Application of sanguinarine in inhibition and removal of multi-drug-resistant providencia rettgeri biofilm

A technology of Providencia rettii organisms and Providencia organisms, which is applied in the direction of antibacterial drugs, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problem of sanguinarine inhibition and Eliminate problems such as scavenging effect, and achieve the effect of wide application value

Active Publication Date: 2020-03-10
SHAANXI UNIV OF SCI & TECH
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  • Abstract
  • Description
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Problems solved by technology

In addition, literature (Ding Hao, Dong Jing, Song Yi, Su Zhijun, Yu Linxue, Ai Xiaohui. Effects of 36 traditional Chinese medicines on antibacterial and biofilm elimination of tilapia-derived Streptococcus agalactiae in vitro[J]. Freshwater Fisheries, 2019,49(03):71-77.) reported that sanguinarine can inhibit the growth and biofilm formation of Streptococcus agalactiae. Capsule inhibition and clearance

Method used

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  • Application of sanguinarine in inhibition and removal of multi-drug-resistant providencia rettgeri biofilm
  • Application of sanguinarine in inhibition and removal of multi-drug-resistant providencia rettgeri biofilm
  • Application of sanguinarine in inhibition and removal of multi-drug-resistant providencia rettgeri biofilm

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[0019] The present invention will be described in further detail below in conjunction with the examples. The examples are only used to explain the content of the present invention, not to limit the present invention.

[0020] The English name of sanguinarine is Sanguinarine, and its molecular formula is C 20 h 14 ClNO 4 , the molecular weight is 367.78, the melting point is 281-285°C, and the CAS number is 5578-73-4. The molecular structure is:

[0021]

[0022] 1. Drug susceptibility test of Providencia rettgeri

[0023] The present invention takes 5 strains of Providencia rettgeri as starting strains, selects ampicillin, ampicillin / sulbactam, cefazolin, cefotetan, ceftriaxone, ceftazidime, tobramycin, piperacillin Zobactam, ciprofloxacin, levofloxacin, amikacin, cotrimoxazole, cefepime, ertapenem, imipenem, nitrofurantoin, aztreonam, gentamicin and other 18 kinds of commonly used antibiotics for testing.

[0024] Pick and culture the pure colonies for 24 hours and ...

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Abstract

The invention discloses an application of sanguinarine in inhibition and removal of a multi-drug-resistant providencia rettgeri biofilm and aims at solving the technical problems of drug resistance ofthe drug-resistant providencia rettgeri biofilm and difficulty in removal once the drug-resistant providencia rettgeri biofilm is formed. According to the fact that sanguinarine has a good providencia rettgeri biofilm inhibiting and removing effect, formation of the providencia rettgeri biofilm can be inhibited, and the lowest inhibition concentration of the biofilm is 7.81 micrograms per milliliter. The sanguinarine can be used for effectively removing a mature providencia rettgeri biofilm, and has the lowest biofilm removal concentration of 125 micrograms per milliliter. According to the invention, a natural product sanguinarine is adopted to inhibit and remove a multi-drug-resistant providencia rettgeri biofilm, can effectively relieve or solve the infection treatment difficulty causedby the providencia rettgeri biofilm, improves the cure rate, provides a new lead compound for inhibiting the formation of the providencia rettgeri biofilm and removing the mature biofilm, and has important practical significance.

Description

technical field [0001] The invention belongs to the technical field of medicine and food safety, and relates to the application of sanguinarine in the inhibition and removal of multidrug-resistant Providencia rettgeri biofilm. Background technique [0002] Providencia is a facultative anaerobic Gram-negative bacillus, which can cause food poisoning, vomiting and diarrhea, urinary tract infection and other extraintestinal infections, and can cause outbreaks in hospitals. The threat of widespread opportunistic pathogenic bacteria to human health has been paid more and more attention. In recent years, there have been increasing reports of clinical sporadic cases caused by Providencia bacteria in China. At the same time, this strain has also been detected in food. In food processing environments, there is an increased risk of cross-contamination due to contaminated food, with subsequent economic losses. Bacterial biofilms are a serious health problem worldwide due to their ab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4741A61P31/04
CPCA61K31/4741A61P31/04
Inventor 钱卫东刘淼付玉婷孙照欢何维维李康帆高悦李靖原
Owner SHAANXI UNIV OF SCI & TECH
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