7 results about "Nitrofurantoin" patented technology

This invention discloses a method for detecting hybridoma cells and nitrofurantoin metabolites, relating to the field of nitrofurantoin metabolite detection technology. Immunoassay experiments demonstrate that the anti-nitrofurantoin metabolite monoclonal antibody provided by this invention has the technical advantage of high specificity against nitrofurantoin metabolite derivatives, and exhibits high detection sensitivity and a wide linear detection range. Therefore, the anti-nitrofurantoin metabolite monoclonal antibody provided by this invention can be used to develop nitrofurantoin metabolite detection kits, test strips, and other products. This invention provides a detection tool and method for the rapid detection of nitrofurantoin antibiotic residues in livestock and poultry products, aquatic products, and feed, which is of great significance for meeting practical detection needs, rapidly controlling risks, and ensuring the quality and safety of agricultural products.

The invention discloses a new application of nitrofurantoin alone or in combination with tigecycline. The application refers to the application of nitrofurantoin alone or in combination with tigecycline in inhibition of tigecycline drug-resistant bacterium infection. According to the present invention, the single use of furantoin or the combination of furantoin and tigecycline provides strong antibacterial activity for lon gene mutation and tet (X4) mediated tigecycline drug-resistant bacteria, and the furantoin single use or the combination of furantoin and tigecycline can enhance the survival rate of greater wax moths, the colonization of the tet (X4)-mediated tigecycline drug-resistant bacteria in mouse organs can be effectively reduced, and the healing of skin wound infection caused by tet (X4)-mediated tigecycline drug-resistant bacteria can be remarkably promoted by the combined medication. Furantoin designed depending on interaction sensitivity and tigecycline combined medication can be used for resisting tigecycline drug-resistant pathogens and treating diseases caused by tigecycline drug-resistant bacterium infection, and meanwhile, the evolution of tigecycline drug resistance can be prevented.

The invention discloses a zinc-orotic acid complex crystal material as well as a preparation method and fluorescent recognition application thereof. The chemical formula of the complex is [Zn2 (HOA) 2 (1, 3-dpp) (H2O) 2] n, and the complex has a 2-heavy interspersed two-dimensional network structure. The preparation method comprises the following steps: respectively preparing orotic acid, potassium hydroxide and zinc acetate into solutions, mixing the solutions with 1, 3-bis (4-pyridyl) propane and water, and carrying out ultrasonic treatment and heating treatment to obtain the crystal. The material has characteristic fluorescence emission at 370 nm, the intensity of the material can be obviously changed when encountering a specific substance, and the material can be used as a fluorescence sensing material to identify solvents such as methanol, DMSO, water and the like, specifically detect Fe < 3 + > ions, identify antibiotics dimethylaminotetracycline hydrochloride, furacilin and nitrofurantoin, identify a drug curcumin, and can be used as a fluorescent sensing material. And identifying food additives potassium sorbate and sodium benzoate.

This invention discloses a zinc-orotic acid complex crystal material, its preparation method, and its fluorescence recognition application. The chemical formula of the complex is [Zn2(HOA)2(1,3-dpp)(H2O)2]. n It possesses a two-dimensional, double-interlaced network structure. Its preparation method involves preparing solutions of orotic acid, potassium hydroxide, and zinc acetate, mixing them with 1,3-bis(4-pyridyl)propane and water, and then subjecting the mixture to ultrasonic and heat treatment to obtain crystals. This material exhibits characteristic fluorescence emission at 370 nm, the intensity of which changes significantly upon contact with specific substances. This property can be utilized as a fluorescent sensing material to identify solvents such as methanol, DMSO, and water, and to specifically detect Fe. 3+ Ions that can identify antibiotics such as dimethylaminetetracycline hydrochloride, nitrofurazone, and nitrofurantoin; drugs such as curcumin; and food additives such as potassium sorbate and sodium benzoate.

The invention discloses a hybridoma cell and a nitrofurantoin metabolite detection method, and relates to the technical field of nitrofurantoin metabolite detection. Immunodetection experiments prove that the monoclonal antibody for resisting the nitrofurantoin metabolite has the technical advantage of high specificity on derivatives of the nitrofurantoin metabolite, the detection sensitivity on the derivatives of the nitrofurantoin metabolite is high, and the linear detection range is wide. Therefore, the monoclonal antibody for resisting the macrodantin metabolite provided by the invention can be used for developing products such as a detection kit, a test strip and the like of the macrodantin metabolite, a detection tool and means are provided for rapid detection of macrodantin antibiotic residues in livestock and poultry products, aquatic products and feeds, and the monoclonal antibody has important significance in meeting actual detection requirements. Risks are quickly controlled, and the method is of great significance in guaranteeing agricultural product quality safety.

This invention discloses a three-dimensional fluorescent covalent organic framework, its preparation method, and its application. A three-dimensional covalent organic framework with an fjh topological network structure is synthesized by a solvothermal method using a four-site pyrene amino monomer and a three-site aldehyde monomer. This covalent organic framework exhibits excellent fluorescence performance in solution and shows sensitive response and specific detection of nitrofurantoin.

The application belongs to the technical field of metal organic coordination compounds, and particularly relates to a copper metal complex and a preparation method and application thereof. The chemical formula of the copper metal complex disclosed by the application is [Cu2(NPTH)2(4,4'-BMIBP)2(H2O)4·6H2O] n wherein H2NPTH=3-nitrophthalic acid, and 4,4'-BMIBP=4,4'-bis(2-methylimidazolyl) biphenyl. The application can obtain a single crystal form, high-purity crystal material, and is easy to be industrially produced. The product has a fluorescence recognition function on nitrofurantoin, can be used for detection of nitrofurantoin in an aqueous solution, and can photocatalytically degrade methylene fuel. Compared with a traditional detection and degradation method, the method has the advantages of qualitative, rapid, sensitive, efficient, simple operation and the like.