3 results about "Nitrofurazone" patented technology

The nifuratel content liquid chromatography detection device comprises a base, the top of one end of the base is fixedly connected with a chromatographic instrument body, the top of the other end of the base is fixedly connected with a working box, a solvent bottle is placed at the top of the chromatographic instrument body, and the top of the solvent bottle is in threaded connection with a first pipe cap; a first cavity and a second cavity are formed in the working box, a medium bottle is fixedly connected to the top of the working box, the bottom of the medium bottle is arranged in the first cavity, the bottom of the medium bottle communicates with a first pipeline, a small pump is fixedly connected to the interior of the first cavity, and the input end of the small pump communicates with the first pipeline; according to the nifuratel detection device, a specified amount of diluting medium can be accurately injected, the accuracy of a detection result is ensured, a nifuratel solution can be automatically diluted and filtered, the labor intensity of workers is reduced, and the detection efficiency is improved.

The present application relates to the technical field of determination of nifursol metabolite content, and particularly relates to a method for determining the residual amount of nifursol metabolite in royal jelly. The method comprises the following steps: the royal jelly sample is sequentially subjected to trichloroacetic acid hydrolysis, o-nitrobenzaldehyde derivatization and ethyl acetate purification, and is treated with acetonitrile aqueous solution to constant volume, the pretreated sample is subjected to gradient elution using 5 mmol / L ammonium acetate aqueous solution-acetonitrile as a mobile phase, and is determined by liquid chromatography-tandem mass spectrometry, and the isotopic internal standard method is used for qualitative and quantitative analysis during determination. The royal jelly sample is hydrolyzed using a trichloroacetic acid solution before derivatization treatment, so that the to-be-measured component is well separated from the sample matrix, the matrix influence is reduced, and then the liquid chromatography-tandem mass spectrometry analysis is performed in combination with the selection of the mobile phase and the isotopic internal standard method, thereby improving the qualitative and quantitative accuracy of the residual amount of nifursol metabolite in royal jelly.

The application provides a nitrofurazone or a pharmaceutically acceptable derivative thereof, and belongs to the technical field of biological medicines. The application comprises the use of nitrofurazone in the preparation of a drug for reducing food intake and / or inhibiting appetite. The nitrofurazone can be independent of blood sugar regulation, independent of the gastrointestinal tract, and does not cause side effects such as nausea and vomiting; the target of the nitrofurazone is not located in the peripheral nervous system, but acts on the central nervous system. The nitrofurazone can significantly reduce the intake of ordinary food and high-fat food of mice in the form of activating Glp1-r, inhibit the appetite of the mice, and thus significantly reduce the body weight of obese mice. Therefore, the nitrofurazone has the potential to treat obesity and can be applied to the preparation of a drug for treating obesity.