17results about How to "Reduce fatality rate" patented technology

The invention discloses an intelligent nursing management system and method for a critical patient, and relates to the technical field of medical health monitoring, and the method comprises the steps: setting a multi-physiological signal collection channel, synchronously collecting multi-dimensional physiological signals of the patient, carrying out the preprocessing of the collected signals, and forming a standardized multi-modal physiological data flow; the preprocessed multi-modal physiological data are input into a deep learning model based on LSTM and a multi-head attention mechanism, intelligent fusion analysis of different physiological signals is achieved in combination with a dynamic weight adaptive algorithm, and a patient individualized physiological system coupling model is established; and based on an analysis result of the deep learning model, calculating an illness state risk assessment value of the patient in real time, and outputting a specific early warning level according to a set multi-level early warning threshold. According to the invention, the multi-stage and multi-dimensional early warning threshold system is constructed, so that the condition of the patient can be monitored and early warned in all directions. The monitoring quality of critically ill patients can be remarkably improved, and the missed judgment rate and the misjudgment rate are reduced.

The invention belongs to the technical field of micro-ecology, and particularly relates to an aquaculture compound micro-ecological preparation and application thereof. The compound microecological preparation for aquaculture comprises bacillus silage YZS-M01, bacillus pettimensis YZS-M02, bacillus velezensis YZS-M03 and bacillus siamensis YZS-M04, and the total viable concentration of the compound microecological preparation is (2-5) * 10 < 9 > cfu / ml or (2-5) * 10 < 9 > cfu / g. The compound micro-ecological preparation for aquaculture has a remarkable purification effect on aquaculture water, and meanwhile, the survival rate and the yield of aquatic animals can be increased.

The invention provides application of chlorogenic acid in inhibition of growth of carbapenem-resistant Escherichia coli, and belongs to the technical field of development of antibacterial materials. The invention discloses an application of chlorogenic acid in inhibiting the growth of carbapenem-resistant Escherichia coli, the chlorogenic acid can inhibit the growth of the carbapenem-resistant Escherichia coli according to the good in-vitro killing effect on the carbapenem-resistant Escherichia coli, the minimum inhibitory concentration is 5mg / mL, and the chlorogenic acid can inhibit the growth of the carbapenem-resistant Escherichia coli. The invention provides the inhibition effect of the chlorogenic acid on the carbapenem-resistant Escherichia coli, and the chlorogenic acid has a wide application value in the fields of medicines and the like, and can effectively destroy the biological membrane of the carbapenem-resistant Escherichia coli, so that the invention provides the inhibition effect of the chlorogenic acid on the carbapenem-resistant Escherichia coli.

The invention discloses a PICC (Peripherally Inserted Central Catheter) dynamic CVP waveform monitoring system which comprises a pressurizing liquid injection device, a blood pressure sensor, an IBP invasive blood pressure detection module, an IBP cable and a monitor, one end of the blood pressure sensor is connected with the pressurizing liquid injection device, and the other end of the blood pressure sensor is connected with the far end of a PICC; the IBP invasive blood pressure detection module is connected with a signal interface of the blood pressure sensor through the IBP cable and is used for detecting CVP data; the monitor is connected with the IBP invasive blood pressure detection module and used for displaying CVP data monitored by the IBP invasive blood pressure detection module in a CVP oscillogram mode. According to the dynamic CVP waveform monitoring system for PICC catheterization provided by the embodiment of the invention, the tip position of the PICC catheter can be accurately positioned in real time in the PICC catheterization process, an infusion channel can be quickly and timely used, and more treatment time is won for patients. The PICC is used for replacing a CVC catheter, related complications are obviously lower than those of CVC catheterization, clinical treatment can be better guided, and prognosis is improved.

The invention provides a composition, a kit and a detection method for early screening of intestinal cancer. The composition comprises a specific primer and a probe of the KCNQ5 gene, and a reference gene primer and a probe. The detection method is based on sulfite treatment and fluorescent quantitative PCR amplification of cfDNA in plasma, the methylation level of the KCNQ5 gene is judged by calculating the Ct value difference (delta Ct) between the specific primer and the internal reference primer, and methylation is positive when the delta Ct value is smaller than 8.09. The method is easy to operate and non-invasive, healthy people and intestinal cancer patients can be efficiently distinguished, and convenience is provided for early screening of intestinal cancer.

The utility model relates to a household high-rise fire escape knapsack device, in particular to a device capable of enabling people to escape quickly and safely when a fire occurs, which comprises a slow descending device, an intelligent detection speed reduction device, a hand brake (safety) device, a five-point safety belt, a safety hook and a knapsack shell. And rapid and safe escape in case of fire is realized. The household high-rise fire escape knapsack device can also realize slow descent and control the speed in a safe range during falling, can realize braking and manual control by people in an emergency, and can also realize intelligent speed reduction when the household high-rise fire escape knapsack device is about to fall to the ground, so that people cannot be hurt when falling to the ground.

