Slow-release film for treating glaucoma and preparation method thereof

A technology of glaucoma and drug film, which is applied in the direction of medical formula, medical preparations containing active ingredients, drug combination, etc., can solve the problem of no glaucoma sustained-release agent film, etc., to reduce the number of times of taking medicine, the process is short, and it is convenient to use Effect

Inactive Publication Date: 2013-12-18
HUNAN UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on glaucoma sustained-release film and its preparation at home and abroad

Method used

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Experimental program
Comparison scheme
Effect test

specific Embodiment approach 2

[0015] The steps of specific implementation mode 2 are:

[0016] 1. Take 60g of Radix Astragali, 20g of Earthworm, 20g of Radix Paeoniae Rubra, 20g of Safflower, 20g of Poria, 20g of Plantago Seed, 20g of Atractylodes Rhizoma Atractylodes Rhizoma Rhizome, 20g of Rehmanniae Rhizoma Rhizoma Rhizoma Rhizoma Rhizome, mix and pulverize, and extract with 1.8L of water for 3 hours, pour out the extract, Centrifuge at a speed of 30r / min for 10min, and then filter under reduced pressure to obtain 340ml filtered solution as Qingguang'an drug solution.

[0017] 2. Prepare film-forming materials: polyvinyl alcohol PVA, chitosan CS (the ratio is 5 to 1).

[0018] 3. Preparation of sustained-release film agent: soak 6g of film-forming material in appropriate amount of water, heat to dissolve, add 0.5ml of glycerin, 20ml of Qingguang’an drug solution, 3 drops of Tween-80, stir well, dry in the air, and irradiate with ultraviolet light for 30min Disinfect and open the membrane.

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PUM

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Abstract

The invention discloses a slow-release film for treating glaucoma and a preparation method thereof. The preparation method is characterized by being a complete set of manufacturing method comprising the steps of extracting traditional Chinese medicine compound Qiangguangan, centrifugal separating, filtering, adding a proper amount of auxiliary material, homogenizing, forming film and sterilizing. The medicine disclosed in the invention is a formulation innovation based on the existing Qiangguangan granules, a novel long-acting film is provided to patients, so as to meet the ever increasing medicine and medical treatment requirements.

Description

technical field [0001] The invention relates to a medicine for treating glaucoma, in particular to a slow-release medicine film for treating glaucoma and a preparation method thereof. Background technique [0002] Qingguang'an granule, which has the effect of nourishing qi, activating blood and diuresis, is composed of astragalus, earthworm, red peony root, safflower, poria cocos, plantain seed, atractylodes macrocephala, and earthworm eight herbs. It is used for the treatment of glaucoma. The preparation in the First Affiliated Hospital of the University has been used for 18 years, and it is mature and reliable. Due to the high production cost of granules, easy deliquescence, high requirements on packaging methods and materials, poor mobility, and slightly poor palatability. [0003] At present, the most common dosage forms for ocular administration are eye drops and eye ointment. However, due to the special anatomical structure and physiological and biochemical properties...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K9/70A61P27/06A61K35/56A61K35/62
Inventor 陈胜璜王敏沈冰冰
Owner HUNAN UNIV OF CHINESE MEDICINE
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