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Application of chelerythrine in inhibition and clearing of multi-drug-resistant Providencia rettgeri biofilm

A technology of Providencia reaeti and Providencia biotechnology, which is applied in the directions of antibacterial drugs, pharmaceutical formulations, medical preparations containing active ingredients, etc. Inhibition and scavenging, etc., to achieve the effect of wide application value

Active Publication Date: 2020-05-12
SHAANXI UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no literature report on the inhibitory and clearing effect of chelerythrine on multidrug-resistant Providencia rettii biofilm

Method used

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  • Application of chelerythrine in inhibition and clearing of multi-drug-resistant Providencia rettgeri biofilm
  • Application of chelerythrine in inhibition and clearing of multi-drug-resistant Providencia rettgeri biofilm
  • Application of chelerythrine in inhibition and clearing of multi-drug-resistant Providencia rettgeri biofilm

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Embodiment Construction

[0019] The present invention will be described in further detail below in conjunction with the examples. The examples are only used to explain the content of the present invention, not to limit the present invention.

[0020] The Chinese name of chelerythrine is chelerythrine, the English name is chelerythrine, and the molecular formula is C 21 h 18 NO 4 + , the molecular weight is 348.37192, the melting point is 195-205°C, the CAS number is 34316-15-9, and the molecular structure is:

[0021]

[0022] 1. Drug susceptibility test of Providencia rettgeri

[0023] The present invention takes 5 strains of Providencia rettgeri as starting bacterial strains, selects ampicillin, ampicillin / sulbactam, cefazolin, cefotetan, ceftriaxone, ceftazidime, tobramycin, piperacillin Zobactam, ciprofloxacin, levofloxacin, amikacin, cotrimoxazole, cefepime, ertapenem, imipenem, nitrofurantoin, aztreonam, gentamicin and other 18 kinds of commonly used antibiotics for testing.

[0024] P...

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Abstract

The invention discloses application of chelerythrine in inhibition and clearing of a multi-drug-resistant Providencia rettgeri biofilm. According to the application, the technical problem that the drug resistance of a drug-resistant Providencia rettgeri biofilm is difficult to clear once formed is solved. The chelerythrine is capable of inhibiting formation of the Providencia rettgeri biofilm, andthe minimum inhibition concentration is 15.6 micrograms per milliliter. Besides, the chelerythrine is capable of clearing a mature Providencia rettgeri biofilm, and the minimum clearing concentrationis 250 micrograms per milliliter. By virtue of the effect of a rooted whole grass extract, namely the chelerythrine of a papaveraceous plant celandine, on the multi-drug-resistant Providencia rettgeri biofilm, the infection caused by the Providencia rettgeri biofilm can be effectively relieved or solved, the healing rate is increased, new thoughts are provided for the inhibition of the Providencia rettgeri biofilm and the clearing of the mature biofilm, and the application has important practical significances.

Description

technical field [0001] The invention belongs to the technical field of medicine and food safety, and relates to the application of chelerythrine in inhibiting and eliminating multidrug-resistant Providencia rettgeri biofilm. Background technique [0002] Providencia is Gram-negative, Enterobacteriaceae, is a normal intestinal flora of humans and animals, and is also an opportunistic pathogen, which can cause diarrhea, extraintestinal infection and urinary tract infection (Jia Qinmei, Sun et al. Le, Man Baohua. Study on the drug resistance mechanism of carbapenem-resistant Providencia rettgeri[J]. Journal of Molecular Diagnosis and Therapeutics, 2018,10(05):332-336.). Biofilm is a structure group composed of multi-layered cell bacteria formed by bacteria in order to adapt to the change of environment. , Moghadam NA, Mamooii Z, et al. Antibiotic resistance and biofilm formation of Enterococcus faecalis in patient and environmental samples [J]. Jundishapur Journal of Microbiol...

Claims

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Application Information

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IPC IPC(8): A61K31/4741A61P31/04
CPCA61K31/4741A61P31/04
Inventor 钱卫东刘淼付玉婷张家宁黄杰高悦何维维崔雅欣
Owner SHAANXI UNIV OF SCI & TECH
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