Compound osseous tissue engineering stephanoporate stent material and preparation thereof

Abstract

The invention discloses a porous support material in the tissue engineering of konjac glucan-mannan / hydroxyapatite / chitosan combined bone, and a preparation thereof, pertaining to the technical field of bioengineering materials. Degradable biomaterials with good biocompatibility, such as konjac glucan-mannan, hydroxyapatite and chitosan, are adopted as basic raw materials and respectively prepared into konjac glucan-mannan solution and hydroxyapatite / chitosan composite powder suspension which are then mixed to prepare mixture gel. After aging, alkali elimination, freeze-drying of the mixturegel, the degradable porous support with regenerated and reparative konjac glucan-mannan / hydroxyapatite / chitosan combined bone tissues. Not only does the support material have simple preparation technology and low cost, but also the prepared degradable porous support has good compatibility with trauma parts. Cell tests and animal tests show that the support can be universally used in vivo (bone defect diseased region, etc.) and is multifunctional and antibacterial composite material with adjustable degradation rate in vivo and can promote and induce the repair of the bone defect.

Description

technical field [0001] The invention relates to a bioengineering material and a preparation method thereof, in particular to a degradable porous scaffold for bone tissue repair and regeneration, which belongs to the technical field of bioengineering materials. Background technique [0002] In the past half century, bone tissue repair has been proposed despite various repair approaches, including the use of tissue engineering products [Langer R, et al. Science, 1993; 260:920-926], gene therapy [Mulligan RC, et al .Science, 1993; 260-932] et al. However, at present, the commonly used clinical methods are still based on autologous bone transplantation, allogeneic bone transplantation and the use of metals, ceramics, polymethyl methacrylate and other alternative materials, of which the use of autologous bone or allogeneic bone accounts for more than 70%; Cause new local lesions to the patient and the source is limited. Allogeneic bone has the possibility of spreading the diseas...

AI Technical Summary

Problems solved by technology

However, at present, the commonly used clinical methods are still based on autologous bone transplantation, allogeneic bone transplantation and the use of metals, ceramics, polymethyl methacrylate and other alternative materials, of which the use of autologous bone or allogeneic bone accounts for more than 70%; Cause new local lesions to the patient and the source is limited. Allogeneic bone has the possibility of spreading the disease and taking it as a reflection. Alternative materials such as metal, ceramics, and polymethyl methacrylate are foreign bodies that cannot be replaced by the body's own tissues. Complications such as fatigue and fracture

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