73 results about "Nitrofurazone" patented technology

The invention provides a detecting Furacilin metabolite ELISA kit, which contains: an ELISA plate covered by the original coated, enzyme marker, Furacilin metabolite specific antibody or Furacilin metabolite derivative antibody, Furacilin metabolite standard solution or Furacilin metabolite derivative standard solution, the substrate color solution, the termination solution, the condensed washing solution, the condensed complex solution. The invention also provides a method to apply the above ELISA kit detecting Furacilin metabolite, which includes steps: firstly, sample pre-treatment, and then using the kit for testing, and finally analyzing testing results. The invention is to provide the Furacilin metabolite residues in the ELISA kit for detection of animal derived foods, such as chicken, pork, fish, shrimp, milk, honey, egg, and other samples, and the detection method is simple, low cost, high sensitivity, and it can monitor on the scene and suitable for screening large number of samples.

The invention relates to an immune nano gold test strip for quickly detecting four nitrofuran medicaments. The immune nano gold test strip is prepared by the following steps of: synthesizing general hapten, immunogen and captured antigen aiming at the four nitrofuran medicaments comprising nitrofurazone, furaltadone, nitrofurantoin and furazolidone by using 5-nitrofurfural as a raw material, immunizing a domestic rabbit serving as an experimental animal to acquire polyclonal IgG antibody, preparing gold labeled antibody by using nano gold and the polyclonal IgG antibody, coating the gold labeled antibody solution on a Glass33 glass cellulose membrane, namely a combined release pad, coating the captured antigen and goat anti-rabbit antibody on a detection line and a quality control line of an AE99 nitrocellulose membrane respectively, sequentially sticking the AE99 nitrocellulose membrane, the combined release pad, namely the Glass33 glass cellulose membrane, an absorption pad Cotton linters 2668 and a sample pad Glass33 on a polyvinyl chloride (PVC) back board, and finally, cutting the back board into 4*50mm test strips. The test strip can simultaneously and quickly detect the four medicaments comprising nitrofurazone, furaltadone, nitrofurantoin and furazolidone in feed; and the cost of the test strip is less than 5 yuan, so the test strip is suitable to be widely applied in feed detection or food animal detection.

The invention utilizes a surface-enhanced raman spectroscopy to detect antibacterial drugs of furazolidone and furacilin. A method which adopts potassium chloroaurate to reduce sodium citrate is used for preparing aurosol; an acetone liquid which contains the furazolidone or the furacilin is mixed with the aerosol, the pH is regulated to 1.0-6.0, and a laser raman spectrometer with a laser light source of 785 nanometers is adopted to scan, so that a raman spectroscopy is obtained; 1611, 1560, 1488, 1472, 1397, 1343, 1260, 1173, 1022, 977, 806 and 775 centimeters <-1> are used as qualitative characteristic peaks for identifying the furazolidone, and 1602, 1554, 1456, 1336, 1162 and 966 centimeters <-l> are used as the qualitative characteristic peaks for identifying the furacilin; and moreover, the peaks of 1611centimeters <-1> and 1602 centimeters <-1> are respectively used for quantitatively determining the furazolidone and the furacilin. The method is convenient, quick, accurate and low in cost, and can be popularized and used in the fields food and drug testing.

The invention discloses hapten and antigen of nitrofurans and a preparation method and application thereof. The antigen is a nitrofuran compound which is conjugate obtained by conjugating the compoundof formula I structure and carrier protein. As the antigens of the invention have 5-nitrofuran ring structure in common, the antibodies of the nitrofurans can be obtained by taking the antigens as immunogen to immunize animals. The antibodies can simultaneously identify four kinds of nitrofurans (nitrofurazone, furazolidone, furaltadone and nitrofurantion). Therefore, the antigen prepared by theinvention can be used for immunoassay and screening of the nitrofurans, improve the detection efficiency, shorten the detection time and lower the detection cost.

