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Application of chelerythrine in inhibiting growth of multi-drug-resistant serratia marcescens

A technology of Serratia marcescens and chelerythrine, applied in the field of medicine, to achieve the effect of reducing mortality, wide application value, and solving drug resistance and infection problems

Active Publication Date: 2020-03-13
NINGBO MUNICIPAL CENT FOR DISEASE CONTROL & PREVENTION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no literature report that chelerythrine has antibacterial effect on multi-drug resistant Serratia marcescens

Method used

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  • Application of chelerythrine in inhibiting growth of multi-drug-resistant serratia marcescens
  • Application of chelerythrine in inhibiting growth of multi-drug-resistant serratia marcescens
  • Application of chelerythrine in inhibiting growth of multi-drug-resistant serratia marcescens

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Embodiment Construction

[0013] The present invention will be described in further detail below in conjunction with the examples. The embodiments are only used to explain the present invention, not to limit the protection scope of the present invention.

[0014] 1. Drug susceptibility test of Serratia marcescens

[0015] The present invention takes multiple strains of human Serratia marcescens (strain samples are taken from Ningbo Women and Children's Hospital) as starting strains, and selects ampicillin, ampicillin / sulbactam, cefazolin, cefotetan, ceftriaxone, ceftazidime , piperacillin / tazobactam, co-trimoxazole, cefepime, aztreonam, gentamicin, ertapenem, imipenem, tobramycin, amikacin, ciproterone 18 kinds of commonly used antibiotics including floxacin, nitrofurantoin and levofloxacin were tested.

[0016] The pure colonies picked and cultured for 18-24 hours were evenly dissolved in 2-5 mL sterile saline, and the turbidity was adjusted to be equal to that of a 0.5 McFarland turbidimetric tube....

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Abstract

The invention discloses the application of chelerythrine in inhibiting the growth of multi-drug-resistant serratia marcescens. The chelerythrine has a relatively good in-vitro killing effect on the multi-drug-resistant serratia marcescens, can inhibit the growth of the multi-drug resistance serratia marcescens, and has the minimum bactericidal concentration of 30-250 [mu]g / mL and the minimal inhibitory concentration of 15-125 [mu] g / mL. The invention provides the inhibition effect of the chelerythrine on the multi-drug resistance serratia marcescens, and has good application values in the fields of medicine and the like.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of chelerythrine in inhibiting the growth of multidrug-resistant Serratia marcescens. Background technique [0002] Serratia marcescens, also known as Serratia marcescens, is a Gram-negative bacterium of the Enterobacteriaceae family Serratia genus, which can cause a variety of infections. Serratia marcescens is known to cause eye, lung, urinary tract and bloodstream infections. Recent reports suggest the presence of this pathogen in 2.5%-7.7% of catheter-associated infections. In recent years, the drug resistance rate and clinical isolation rate of carbapenem-resistant Serratia marcescens have gradually increased, which has brought great challenges to the prevention and control of nosocomial infection and clinical anti-infection treatment. [0003] Chelidonine is a natural triphenanthridine alkaloid extracted from plants, such as Nuxseed, Centipede, and Canadian Red Cli...

Claims

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Application Information

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IPC IPC(8): A61K31/4741A61P31/04
CPCA61K31/4741A61P31/04Y02A50/30
Inventor 李永东倪红霞许国章焦素黎刘昱慧
Owner NINGBO MUNICIPAL CENT FOR DISEASE CONTROL & PREVENTION
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