30results about How to "Definite inhibitory effect" patented technology

The invention discloses a preparation method of a cross-linked antibiotic specific demineralized extracellular matrix scaffold, and belongs to the technical field of bone infection treatment. The invention discloses a method for preparing a specific demineralized extracellular matrix scaffold of cross-linked antibiotics. The specific demineralized and decellularized cancellous bone extracellular matrix scaffold (SDECM) is used as a substrate, and the specific demineralized and decellularized cancellous bone extracellular matrix scaffold (SDECM) is used as a substrate, and the antibiotic is electrostatically adsorbed and chemically adsorbed. Cross-linking two forms of composite drug loading, releasing antibiotics through rapid pH response and accompanying material degradation in an acidic environment, anti-infection through antibiotics and promoting repair through SDECM, so as to achieve pH-sensitive drug release in an acidic environment in the early stage of infection Rapid sterilization, sustained sterilization by slow release of drugs in the mid-late physiological environment, and permanent sterilization ability to prevent infection recurrence in the absence of infection provide new ideas and tools for the antibacterial and repairing treatment of bone infections.

The invention discloses the application of sanguinarine in inhibiting the growth of multidrug-resistant Enterobacter hallii. Ceftiaquine, azithromycin and nalidixic acid have good killing effect on multidrug-resistant Enterobacter hallii in vitro, and can inhibit the growth of multidrug-resistant Enterobacter hallii, and the minimum inhibitory concentration is 0.12 mg / mL, the lowest The bactericidal concentration is 0.24 mg / mL, and the invention proposes the inhibitory effect of sanguinarine on multidrug-resistant Enterobacter hallii, which has wide application value in the fields of medicine and the like.

The invention discloses a Herpetetrone nano-suspension and its dry powder, preparation method and application, and belongs to the technical field of traditional Chinese medicine oral medicine. The Herpetetrone nanosuspension is prepared by ultrasonic precipitation. The preparation method of the suspension dry powder comprises: preparation of Herpetetrone nano-suspension; preparation of Herpetetrone nano-suspension dry powder. The Herpetetrone nanosuspension or the Herpetetrone nanosuspension dry powder dissolves more than 90% within 2 hours; it has a significant inhibitory effect on the proliferation of HSC-T6 liver fibroblasts. The application is in the preparation of medicines for treating liver diseases. The invention has the following advantages: the dissolution rate in vitro is obviously improved, the oral bioavailability in vivo is obviously improved, and the inhibitory effect on HSC-T6 cells is enhanced simultaneously.

The invention discloses a method for preparing for tumour formingblood vessel peculiarity binding polypeptide and the admixture protein of human-5. The tumour formingblood vessel peculiarity binding polypeptid-CNGRCVSGCAGRC can separately combine with the tumour formingblood vessel endothelium cell surface high effect expressed aminopeptidase N (CD13). It establishes tumour formingblood vessel peculiarity binding polypeptide and the admixture protein of human-5 and obtains the high effect express in bacillus coli. It also discloses a method for preparing for human Tum-5. The Tum-5 is formed by the 54-132 bits amino acid near the N end of the Tumstatin, which is the function structure area of the Tumstatin anti-vascularization.

The invention discloses the application of luteolin in inhibiting the growth of multi-drug-resistant Providencia rettgeri. According to the fact that luteolin has a good in vitro killing effect on multi-drug-resistant Providencia rettgeri, it can inhibit multiple The growth of drug-resistant Providencia rettgeri, and the minimum bactericidal concentration is 30 ~ 250 μg / mL, the minimum inhibitory concentration is 15 ~ 125 μg / mL, the present invention proposes that luteolin is effective against multidrug-resistant Providencia rettgeri The inhibitory effect of S. spp. has wide application value in medicine and other fields.

A method for preparing 13-docosenamide by fermenting a marine bacillus amyloliquefaciens BMF01 bacterial strain comprises the following steps: fermentation of the BMF01 bacterial strain and preparation of fermentation broth thereof, acid precipitation of the fermented broth of the BMF01 bacterial strain and methanol extraction, silica gel column chromatography of BMF01 bacterial strain fermentation broth methanol extract, Sephadex LH-20 column chromatography, then the absorption peak of MD-4 components appear at 11.5 min, and is identified to be a structure of the compound 13-docosenamide. The invention also relates to a method for preparing ester compounds from marine bacillus amyloliquefaciens BMF01. The method of the invention produces the 13-docosenamide and ester compounds having the application of inhibiting root rot of wheat. For the first time, five kinds of compounds with bacteriostatic action are prepared on the basis of BMF01 strain. The method has the advantages of simple method and high operability.

The present invention provides proto-opioid alkaloids and pharmaceutically acceptable salts, solvates, polymorphs, enantiomers or racemic mixture salts, polymorphs, optical isomers, racemates, and Application of Corydalis Corydalis and its extracts containing proto-opioid alkaloids, Xia Wu and its extracts, Boluohui and its extracts in the preparation of drugs for inhibiting P-gp function. The present invention also provides proto-opioid alkaloids and pharmaceutically acceptable salts, solvates, polymorphs, enantiomers or racemic mixture salts, polymorphs, optical isomers, and racemates, And the application of Corydalis Corydalis and its extracts containing original opioid alkaloids, Xia Wu and its extracts, Boluohui and its extracts in the preparation of drugs for adjuvant tumor treatment, the adjuvant tumor treatment refers to the reversal of the combination of P ‑Gp high expression related tumor multidrug resistance, synergistic antitumor drugs.

The invention discloses a bacteriostatic and antiviral preparation taking kidney bean phytohemagglutinin as a major ingredient, and belongs to the technical field of medicines. The bacteriostatic andantiviral preparation consists of the following active components according to relative parts by weight: 0.1-1.0 part of the kidney bean phytohemagglutinin, 0.2-2.0 parts of one or two of stachyose and raffinose as well as one or more of the following active components: 0.1-0.5 part of povidone iodine, 0.1-0.3 part of polyhexylene biguanidine and 0.1-0.5 part of chlorhexidine; and in addition, a thickening agent, which is hydroxyethyl cellulose, is required. The bacteriostatic and antiviral preparation provided by the invention is concrete in components, and is capable of achieving quantitative control and guaranteeing the consistency and stability of overall quality; a concrete inhibitory effect can be achieved on bacteria, fungi and viruses; therefore, the bacteriostatic and antiviral preparation is relatively broad in antibacterial and antiviral ranges; and the product (the bacteriostatic and antiviral preparation), which is required to be preserved at low temperature, is long in preservation duration and convenient to use.

The invention relates to the field of preparation of antitumor drugs and especially relates to a use of Asterias rollestoni Bell extract in preparation of an antitumor drug. The Asterias rollestoni Bell extract is Asterias rollestoni Bell alcohol extract extracted from Asterias rollestoni Bell by a solvent. The solvent is a methanol aqueous solution or an ethanol aqueous solution or a mixed solution of methanol and ethanol. The Asterias rollestoni Bell extract also can be ethyl acetate extract or n-butanol extract of the Asterias rollestoni Bell alcohol extract. An experiment proves that the Asterias rollestoni Bell extract has moderate antitumor activity, and can obviously inhibit mice H22 solid tumor and mice S180 solid tumor, and especially, the ethyl acetate extract of the Asterias rollestoni Bell alcohol extract has obvious inhibition effects. Therefore, the Asterias rollestoni Bell extract can be used for treating cancers and especially for liver cancer.