The invention discloses a prevention and control method for cryptocaryon irritans of scatophagus argus. According to physiological and ecological features of the scatophagus argus, the purpose of preventing and controlling the cryptocaryon irritans of the scatophagus argus is met with a combined method of nutrient enrichment cultivation and disease prevention of the scatophagus argus, drug therapy of the cryptocaryon irritans and ecological regulation, wherein therapeutic drugs are copper acetate and zeolite powder combined with copper acetate, furacilin antibiotics or an algae-inhibitory compound and furacilin antibiotics combined with the algae-inhibitory compound. The survival rate of the young scatophagus argus intensively cultivated with the method is greatly increased and reaches more than 95%; the fry survival rate of the diseased scatophagus argus is increased from 0% to 64-88%, so that the economical loss is greatly reduced. The method is remarkable and stable in effect and easy to master, popularize and apply, has the characteristics of economy, good actual effect, low toxicity, easiness for operation and the like, and has an important actual effect for establishing a technical system for disease prevention and control of the scatophagus argus and promoting the development of the breeding industry of the scatophagus argus.

The present invention relates to an agent for use in selectively killing one or more senescent cells, wherein the agent is selected from the following: a cardiac glycoside or alglycone, a focal adhesion kinase (FAK) inhibitor, an HMG-CoA reductase inhibitor, JFD00244, Cyclosporine, Tyrphostin AG879, Cantharidin, Diphenyleneiodonium chloride, Rottlerin, 2,3-Dimethoxy-1,4-naphthoquinone, LY-367,265,Rotenone, Idarubicin, Dequalintum chloride, Vincristine, Nitazoxanide, Nitrofurazone, Temsirolimus, Eltrombopag, Adapalene, Azacyclonol, Enoxacin and Raltegravir, and pharmaceutically acceptable salts thereof. Another aspect relates to compounds for use in treating or preventing a senescence- associated disease or disorder, and methods relating thereto.

The invention relates to a medicinal composition for treating skin diseases, which comprises the following active ingredients in part by weight: 45 to 55 parts of benzoic acid, 45 to 60 parts of boric acid, 20 to 30 parts of salicylic acid, 0.5 to 2.5 parts of furacilin, 10 to 20 parts of lightyellow sophora root and 2 to 10 parts of dehydrated alum. During the treatment of the skin diseases, the invention has the advantages that (1) the medicinal composition is superactive and bactericidal, has quick response and high cure rate and can prevent relapse; (2) sterilization, itching relieving, pain relieving, hidroschesis and podobromidrosis removal are realized simultaneously; (3) dosage is little; and (4) the safety is high.

The invention provides a chewing gum for treating and preventing oral cavity ulcer and teeth pains, which comprises chewing gum rubber base, sweetener and perfume as the basic components, one of added borax or aldomycin or dexamethasone acetate, and several of added sodium chloride, magnesium oxide, sodium hydrogen carbonate, menthol, vitamin B1, vitamin C as adjuvant.

The invention provides a nitrofurans drug metabolite assay kit, which consists of a furazolidone metabolite test paper strip, a furaltadone metabolite test paper strip, a nitrofurazone metabolite test paper strip and a furantoin metabolite test paper strip. Each test paper strip consists of a sample pad, a colloidal gold pad, a nitrocellulose membrane, a sample adsorbing pad and a PVC (polyvinyl chloride) supporting plate, wherein the colloidal gold layer is a nitrofurans drug metabolite monoclonal antibody polyester film marked with colloidal gold, the nitrocellulose membrane is sequentially coated with nitrofurans drug metabolite coupled carrier protein as a test line (a T-line) and goat anti-mouse IgG antibody as a quality control line (a C-line). The nitrofurans drug metabolite assay kit is produced according to the nano colloidal gold technology, antigen-antibody specificity reactions and principles of immunity competitive inhibition reaction, and is used for testing whether samples contain nitrofurans drug metabolites or not.

