A composition for preventing and treating respiratory diseases of livestock and poultry and its preparation method

A respiratory and composition technology, applied in the field of livestock and poultry respiratory disease prevention and control, can solve the problems of affecting extraction efficiency, instability, large loss, etc., and achieve the effects of improving extraction efficiency, safe use, and reasonable proportioning

Active Publication Date: 2021-02-09
MICOLTA BIORESOURCE INC LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main components of the Boluohui injection disclosed in Comparative Document 2 are Boluohui and Andrographis paniculata. Active ingredients, but the active ingredients of Boluohui alkaloids are unstable in ethanol, and the loss is large, which greatly affects the extraction efficiency, and because it is an injection, its administration method is injection

Method used

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  • A composition for preventing and treating respiratory diseases of livestock and poultry and its preparation method
  • A composition for preventing and treating respiratory diseases of livestock and poultry and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0057] Embodiment 1: preparation embodiment

[0058] (1) Take 5000g of Anhui-produced Phyllostachys praecox leaves, and detect by HPLC method that the content of original opioid is 0.65%, allocryptine 0.12%, sanguinarine 0.15%, and chelerythrine 0.08%, with 20L not less than 80% The 0.5% sulfuric acid solution at ℃ was used for percolation, and sodium hydroxide was added to the percolation liquid to adjust pH=10 to alkali precipitation, and the obtained precipitate was vacuum-dried under reduced pressure. Allocryptine 0.3%, sanguinarine 0.18%, chelerythrine 0.12%.

[0059] (2) Take 1000 g of Coptis Rhizoma, pulverize it, and extract twice with 10 times the amount of 70% ethanol under reflux for 2 hours, then concentrate and dry the extract under reduced pressure to obtain 285 g of Coptidis Rhizoma extract; 28% of berberine hydrochloride was detected by HPLC method.

[0060] (3) Take 1000 g of dandelion, pulverize it, and extract twice with 10 times the amount of 80% ethanol u...

Embodiment 2

[0063] Embodiment 2: preparation embodiment

[0064] (1) Get 5000g of Anhui-produced fallen leaves, detect by HPLC method 0.65% of the original opioid content, 0.12% of allocryptine, 0.15% of sanguinarine, 0.08% of chelerythrine, and use 20L of 5% sulfuric acid solution Heated and refluxed at 100°C for extraction, added KOH to the extract to adjust pH=10 to alkali precipitation, and the resulting precipitate was air-dried to obtain 1750 g of extract. The content of pro-opiate was 1.18%, allocryptine was 0.26%, and sanguinarine was detected by HPLC. 0.16%, chelerythrine 0.10%.

[0065] (2) Take 1000 g of Coptidis rhizome, pulverize it, and extract 3 times with 8 times the amount of 65% ethanol under reflux for 1 h, then concentrate and dry the extract under reduced pressure to obtain 320 g of Coptidis rhizome extract; 31% berberine hydrochloride was detected by HPLC method.

[0066] (3) Take 1000 g of dandelion, pulverize it, and extract 3 times with 6 times the amount of 75% ...

Embodiment 3

[0069] Embodiment 3: preparation embodiment

[0070] (1) Get 5000g of Anhui-produced Phyllostachys abaculi, and detect by HPLC method that the original opioid content is 0.65%, allocryptine 0.12%, sanguinarine 0.15%, chelerythrine 0.08%, and use 20L 0.1% hydrochloric acid solution Soak at room temperature for 48 hours, add Ca(OH) to the extract 2 Adjust the pH to 10 for alkali precipitation, and microwave-dry the obtained precipitate to obtain 2050 g of the extract. The HPLC method is used to detect that the content of protopine is 0.98%, allocryptine is 0.22%, sanguinarine is 0.15%, and chelerythrine is 0.09%.

[0071] The extraction method of Coptidis Rhizoma extract and Dandelion extract in this embodiment is the same as that in Example 1. The percentages of the above substances are all percentages by mass.

[0072] Then in the step (1), the Boluohui leaf extract, Coptidis Rhizoma extract, and Dandelion extract were mixed at a ratio of 50%:30%:20% by mass, and the mixture...

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Abstract

The invention provides a composition for preventing and treating respiratory diseases of livestock and poultry and a preparation method thereof. The composition includes the following components in mass percentage: 50-90% of the extract of Boluohui leaves; 5%-30% of the extract of Coptidis Rhizoma; Dandelion extract 5% to 30%; Boluohui leaf extract: the mass percentage content of protopine is not less than 0.1%, the mass percentage content of allocryptine is not less than 0.1%, sanguinarine and chelidonine The sum of the mass percentages of kalethrine is not less than 0.2%. The present invention also provides a preparation method of the above composition. The pharmaceutical composition provided by the invention can be used to prevent and treat respiratory diseases of livestock and poultry, promote faster recovery of livestock and poultry, and effectively reduce the mortality rate of sick livestock and poultry.

Description

technical field [0001] The invention belongs to the technical field of prevention and treatment of respiratory diseases of livestock and poultry, in particular relates to a composition for preventing and treating respiratory diseases of livestock and poultry and a preparation method thereof, in particular to a combination of various natural plant extracts for preventing and treating respiratory diseases of livestock and poultry substances and their preparation methods. Background technique [0002] In recent years, with the rapid development of the livestock and poultry breeding industry and the improvement of the level of intensification, the density of livestock and poultry breeding has increased, resulting in an increasing incidence of some diseases. Pathogenic microorganisms are very harmful to the livestock and poultry breeding industry. They often cause diseases of the digestive tract and respiratory tract, retard the growth of young livestock and poultry, and make it ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/718A61P11/00
CPCA61K36/288A61K36/66A61K36/718A61K2236/33A61K2236/331A61K2236/333A61P11/00A61K2300/00Y02A40/70
Inventor 曾建国陈燕乐杨广民
Owner MICOLTA BIORESOURCE INC LTD
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