Application of eucalyptol in the preparation of anti-esbls-producing Escherichia coli medicine

Abstract

The invention belongs to the field of medicines, and particularly discloses application of eucalyptol to the preparation of a drug resistant to ESBLs (Extended Spectrum Beta-Lactamases)-producing escherichia coli. According to the application of the eucalyptol to the preparation of the drug resistant to the ESBLs-producing escherichia coli, aiming at the current research situation of an existing drug resistant to the ESBLs-producing escherichia coli, and through in-depth research, an active monomer, which inhibits the ESBLs-producing escherichia coli, in volatile oil from herba origani is discovered to be the eucalyptol; the monomer eucalyptol can influence the formation of a drug-resistant target spot-biological envelope of the ESBLs-producing escherichia coli; meaningful research foundations are laid for relieving or eliminating the infection of the ESBLs-producing escherichia coli, improving a clinical treatment effective rate, decreasing a fatality rate and saving a medical resource; a novel research thought is proposed for the prevention and the treatment of drug-resistance bacteria; the application of the eucalyptol to the preparation of the drug resistant to the ESBLs-producing escherichia coli has an important search meaning.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of eucalyptol, one of oregano volatile oil monomers, in the preparation of anti-ESBLs-producing Escherichia coli drugs. Background technique [0002] Bacterial multi-drug resistance has become a serious public health threat and a clinical problem of worldwide concern, resulting in an increase in the mortality rate and a waste of medical resources. In actual clinical treatment, the infection rate of ESBLs-producing Escherichia coli is relatively high. Due to the production of Extended Spectrum β-lactamases (ESBLs), its drug resistance range is relatively wide, which means that the existing The choice of anti-infective drugs is limited. In addition to choosing existing anti-infective drugs, we have no other way to fundamentally block or solve the problem of drug resistance. This requires people to continuously develop new antibiotics, but the speed of developin...

AI Technical Summary

Problems solved by technology

[0005] The present invention aims at the current research status of existing ESBLs-producing Escherichia coli drugs. After in-depth research, it is found that the active monomer in oregano volatile oil that inhibits ESBLs-producing Escherichia coli is eucalyptol, and eucalyptol, one of the monomers of oregano volatile oil, can affect the production of ESBLs. Bacteria drug resistance target - the formation of biofilm, which has laid a meaningful research foundation for alleviating or solving the infection of ESBLs-producing Escherichia coli, improving the efficiency of clinical treatment, reducing the mortality rate, and saving medical resources. Prevention and control put forward a new research idea, which has important research significance

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