The invention provides an enzyme linked immunosorbent kit for detecting furacilin metabolites, which comprises an enzyme-linked plate which is coated with a coating source, an enzyme marker, a furacilin metabolite derivant specific antibody, furacilin metabolite derivant standardized product solution, substrate coloured solution, stopping solution, concentrated cleaning mixture and concentrated complex solution. Furacilin metabolite derivant which is coated with antigen is got through coupling furacilin metabolite derivant hapten and bovine gamma globulin, and the antibody is a polyclonal antibody or a monoclonal antibody. The invention also provides a method for detecting furacilin metabolites in animal derived food, which comprises the following steps: preprocessing samples, detecting by agent in a kit, and analyzing detection results. The invention aims at providing an enzyme linked immunosorbent kit and a detection method for detecting furacilin metabolites in animal derived food, which has simple operation and low cost, and is suitable for screening a great amount of sample copies.

The present invention relates to a monoclonal antibody and applications thereof, especially to a semicarbazide (nitrofural metabolite) derivative monoclonal antibody and applications thereof, and belongs to the technical field of immunochemistry. The semicarbazide derivative monoclonal antibody 9B10' is produced by mouse hybridoma cell line 9B10, wherein a subtype is IgG1 type. According to the present invention, the monoclonal antibody 9B10' produced by the mouse hybridoma cell line 9B10 can be abundantly produced, and can be used to prepare an enzyme linked immunoassay kit and colloidal gold test paper strips for semicarbazide residue detection so as to achieve a purpose of rapid and sensitive detection of semicarbazide residues in honey and animal tissues.

The invention discloses a preparation method and application of a fluorescent nanofiber film based on a bimetallic organic framework. The fluorescent nanofiber film is prepared by taking the bimetallic organic framework and a PMMA polymer as raw materials and utilizing an electrostatic spinning technology. The purpose of detection is achieved through the quenching amount of the fluorescent signalof the fluorescent nanofiber film. The fluorescent nanofiber film has the unique advantages of high sensitivity, good selectivity, short response time and the like when used for detecting nitro-explosive { (4-NA (p-nitroaniline), TNP (picric acid) } and antibiotic { (NFT nitrofurantoin, NFZ nitrofurazone) } in water.

The invention discloses a kit and method for detecting a furacilin metabolin. The kit comprises a microporous reagent and test paper, wherein a specific antibody of the furacilin metabolin, which is marked by collaurum, is freeze-dried in the microporous reagent; the specific antibody of the furacilin metabolin can be taken as a monoclonal antibody or a polyclonal antibody of the furacilin metabolin; the test paper is formed by sequentially connecting a sample absorbing pad, a reaction membrane, a water absorbing pad, a protective membrane and a bottom plate, wherein a detecting area and a quality control area are formed on the reaction membrane; a hapten-carrier protein conjugate of the furacilin metabolin is wrapped in the detecting area; and an antibody is wrapped in the quality control area. The kit for detecting the furacilin metabolin is simple, rapid, visual and accurate in method, wide in application range and low in cost, thereby being easy to popularize.

The invention discloses a monoclonal antibody of furacilin residue marker semicarbazide, and a preparation method and application thereof. The monoclonal antibody is secreted by a hybridoma cell SEM / 4G6 of which the collection number is CCTCC NO:C201150. The preparation method comprises the following steps: A, coupling hapten CPSEM and bovine serum albumin to obtain immunogen; B, coupling hapten CPSEM and ovalbumin to obtain coating antigen; C, preparing the monoclonal antibody from the immunogen in the step A, wherein the monoclonal antibody is secreted by a hybridoma cell strain SEM / 4G6 of which the collection number is CCTCC NO:C201150; D, coating a solid-phase carrier with the coating antigen in the step B; E, treating a sample to be detected with acid, adding benzaldehyde, performing ultrasonic derivation, extracting with ethyl acetate, taking nitrogen gas at the ethyl acetate layer, performing blow-drying, purify n-hexane, and redissolving a sample diluent to obtain a substance to be detected; and F, performing ELISA (enzyme-linked immunosorbent assay) detection on the substance to be detected. The invention also discloses application of a kit in furacilin residue detection of animal edible tissues. The method is convenient, quick, sensitive and accurate, and can be used for developing an ELISA kit capable of detecting semicarbazide residue in animal edible tissues.

