Application of chelerythrine in inhibition of colistin drug resistance gene transfer

Abstract

The invention discloses an application of chelerythrine in inhibition of colistin drug resistance gene transfer. A conjugational transfer test proves that chelerythrine can obviously inhibit the transfer of plasmids carrying a colistin drug-resistant gene mcr-1 between escherichia coli. Therefore, the chelerythrine can inhibit propagation of colistin drug-resistant plasmids, provides a new thought and source for control of colistin drug resistance, and has wide application value in the fields of medicine, food, veterinary public health and the like.

Description

technical field

[0001] The invention belongs to the field of biomedicine, in particular to the application of chelerythrine in inhibiting the transfer of colistin resistance genes. Background technique

[0002] Colistin resistance has attracted much attention in recent years. The main mechanism of colistin resistance is mutation of the binary regulatory system on the chromosome, and the resistance does not spread easily. In 2015, Chinese researchers first reported the plasmid-mediated transferable colistin resistance gene mcr-1 in pig-derived Escherichia coli, revealing the reasons for the increase of colistin resistance in animal-derived bacteria in recent years. At present, it is found that mcr-1 gene mainly exists on IncI2, IncX4 and IncHI2 plasmids of Escherichia coli, and it has been widely spread in more than 60 countries around the world. The IncI2 and IncX4 plasmids are still the most popular plasmids carrying the mcr-1 gene, and the prevalence of the mcr-1 gene se...

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