The invention provides a neonatal acute respiratory distress syndrome antenatal prediction model, which is characterized in that 15 key variables for predicting neonatal acute respiratory distress syndrome are screened out by using an LASSO regression algorithm according to perinatal high-risk factors; and taking the key variables as input, taking the neonatal acute respiratory distress syndrome as output, and training by using a BP neural network to obtain the neonatal acute respiratory distress syndrome antenatal prediction model. According to the method, personalized early prediction of the NARDS can be realized, and the possibility of occurrence of the neonatal acute respiratory distress syndrome can be predicted before a fetus is born; in the prediction process, the examination result can be obtained only by inputting various existing examination data into the prediction model, the method is simple and easy to operate, visual, reliable and rapid, evaluation can be conducted at any time, and the requirements for professional knowledge of medical staff and hospital instruments and equipment are low.

The invention discloses a kit for detecting susceptibility and severity of children acute respiratory distress syndrome, and relates to the technical field of biomedical detection. The kit comprises a detection reagent combination and a standardized reference system, the detection reagent combination is prepared from specific binding angiogenin 2, a soluble advanced glycosylation end product receptor, pulmonary surfactant protein D, a soluble tumor necrosis factor receptor 1, interleukin 6, interleukin 8, a plasminogen activator inhibitor 1 and a capture and detection antibody of III type procollagen N-terminal peptide. The primer pair and the probe are used for specifically amplifying a single nucleotide polymorphism site rs4073 in a promoter region of the interleukin 8 gene; the standardized reference product system comprises gradient standard products covering the physiological concentration dynamic ranges of the markers on the 0th day, the 3rd day and the 7th day of morbidity; the kit is used for early-stage precise layering and dynamic prognosis evaluation of the acute respiratory distress syndrome of children.

The embodiment of the present disclosure provides a method and device for predicting the prognosis of post-stent retrieval tissue hypoperfusion, equipment and medium, which relates to the technical field of medical intelligent analysis, and includes: collecting clinical feature information of a patient, preoperative multi-modal brain images before stent retrieval and postoperative multi-modal brain images after stent retrieval; determining preoperative perfusion feature parameters based on the preoperative multi-modal brain images, determining postoperative perfusion feature parameters and postoperative tissue hypoperfusion phenotype information based on the postoperative multi-modal brain images; constructing a multi-dimensional feature vector by using the clinical feature information, the preoperative perfusion feature parameters, the postoperative perfusion feature parameters and the postoperative tissue hypoperfusion phenotype information, inputting the multi-dimensional feature vector into a prognosis prediction model, and obtaining the prediction state information of the prognosis of the patient output by the prognosis prediction model. The present application can improve the prediction accuracy of prognosis.

The invention discloses application of piperlongumine in treating and preventing lung injury, and belongs to the technical field of medicines. Aiming at the technical bottlenecks of limited treatment means and high case fatality rate of the existing acute lung injury (ALI) / acute respiratory distress syndrome (ARDS), the invention discovers that piperlongumine can specifically inhibit cGAS-STING signal channel activation for the first time, and expression release of inflammatory factors IFN-beta, IL-6 and TNF-alpha is reduced by regulating phosphorylation of a downstream interferon regulatory factor 3 (IRF3). In-vitro experiments prove that piperlongumine inhibits ISD-induced inflammatory response in a dose-dependent manner, and in-vivo experiments show that piperlongumine can significantly relieve LPS-induced mouse acute lung tissue inflammatory cell infiltration, reduce serum IL-6 and TNF-alpha levels, and improve lung tissue pathological injury. According to the invention, the medicinal application of piperlongumine is expanded, a new lung injury treatment scheme based on natural active compounds is provided, and the piperlongumine can be widely applied to prevention and treatment of acute lung injury and related inflammatory lung diseases.

The application discloses an algae feed preparation device for shrimp fry opening, and belongs to the technical field of feed preparation equipment, which is used for providing an algae feed preparation device for shrimp fry opening, which can improve economic benefits of breeding, and comprises a circulating device, a cleaning device and a refining device. The cleaning device comprises a pair of pool walls, the top of the cleaning device is open, and the two pool walls are rotationally connected with a low roller shaft, a high roller shaft, an upper roller shaft and a lower roller shaft. The shaft lines of the low roller shaft, the high roller shaft, the upper roller shaft and the lower roller shaft are parallel, and the conveying belt is provided with dense through holes. The pool bottom is arranged between the two pool walls, the circulating device comprises a water storage pool, the top of the water storage pool is provided with a communicating pump body, and the side surface is provided with a communicating filter. The application continuously provides the disinfecting cleaning liquid for the cleaning device through the design of the circulating device, sterilizes and disinfects the algae raw materials, washes away the mud and sand adhered to the surface of the algae raw materials, improves the edible safety of the algae feed, reduces the mortality rate of the shrimp fry, and improves the breeding benefits.

