Application of chelerythrine in inhibiting and clearing biofilm of multi-drug resistant Providencia rettleri
A technology of Providence Reishi biology and Providence biology, which is applied in the directions of pharmaceutical formulations, antibacterial drugs, medical preparations containing active ingredients, etc. Inhibition and scavenging effects, etc., to achieve wide application value, solve infection problems, and reduce the effect of fatality rate
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[0019] The present invention will be described in further detail below in conjunction with the examples. The examples are only used to explain the content of the present invention, not to limit the present invention.
[0020] The Chinese name of chelerythrine is chelerythrine, the English name is chelerythrine, and the molecular formula is C 21 h 18 NO 4 + , the molecular weight is 348.37192, the melting point is 195-205°C, the CAS number is 34316-15-9, and the molecular structure is:
[0021]
[0022] 1. Drug susceptibility test of Providencia rettgeri
[0023] The present invention takes 5 strains of Providencia rettgeri as starting bacterial strains, selects ampicillin, ampicillin / sulbactam, cefazolin, cefotetan, ceftriaxone, ceftazidime, tobramycin, piperacillin Zobactam, ciprofloxacin, levofloxacin, amikacin, cotrimoxazole, cefepime, ertapenem, imipenem, nitrofurantoin, aztreonam, gentamicin and other 18 kinds of commonly used antibiotics to test.
[0024] Pick ...
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