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Composite medicinal preparation containing inosine matters

A preparation, the technology of inosine, which is applied in the field of combined pharmaceutical preparations containing inosine substances, can solve the problems of low drug compliance, pollution, and large dosage of patients

Inactive Publication Date: 2004-04-28
YANGPU HG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In long-term medical practice, although vitamin C and inosine have been used in combination in large quantities, there are still the following problems: when taking oral medication, patients are administered in multiple dosage forms, the dosage is large, and the patient's medication compliance Low sensitivity; when injecting medicine, vitamin C and inosine need to be prepared temporarily, and there are many procedures at the same time, which is inconvenient for both doctors and patients, and also increases the chance of pollution in the dispensing process

Method used

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  • Composite medicinal preparation containing inosine matters

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0019] - control sample

[0020] Control sample I: Weigh 1.20 grams of vitamin C, add 10% glucose injection to 500 milliliters and shake well,

[0021] Control sample II: Weigh 2.40 grams of vitamin C, add 10% glucose injection to 500 ml and shake well,

[0022] Control sample III: Weigh 0.6 g of inosine, add 10% glucose injection to 500 ml and shake well,

[0023] - for samples

[0024] For sample A: weigh 1.20 grams of vitamin C, weigh 0.6 grams of inosine, add 10% glucose injection to 500 ml and shake well,

[0025] For sample B: weigh 2.40 grams of vitamin C, weigh 0.6 grams of inosine, add 10% glucose injection to 500 ml and shake well,

[0026] Use the above-mentioned control sample and the sample for the paper chromatography composition test as follows.

[0027] --Paper chromatography composition test:

[0028] Chromatographic filter paper: No. 1 medium speed,

[0029] Developing solvent: n-butanol-glacial acetic acid-purified water,

[0030] Chromogen: 254nm ult...

Embodiment approach 2

[0037] Freeze-dried powder injection:

[0038] Ingredient Vial Dose (mg)

[0039] active ingredient

[0040] Inosine 100

[0041] Vitamin C 100

[0042] The finished product is obtained by following the freeze-dried powder injection preparation process: take 100 g of injection-grade mannitol, add 500 ml of water for injection to dissolve. Weigh inosine 100g, Vc100g and dissolve in the above solution. Add 0.25g of activated carbon for injection, heat to 60°C-80°C, stir for 20 minutes, coarsely filter and decarbonize, wash the filter with an appropriate amount of water for injection, combine the filtrate, add water for injection to 1900ml, measure the pH value of the solution, and use Hydrochloric acid solution or sodium hydroxide solution to adjust the pH value of the solution to 5.5-6.0, add water for injection to the full amount, measure the pH value and content of the solution, control the pH value between 5.5-6.0, and then use 0.22 Sterilize by microporous ...

Embodiment approach 3

[0044] tablet:

[0045] Ingredient Vial Dose (mg)

[0046] active ingredient

[0047] Inosine 200

[0048] Vitamin C 100

[0049] medical supplements

[0050] powdered sugar 50

[0051] Starch 120

[0052] Low-substituted hydroxypropyl cellulose 10

[0053] Magnesium stearate 40

[0054] Starch slurry 15

[0055] According to tablet preparation standard process operation, the finished product is obtained.

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Abstract

The composite medicinal preparation contains inosine and / or its derivative, vitamin C and / or its derivative and medicinal supplementary material and is prepared into freeze dried powder, tablet, injection or capsule. The freeze dried powder, the tablet and the capsule have medicinal supplementary material content not over 45 %. The present invention is suitable for patient to take inosine and vitamin C simultaneously.

Description

【Technical field】 [0001] The invention relates to a western medicine combination preparation, more specifically, the invention relates to a combination medicine preparation containing inosine substances. 【Background technique】 [0002] In today's world, probably due to reasons such as diet and culture, my country has become a country with high prevalence of diseases such as hepatitis, liver cirrhosis, and liver cancer. Among them, liver cirrhosis and liver cancer are common diseases and major diseases in my country. one of the causes of death. Hepatitis, liver cirrhosis, liver cancer and other diseases can be caused by various reasons, not a single disease, but a clinical and pathological syndrome. Their clinical manifestations vary in severity, ranging from asymptomatic to mild discomfort to severe liver failure. Hepatitis, liver cirrhosis, liver cancer and other diseases, no matter what the etiology is and what the clinical symptoms are, all show liver function damage cau...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61K9/20A61K9/48A61K31/7076A61P1/16A61P31/12
Inventor 郭德
Owner YANGPU HG PHARMA
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