6 results about "Chelirubine" patented technology

The invention discloses a botanical alkaloid and trichoderma synergistic preparation and application thereof, and belongs to the technical field of biological control. The invention provides a preparation containing trichoderma haworthia and chelerythrine in order to solve the technical problems of long period, low prevention and treatment efficiency and easiness in causing harm to environment and human health in a tobacco mosaic disease prevention and treatment method in the prior art. According to the preparation provided by the invention, under the condition that the dilution multiple is 50, the control effect on the tobacco mosaic virus is improved through multi-mechanism synergism, the provided preparation can be applied to tobacco planting production, the control efficiency of the tobacco mosaic disease can be effectively improved, and the economic benefit of tobacco planting is improved.

The application discloses an AS1411 aptamer functionalized liposome which comprises lipids, indocyanine green, chelidonium red base and AS1411 aptamer. The application also discloses a preparation method and application of the AS1411 aptamer functionalized liposome. The AS1411 aptamer functionalized liposome provided by the application has excellent fluorescence imaging and chemical-photothermal treatment effects, and is expected to become an ideal diagnosis and treatment nano system and has the potential for future clinical application in cancer treatment.

The application discloses application of chelerythrine combined with polymyxin E in inhibition of polymyxin E drug-resistant bacteria, and the polymyxin E drug-resistant bacteria are mcr positive bacteria. Experiments prove that chelerythrine can inhibit (such as mcr-1 positive escherichia coli ZJ807, mcr-8 positive klebsiella pneumoniae KP91 and mcr-9 positive salmonella SLM183) in cooperation with polymyxin E, and can reduce the use amount of polymyxin E and reverse the drug resistance to polymyxin E. Chelerythrine can restore the inhibitory effect of polymyxin E on the polymyxin E drug-resistant bacteria. The application has important application value.

The invention discloses application of chelerythrine in preparation of drugs or antibiotic synergists for treating bacterial infectious diseases, bacteria are carbapenem antibiotic resistant bacteria, and antibiotics are carbapenem antibiotics. The invention discloses that chelerythrine can restore the sensitivity of carbapenem drug-resistant bacteria for the first time, can reduce the minimum inhibitory concentration of meropenem to bacteria for producing metal beta-lactamase by 16 times, and provides a new strategy for solving the drug resistance of bacteria.

This invention relates to the field of bactericide technology, specifically to a celandine bactericide and its preparation method. The bactericide is composed of the following parts by weight: antibacterial active ingredient: 0.1-0.5 parts; functional microbial agent: 2-20 parts; carrier: 70-90 parts; wherein the antibacterial active ingredient is composed of celandine and N-aryl-3,4-dihydroisoquinoline derivative in a mass ratio of 1:(0.2-5). This application introduces iodine and bromohalogen atoms at specific positions of N-aryl-3,4-dihydroisoquinoline, enabling it to produce a significant synergistic antibacterial effect with celandine. Beneficial bacteria such as Bacillus amyloliquefaciens and Pseudomonas fluorescens can resist the effects of sub-inhibitory drug concentrations by secreting cyclic lipopeptides and upregulating efflux pumps. The technology of encapsulating the antibacterial active ingredient into a sustained-release unit and combining it with a carrier that adsorbs live bacteria significantly improves the retention rate of live bacteria, achieving a long-term balance between stable drug release and beneficial bacterial activity.

The invention discloses application of chelerythrine and derivatives thereof in prevention and treatment of tobacco mosaic diseases, and belongs to the technical field of plant disease prevention and treatment. The invention provides application of chelerythrine and derivatives thereof in prevention and treatment of tobacco mosaic diseases in order to solve the problem of lack of effective prevention and treatment measures for plants infected with tobacco mosaic viruses in the prior art, and respectively limits the application concentration of chelerythrine and derivatives thereof in prevention and treatment of tobacco mosaic diseases. And the chelerythrine and the derivative dihydrochelerythrine thereof are used as effective components to prepare a compound pesticide preparation. The compound pesticide preparation provided by the invention is relatively low in biotoxicity, relatively high in safety and free of phytotoxicity; the influence on the growth state of the treated tobacco plants is small, the treated tobacco plants have no obvious inhibition or poor growth phenomenon, and the method can be applied to agricultural biological prevention and treatment of tobacco mosaic diseases.