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Application of sanguinarine in the inhibition and clearance of multidrug-resistant Providencia rettgeri biofilm

A Providencia spp. biotechnology, Providencia readenii technology, is applied in pharmaceutical formulations, antibacterial drugs, medical preparations containing active ingredients, etc. It can achieve the effect of wide application value, reduce the fatality rate, and solve the infection problem.

Active Publication Date: 2021-06-15
SHAANXI UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, literature (Ding Hao, Dong Jing, Song Yi, Su Zhijun, Yu Linxue, Ai Xiaohui. Effects of 36 traditional Chinese medicines on antibacterial and biofilm elimination of tilapia-derived Streptococcus agalactiae in vitro[J]. Freshwater Fisheries, 2019,49(03):71-77.) reported that sanguinarine can inhibit the growth and biofilm formation of Streptococcus agalactiae. Capsule inhibition and clearance

Method used

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  • Application of sanguinarine in the inhibition and clearance of multidrug-resistant Providencia rettgeri biofilm
  • Application of sanguinarine in the inhibition and clearance of multidrug-resistant Providencia rettgeri biofilm
  • Application of sanguinarine in the inhibition and clearance of multidrug-resistant Providencia rettgeri biofilm

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Embodiment Construction

[0019] The present invention will be described in further detail below in conjunction with the examples. The examples are only used to explain the content of the present invention, not to limit the present invention.

[0020] The English name of sanguinarine is Sanguinarine, and its molecular formula is C 20 h 14 ClNO 4 , the molecular weight is 367.78, the melting point is 281-285°C, and the CAS number is 5578-73-4. The molecular structure is:

[0021]

[0022] 1. Drug susceptibility test of Providencia rettgeri

[0023] The present invention takes 5 strains of Providencia rettgeri as starting strains, selects ampicillin, ampicillin / sulbactam, cefazolin, cefotetan, ceftriaxone, ceftazidime, tobramycin, piperacillin Zobactam, ciprofloxacin, levofloxacin, amikacin, cotrimoxazole, cefepime, ertapenem, imipenem, nitrofurantoin, aztreonam, gentamicin and other 18 kinds of commonly used antibiotics for testing.

[0024] Pick and culture the pure colonies for 24 hours and ...

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Abstract

The invention discloses the application of sanguinarine in the inhibition and removal of multi-drug-resistant Providence recei biofilms, and is used to solve the drug resistance of drug-resistant Providence recei biofilms and the formation of biofilms that are difficult to remove once formed. technical problem. According to the fact that sanguinarine has good biofilm inhibitory and scavenging effects on Providencia revei, it can inhibit the formation of biofilm of Providencia revei, and the minimum inhibitory concentration of biofilm is 7.81 μg / mL. Sanguinarine can effectively remove mature Providencia reinhardtii biofilm, and the minimum biofilm removal concentration is 125μg / mL. It uses the natural product sanguinarine to inhibit and clear the biofilm of the multi-drug-resistant Providencia raptorii, which can effectively alleviate or solve the difficulty in the treatment of infections caused by the biofilm of Providencia reinhardtii, and improve the cure rate. Inhibiting the formation of Providencia reinhardtii biofilms and clearing mature biofilms provides new lead compounds with important practical significance.

Description

technical field [0001] The invention belongs to the technical field of medicine and food safety, and relates to the application of sanguinarine in the inhibition and removal of multidrug-resistant Providencia rettgeri biofilm. Background technique [0002] Providencia is a facultative anaerobic Gram-negative bacillus, which can cause food poisoning, vomiting and diarrhea, urinary tract infection and other extraintestinal infections, and can cause outbreaks in hospitals. The threat of widespread opportunistic pathogenic bacteria to human health has been paid more and more attention. In recent years, there have been increasing reports of clinical sporadic cases caused by Providencia bacteria in China. At the same time, this strain has also been detected in food. In food processing environments, there is an increased risk of cross-contamination due to contaminated food, with subsequent economic losses. Bacterial biofilms are a serious health problem worldwide due to their ab...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4741A61P31/04
CPCA61K31/4741A61P31/04
Inventor 钱卫东刘淼付玉婷孙照欢何维维李康帆高悦李靖原
Owner SHAANXI UNIV OF SCI & TECH
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