The invention relates to a cosmetic which functions to remove acne and facial beautifying and skincare. The product made of the essences of traditional Chinese medicine and western drugs is for external use and invented by beauty expert Sun Min by combining the advantages of the treatments of acne in China and in the West. The product is prepared by rennin, ranitidine, Chinese goldthread injection solution, furacilin, metronidazole, boric acid solution and distilled water according to certain volume proportion and the components function coordinately to prevent and treat acne and beatify and protect skin. The invention has the functions of skin care, facial beautifying, prevention and treatment of acne, comedo, pimple, itch and skin toughness, etc., promotion of the recovery of acne scar and delicate, smooth and fair skin. The invention has scientific components, simple fabrication and unique treatment effect and can thoroughly cure acne without scar left and has good facial-beautifying effect.

A medicine for treating rhinitis is provided. The medicine is paste prepared from herba centipedae, borneol, angelica dahurica, flos magnoliae, menthol, Furacilin powder, a watermelon frost, vaseline, sesame oil, and the like. Using results show that the medicine utilizes comprehensive functions of each medicine to treat the rhinitis, has anti-inflammation, sterilizing and antiallergic functions and is non-toxic and harmless to human bodies and convenient to use, medicine taking can be performed by only one person, and normal study and working are not influenced after medicine taking. The medicine is good in treating effects, and largely increases the curative rate of chronic rhinitis, nasosinusitis and allergic rhinitis.

The invention provides a fish and shrimp common disease treating method with a good effect. The method specifically comprises the step of selecting drugs according to fish and shrimp diseases; when fish or turtle suffer from the bacterial rotten skin disease, furacilin and salt are adopted according to the mass ratio of 2:3. EM culture is conducted with a plastic bucket, a measuring cylinder and a mineral water bottle, and the plastic bucket, the measuring cylinder and the mineral water bottle are recyclable devices, so that culture equipment is saved and culture cost is reduced. During culturing, EM nitrobacteria with long drug property are added, the drug property of EM is prolonged by adding EM nitrobacteria during EM culturing, constant adding of EM is not needed in use, and therefore EM is saved. According to the method, a solid product is obtained from EM culture, so that the problem that liquid is hard to place and store is solved and using is convenient.

The invention relates to a preparation method of nitrofurazone alpha crystal, and provides characterization data of DSC, infrared and Raman spectra of the nitrofurazone alpha crystal. The preparationmethod is solvent-mediated crystal transformation or ultrasonic assisted solvent-mediated crystal transformation. The predation method comprises the steps of adding crude nitrofurazone to an organic solvent to prepare a 0.12-0.40g solute / g solvent suspension, and then stirring the suspension at a constant temperature of 5-30 DEG C for 15-24 h; or performing ultrasonic treatment for 10-60 min whilestirring the suspension at a constant temperature of 5-30 DEG C, and then continuing to stir the suspension at a constant temperature of 5-30 DEG C for 5-18 h; and finally, filtering the suspension,and drying the crystal product at 50-80 DEG C to a constant weight. The nitrofurazone alpha crystal has a bulk density of 0.35-0.38g / cm3 and a purity of more than 98. 5%, and the method is simple andlow in energy consumption; and the crystal is easy to filter, good in thermodynamic stability, etc.

The invention discloses a manufacturing method of a urinary catheter, belonging to the technical field of medical materials. The manufacturing method comprises the following steps: a, preparing a solvent by adopting acetone and alcohol at the ratio of 1 to 1, and dissolving polyactic-co-glycolic acid in the solvent; b, adding with furacilin, carrying out uniform mixing for dissolving, carrying out centrifugation, taking the supernate, adding the supernate into a container, immersing the urinary catheter into the supernate in the container, uniformly pulling out the urinary catheter, placing the urinary catheter into a drying box, and carrying out drying at room temperature till the solvent volatilizes completely; and c, soaking the urinary catheter in hydrogen peroxide solution with the concentration being 3% for 15 min. With the adoption of the technical scheme, the urinary catheter infection during short-term indwelling is prevented, the cost is low, the manufacturing cost is simple, and the manufacturing time is short.

