Application of chelerythrine to restraining growth of staphylococcus lugdunensis

A technology of Staphylococcus ludan and chelerythrine, which is applied in the directions of antibacterial drugs, medical preparations containing active ingredients, organic active ingredients, etc., to solve the problems of drug resistance and infection, reduce the fatality rate, and have wide application value Effect

Pending Publication Date: 2020-04-03
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report about the inhibition of chelerythrine on the growth of Staphylococcus ludunensis

Method used

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  • Application of chelerythrine to restraining growth of staphylococcus lugdunensis
  • Application of chelerythrine to restraining growth of staphylococcus lugdunensis
  • Application of chelerythrine to restraining growth of staphylococcus lugdunensis

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Embodiment Construction

[0014] The present invention will be described in further detail below in conjunction with the examples. The embodiments are only used to explain the present invention, not to limit the protection scope of the present invention.

[0015] 1. Drug susceptibility test of human-sourced Staphylococcus ludunensis

[0016] The present invention takes multiple strains of human-derived Staphylococcus ludunensis (strain samples are taken from Ningbo Center for Disease Control and Prevention) as starting strains, and selects penicillin, clindamycin, tetracycline, gentamicin, linezolid, and moxifloxacin6 Antimicrobial susceptibility tests were carried out on the susceptibility test strips of commonly used antibiotics.

[0017] The pure colonies picked and cultured for 18-24 hours were evenly dissolved in 2-5 mL sterile saline, and the turbidity was adjusted to be equal to that of a 0.5 McFarland turbidimetric tube. Aseptically draw 50-200 μL of bacterial solution, spread evenly on the p...

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Abstract

The invention discloses an application of chelerythrine to restraining growth of staphylococcus lugdunensis. The chelerythrine has better in vitro destroying effects on medicine-resistant staphylococcus lugdunensis and can restrain the growth of the medicine-resistant staphylococcus lugdunensis, the minimum bactericidal concentration is 16 [mu]g / mL, and the minimal inhibition concentration is 7.8[mu]g / mL. The invention provides the restraining effects of the chelerythrine on the staphylococcus lugdunensis, and the chelerythrine has wide application value in the field of pharmaceuticals and thelike.

Description

technical field [0001] The invention relates to the research, development and application of chelerythrine, an active ingredient of traditional Chinese medicine, as an inhibitor of Staphylococcus ludunum, in particular to the application of chelerythrine in inhibiting the growth of Staphylococcus ludunum. Background technique [0002] Staphylococcus lugdunensis is one of the coagulase-negative staphylococcus, which likes to colonize the skin of the perineum. Staphylococcus ludunensis can also cause medical procedure-related infections, the most common of which is infective endocarditis (IE), including primary IE, IE after prosthetic valve replacement, and pacemaker-related IE. In addition, Staphylococcus ludunum can also cause peritonitis, urinary tract infection, central nervous system infection, bone and joint infection (septic arthritis, osteomyelitis), eye infection (suppurative keratitis, postoperative endophthalmitis), Mouth infection etc. With the widespread use of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4741A61P31/04
CPCA61K31/4741A61P31/04
Inventor 钱卫东孙照欢杨敏刘淼张家宁王文静付玉婷李鑫辰
Owner SHAANXI UNIV OF SCI & TECH
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