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Application of antibacterial traditional Chinese medicine ingredient composition to killing of biofilm

A technology of biofilm and composition, applied in the direction of medical preparations containing active ingredients, antibacterial drugs, antifungal agents, etc., can solve the problems of body damage, lack of traditional Chinese medicine antibacterial agents, etc., and achieve the effect of wide application value

Active Publication Date: 2020-06-05
SHAANXI UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although it has been reported that chelerythrine or berberine can be used together with azole drugs to exert a synergistic effect against drug-resistant fungi, these drugs often cause certain damage to the body
At present, there is still a lack of effective traditional Chinese medicine antibacterial agents against the double-species biofilm of Candida albicans and Streptococcus mutans

Method used

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  • Application of antibacterial traditional Chinese medicine ingredient composition to killing of biofilm
  • Application of antibacterial traditional Chinese medicine ingredient composition to killing of biofilm
  • Application of antibacterial traditional Chinese medicine ingredient composition to killing of biofilm

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Embodiment Construction

[0021] The present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments. The embodiments are only used to explain the content of the present invention, not to limit the protection scope of the present invention.

[0022] (1) Materials, reagents and instruments

[0023] 1.1 Experimental strains

[0024] Candida albicans SC5314 was purchased from the American Type Culture Collection; Streptococcus mutans ATCC25175 was purchased from the American Type Culture Collection.

[0025] 1.2 Sources of reagents

[0026] Dimethyl sulfoxide (DMSO), normal saline, methanol, yeast extract powder, glucose, peptone, glutaraldehyde, absolute ethanol, and pentaethyl acetate were all purchased from Shanghai Sigma-Aldrich Trading Co., Ltd.

[0027] 1.3 Preparation of main reagents

[0028] YPD liquid medium: Weigh 5g of yeast extract powder, 10g of glucose and 10g of peptone, add 500mL of distilled water, and sterilize by high-pressu...

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Abstract

The invention discloses application of an antibacterial traditional Chinese medicine ingredient composition to killing of a biofilm. A biofilm in vitro model is used for study, and an in vitro intervention effect of a mixture of chelerythrine, sanguinarine and berberine on a candida albicans and streptococcus mutans two-species biofilm is discovered. By using the mixture, the obvious inhibition and clearing effects can be achieved on the candida albicans and streptococcus mutans two-species biofilm.

Description

technical field [0001] The invention belongs to the technical field of medicine and food safety, and relates to the application of a mixture of chelerythrine, sanguinarine and berberine in inhibiting and eliminating dual-species biofilms of Candida albicans and Streptococcus mutans. Background technique [0002] Candida albicans, also known as Candida albicans, is a common oral flora and an important opportunistic pathogenic fungus in the oral cavity. Under certain conditions, it can cause a variety of oral mucosal diseases. Candida albicans is one of the most common pathogens causing deep fungal infections clinically. Streptococcus mutans is a bacterial pathogen that causes dental caries, can secondary to pulpitis and periapical periodontitis, and can even cause alveolar bone and jaw inflammation. Mixed infection of fungi and bacteria can cause local abscess, cellulitis, and severe sepsis or even death. [0003] In recent years, with the advancement of medical technology,...

Claims

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Application Information

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IPC IPC(8): A61K31/4741A61K31/4375A61P31/04A61P31/10
CPCA61K31/4375A61K31/4741A61P31/04A61P31/10A61K2300/00
Inventor 钱卫东王文静张家宁刘淼孙照欢杨敏付玉婷李鑫辰
Owner SHAANXI UNIV OF SCI & TECH
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