The pharmaceutical compositions having analgesic effect referred to in this invention are composed of the aconitine ingredients as the active medical ingredients and other acceptable auxiliary ingredients. The active medical ingredients shall at least include the fuziline compound of Formula (I). The drugs exert desirable analgesic effect with low toxicity. They can be made into commonly used oral preparations, injectable preparations and / or external preparations, including ointments, suppositories lotions, medicinal dressings, etc.

The invention discloses a preparation method of a quality control sample of nitrofuran metabolite residues in fish muscle. The preparation method comprises the following steps: selecting negative living fish which meets pre-set specification and size and is not fed by a nitrofuran medicine; carrying out medicine bath treatment under pre-set conditions, wherein a water body of a medicine bath tankcontains four types of nitrofuran drugs including a furazolidone crude drug, a furaltadone crude drug, a furacilin crude drug and a furantoin crude drug; fishing out a positive sample subjected to themedicine bath treatment and killing the fish and taking back muscle to obtain a fish muscle sample; adding a vitamin C solution and uniformly stirring to obtain minced fish; after pre-cooling the minced fish, putting into a freezing drying machine and carrying out freezing drying to obtain a freeze-dried sample; carrying out crushing, blending and sieving treatment on the freeze-dried sample to obtain the quality control sample containing nitrofuran metabolite residues with a target content level. By adopting the scheme, the quality control sample contains four types of nitrofuran metabolitesand can meet the requirements of actual inspection better.

The invention relates to a dragon fish white-eye disease treatment liquid, which is characterized by comprising the following components in parts by weight: 1 to 2 parts of gentamicin sulfate, 3 to 5 parts of ethyl paraben, 5 to 8 parts of nitrofurazone, 5 to 10 parts of bendazac lysine, 5 to 10 parts of sodium chloride (NaCl), and 20 to 30 parts of traditional Chinese medicine liquid, wherein the traditional Chinese medicine liquid is prepared by boiling the following traditional Chinese herbals in water (50 to 60 parts by weight): 2 to 5 parts of cassia seed, 2 to 4 parts of wild chrysanthemum, 3 to 4 parts of inula flower, and 1 to 2 parts of Chinese milk vetch. The treatment liquid is prepared by adding gentamicin sulfate, ethyl paraben, nitrofurazone, bendazac lysine, and NaCl into the traditional Chinese medicine liquid and evenly mixing.

The invention discloses a compound rupatadine bioadhesion nasal gel product and a preparation method. The compound rupatadine bioadhesion nasal gel product is characterized by being prepared from, 10-100 parts of rupatadine and salts thereof, 5-20 parts of xylometazoline hydrochloride / naphazoline / pseudoephedrine hydrochloride, 1-4 parts of furacilin, 300-5000 parts of polymer gel materials, 2-200 parts of a biological adhesive, 180-200 parts of a buffer salt, 800-1600 parts of a wetting agent and 20000 parts of sterile water for injection. The wetting agent is dissolved into 2 / 3 of the sterile water for injection to obtain a solution A; the polymer gel material is stirred and added into the solution A to obtain a gel system B; the biological adhesive is dispersed into the gel system B to obtain a gel system C; the rupatadine and salts thereof, the xylometazoline hydrochloride / naphazoline / pseudoephedrine hydrochloride, the furacilin and the buffer salt are successively added into 1 / 3 of the sterile water for injection, and sonication is performed to obtain a solution D; the solution D is dispersed into the gel system C, and stirring is performed to obtain the final product.

The invention relates to the technical field of drugs, and relates to a preparation method of a two-component drug for treating tinea pedis. By virtue of oral administration and external application,the tinea pedis can be jointly healed; a component A is prepared, an extracted vitamin B family belongs to water soluble vitamins and has efficacies for regulating the metabolism, facilitating the regeneration of cells, keeping the health of the foot skin, preventing reoccurrence of the tinea pedis and improving the immunity system and the nervous system; the Chinese herb decoction has efficaciesfor clearing away the internal heat, eliminating the toxicity, repelling the wind, removing the dampness, nourishing the kidney, tonifying Qi, clearing and activating the channels and collaterals, promoting the foot bottom blood circulation, improving the immunity defense capacity of the body, promoting the healing of the tinea pedis, adjusting the immunity mechanism of the body, and controlling the reoccurrence and reducing the occurrence of the tinea pedis. The boric acid has an effect of inhibiting mycete, the salicylic acid can inhibit the fungus, soften the epidermis and remove cutin; methenamine has an effect of hidroschesis and convergence; the zinc oxide has an effect for relieving the itching and converging; phenol has a sterilizing and disinfecting effect; metronidazole can resist the anaerobic infection; nitrofurazone has an inflammation eliminating effect; and the two-component drug easily coats the skin surface to form a film, thereby playing the effect and promoting the healing of the tinea pedis.

