Application of sanguinarine in inhibiting the growth of multi-drug resistant Enterobacter hallii

A technology for treating Enterobacter halleri and Enterobacter halleri, which is applied in the field of application of sanguinarine in inhibiting the growth of Enterobacter halleri, to achieve the effects of reducing mortality, solving drug resistance and infection problems, and having wide application value

Active Publication Date: 2021-10-08
SHAANXI UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, there are few reports on the use of sanguinarine as an active bacteriostatic ingredient to inhibit the growth of multidrug-resistant Enterobacter hallii

Method used

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  • Application of sanguinarine in inhibiting the growth of multi-drug resistant Enterobacter hallii
  • Application of sanguinarine in inhibiting the growth of multi-drug resistant Enterobacter hallii
  • Application of sanguinarine in inhibiting the growth of multi-drug resistant Enterobacter hallii

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Embodiment Construction

[0014] The present invention will be described in further detail below in conjunction with the examples. The embodiments are only used to explain the present invention, not to limit the protection scope of the present invention.

[0015] 1. Drug susceptibility test of Enterobacter hallii

[0016] The present invention uses multiple strains of human Enterobacter hallii (strain samples taken from a hospital in Beijing) as starting strains, and selects piperacillin, levofloxacin, gentamicin, broguementin, imipenem, and ofloxacin , nitrofurantoin, ceftaquine, azithromycin, nalidixic acid 10 kinds of commonly used antibiotic susceptibility test strips for drug susceptibility test.

[0017] Pick and culture a single colony for 18-24 hours and evenly dissolve it in 2-5 mL sterile saline, adjust its turbidity to be equal to that of a 0.5 McFarland turbidimetric tube. Draw up 50-200 μL of bacterial solution under sterile conditions, spread the bacterial solution evenly on the plate w...

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Abstract

The invention discloses the application of sanguinarine in inhibiting the growth of multidrug-resistant Enterobacter hallii. Ceftiaquine, azithromycin and nalidixic acid have good killing effect on multidrug-resistant Enterobacter hallii in vitro, and can inhibit the growth of multidrug-resistant Enterobacter hallii, and the minimum inhibitory concentration is 0.12 mg / mL, the lowest The bactericidal concentration is 0.24 mg / mL, and the invention proposes the inhibitory effect of sanguinarine on multidrug-resistant Enterobacter hallii, which has wide application value in the fields of medicine and the like.

Description

technical field [0001] The invention relates to the application of sanguinarine, an active ingredient of traditional Chinese medicine, as an inhibitor of enterobacteriaceae, in particular to the application of sanguinarine in inhibiting the growth of enterobacteria hallii. Background technique [0002] Enterobacter hormaechei is a Gram-negative enteric bacterium (Enterobacteriaceae Enterobacter genus), the main source of this bacterium is humans, animals and food, food sources include dairy products, dried meat, milk and fruits, vegetables, rice, etc., and Enterobacter hallii was also isolated from infant milk powder. Analysis [J]. Chinese Journal of Veterinary Medicine (12): 78-82.) According to the mouse infection test, it was verified that Enterobacter hallii had certain conditional pathogenicity. And there are reports that Enterobacter hallii infection can also cause bacteremia including stroke, premature birth and frail infants. Enterobacter hallii is the main pathoge...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4741A61P31/04
CPCA61K31/4741A61P31/04
Inventor 钱卫东李鑫辰杨敏刘淼付玉婷王文静孙照欢张家宁
Owner SHAANXI UNIV OF SCI & TECH
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