The application discloses a method for constructing a cirrhosis dilution hyponatremia rat model and application thereof. Based on the constructed cirrhosis pathological model, combined with continuous infusion of DDAVP (desmopressin) to simulate abnormal secretion of antidiuretic hormone (ADH), and supplemented with precise liquid diet regulation, an animal model highly consistent with the clinical pathological mechanism is constructed. The method is suitable for biological and pharmaceutical research scenes such as pathogenesis research of cirrhosis complications, drug screening targeting ADH pathway, and efficacy evaluation of anti-water retention drugs, and has advantages such as short modeling cycle (≤5 days), high stability (modeling rate ≥ 85%), low mortality (≤10%) and multi-index stratified verification.

This invention discloses the application of substances that reduce CCR2 content or activity in the treatment or prevention of fever with thrombocytopenia syndrome (FPS). This invention discovers that CCR2 is a target for the prevention and treatment of FPS virus infection, revealing that CCR2 plays an important role in the infection and proliferation of FPS virus and can serve as a target for inhibiting FPS virus infection. Utilizing CCR2 inhibitors as candidate drugs for the prevention and treatment of FPS virus shows great research potential. This invention provides a theoretical basis for using CCR2 as a target for the treatment of FPS and has significant application value for the treatment of FPS virus infection and the development of drugs for treating FPS virus infection.

The invention discloses dihydropyrimidine (thio) ketone as shown in a general formula I or pharmaceutically acceptable salt thereof, and preparation and antiviral application of the dihydropyrimidine (thio) ketone or the pharmaceutically acceptable salt thereof. The compound has the effects of inhibiting PEDV virus replication and reducing virus titer, is used for preventing and treating PED in the pig breeding industry, and reduces the incidence rate and case fatality rate of PED. # imgabs0 #

The present invention discloses an intelligent nursing management system and method for critically ill patients, which relates to the field of medical health monitoring technology, including setting up multiple physiological signal acquisition channels, synchronously acquiring multi-dimensional physiological signals of patients, and preprocessing the acquired signals to form a standardized multimodal physiological data stream; inputting the preprocessed multimodal physiological data into a deep learning model based on LSTM and multi-head attention mechanism, combining with a dynamic weight adaptive algorithm, to realize intelligent fusion analysis of different physiological signals, and establish an individualized physiological system coupling model for patients; based on the analysis results of the deep learning model, the patient's condition risk assessment value is calculated in real time, and a specific warning level is output according to the set multi-level warning threshold. The present invention realizes all-round monitoring and early warning of the patient's condition by constructing a multi-level and multi-dimensional warning threshold system. It can significantly improve the quality of monitoring of critically ill patients and reduce the rate of missed judgment and misjudgment.

The application discloses application of varenicline in preparation of an antibiotic enhancer, and belongs to the technical field of medicinal chemistry.The application proves that varenicline can improve the bacteriostatic effect of an antibiotic when the antibiotic is used in combination with varenicline.The effect is achieved by inhibiting cystathionine gamma-lyase activity, thereby inhibiting the generation of hydrogen sulfide and reducing antibiotic resistance.The inhibiting capacity of varenicline on bacterial cystathionine gamma-lyase activity is obviously superior to that on human cystathionine gamma-lyase, and varenicline has the potential to develop into an antibiotic enhancer.

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition and a preparation method and application thereof. Aiming at pathogenesis treatment of phlegm-heat internal disturbance type atrial fibrillation, the traditional Chinese medicine composition is formed by compounding multiple traditional Chinese medicine components, active components of the medicines have a mutual synergistic effect, in the formula, lapis chloriti has the effects of descending qi and dissolving phlegm, tabasheer has the effects of clearing heat and eliminating phlegm, rhizoma nardostachyos has the effects of regulating qi and relieving depression, cicada slough has the effects of dissipating heat and dispelling wind, and the effects of clearing heat and eliminating phlegm are achieved. The rhizoma coptidis has the effects of clearing heat, eliminating phlegm and drying dampness, the antelope horn powder has the effects of clearing heat and calming endogenous wind, and the rhizoma corydalis has the effects of promoting qi to activate blood. The traditional Chinese medicine is used for comprehensively treating various pathological factors of phlegm-heat internal disturbance type atrial fibrillation, and is remarkable in curative effect and outstanding in effect.