Application of chelerythrine in inhibiting and clearing biofilm of multi-drug resistant Providencia rettleri

A technology of Providence Reishi biology and Providence biology, which is applied in the directions of pharmaceutical formulations, antibacterial drugs, medical preparations containing active ingredients, etc. Inhibition and scavenging effects, etc., to achieve wide application value, solve infection problems, and reduce the effect of fatality rate

Active Publication Date: 2022-01-14
SHAANXI UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no literature report on the inhibitory and clearing effect of chelerythrine on multidrug-resistant Providencia rettii biofilm

Method used

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  • Application of chelerythrine in inhibiting and clearing biofilm of multi-drug resistant Providencia rettleri
  • Application of chelerythrine in inhibiting and clearing biofilm of multi-drug resistant Providencia rettleri
  • Application of chelerythrine in inhibiting and clearing biofilm of multi-drug resistant Providencia rettleri

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Embodiment Construction

[0019] The present invention will be described in further detail below in conjunction with the examples. The examples are only used to explain the content of the present invention, not to limit the present invention.

[0020] The Chinese name of chelerythrine is chelerythrine, the English name is chelerythrine, and the molecular formula is C 21 h 18 NO 4 + , the molecular weight is 348.37192, the melting point is 195-205°C, the CAS number is 34316-15-9, and the molecular structure is:

[0021]

[0022] 1. Drug susceptibility test of Providencia rettgeri

[0023] The present invention takes 5 strains of Providencia rettgeri as starting bacterial strains, selects ampicillin, ampicillin / sulbactam, cefazolin, cefotetan, ceftriaxone, ceftazidime, tobramycin, piperacillin Zobactam, ciprofloxacin, levofloxacin, amikacin, cotrimoxazole, cefepime, ertapenem, imipenem, nitrofurantoin, aztreonam, gentamicin and other 18 kinds of commonly used antibiotics to test.

[0024] Pick ...

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Abstract

The invention discloses the application of chelerythrine in inhibiting and clearing the biofilm of multi-drug-resistant Providence recei, which is used to solve the drug resistance of the biofilm of the drug-resistant Providence rebei and once formed Difficult to clear technical issues. According to chelerythrine, it can inhibit the formation of Providencia reinhardtii biofilm, and the minimum inhibitory concentration is 15.6μg / mL. In addition, chelerythrine can clear mature Providence recei biofilms with a minimum clearance concentration of 250 μg / mL. The invention adopts the effect of chelerythrine, a rooted whole grass extract of Celandine celandine of the papaveraceae plant, on the biofilm of multi-drug-resistant Providence recei, which can effectively alleviate or solve the biological problems of Providence recei. The infection caused by the film can improve the cure rate, and it is of great practical significance to propose a new idea for inhibiting the formation of the Providencia rebei biofilm and clearing the mature biofilm.

Description

technical field [0001] The invention belongs to the technical field of medicine and food safety, and relates to the application of chelerythrine in inhibiting and eliminating multidrug-resistant Providencia rettgeri biofilm. Background technique [0002] Providencia is Gram-negative, Enterobacteriaceae, is a normal intestinal flora of humans and animals, and is also an opportunistic pathogen, which can cause diarrhea, extraintestinal infection and urinary tract infection (Jia Qinmei, Sun et al. Le, Man Baohua. Study on the drug resistance mechanism of carbapenem-resistant Providencia rettgeri[J]. Journal of Molecular Diagnosis and Therapeutics, 2018,10(05):332-336.). Biofilm is a structure group composed of multi-layered cell bacteria formed by bacteria in order to adapt to the change of environment. , Moghadam NA, Mamooii Z, et al. Antibiotic resistance and biofilm formation of Enterococcus faecalis in patient and environmental samples [J]. Jundishapur Journal of Microbiol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4741A61P31/04
CPCA61K31/4741A61P31/04
Inventor 钱卫东刘淼付玉婷张家宁黄杰高悦何维维崔雅欣
Owner SHAANXI UNIV OF SCI & TECH
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