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Composite multilayer and porous scaffold and preparation method thereof

A porous scaffold and artificial synthesis technology, applied in the field of biomedical artificial bone graft materials, can solve the problems of brittleness, insufficient toughness, insufficient mechanical strength, etc., and achieve the effects of wide source of raw materials, low cost, and promotion of bone growth.

Inactive Publication Date: 2017-09-08
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But its disadvantage is that the mechanical strength is not enough, the quality is brittle, and the toughness is not enough.

Method used

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  • Composite multilayer and porous scaffold and preparation method thereof
  • Composite multilayer and porous scaffold and preparation method thereof
  • Composite multilayer and porous scaffold and preparation method thereof

Examples

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Embodiment 1

[0036] In this embodiment, a composite multilayer porous scaffold is formed by compounding konjac glucomannan, polycaprolactone and hydroxyapatite whiskers, and konjac glucomannan / polycaprolactone / hydroxyapatite whiskers The chemical materials used in the preparation of composite multilayer porous scaffolds are: konjac glucomannan, polycaprolactone, methylene chloride, hydroxyapatite whiskers, deionized water, glycerol, lactic acid, methanol, mass fraction 25 % ammoniacal liquor, dehydrated alcohol, its preparation consumption is as follows:

[0037]

[0038] The preparation method of the present embodiment konjac glucomannan / polycaprolactone / hydroxyapatite whisker composite multilayer porous support specifically comprises the following steps:

[0039] (1) Add 1.2mL of glycerin and 1.8mL of lactic acid to 400mL of deionized water and mix them evenly to obtain a solvent, then add 5g of konjac glucomannan KGM to the solvent with a stirring speed of 500 rpm, konjac glucomannan...

Embodiment 2

[0052] This embodiment is a composite multilayer porous scaffold, which is composed of konjac glucomannan, polylactic acid and hydroxyapatite whiskers, konjac glucomannan / polylactic acid / hydroxyapatite whiskers composite multilayer porous The chemical materials used in the preparation of the scaffold are: konjac glucomannan, polylactic acid, methylene chloride, hydroxyapatite whiskers, deionized water, glycerol, lactic acid, methanol, ammonia water with a mass fraction of 25%, anhydrous Ethanol, its preparation consumption is as follows:

[0053]

[0054] The preparation method of the konjac glucomannan / polylactic acid / hydroxyapatite whisker composite multilayer porous scaffold in this embodiment specifically includes the following steps:

[0055] (1) Add 1.2mL of glycerin and 1.8mL of lactic acid to 400mL of deionized water and mix them evenly to obtain a solvent, then add 4g of konjac glucomannan KGM to the solvent with a stirring speed of 500 rpm, konjac glucomannan Add...

Embodiment 3

[0066]This embodiment is a composite multi-layer porous scaffold, which is composed of konjac glucomannan, polyether ether ketone, and hydroxyapatite whiskers, konjac glucomannan / polyether ether ketone / hydroxyapatite whiskers The chemical materials used in the preparation of composite multilayer porous scaffolds are: konjac glucomannan, polyether ether ketone, dichloromethane, hydroxyapatite whiskers, deionized water, glycerol, lactic acid, methanol, mass fraction 25 % ammoniacal liquor, dehydrated alcohol, its preparation consumption is as follows:

[0067]

[0068] The preparation method of the present embodiment konjac glucomannan / polyether ether ketone / hydroxyapatite whisker composite multilayer porous support specifically comprises the following steps:

[0069] (1) Add 1.2mL of glycerin and 1.8mL of lactic acid to 400mL of deionized water and mix them evenly to obtain a solvent, then add 4g of konjac glucomannan KGM to the solvent with a stirring speed of 500 rpm, konj...

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Abstract

The invention discloses a composite multilayer and porous scaffold and a preparation method of the scaffold. The konjac glucomannan / artificially synthesized high polymer / hydroxyapatite whisker composite multilayer and porous scaffold is prepared by taking konjac glucomannan, an artificially synthesized high polymer and a hydroxyapatite whisker as raw materials, performing film formation in a layer-by-layer composite superposition manner via flow casting and freezing technologies, and finally performing technologies of freeze-drying, cross linking, cleaning and the like. The method is simple in technology, convenient to operate and stable in yield; the prepared multilayer and porous composite scaffold has the characteristics of good biocompatibility, stability, appropriate aperture and the like; since the scaffold is crosswise composited in a layer-by-layer manner by a konjac glucomannan film, and an artificially synthesized high polymer / hydroxyapatite whisker film; the films of different layers have different ingredients and different degradation rates; further, the degradation rates can be regulated to be matched with a growth rate of a new bone; and therefore, the scaffold has good application prospects in an aspect of cartilaginous tissue implantation.

Description

technical field [0001] The invention relates to a composite multi-layer porous support and a preparation method thereof, belonging to the technical application field of biomedical artificial bone graft materials. Background technique [0002] The earliest research materials for tissue engineering were natural materials. As time went by, scientists further studied the combination of natural materials and synthetic materials, and the hybrid cross-linking of synthetic materials and biological materials. At the same time, people also synthesized natural-like materials. Materials, that is, bionic materials, but these materials cannot meet the needs of tissue engineering due to various defects. The degradation rate, biocompatibility, physical and chemical properties, toxicity, biological activity, and scaffold preparation methods and processes of materials must meet specific tissue requirements, especially biocompatibility is the key to material selection, because tissue engineeri...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/20A61L27/18A61L27/12A61L27/56A61L27/58A61L27/50
CPCA61L27/12A61L27/18A61L27/20A61L27/50A61L27/56A61L27/58A61L2430/02C08L5/00C08L67/04C08L71/00C08L71/02C08L5/08
Inventor 颜廷亭秦晓素陈庆华
Owner KUNMING UNIV OF SCI & TECH
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