6results about How to "Reduce fatality rate" patented technology

The invention discloses a kit for detecting susceptibility and severity of children acute respiratory distress syndrome, and relates to the technical field of biomedical detection. The kit comprises a detection reagent combination and a standardized reference system, the detection reagent combination is prepared from specific binding angiogenin 2, a soluble advanced glycosylation end product receptor, pulmonary surfactant protein D, a soluble tumor necrosis factor receptor 1, interleukin 6, interleukin 8, a plasminogen activator inhibitor 1 and a capture and detection antibody of III type procollagen N-terminal peptide. The primer pair and the probe are used for specifically amplifying a single nucleotide polymorphism site rs4073 in a promoter region of the interleukin 8 gene; the standardized reference product system comprises gradient standard products covering the physiological concentration dynamic ranges of the markers on the 0th day, the 3rd day and the 7th day of morbidity; the kit is used for early-stage precise layering and dynamic prognosis evaluation of the acute respiratory distress syndrome of children.

The embodiment of the present disclosure provides a method and device for predicting the prognosis of post-stent retrieval tissue hypoperfusion, equipment and medium, which relates to the technical field of medical intelligent analysis, and includes: collecting clinical feature information of a patient, preoperative multi-modal brain images before stent retrieval and postoperative multi-modal brain images after stent retrieval; determining preoperative perfusion feature parameters based on the preoperative multi-modal brain images, determining postoperative perfusion feature parameters and postoperative tissue hypoperfusion phenotype information based on the postoperative multi-modal brain images; constructing a multi-dimensional feature vector by using the clinical feature information, the preoperative perfusion feature parameters, the postoperative perfusion feature parameters and the postoperative tissue hypoperfusion phenotype information, inputting the multi-dimensional feature vector into a prognosis prediction model, and obtaining the prediction state information of the prognosis of the patient output by the prognosis prediction model. The present application can improve the prediction accuracy of prognosis.

The invention discloses application of piperlongumine in treating and preventing lung injury, and belongs to the technical field of medicines. Aiming at the technical bottlenecks of limited treatment means and high case fatality rate of the existing acute lung injury (ALI) / acute respiratory distress syndrome (ARDS), the invention discovers that piperlongumine can specifically inhibit cGAS-STING signal channel activation for the first time, and expression release of inflammatory factors IFN-beta, IL-6 and TNF-alpha is reduced by regulating phosphorylation of a downstream interferon regulatory factor 3 (IRF3). In-vitro experiments prove that piperlongumine inhibits ISD-induced inflammatory response in a dose-dependent manner, and in-vivo experiments show that piperlongumine can significantly relieve LPS-induced mouse acute lung tissue inflammatory cell infiltration, reduce serum IL-6 and TNF-alpha levels, and improve lung tissue pathological injury. According to the invention, the medicinal application of piperlongumine is expanded, a new lung injury treatment scheme based on natural active compounds is provided, and the piperlongumine can be widely applied to prevention and treatment of acute lung injury and related inflammatory lung diseases.

The application discloses an algae feed preparation device for shrimp fry opening, and belongs to the technical field of feed preparation equipment, which is used for providing an algae feed preparation device for shrimp fry opening, which can improve economic benefits of breeding, and comprises a circulating device, a cleaning device and a refining device. The cleaning device comprises a pair of pool walls, the top of the cleaning device is open, and the two pool walls are rotationally connected with a low roller shaft, a high roller shaft, an upper roller shaft and a lower roller shaft. The shaft lines of the low roller shaft, the high roller shaft, the upper roller shaft and the lower roller shaft are parallel, and the conveying belt is provided with dense through holes. The pool bottom is arranged between the two pool walls, the circulating device comprises a water storage pool, the top of the water storage pool is provided with a communicating pump body, and the side surface is provided with a communicating filter. The application continuously provides the disinfecting cleaning liquid for the cleaning device through the design of the circulating device, sterilizes and disinfects the algae raw materials, washes away the mud and sand adhered to the surface of the algae raw materials, improves the edible safety of the algae feed, reduces the mortality rate of the shrimp fry, and improves the breeding benefits.

This invention discloses the application of substances that reduce CCR2 content or activity in the treatment or prevention of fever with thrombocytopenia syndrome (FPS). This invention discovers that CCR2 is a target for the prevention and treatment of FPS virus infection, revealing that CCR2 plays an important role in the infection and proliferation of FPS virus and can serve as a target for inhibiting FPS virus infection. Utilizing CCR2 inhibitors as candidate drugs for the prevention and treatment of FPS virus shows great research potential. This invention provides a theoretical basis for using CCR2 as a target for the treatment of FPS and has significant application value for the treatment of FPS virus infection and the development of drugs for treating FPS virus infection.

The application discloses application of varenicline in preparation of an antibiotic enhancer, and belongs to the technical field of medicinal chemistry.The application proves that varenicline can improve the bacteriostatic effect of an antibiotic when the antibiotic is used in combination with varenicline.The effect is achieved by inhibiting cystathionine gamma-lyase activity, thereby inhibiting the generation of hydrogen sulfide and reducing antibiotic resistance.The inhibiting capacity of varenicline on bacterial cystathionine gamma-lyase activity is obviously superior to that on human cystathionine gamma-lyase, and varenicline has the potential to develop into an antibiotic enhancer.