Cancer treating medicine

A drug and cancer technology, applied in the direction of drug delivery, drug combination, anti-tumor drugs, etc., to achieve the effect of large promotion and use value, various dosage forms, and no toxic and side effects

Inactive Publication Date: 2004-04-07
秦吉兴
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no traditional Chinese medicine preparation for treating cancer with Boluohui as raw material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] The preparation of embodiment 1 Bo falls back to total alkaloid

[0013] Take 20Kg Boluohui fruit, grind it, put it into an extraction tank, add 10 times the amount of 75% ethanol with hydrochloric acid to adjust the pH to 3-4, and reflux extraction twice, each time for 1 hour. Combine the extracts and filter. Put the filtrate in a concentration tank, recover ethanol under reduced pressure and concentrate to a relative density of 1.08, let it stand, let it cool, and centrifuge. Take the supernatant and adjust the pH value of the solution to 10 with 40% sodium carbonate solution, stir evenly, let stand for 48 hours, centrifuge, collect the precipitate, and dissolve it with ethanol 8 times the weight of the precipitate. Centrifuge and separate the supernatant, dissolve the residue twice in the same way, combine the solutions, adjust the pH of the solution to 3-4 with hydrochloric acid, recover ethanol under reduced pressure, let the concentrated solution stand, and refri...

Embodiment 2

[0015] The preparation of embodiment 2 boluohui total alkali capsules

[0016] Take 20g of Boluohui total alkali and mix with 200g of starch, crush it and pass through a 120-mesh sieve, mix evenly, put it into capsules, and obtain.

Embodiment 3

[0017] The preparation of embodiment 3 Bo Luohui total alkali granules

[0018] Take 10g of Boluohui total alkali fine powder, add 150g of dextrin, 150g of mannitol, 40g of soluble starch, and 2g of stevioside, mix well, granulate with 80% ethanol, dry, and pack.

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Abstract

The cancer treating medicine is prepared with bocconia cordata total alkali as material and through adding medicinal supplementary material and conventional preparation process. The bocconia cordata total alkali contains chelirubine hydrochloride over 25 wt% and sanguinarine hydrochloride over 30 wt%. The preparation process of bocconia cordata total alkali comprising three steps of ethanol extraction, acid and alkali treatment to eliminate impurity and ethanol re-crystallization to purify is also disclosed. The medicine of the present invention has high effective component content, determined treating effect, fast effect, few toxic side effect and other advantages.

Description

Technical field [0001] The invention relates to a medicine for treating cancer, in particular to a Chinese patent medicine prepared from the Chinese herbal medicine Boluohui. Background technique [0002] Bocconia cordata (Willd) R.B [Bocconiacordata] is a perennial plant of the poppy family Bocconia cordata, which is widely distributed in my country. Use it to root the whole plant, including the fruit. It has the functions of killing insects, dispelling wind and detoxification, dispelling blood stasis and reducing swelling. It is clinically used for the treatment of diseases such as trichomonas vaginalis, furuncle carbuncle, bruises, rheumatic joint pain, athlete's foot, eczema, and lower extremity ulcers. Studies at home and abroad have shown that Boluogui contains Sarguinarine, Chelerythine, Protopine, α-Allacryptine, bocconoline ) and many other alkaloids. These alkaloids are all isoquinoline derivative alkaloids, which have multiple pharmacological effects such as ant...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/4741A61P35/00
Inventor 秦吉兴
Owner 秦吉兴
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