Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of chelerythrine to restraining growth of staphylococcus lugdunensis

A technology of Staphylococcus ludan and chelerythrine, which is applied in the directions of antibacterial drugs, medical preparations containing active ingredients, organic active ingredients, etc., to solve the problems of drug resistance and infection, reduce the fatality rate, and have wide application value Effect

Pending Publication Date: 2020-04-03
SHAANXI UNIV OF SCI & TECH
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report about the inhibition of chelerythrine on the growth of Staphylococcus ludunensis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of chelerythrine to restraining growth of staphylococcus lugdunensis
  • Application of chelerythrine to restraining growth of staphylococcus lugdunensis
  • Application of chelerythrine to restraining growth of staphylococcus lugdunensis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0014] The present invention will be described in further detail below in conjunction with the examples. The embodiments are only used to explain the present invention, not to limit the protection scope of the present invention.

[0015] 1. Drug susceptibility test of human-sourced Staphylococcus ludunensis

[0016] The present invention takes multiple strains of human-derived Staphylococcus ludunensis (strain samples are taken from Ningbo Center for Disease Control and Prevention) as starting strains, and selects penicillin, clindamycin, tetracycline, gentamicin, linezolid, and moxifloxacin6 Antimicrobial susceptibility tests were carried out on the susceptibility test strips of commonly used antibiotics.

[0017] The pure colonies picked and cultured for 18-24 hours were evenly dissolved in 2-5 mL sterile saline, and the turbidity was adjusted to be equal to that of a 0.5 McFarland turbidimetric tube. Aseptically draw 50-200 μL of bacterial solution, spread evenly on the p...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
concentrationaaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses an application of chelerythrine to restraining growth of staphylococcus lugdunensis. The chelerythrine has better in vitro destroying effects on medicine-resistant staphylococcus lugdunensis and can restrain the growth of the medicine-resistant staphylococcus lugdunensis, the minimum bactericidal concentration is 16 [mu]g / mL, and the minimal inhibition concentration is 7.8[mu]g / mL. The invention provides the restraining effects of the chelerythrine on the staphylococcus lugdunensis, and the chelerythrine has wide application value in the field of pharmaceuticals and thelike.

Description

technical field [0001] The invention relates to the research, development and application of chelerythrine, an active ingredient of traditional Chinese medicine, as an inhibitor of Staphylococcus ludunum, in particular to the application of chelerythrine in inhibiting the growth of Staphylococcus ludunum. Background technique [0002] Staphylococcus lugdunensis is one of the coagulase-negative staphylococcus, which likes to colonize the skin of the perineum. Staphylococcus ludunensis can also cause medical procedure-related infections, the most common of which is infective endocarditis (IE), including primary IE, IE after prosthetic valve replacement, and pacemaker-related IE. In addition, Staphylococcus ludunum can also cause peritonitis, urinary tract infection, central nervous system infection, bone and joint infection (septic arthritis, osteomyelitis), eye infection (suppurative keratitis, postoperative endophthalmitis), Mouth infection etc. With the widespread use of ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4741A61P31/04
CPCA61K31/4741A61P31/04
Inventor 钱卫东孙照欢杨敏刘淼张家宁王文静付玉婷李鑫辰
Owner SHAANXI UNIV OF SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com