A kind of external Chinese medicine composition, external Chinese medicine preparation and its preparation method and application

A technology of composition and traditional Chinese medicine, which is applied in the field of external Chinese medicine composition, and can solve problems such as the addiction and tolerance of western medicine analgesics that restrict the wide application

Active Publication Date: 2017-05-31
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the side effects such as addiction and tolerance of western medicine analgesics still restrict the wide clinical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Preparation of external Chinese medicine composition spray:

[0061] The raw materials include: 70 parts of white mustard seeds, 20 parts of Gansui, 180 parts of Qingfengteng, 70 parts of Corydalis Corydalis, 60 parts of Asarum, 70 parts of Aconitum Aconitum and 60 parts of Tripterygium wilfordii.

[0062] Preparation:

[0063] 1) Pulverize the raw materials, decoct 3 times, use 1000ml of water for each decoction, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to obtain a clear paste;

[0064] 2) Stir 3% glycerin with the extract in step 1), add 3% dimethyl sulfoxide and 0.2% sorbic acid, and mix with distilled water to 2000ml; The weight percent of described external use Chinese medicine composition;

[0065] 3) Put it into a spray bottle and sterilize it. The specification of the spray can be 20ml / bottle.

Embodiment 2

[0067] Preparation of external Chinese medicine composition patch:

[0068] The raw materials include: 60 parts of white mustard seed, 15 parts of Gansui, 60 parts of Qingfengteng, 60 parts of Corydalis Corydalis, 15 parts of Asarum, 60 parts of Aconitum Aconitum and 60 parts of Tripterygium wilfordii.

[0069] Preparation:

[0070] 1) Roll the raw material into coarse powder, heat and reflux with 70% ethanol aqueous solution to extract twice, add 10 times the amount of ethanol aqueous solution for the first time, and the extraction time is 1 hour, add 8 times the amount of ethanol aqueous solution for the second time, extract for 1 hour, and depressurize Recover the aqueous ethanol solution and concentrate to obtain extract; the percentage is the volume percentage of ethanol in the solution;

[0071] 2) Dissolve acrylate pressure-sensitive adhesive and azone with ethyl acetate, add extract, stir evenly with glycerin, coat on the non-woven fabric backing layer, dry at 70°C, a...

Embodiment 3

[0073] Preparation of external Chinese medicine composition cataplasm:

[0074] The raw materials include: 70 parts of white mustard seeds, 30 parts of Gansui, 120 parts of Qingfengteng, 70 parts of Corydalis Corydalis, 20 parts of Asarum, 40 parts of Aconitum Aconitum and 60 parts of Tripterygium wilfordii.

[0075] Preparation:

[0076] 1) Roll the raw material into coarse powder, heat and reflux with 70% ethanol aqueous solution to extract twice, add 10 times the amount of ethanol aqueous solution for the first time, extract for 1 hour, add 8 times the amount of ethanol aqueous solution for the second time, extract for 1 hour, and depressurize Recover the aqueous ethanol solution and concentrate to obtain extract; the percentage is the volume percentage of ethanol in the solution;

[0077] 2) 3% carbomer is mixed with the clear paste obtained in step 1), and stirred to make it fully swell to form mixed solution A; 20% polyvinyl alcohol (PVA) and 2% azone are dispersed in 1...

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PUM

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Abstract

The invention discloses an externally-applied traditional Chinese medicine composition, an externally-applied traditional Chinese medicine preparation as well as a preparation method and application of the externally-applied traditional Chinese medicine composition. The externally-applied traditional Chinese medicine composition is prepared from the raw materials comprising the following components in parts by weight: 30-70 parts of semen brassicae, 15-60 parts of euphorbia kansui, 60-180 parts of sabia japonica, 30-70 parts of rhizoma corydalis and 15-60 parts of asarum. The traditional Chinese medicine composition disclosed by the invention has the efficacies of warming and activating meridians to stop pain, resisting inflammation, reducing swelling and easing pain to improve the symptoms of chronic pain, combines acupoint stimulation with chemical action of drugs through moxibustion when applied to acupuncture and moxibustion therapy, plays a role in easing pain and reducing inflammation by moxibustion therapy, and can be used for enhancing the curative effect of an externally-applied drug. In addition, the externally-applied traditional Chinese medicine composition is an externally-applied preparation; the first-pass effect of a toxic drug is relieved by transdermal absorption; the target of treating the pain is realized; and meanwhile, the dosage of the drugs is reduced, so that the safe and effective targets are realized.

Description

technical field [0001] The invention relates to an external Chinese medicine composition, an external Chinese medicine preparation, a preparation method and application thereof. Background technique [0002] The mechanism of pain has not been explained clearly so far, but pain is often the main reason why patients visit the hospital. Pain can usually be divided into two categories: one is the signal of disease, that is, pain is only a symptom of disease, such as cold, fever, headache, brain fever, etc., as long as the disease is cured, the pain as a signal of disease will disappear. Another type of pain itself is a disease, such as pain in affected limbs, intractable low back pain, trigeminal neuralgia, postherpetic neuralgia, and cancer pain (cancer pain has been cured in the advanced stage, but there is still a six-month to one-year survival period, But the pain often makes the patient may only survive for two or three months) and so on. Generally speaking, when the pain...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/714A61K9/00A61K9/12A61K9/06A61K9/70A61P29/00
CPCA61K9/0014A61K9/06A61K9/12A61K9/7023A61K36/268A61K36/31A61K36/37A61K36/47A61K36/59A61K36/66A61K36/714A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 裴建陈宇杰宋毅史秀峰汤春琳
Owner LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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