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Application of an antibacterial traditional Chinese medicine component composition in killing biofilm

A biofilm and composition technology, applied in the direction of medical preparations containing active ingredients, antibacterial drugs, antifungal agents, etc., can solve the problems of lack of traditional Chinese medicine antibacterial agents, body damage, etc., achieve wide application value, and inhibit the formation of Effect

Active Publication Date: 2021-06-25
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although it has been reported that chelerythrine or berberine can be used together with azole drugs to exert a synergistic effect against drug-resistant fungi, these drugs often cause certain damage to the body
At present, there is still a lack of effective traditional Chinese medicine antibacterial agents against the double-species biofilm of Candida albicans and Streptococcus mutans

Method used

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  • Application of an antibacterial traditional Chinese medicine component composition in killing biofilm
  • Application of an antibacterial traditional Chinese medicine component composition in killing biofilm
  • Application of an antibacterial traditional Chinese medicine component composition in killing biofilm

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Embodiment Construction

[0021] The present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments. The embodiments are only used to explain the content of the present invention, not to limit the protection scope of the present invention.

[0022] (1) Materials, reagents and instruments

[0023] 1.1 Experimental strains

[0024] Candida albicans SC5314 was purchased from the American Type Culture Collection; Streptococcus mutans ATCC25175 was purchased from the American Type Culture Collection.

[0025] 1.2 Sources of reagents

[0026] Dimethyl sulfoxide (DMSO), normal saline, methanol, yeast extract powder, glucose, peptone, glutaraldehyde, absolute ethanol, and pentaethyl acetate were all purchased from Shanghai Sigma-Aldrich Trading Co., Ltd.

[0027] 1.3 Preparation of main reagents

[0028] YPD liquid medium: Weigh 5g of yeast extract powder, 10g of glucose and 10g of peptone, add 500mL of distilled water, and sterilize by high-pressu...

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Abstract

The invention discloses the application of an antibacterial traditional Chinese medicine component composition in killing biofilms. The invention adopts the in vitro model of biofilms to study and finds that the mixture of chelerythrine, sanguinarine and berberine is effective against Candida albicans and In vitro intervention of Streptococcus mutans dual-species biofilm, the mixture can significantly inhibit and clear the dual-species biofilm of Candida albicans and Streptococcus mutans.

Description

technical field [0001] The invention belongs to the technical field of medicine and food safety, and relates to the application of a mixture of chelerythrine, sanguinarine and berberine in inhibiting and eliminating dual-species biofilms of Candida albicans and Streptococcus mutans. Background technique [0002] Candida albicans, also known as Candida albicans, is a common oral flora and an important opportunistic pathogenic fungus in the oral cavity. Under certain conditions, it can cause a variety of oral mucosal diseases. Candida albicans is one of the most common pathogens causing deep fungal infections clinically. Streptococcus mutans is a bacterial pathogen that causes dental caries, can secondary to pulpitis and periapical periodontitis, and can even cause alveolar bone and jaw inflammation. Mixed infection of fungi and bacteria can cause local abscess, cellulitis, and severe sepsis or even death. [0003] In recent years, with the advancement of medical technology,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4741A61K31/4375A61P31/04A61P31/10
CPCA61K31/4375A61K31/4741A61P31/04A61P31/10A61K2300/00
Inventor 钱卫东王文静张家宁刘淼孙照欢杨敏付玉婷李鑫辰
Owner SHAANXI UNIV OF SCI & TECH
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