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Medical degradable polyester asymmetric membrane and preparation method thereof

A technology for degrading polyester and asymmetric membranes, applied in medical science, surgery, etc., can solve the problems of high production cost, easy mutual peeling, low connectivity rate between pores, etc., and achieves short production cycle, low production cost, and simple process. easy effect

Inactive Publication Date: 2010-05-12
CHENGDU MAIDIMEI SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the deficiencies in the existing medical degradable polyester asymmetric membrane, the purpose of the present invention is to provide a new degradable polyester asymmetric membrane and its preparation method to solve the problem of the prior art electrospinning method. The dense layer and the porous layer of the barrier film are relatively independent, the strength is not high, they are easy to peel off each other, and the production cost is high. It can also solve the problems of the degradable polyester asymmetric film prepared by the prior art impregnation / precipitation method. Small pore size, low connectivity between pores, etc.

Method used

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  • Medical degradable polyester asymmetric membrane and preparation method thereof
  • Medical degradable polyester asymmetric membrane and preparation method thereof
  • Medical degradable polyester asymmetric membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Dissolve 0.1 g of L-polylactic acid PLLA with a number average molecular weight of 500,000 in 10 ml of methylene chloride to form a polymer solution. Weigh 0.5g of sodium carbonate (50-300μm) and mix it with the prepared polymer solution. After stirring evenly, perform ultrasonic defoaming treatment (1000Hz, 5min), and pour the solution into a polytetrafluoroethylene mold (4cm×8cm×0.5cm ), then sink the mold into a container containing 0.1N hydrochloric acid solution, keep it at about 4°C for about 1 hour, remove the mold in water, take out the film, rinse with running water, soak the film in distilled water until silver nitrate detects that there is no precipitation in the water, Freeze-dry to obtain PLLA asymmetric barrier membrane.

[0025] According to the scanning electron microscope, the average thickness of the film is 0.45mm, and the dense layer has micropores with a pore size of 0.5-5μm; the porous layer has a pore size of 50-300μm, and the pores are connected ...

Embodiment 2

[0027] Dissolve 2.5 g of D, L-type polylactic acid PDLLA with a number average molecular weight of 50,000 in 10 ml of chloroform to form a polymer solution. Weigh 10g of ammonium bicarbonate (50-600μm) and mix it with the prepared polymer solution. After stirring evenly, perform ultrasonic defoaming treatment (500Hz, 10min), and pour the solution into a polytetrafluoroethylene mold (4cm×8cm×0.5cm ), then submerge the mold into a container filled with distilled water, keep it at about 100°C for about 12 minutes, remove the mold in water, take out the film, rinse with running water, soak the film in distilled water until neutral, and freeze-dry to obtain the PDLLA asymmetric barrier film.

[0028] According to the scanning electron microscope, the average thickness of the membrane is 0.6mm, and the dense layer has micropores with a pore diameter of 0.5-5μm; the porous layer has a pore diameter of 50-600μm, and the pores are connected to each other; the membrane is soft and can be...

Embodiment 3

[0030] 1.0 g of PGA with a number average molecular weight of 100,000 was dissolved in 10 ml of N,N-dimethylformamide to form a polymer solution. Weigh 5g of ammonium carbonate (50-600μm) and mix it with the prepared polymer solution. After stirring evenly, perform ultrasonic defoaming treatment (1000Hz, 3min), and pour the solution into a polytetrafluoroethylene mold (4cm×8cm×0.5cm) Then submerge the mold into a container filled with distilled water, keep it at about 75°C for about 15 minutes, remove the mold in water, take out the film, rinse with running water, soak the film in distilled water until neutral, and freeze-dry to obtain the PGA asymmetric barrier film .

[0031] According to the scanning electron microscope, the average thickness of the film is 0.5mm. The dense layer has micropores with a pore size of 0.5-5μm; the porous layer has a pore size of 50-600μm, and the pores are connected to each other; The elongation rate is 5-8%, and the shape remains unchanged fo...

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Abstract

The invention discloses a medical degradable polyester asymmetric membrane and a preparation method thereof. The asymmetric membrane uses degradable polyester as a membrane material, one surface of the asymmetric membrane is a compact layer, the other surface of the asymmetric membrane is a porous layer, the compact layer and the porous layer are molded integrally once, the aperture of micropores in the compact layer is 0.5 to 5 mu m, the aperture in the porous layer is 50 to 600 mu m, and the pores are intercommunicated. The preparation method for the asymmetric membrane mainly comprises the following steps: dissolving polymers such as PLA and the like into solvents such as methylene dichloride and the like to prepare solution, adding a powdery pore-forming agent into the polymer solution, stirring, fully mixing and defoaming the solution and then pouring the solution into a die, then soaking the die into neutral or acid distilled water at the temperature of between 4 and 100 DEG C to perform membrane forming, removing the die in water and taking the formed membrane out, flushing the formed membrane by running water or / and soaking the formed membrane into running water to remove residual inorganic salt, and drying the formed membrane to obtain the medical degradable polyester asymmetric membrane. The asymmetric membrane provided by the invention has the characteristics of biodegradability and adjustable performance such as degrading rate, thickness, aperture, pore communication, tensile strength and the like.

Description

technical field [0001] The invention relates to a degradable polyester asymmetric membrane used in bone tissue defect treatment and oral implantation to prevent non-osteogenic cells from growing into the defect and allow osteoblast cells to migrate and grow preferentially and a preparation method thereof. Background technique [0002] Bone tissue guided regeneration provides an ideal solution for bone tissue defect treatment, oral implants and other fields. Its basic principle is to place the membrane material in the bone defect area, use the barrier function of the membrane to prevent non-osteogenic cells from growing into the defect area, and at the same time form a space under the membrane to allow the preferential migration and growth of osteoblast cells. To achieve the purpose of bone regeneration and repair. Among them, the material of the membrane is the key to this technology. Its basic structural feature is asymmetry, that is, one side is dense and the other is por...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/14
Inventor 李媛罗祥云
Owner CHENGDU MAIDIMEI SCI & TECH
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