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An encircling fracture internal fixation device and its preparation method

A fixed device, embracing technology, applied in medical science, surgery, etc., can solve the problems of non-degradable metal materials, non-degradable, and inconvenience for patients, achieve excellent biocompatibility, reduce pain and inflammation, and accelerate clinical healing Effect

Active Publication Date: 2019-11-12
SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it also has the following disadvantages: First, the metal material is not degradable, and long-term implantation in the human body brings inconvenience to the patient's life, and there is a risk of infection, which requires a second surgery to remove it; Causes artifacts, which is not conducive to the medical observation of the fracture site and internal organs of the chest
The embracing device made of this kind of polymer material has poor mechanical properties and fixation performance, and it is difficult to meet clinical needs
[0006] It can be seen from the above that the existing metal alloys and degradable polymers cannot well meet the requirements of fracture repair. Metal alloys have poor mechanical compatibility and biocompatibility, are easily corroded and non-degradable, and require secondary surgery. or image development under nuclear magnetic resonance or cause artifacts; and the polymer materials currently used generally have problems of insufficient mechanical strength and poor fixation performance

Method used

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  • An encircling fracture internal fixation device and its preparation method
  • An encircling fracture internal fixation device and its preparation method
  • An encircling fracture internal fixation device and its preparation method

Examples

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preparation example Construction

[0060] The preparation method of the embracing fracture internal fixation device of the present invention can be a conventional processing and molding method in the polymer field, including but not limited to injection molding, injection molding-laser cutting molding, hot pressing-laser cutting molding, extrusion molding, extrusion- Laser cutting molding, etc.

[0061] For the processing and molding of cross-linked polymers, the cross-linking reaction of the polymer can occur during processing or after processing. The crosslinking reaction adopts crosslinking methods such as ultraviolet irradiation crosslinking or thermal polymerization.

[0062] Optionally, during the processing and molding process, an orientation force is applied to the polymer melt to orient the molecules of the degradable polymer material, so that the obtained polymer has higher mechanical properties; or the device is heated and stretched after molding The copolymer molecules are oriented at a temperature...

Embodiment 1

[0066] Preparation of linear degradable polymer embracing fracture internal fixation device with shape memory function

[0067] (1) Synthesis of degradable polymers

[0068] The reaction kettle was vacuum-dried at 60°C for 1 hour, and L-lactide (L-lactide) was added to the reaction kettle under nitrogen protection, vacuum-dried for 1 hour, and then 1,4-butanediol (M / I = 54.9), 100ppm of stannous octoate, heated to 140°C for 10h through ring-opening polymerization to synthesize polylactic acid PLLA-diol with terminal hydroxyl groups, dissolved the obtained solid in dichloromethane, filtered through anhydrous ethanol precipitation, and vacuum-dried. The final product was obtained with a number average molecular weight of about 8000.

[0069] The reaction kettle was vacuum-dried at 60°C for 1 hour, caprolactone was added to the reaction kettle under nitrogen protection, and vacuum-dried for 1 hour, then 1,4-butanediol (M / I=69.3), 100ppm octanoic acid sulfide Tin, heat up to 120...

Embodiment 2

[0076] Preparation of cross-linked degradable polymer embracing fracture internal fixation device with shape memory function

[0077] (1) Synthesis of degradable polymer prepolymer

[0078] Reactor was vacuum-dried at 60°C for 1 hour, and L-lactide (L-lactide), glycolide (glycolide) and initiator trimethylolpropane (TMP) were added to the reactor under nitrogen protection (lactide) The lactide / glycolide molar ratio is 90 / 10, the weight ratio of TMP to monomer lactide and glycolide is 0.9%), and vacuum-dried at 60° C. for 1 hour. Then add stannous octoate (100ppm, weight sum of monomer lactide and glycolide and initiator), heat up to 145°C and react for 3 hours to obtain star-shaped polylactic acid prepolymer PLGA90 / 10, with a number average molecular weight of 15,000 . Then add methacryloyl chloride (-COCl and -OH molar ratio is 1:1), free radical inhibitor p-hydroxyanisole (4-Methoxyphenol) 300ppm (monomer lactide and glycolide and initiator weight and ) and 1wt% (monomer ...

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Abstract

The invention discloses an encircling-type fracture internal fixation device and a making method. The encircling-type fracture internal fixation device is made of a degradable polymer with a shape memory characteristic and comprises a center ridge beam plate and lateral encircling claws; the lateral encircling claws are arranged on the two sides of the center ridge beam plate and integrally formed with the center ridge beam plate, and the degradable polymer is one or a combination of a linear polymer and a crosslinked polymer. The encircling-type fracture internal fixation device has the shape memory function and is integrally formed by the degradable polymer with the shape memory function, the degradable polymer replaces an existing memory alloy or degradable polymer material and can rapidly restore to an initial shape when heated, the degradable polymer has a continuous self-pressurization function at body temperature, is high in fit degree with a fracture part and has excellent biocompatibility, degradation controllability and high mechanical strength, and the influence on observation and treatment of other organs is avoided.

Description

technical field [0001] The invention relates to an embracing fracture internal fixation device and a preparation method thereof, in particular to an embracing device and a preparation method thereof. Background technique [0002] Fractures of ribs, radius, and clavicles caused by traumatic accidents or surgical operations are very common in clinical practice. If they cannot be treated in a timely and effective manner, they may cause pain, deformity and other risks, and even affect the physiological functions of other organs. [0003] At present, the use of internal fixation instruments for surgical internal fixation has become a trend. There are many kinds of internal fixators commonly used, such as steel wire, Kirschner wire, thin steel plate, embracing device, etc., and the materials used are all metal materials. [0004] Chinese patent documents CN101669839A and CN201379638Y disclose shape memory alloy bone plates. This shape memory alloy embracing device has a unique m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/14A61L31/06
Inventor 候娟姜闻博姜洪焱康亚红罗七一
Owner SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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