material and a preparation method thereof. The main phase of the ceramic material consists of calcium sulfate and amorphous calcium polyphosphate or beta calcium polyphosphate. The preparation method comprising the following steps of: selecting the calcium sulfate and amorphous calcium polyphosphate as ingredients, wherein the content of the calcium sulfate is 5 to 45 volume percent; weighing calcium sulfate and amorphous calcium polyphosphate according to a proportion, mixing the materials uniformly, using absolute ethyl alcohol as the medium, ball milling and mixing the materials to slurry materials, drying the mixed slurry materials at 60 to 80 DEG C, pelleting the dried powder by polyving alcohol solution and passing a 40-60 mesh screen, and then dry pressing and forming, wherein the forming pressure is 100 to 200 MPa; calcining a formed sample at 550 to 700 DEG C, keeping the temperature for 2 to 8 hours and then furnace cooling the sample. The method disclosed by the invention composes the calcium polyphosphate and calcium sulfate and ensures the aim of regulating degradation rate possibly in the degradation process of the complex phase ceramics through regulating Ca / P rate. The biologic ceramic can be used as a bone to replace repairing materials.

Description

technical field [0001] The invention belongs to the field of bioceramic materials. In particular, it relates to a calcium polyphosphate / calcium sulfate composite bioceramic material and a preparation method thereof. Background technique [0002] Calcium sulfate (CaSO 4 ) and various crystal forms of calcium polyphosphate (CPP) can be used as bone replacement repair materials, they have good biocompatibility, osteoconductivity and biodegradability. However, their degradation rates in vivo are significantly different: calcium sulfate degrades faster in the human body and often cannot match the growth rate of new bone at the repair site; while the degradation rate of calcium polyphosphate is greatly affected by the crystal form. SUMMARY OF THE INVENTION [0003] The purpose of the present invention is to prepare a novel composite bioceramic material, which can be used for bone repair. [0004] The technology of the present invention is as follows: [0005] A calcium polyp...

Claims

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Application Information

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IPC IPC(8): A61L27/10A61L27/56C04B35/447C04B35/622
Inventor 杨德安辛玉王颖娟杨帆
Owner TIANJIN UNIV
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