The invention discloses a fish feed capable of preventing and curing ichthyophthiriasis. The feed is prepared from the following raw materials in parts by weight: 10-33 parts of soya-bean cake, 30-50parts of herba violariae chinensis, 10-15 parts of straw, 1-3 parts of furacilin powder, 1-2 parts of butylated hydroxytoluene, 2-6 parts of sweet wormwood herb juice, 10-20 parts of corn meal, 5-10 parts of fishbone dust, 1-2 parts of table salt and 2-8 parts of vitamin A. Since the fish feed capable of preventing and curing ichthyophthiriasis is adopted, the deficiency of an original fish feed can be optimized, the furacilin powder and the butylated hydroxytoluene are added into the fish feed, and in addition, a great quantity of green herbaceous plants are supplemented in the fish feed so as to prevent and cure the ichthyophthiriasis of the fish, accelerate the even nutrition of the fish and guarantee to improve the economic benefit of fish farm culture.

The present invention provides an enzyme-linked immunoassay kit and a method for nitrofural metabolite detection. The enzyme-linked immunoassay kit comprises an enzyme label plate coated with coating antigen, specific nitrofural metabolite antibody, an enzyme marker, nitrofural metabolite standard solutions, a substrate coloration solution, a termination solution, a concentration washing solution, a concentration reconstituted solution, and 2-nitrobenzaldehyde. The present invention further provides a nitrofural metabolite enzyme-linked immunoassay kit detection method, which mainly comprises: carrying out a sample pretreatment, adopting the kit to detect, and finally analyzing a detection result. With the detection kit, nitrofural metabolite drugs in animal tissues and aquatic products can be rapidly detected, characteristics of simple and rapid operation, high accuracy, high sensitivity, low cost and the like are provided, and the kit and the method are applicable for screening and on-site monitoring of a large number of samples.

The invention discloses emulsifiable paste for treating scabies, which comprises the following components in percentage by weight: 55 to 75 percent of vaseline, 15 to 30 percent of sulphur powder, 2 to 6 percent of diphenhydramine hydrochloride, 3 to 6 percent of camphor alcohol liquid and 0.04 to 0.1 percent of furacilin powder, wherein the camphor alcohol liquid is prepared by dissolving 15 to 20 grams of camphor block in 85 to 130 millimeters of medical alcohol. The emulsifiable paste for treating the scabies has the quick treatment effect on the scabies, takes effect obviously on mild and moderate patients within 3 days, cures the patients for about one week, and can relieve the uneasiness or pain of the patients fundamentally, and the scabies can be treated completely, and is difficult to relapse basically. In addition, the emulsifiable paste of the formula has low cost and a wide application range, is readily available, and is suitable for extensive ordinary families.

The present invention relates to a magnetic particle chemiluminescence kit for detecting nitrofural metabolites. The kit comprises a luminous marker, a fluorescein marker, a standard substance, a quality control substance and a separation reagent, wherein the luminous marker is isoluminol luminous marker labeled nitrofural metabolite hapten, the fluorescein marker is fluorescein labeled nitrofural metabolite monoclonal antibody or fluorescein derivative labeled nitrofural metabolite monoclonal antibody, and the separation reagent is sheep anti-FITC monoclonal antibody coated paramagnetic nanometer microbeads. The present invention further relates to a method for detecting nitrofural metabolites in foods of animal origin by using the kit, wherein the method provides characteristics of high sensitivity, high specificity and rapid detection for nitrofural metabolite detection.